Molecular Design

JULY 6, 2025

A bioactivity data set assembled in this manner would have a single bioactivity data value for each compound and I would take a look at how many compounds that data is available for because it might be possible to use this information for deciding whether or not to build a QSAR-like ML model.

Biochemical Assays 71

Biochemical Assays Biophysical Assays Targeted Protein Degradation Drugs 71

Drug Target Review

NOVEMBER 1, 2023

We often screen using a biochemical assay, but we can conduct cell-based screening as well. For fragment screening, we can screen with biophysical methods, such as thermal shift assays or, you may have heard about Surface Plasmon Resonance (SPR) which is a very sensitive biophysical technique used for fragment screening.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Molecular Design

SEPTEMBER 18, 2024

In the Compatibility Issues section the authors state: Looking beyond laboratory-to-laboratory variability of assays that are nominally the same, there are numerous reasons why literature results for different assays measured against the same “target” may not be comparable. and f > 1.0 and 27% are greater than 1.0.

Biochemical Assays 68

Biochemical Assays Drugs Biophysical Assays Cell Based Assays 68