The Pharma Data

NOVEMBER 22, 2020

The two companies have been in a strategic research collaboration agreement since 2015, focused on using CRISPR Cas-9 to discover new potential treatments. Cas-9 represents the Cas9 protein, an enzyme that cuts foreign DNA. Once the DNA has been cut, the cell’s natural repair mechanisms kick in. ” Source link.

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PLOS: DNA Science

JUNE 8, 2023

That was so in 1977, when “intervening DNA sequences” – aka “introns” – were discovered to interrupt protein-encoding genes. Because the edits are in RNA, and not DNA, they are fleeting. The post How (and Why) the Octopus Edits its RNA appeared first on DNA Science.

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Broad Institute

JULY 10, 2023

At the Broad, Martin is also helping lead data analysis in two large international studies that are sequencing the DNA of people from Africa and Latin America to learn about the genetics of severe mental illness. “I think our work is helping move a lot of researchers to study underrepresented populations, and I’m really proud of that.”

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Drug Target Review

APRIL 9, 2024

For his postdoctoral stay he joined the group of André Nussenzweig, where he started to work on DNA repair, particularly focusing on the role of histone H2AX. Since 2015 Oscar is also the Vice Director of CNIO as well as Director of its Molecular Oncology Programme, and professor at the Karolinska Institute in Sweden.

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Dark Matter Blog

APRIL 4, 2023

Prior to 2015, I had a casual relationship, at best, with targeting RNA. Targeting RNA is a Whole New World Then in 2015, I became smitten and eloped with RNA, setting out to build a company devoted to bringing to bear industrial drug discovery concepts and methods on a new problem of drugging RNA with small molecules.

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The Pharma Data

DECEMBER 17, 2020

She assists both patients and physicians in completing this revolutionary gene test that determines if a patient is on the right drug, at the right dose, for their specific DNA. After relocating to Montgomery, Alabama, she retained this title and its responsibilities at Jackson Hospital from 2008 to 2015.

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Molecule Blog

AUGUST 13, 2021

His work focused on the cross-talk between DNA repair and mitochondrial function in aging and has been honored by a number of competitive awards. He now runs one of the largest research programmes in Europe focusing on aging.

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DrugBank

JUNE 27, 2023

In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., whitehouse.gov [link] (2015). Nature 526 , 68–74 (2015). Coding mutations have a more direct effect through direct alteration of a gene product.  Obama White House Archive.

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Agency IQ

AUGUST 11, 2023

The International Agency for Research on Cancer (IARC), part of the World Health Organization (WHO), deemed glyphosate to be “ probably carcinogenic to humans ” (Carcinogen 2A) in 2015. and EU, however, have diverged from this conclusion. A close examination of the full risk assessment indicates exactly what these data gaps are.

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Codon

JUNE 13, 2024

billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end. Credit: Oriane Hidalgo Per the book Cell Biology by the Numbers , each base pair of DNA occupies 1 nm 3 of space.

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DNA Molecular Biology Virus Cell Biology 63

Drug Target Review

SEPTEMBER 4, 2023

5 Cytology-based profiling can facilitate antibiotic discovery efforts and, these assays assess cell cycle progression, nuclear and mitochondrial DNA content, mitochondrial DNA replication, nuclear DNA damage, mitochondrial membrane potential, and lysosome structure and function. and Wolfgang, H. Gabriela, S. Andreas, B.,

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Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. Nature Communications 6 , 6246 (2015). 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases. Münch RC, et al.

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Codon

APRIL 23, 2024

While astronauts are easily protected from UV by glass or a thin sheet of metal, microbes placed outside on Mars would be killed in mere minutes as the ultraviolet radiation shreds through DNA and destabilizes proteins that carry out important cellular processes. 2 Our microbial engineering efforts include plans for biocontainment.

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Broad Institute

FEBRUARY 29, 2024

Related news Antibiotic-resistant microbes date back to 450 MYA, well before the age of dinosaurs One day in 2015, Joseph Manson placed in his refrigerator the colon of a wild turkey he’d just hunted near his small farm in South Carolina.

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PLOS: DNA Science

SEPTEMBER 5, 2024

Diagnosis began to shift from a body-part basis to a molecular one, which I wrote about in “Mutation and location important in cancer treatment” for The Lancet in 2015. Analyzing DNA patterns using AI may replace time-consuming process DNA and genomic sequencing tests, Yu said.

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Drug Target Review

AUGUST 9, 2023

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

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DrugBaron

NOVEMBER 22, 2022

In 2015, Methuselah Health was founded to investigate the role of proteome instability during ageing, and the extent to which the instability of specific proteins might underlie development of age-related diseases – a concept that arose from the ground-breaking work of Professor Miro Radman (which DrugBaron highlighted previously).

