Remove Biophysical Assays Remove Drug Development Remove Screening Hits
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Advancements in hit identification for membrane protein drug discovery

Drug Target Review

GPCRs are critical targets for drug development due to their involvement in numerous disease pathologies, with many medications working by either activating or inhibiting these receptors. This stability enables the application of hit identification approaches such as fragment-based screening (FBS). doi:10.1016/j.apsb.2022.02.002.

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Target-directed cancer: protein-ligand interactions  

Drug Target Review

We can look at the detailed binding modes of our compounds bound to their protein targets in X-ray crystallography, and for drug targets or complexes that are difficult to crystallise we can use cryo-electron microscopy (cryoEM) as well. In 2019 he became Reader in Structural Biology and Cancer Drug Discovery.