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By Leah Eisenstadt January 6, 2025 Credit: Courtesy of the Xavier and Schreiber labs. Also featured are the FKBP12 binding motif (light blue triangle), the DNA barcode (red double helix), and the combinatorial library element (red hexagon). Online Jan 2, 2025. Paper cited Tan ZY, et al. Cell Chemical Biology.
Keserű ACS Medicinal Chemistry Letters 2025 16 (6), 991-997 DOI: 10.1021/acsmedchemlett.4c00622 Here, we have targeted a sparsely studied binding site at the junction of the coiled-coil and DNA-binding domains and discovered several new lead-like covalent inhibitors by virtual screening. Mihalovits, László Petri, Qirat F.
Their latest assay processes four to 24 libraries per batch and detects gene amplifications, fusions, deletions and other cancer biomarkers from both DNA and RNA inputs. Their latest assay processes four to 24 libraries per batch and detects gene amplifications, fusions, deletions and other cancer biomarkers from both DNA and RNA inputs.
Nomura Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.5c02801 However, these compounds cannot therapeutically access largely intrinsically disordered truncated splice variants of AR, such as AR-V7, which only possess the N-terminal transactivation domain and DNA-binding domain and are missing the ligand-binding domain.
Scientists engineer CRISPR enzymes that evade the immune system By Allessandra DiCorato January 9, 2025 Breadcrumb Home Scientists engineer CRISPR enzymes that evade the immune system The new genome-editing tools could lead to safer, more efficient gene therapies. Online January 2, 2025. Tan Molecular Therapeutics Center at MIT.
Scientists create next generation of tools in battle against brain disease By Corie Lok May 21, 2025 Breadcrumb Home Scientists create next generation of tools in battle against brain disease The findings contained in eight studies could lead to targeted gene therapies for brain disorders.
Altasciences at ASGCT 2025: An Open Forum for All Things Gene and Cell Therapy | By Kaylyn Koenig aasimakopoulos Thu, 07/10/2025 - 08:00 I recently returned from attending the American Society of Gene and Cell Therapy (ASGCT) Annual Meeting. WHO WAS AT ASGCT 2025? Curious to see the science in action?
An ancient RNA-guided system could simplify delivery of gene editing therapies By Corie Lok February 27, 2025 Breadcrumb Home An ancient RNA-guided system could simplify delivery of gene editing therapies The programmable proteins are compact, modular, and can be directed to modify DNA in human cells.
David Liu receives Breakthrough Prize in Life Sciences By Corie Lok April 5, 2025 Breadcrumb Home David Liu receives Breakthrough Prize in Life Sciences Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine.
By Allessandra DiCorato May 19, 2025 Related content The Genetics of Eating Disorders study A new direct-to-participant effort now underway is giving people the opportunity to participate in the largest and most diverse genetic study of anorexia nervosa and other eating disorders to date.
2025) For a second round of filtering, the team introduced a new method called PLACER (Protein- Ligand Atomistic Conformational Ensemble Resolver), which predicts how atoms should arrange themselves based on physical and chemical principles. They synthesized DNA encoding each protein variant, expressed the proteins in E.
To make the MM-like score more clinically accessible, the team is developing a test based on liquid biopsies instead of bone marrow biopsies to collect DNA. Online May 21, 2025. In the future, the MM-like score could be used in clinical practice to inform decisions about early intervention. Nature Genetics.
mcottam Tue, 06/24/2025 - 12:43 Download now to learn from biopharma industry leaders about how methylation-based ctDNA detection for precise MRD and response monitoring can accelerate your clinical trials.
Case Study: Two Examples of Successful Automation Integration at Altasciences for Pharmacokinetic Studies pmjackson Fri, 06/06/2025 - 09:01 By Martin Rougée, Optimization Scientist, Bioanalytical Operations Automation offers several advantages to any industry.
Regulatory Guidance for Oligonucleotide Bioanalysis in Drug Development pmjackson Wed, 02/19/2025 - 21:30 The unique physicochemical properties of oligonucleotides require the use of specialized bioanalytical approaches, with key considerations including selectivity and specificity, sensitivity, stability, and matrix effects.
By Broad Communications June 24, 2025 Credit: Casey Atkins David Liu is a core member at the Broad Institute where he is the Richard Merkin Professor and director of the Merkin Institute for Transformative Technologies in Healthcare. Some of these treatments, like K.J.’s,
By Allessandra DiCorato January 14, 2025 Credit: Maria Nemchuk, Broad Communications Eric Minikel and Sonia Vallabh run a lab with a singular focus: preventing and treating prion disease within their lifetime. Online January 14, 2025. Theres still a long way to go to make this a therapy, Minikel said. Paper cited An M, Davis JR, et al.
On April 10, 2025, the US FDA announced that it has a long-term plan to eliminate conventional animal testing in drug development, starting with monoclonal antibodies (mAbs).[ REFERENCES: [1] FDA News Release (April 10, 2025): FDA Announces Plan to Phase Out Animal Testing Requirement for Monoclonal Antibodies and Other Drugs.
Gene editing disrupts Huntingtons mutation in mice By Allessandra DiCorato May 27, 2025 Breadcrumb Home Gene editing disrupts Huntingtons mutation in mice Making single-letter edits in stretches of repeated DNA stopped or reversed the genetic change that causes Huntingtons disease and Friedreichs ataxia.
Retrieved 17 April 2025. ^ “Qalsody- tofersen injection” DailyMed. It is administered as an intrathecal injection. [3] 3] The most common side effects include fatigue, arthralgia (joint pain), increased cerebrospinal (brain and spinal cord) fluid white blood cells, and myalgia (muscle pain). [3] 3 November 2006. 25 April 2023.