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PLOS: DNA Science

SEPTEMBER 21, 2023

What steps should researchers take when attempting to acquire DNA samples from modern descendants? I was lucky at the ASHG meeting in October 2015. I didn’t even recall providing a DNA sample to Ancestry.com years ago at a conference, when, in 2018, a woman who thought she was my cousin contacted me.

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The Premier Consulting Blog

APRIL 25, 2023

ICH Harmonised Guideline M7(R1): Assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk. Summary basis of approval (SBA) for Aristada (NDA 207533, 10/5/2015), [link] [accessed 23 March 2023]. 8] US Food and Drug Administration (FDA).

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The Pharma Data

OCTOBER 14, 2020

Lanifibranor is believed to be the first drug candidate to be granted this status for the treatment of NASH since January 2015. Food and Drug Administration granted Breakthrough Therapy designation to France-based Inventiva’s experimental NASH treatment lanifibranor.

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Codon

APRIL 19, 2023

kilograms of CO 2 and 330 liters of water to make one kilogram of bananas, according to a 2015 study from Ecuador. In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening.

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Codon

APRIL 19, 2023

kilograms of CO 2 and 330 liters of water to make one kilogram of bananas, according to a 2015 study from Ecuador. In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening.

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Codon

MARCH 19, 2024

Most cells (excluding T-cells and B cells after V(D)J recombination) in our body contain the same DNA but appear and behave in distinct ways: A neuron looks and acts very differently from a hepatocyte. While DNA is relatively stable , the epigenome is not; it has to orchestrate changes in cell state, cell type, and more.

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The Pharma Data

MAY 18, 2021

MMR is a molecular mechanism that functions to correct certain errors that can spontaneously occur during DNA replication. This companion diagnostic (CDx) provides clinicians with a standardised testing option that uses a comprehensive panel of DNA mismatch repair (MMR) biomarkers tested by immunohistochemistry (IHC). 2015:26(1):40-45.

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The Pharma Data

SEPTEMBER 2, 2021

Changing treatment paradigms with industry-leading PARP inhibitors and next-wave DNA damage response therapies. AstraZeneca obtained full oncology rights to monalizumab from Innate Pharma in October 2018 through a co-development and commercialisation agreement initiated in 2015. DNA damage response. Abstract #LBA49.

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Advarra

AUGUST 10, 2023

However, recent advancements in the clinical use of recombinant DNA (rDNA) technology creates opportunities for changing this calculation and addressing a great, unmet medical need. “I The pace has since increased: 2022 and 2023 each saw three approvals issued.

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The Pharma Data

JUNE 30, 2021

Mismatch repair deficiency (dMMR) occurs when the proteins that repair mismatch errors in DNA replication are missing or non-functional, leading to microsatellite instability-high (MSI-H) tumors. Approximately 5% of metastatic CRC patients have dMMR or MSI-H tumors.

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Broad Institute

MAY 14, 2024

By 1984, he and Brookhaven colleague John Dunn successfully identified and cloned the protein within T7 that was responsible for rapidly copying T7 DNA into many corresponding strands of RNA — a critical step in the bacteriophage’s ability to infect E. coli genome and let the E. coli had no built-in way to shut it off.

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Codon

SEPTEMBER 22, 2024

The first reliable protocols to differentiate human iPSCs into PGC-like cells in vitro were published in 2015. Erasing methyl groups on DNA is necessary for normal egg and sperm development. The most important step seems to be erasing DNA methylation. A meiotic cell nucleus beneath the microscope. Image provided by the author.

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Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

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Codon

MAY 15, 2023

Ratcliff, figured this out back in 2015. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. From Davis J.R.

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Codon

MAY 15, 2023

Ratcliff, figured this out back in 2015. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. From Davis J.R.

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Drug Target Review

OCTOBER 4, 2023

2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. DNA damaging agent-based antibody-drug conjugates for cancer therapy. While highly effective against proliferating tumour cells, ADCs with antimitotic payloads typically struggled against slower-growing cancer types.

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PLOS: DNA Science

MARCH 30, 2023

Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA). The agency started tracking it in 2013, and the spread accelerated in 2015. The post The New Fungus Among Us, Candida auris appeared first on DNA Science.

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PLOS: DNA Science

APRIL 4, 2024

It debuted in January 2024 , but the company has been around since 2015. The post How Lume Whole Body Deodorant Was Inspired by a Genetic Disease appeared first on DNA Science. As soon as I started researching Lume, my social media and even TV blew up with ads for these products, as if I have suddenly begun to stink.

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Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

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