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Time for change: non-human primates in drug research

Drug Target Review

Persistent challenges with NHP use Despite their biological relevance, using live NHPs in research poses several major challenges: Ethical concerns NHPs, due to their advanced cognition and social behaviour, are at the centre of ongoing ethical debates. Supply chain disruptions Availability is a critical bottleneck in NHP-based research.

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Guest Blog: Reflecting on the 2024 Society of Toxicology of Canada Symposium, by Ria Falvo, Director, Reporting

Alta Sciences

Guest Blog: Reflecting on the 2024 Society of Toxicology of Canada Symposium, by Ria Falvo, Director, Reporting pmjackson Fri, 01/31/2025 - 15:47 Ria Falvo, Director of Reporting, and Rina Massarelli, Associate Director of Safety Reporting, in Toronto, Ontario, for the 2024 STC Symposium.

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A New Type of Bookworm: Bringing Patient Perspectives Into the Classroom?

KIF1A

In this blog post, KIF1A.ORG Chief Science Officer Dr. Dominique Lessard describes a unique cross disciplinary experience with multiple scientific stakeholders in the rare disease space, all focused around our holistic understanding of KAND. What do worms, a classroom full of students, and members of the KAND family community have in common?

Disease 98
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A Ray of Molecular Beauty from Cryo-EM

NIH Director's Blog: Drug Development

The research team was led by NIH’s Sriram Subramaniam, H. Eric Xu, Van Andel Research Institute, Grand Rapids, MI, and Anthony Kossiakiff, University of Chicago. They did it using cryo-electron microscopy (cryo-EM), a groundbreaking technique featured several times here on my blog. 2011 Jul 19;477(7366):549-55.

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Role of second messengers in the cell | BMG LABTECH

BMG Labtech

Effectors of signal transmission events Second messengers are small molecules or ions that transmit signals received at the cell surface to the inside environment of the cell (Fig.

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Engineering the brightest proteins from the depths | BMG LABTECH

BMG Labtech

In this blog, we look at some of the bioluminescent tools that have been developed from proteins isolated from luminescent organisms flourishing in these environments. Researchers eventually cloned the genes encoding different luciferase enzymes to overexpress these light-emitting proteins for further study.

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A Defense of Peer Review

Codon

He suggests that peer review doesn’t “do the thing it’s supposed to do” — namely, “catch bad research and prevent it from being published,” so perhaps scientists would be better off uploading PDFs to the internet where review and oversight can happen post-publication. Some politicians, such as Rep.

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