Drug Target Review

APRIL 7, 2025

The challenge of GPCR drug discovery G protein-coupled receptors (GPCRs) are one of the most desirable and challenging target classes in drug discovery, as their mutation can lead to a wide range of diseases such as cancer, cardiovascular disorders and neurological conditions.

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The Pharma Data

JUNE 25, 2025

The designation is reserved for medicines aimed at treating rare diseases that affect fewer than 200,000 people annually in the United States. The company has emphasized that its investigational therapies are designed not only to control symptoms but to alter the course of disease.

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Broad Institute

MAY 21, 2025

The $400,000 prize, to be shared among the four winners, recognizes their role in creating and advancing a technology that has reshaped how physicians treat leukemia, lymphoma, and multiple myeloma, and is now showing promise in treating autoimmune and infectious diseases. A single dose of the engineered cells wiped out signs of disease.

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SugarCone Biotech

MARCH 24, 2025

These agents simultaneously bind to a tumor-associated protein on cancer cells and the CD3 protein on T-cells, facilitating a targeted anti-cancer immune response. Consequently, these drugs have limited ability to keep patients disease-free and limited impact on patient survival.

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The Pharma Data

JUNE 15, 2025

Importantly, both cases of ALF have been reported exclusively in non-ambulatory individuals with Duchenne muscular dystrophy — a population that typically bears a heavy disease burden — underscoring the need for careful and tailored approaches to their care. Sarepta’s Chief Scientific Officer and Head of Research and Development.

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Alta Sciences

JULY 7, 2025

One important aspect of toxicity studies is determining whether the drug produces undesired immune effects. The focus is to ensure that the drug does not have any potential to induce an excessive immune response, particularly cytokine storm, which can lead to severe adverse effects and impede clinical development.

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Drug Target Review

APRIL 18, 2025

With an extensive background in these fields, Ichim is dedicated to advancing personalised cellular therapies aimed at addressing age-related diseases, with a special focus on cancer and liver failure. Ichim’s work at Immorta Bio is focused on transforming the way we approach age-related diseases and cancer treatment.

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Drug Target Review

DECEMBER 4, 2024

G protein-coupled receptors (GPCRs) represent a cornerstone of modern drug discovery due to their crucial role in regulating human physiology and their involvement in numerous diseases. The MC4R-based ConfoGen was used to immunize llamas, resulting in an immune response that generated a highly diverse panel of MC4R-specific agonists.

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The Pharma Data

JUNE 15, 2025

.” Duchenne muscular dystrophy is a rare, X-linked, degenerative muscle disease predominantly affecting boys. The disease profoundly impacts the ability to walk and perform daily routines, with most patients becoming non-ambulatory by their teenage years.

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The Pharma Data

JUNE 9, 2025

According to Thomas Triomphe, Executive Vice President of Vaccines at Sanofi, the product has been administered to over 250,000 infants in real-world settings, backed by more than 40 studies demonstrating its effectiveness in preventing RSV lower respiratory tract disease.

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Codon

NOVEMBER 3, 2024

Physicians working in the early 20th century had little choice but to treat the world’s most rampant infectious disease with methods such as these. But even now, more than a century later, TB remains the deadliest infectious disease on Earth, killing about 1.2 million people every year. tuberculosis.

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Codon

JUNE 5, 2025

Gray, in London to discuss the significance of her recovery at the Third International Summit on Human Genome Editing , described Casgevy as “a new beginning for people with sickle cell disease.” ” Despite its association with genome editing, 1 CRISPR didn’t start out as a tool for fighting genetic disease.

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The Open Targets Blog

JANUARY 30, 2025

Amongst other tasks, gget opentargets can quickly find diseases and drugs associated with a specific gene. For example, to find drugs associated with the human IL13 gene (Ensembl ID ENSG00000169194*), a cytokine that plays an important role in allergic inflammation and immune response to parasite infection, you can use: # Install gget !pip

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The Pharma Data

JUNE 12, 2025

GSK Licenses Shigella Vaccine Candidate to Bharat Biotech in Push for Global Health Equity GSK today announced a significant step forward in the battle against Shigella a leading cause of diarrhoeal disease and death in children under five by licensing its Shigella vaccine candidate, altSonflex1-2-3 , to Bharat Biotech International Limited (BBIL).

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Broad Institute

JUNE 25, 2025

Related news Single-cell analysis of Crohn’s disease reveals a detailed picture of inflammation in the gut Up to half of patients with Crohn’s disease, an inflammatory bowel disease, develop a complication called fibrosis, where the gut becomes scarred and obstructed, causing pain and bloating.

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Conversations in Drug Development Trends

OCTOBER 14, 2024

Autoimmune diseases and bone health conditions are not just medical challenges – they’re personal battles that millions of people fight every day. Furthermore, the diagnosis of the autoimmune diseases could be a challenge and requires several kinds of evidence.

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Perficient: Drug Development

APRIL 15, 2025

This pattern may relate to differences in immune response, organ-specific vulnerability, or patterns of healthcare utilization. Differential Immune Response: Women with Long COVID typically show higher levels of IL-6 compared to men, particularly those with central sensitization phenotypes.