Plastic leaves do not emit organic signals and contain no DNA, so any mimicry could imply some kind of primitive vision. ” Asimov Press (2025). Martin Bourdev is an engineer at Amgen Thousand Oaks supporting antibody drug production. He is from Palo Alto and is currently based in Los Angeles. Cite: Bourdev M.
2025 holds to be a transformative year for us, with the potential for multiple milestones to come to fruition, with the biggest value inflection being the interim clinical data from our lead asset KRRO-110, a potential best in class compound for patients with Alpha-1 antitrypsin deficiency (AATD). Over the last 4.5
Certain CRISPR components can add short DNA sequences from the genomes of defeated viruses into the bacterium’s own genome, creating a type of protective “memory.” If the same virus invades the cell a second time, the gRNA’s spacer sequence will bind to the matching viral DNA sequence, then be cut by the Cas protein.
Art and technology often intersect in this way: a brush, a chisel, a 3D printer, DNA encoded with the image of a Germanic Rune , a biocompatible implant that induced the growth of an ear on a forearm, a bioprinter, CRISPR editing that induces pigmentation in bacteria. ” Asimov Press (2025). Cite: Nitkey S. Join Asimov Press.
Published June 11, 2025 Ben Fidler Senior Editor post share post print email license The FDA on June 11, 2025 approved Nuvation's Ibtrozi for ROS1-positive non-small cell lung cancer. Track the deals that are happening here. Sanofi’s $9.1
A post-ASCO update on tumor targets DLL3, B7H3 and HER3 July 2025 Paul D Rennert, SugarCone Biotech LLC Introduction: DLL3, B7H3 and HER3 are compelling tumor antigens to target with cancer therapeutics. Clinical development is extensive, as detailed by @ByMadeleineA at ApexOnco ( [link] ; [link] ).
DNA sequencing and synthesis costs have dropped precipitously, in part, because maintaining Carlson curves became a rallying point for the field. ” Asimov Press (2025). For starters, we not only need faster, cheaper options (supply) but also people excited to use them (demand). ” by Heidi Huang. Cite: Malina, S.
FRIDAY, July 18, 2025 — A new IVF technique helped eight babies in the U.K. All eight children were born using a method that uses DNA from three people: the. avoid serious inherited diseases, and scientists are calling it a breakthrough.
Unfortunately, this years event, scheduled for February 27-28, 2025, in Washington, DC, was abruptly postponed less than one week before it began. Thats why Worldwide Clinical Trials was committed to ensuring the rare disease community still had a space to share knowledge, resources, and support on Rare Disease Day 2025.
DNA sequencing with the Blended Genome Exome (BGE) By Rose Circeo June 12, 2025 Breadcrumb Home DNA sequencing with the Blended Genome Exome (BGE) The Primer on Medical and Population Genetics is a series of informal weekly discussions of basic genetics topics that relate to human populations and disease.
FRIDAY, June 13, 2025 — CT scans might be able to prevent more colon cancers than stool DNA tests, a new study says.CT colonography performed every three to five years could ward off more cases of cancer than DNA testing of stool to look for e.
TUESDAY, March 25, 2025 -- If you’re one of the 15 million people who shared your DNA with 23andMe, stop whatever you're doing. Experts say now is the time to delete your data. The genetic testing company filed for bankruptcy March 23 and is.
THURSDAY, April 3, 2025 -- An experimental blood test might be able to help doctors predict whether someone will recover their mobility following a spinal cord injury.The test looks for fragments of spinal cord DNA floating freely in a persons b.
WEDNESDAY, April 16, 2025 -- A new blood test can help predict if melanoma survivors will have a future bout with skin cancer, researchers say.The test looks for DNA fragments that are shed by tumors and float free in a persons bloodstream.About 8.
These protein designs often require complex cloning strategies, including minimal sequence designs and repetitive motifs, which can be tedious to clone without modern DNA synthesis techniques.
Cas9 ancestor engineered into a compact genome editing tool By Tom Ulrich May 14, 2025 Breadcrumb Home Cas9 ancestor engineered into a compact genome editing tool Researchers adapt a compact RNA-guided enzyme from bacteria for a variety of DNA editing tasks in human cells. Ten were capable of editing DNA in human cells.
Modifications to the epigenome, such as DNA hypermethylation, modify the expression of genes by increasing or decreasing their expression without altering the genes themselves. One way we are doing this at Life Biosciences is through partial epigenetic reprogramming. The epigenome drifts with age, leading to dysregulated gene expression.
Nonviral CRISPR-based knock-in of chimeric antigen receptor transgenes into T cells for cell therapy dwunderlin Fri, 02/14/2025 - 14:52 Thu, 04/03/2025 - 11:00 Resource Type Webinar Krishanu Saha, PhD Max Sellman Join us for an insightful webinar on the latest advancements in cell and gene therapy, focusing on the innovative Cas9-CLIPT technology.
Building bridges between Denmark-based and Broad researchers By Corie Lok March 27, 2025 Breadcrumb Home Building bridges between Denmark-based and Broad researchers The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease is forging connections between Danish and Broad scientists. Here are two of their stories.
This energy effectiveness is aligned to the Company’s Ambition Zero Carbon programme that commits to zero carbon emigrations from its operations across the world by 2025, and for its entire value chain to be carbon negative by 2030. The life lores cluster in Cambridge The life lores cluster in Cambridge is the most productive in Europe.
In its Fiscal Year 2025 budget proposal , the FDA requested that Congress “eliminate the statutory distinction between the approval standard for biosimilar and interchangeable biosimilar products” and “deem all approved biosimilars to be interchangeable with their respective reference products.” Any CMC changes (e.g.,
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