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Driving Toward Nanopores

Codon

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA 100
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How nucleolar stress accelerates aging in mice

Drug Target Review

For his postdoctoral stay he joined the group of André Nussenzweig, where he started to work on DNA repair, particularly focusing on the role of histone H2AX. In 2005, he joined CNIO to lead the Genomic Instability Group where he has been ever since.

RNA 65
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Precision Medicine in the Genomic Era

DrugBank

In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., Conclusion Since the first GWAS was published in 2005, there have been more than 50,000 significant variant-trait associations identified. by altering its accessibility to transcriptional machinery).

Disease 98
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Genetic Signature for Drug Addiction Revealed in New Analysis of More Than A Million Genomes

PLOS: DNA Science

Now a report in Nature Mental Health from an international team led by researchers at Washington University in St. “RFLPs” are sites in a DNA sequence where a bacterial enzyme, called a restriction enzyme, cuts. See The Age of the Pangenome Dawns , here at DNA Science from a few months ago.)

DNA 52
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HOOKIPA Announces Positive Phase 2 Interim Safety, Immunogenicity, and Efficacy Data for its Cytomegalovirus Vaccine Candidate HB-101

The Pharma Data

Compared to placebo, participants vaccinated with three HB-101 doses had: a 48 percent reduction in CMV viremia (presence of CMV DNA in the blood); a 42 percent reduction in the use of antiviral therapy; and. 2005; 49(3):873-883. no CMV disease (compared to 2 out of 14 cases in the placebo group).

Vaccine 40
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Article FDA Thank You FDA advisors endorse minimal residual disease (MRD) as accelerated approval endpoint for multiple myeloma

Agency IQ

The approvals were granted on the basis of two intermediate endpoints – overall response rate (ORR) and duration of response (DOR), based on International Myeloma Working Group (IMWG) criteria. These drugs were both approved for relapsed or refractory (RR) MM patients who had already received at least four prior lines of therapy.

FDA 40
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Measuring the Black Death

Codon

pestis DNA in the dental pulp of skeletons in various medieval burial sites across Europe, which corresponded to recorded outbreaks, including in cemeteries used exclusively for Black Death victims. For example, in 2005, statistician George Christakos and his colleagues compiled data from over a hundred European cities.

Disease 118