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The Pharma Data

JUNE 12, 2025

Evidence shows that NUMELVI is at least 10-fold more selective for JAK1 than for the other JAK family members , which underpins its ability to ease pruritus without causing significant side effects related to hematopoietic dysfunction or a broad dampening of the immune response. Source link

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Science Daily: Pharmacology News

JUNE 18, 2024

Tests, in mice, of a drug developed by the researchers showed that regulatory T cells can be attracted to specific body parts, boosted in number, and activated to suppress immune response and rebuild tissue.

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Science Daily: Pharmacology News

DECEMBER 13, 2023

Their findings uncover detailed information that could help overcome the limitations of today's immunotherapies and identify new drug targets for a wide range of diseases, including autoimmune diseases and cancer.

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Science Daily: Pharmacology News

JULY 10, 2024

Scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and show that reversing this defect may potentially reverse the disease.

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Science Daily: Pharmacology News

APRIL 3, 2025

A switch of just two weeks from a traditional African diet to a Western diet causes inflammation, reduces the immune response to pathogens, and activates processes associated with lifestyle diseases. This study highlights the significant impact of diet on the immune system and metabolism.

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Science Daily: Pharmacology News

OCTOBER 24, 2024

A strain of the bacterium harbored in the children's gut microbial communities possessed a previously unknown gene capable of producing and metabolizing key molecules involved in regulating many important functions ranging from appetite, immune responses, neuronal function, and the ability of pathogenic bacteria to produce disease.

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Drug Target Review

OCTOBER 16, 2023

How can PDOs revolutionise drug discovery and deepen our understanding of disease? Patient-derived organoids (PDOs) are proliferative 3D cell structures derived from tissue samples of both healthy and diseased tissue. Improved translatability to the patient and the disease state.

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Drug Target Review

SEPTEMBER 5, 2023

By employing a mouse model of Parkinson’s disease, the researchers have illuminated a surprising revelation: it’s the border-associated macrophages (BAMs), not the microglia, that steer the neuroinflammatory response within the brain. However, identifying the precise cells presenting the antigens remained elusive.

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SCIENMAG: Medicine & Health

JUNE 12, 2023

Peer-reviewed / Randomised Controlled Trial / People Study of healthy US adults found that a single dose of the VLA1553 vaccine candidate was generally safe, well tolerated and provokes an immune response.

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Plenge Gen

APRIL 7, 2020

Pharmacologic intervention has the opportunity to impact disease progression in the SARS-CoV-2 / COVID-19 crisis. … The post Drug repurposing in SARS-CoV-2 / COVID-19: preventing the maladaptive immune response leading to critical disease requiring ICU care. The views expressed here are my own.]

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Drug Target Review

JULY 4, 2023

Among the many remarkable components that make up this complex defence network, T cells have emerged as powerful guardians, orchestrating an array of immune responses with great precision.

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Immune Response Engineering Treatment Therapies 52

Broad Institute

OCTOBER 15, 2024

By Ari Navetta October 15, 2024 Credit: Allison Colorado, Broad Communications Eric Brown is studying the links between the microbiome and disease. The Xavier Lab looks at interactions between microbes in your gut and your immune system, and diseases such as arthritis and inflammatory bowel disease (IBD).

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The Pharma Data

DECEMBER 4, 2021

The first peer-reviewed study in North America examining the timing between the first and second doses of COVID-19 mRNA vaccines shows that a longer dose interval leads to a stronger immune response. The study is funded by the Government of Canada through its COVID-19 Immunity Task Force (CITF).

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The Pharma Data

AUGUST 16, 2021

Better activation of innate and adaptive immune responses was achieved with CV2CoV, resulting in faster response onset, higher titers of antibodies, and stronger memory B and T cell activation as compared to the first-generation candidate, CVnCoV. “In Induction of innate immunity was investigated via specific cytokine markers.

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Drug Target Review

SEPTEMBER 9, 2024

functions to reset the immune system and potentially provide remission for allergic diseases? 1104 acts upstream in the inflammatory response, targeting one of the first key players: antigen-presenting cells (APCs). In allergic diseases, APCs identify and present unknown antigens to the immune system.

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Drug Target Review

AUGUST 11, 2023

1 The study reveals a novel bioinformatic approach and tool that holds the potential to empower researchers in designing vaccines capable of inducing a stronger immune response. By selecting specific segments of proteins that elicit robust immune reactions, these vaccines could offer enhanced protection against diseases.

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Broad Institute

JANUARY 19, 2024

By examining the genomes of bacteria collected from hundreds of people with persistent Salmonella infections, they discovered genetic mutations that both reduce the bacteria’s “virulence,” or ability to infect, and dampen the host’s immune responses, creating a kind of molecular camouflage that shields the bacteria from the immune system’s gaze.

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addgene Blog

FEBRUARY 13, 2024

Monoclonal antibody drugs are popular therapeutics for a plethora of disease conditions, from cancer to autoimmune disorders. Antibodies administered as drugs are still immunogenic, meaning that they elicit an immune response from the body.

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The Pharma Data

NOVEMBER 10, 2020

Canadian biopharmaceutical company Medicago has announced that its investigational COVID-19 vaccine generated “significant antibody and cellular immune responses” after two doses in all subjects in an early-stage clinical trial. Based on the promising phase 1 data, the company plans to proceed with a phase 2/3 clinical trial. “We

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Drug Target Review

JUNE 27, 2023

Lastly, Brent Warner, President of Gene Therapy at Poseida Therapeutics, elucidates the groundbreaking advancements in gene editing that are reshaping the landscape of genetic disease treatment.

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