Elrig

APRIL 29, 2024

Srinivasan has led the development of multiple computational pipelines to process data from different next generation sequencing techniques with applications in oncology, genome editing systems including CRISPR-Cas mediated DNA editing, and ADAR-mediated RNA editing. Bioinformatics is all about bringing together different areas of knowledge.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Codon

JULY 17, 2024

Backyard astronomers discovered 42 new planets in 2012 , hobbyist paleontologists discovered the world’s largest dinosaur footprint near the Yorkshire coast in 2021, and Sebastian himself open-sourced protocols that make it easier for scientists to engineer plants. And what genes will I need to engineer these flowers?

Laboratories 110

Laboratories Engineering Molecular Biology Science 110

Codon

JUNE 25, 2024

Kamal Nahas highlights the biological limits on cell division speed and explores how we might engineer cells to grow faster. However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide.

DNA 95

DNA RNA Laboratories Research 95

Codon

JULY 10, 2024

But in the 1950s, at the dawn of molecular biology, scientists gained a new appreciation for it after searching for organisms that were easy to work with and quick to grow. In 1952, when the famous Hershey-Chase experiment indicated that DNA—and not protein—was the source of genetic material, just 285 papers mentioned E.

Laboratories 95

Laboratories DNA Molecular Biology Engineering 95

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Paul Blainey , the Karl Van Tassel Associate Professor of Biological Engineering at MIT, a core institute member of Broad, and a member of the Koch Institute, is also an author of the paper.

Regulations 91

Regulations Clinical Trials Engineering Science 91

Codon

FEBRUARY 13, 2024

Some algorithms simply look for important similarities between phage and bacterial DNA sequences, a signal of the extensive gene-swapping that goes on when a particular virus and bacteria have shared history. Left) A molecular structure of bacteriophage T4, which infects E. The tech for this process already exists.

Therapies 138

Therapies Virus DNA Clinical Trials 138

DrugBaron

NOVEMBER 22, 2022

Regulated cleavage is central to some of the most important signalling cascades in biology, such as blood coagulation and complement activation. In one study, ProQuant has been used to study an engineered protein that was intended to be cleaved in two different places, one yielding activation and then at a second site to deactivate it.

Bioinformatics 100

Bioinformatics Regulations Molecular Biology Engineering 100

Codon

APRIL 2, 2024

in physics at Princeton University, he had a remarkable idea: What if it were possible to build a circuit out of DNA, rather than electronics, and use it to “program” a living cell? These papers became the standard-bearers for a new scientific field: synthetic biology. In other words, they could “program biology.”

RNA 58

RNA Engineering Molecular Biology Synthetic Chemistry 58

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? DNA vectors in mouse models? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

Therapies 59

Therapies RNA Protein Expression DNA 59

Codon

JUNE 18, 2024

When these engineered cells are then placed into a mouse, one can use ultrasound to “hear” the cells as they move around. One can even explode the gas vesicles using high pressure soundwaves, akin to molecular warheads, with astounding implications for medicine. coli cell that had been engineered to express gas vesicles.

Engineering 71

Engineering Laboratories International Clinical Trials 71

Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. The tool outputs a DNA sequence that encodes all the required enzymes.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. The tool outputs a DNA sequence that encodes all the required enzymes.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” You can read all of them here.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” You can read all of them here.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Our machine would make proteins without using any DNA or cells. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein.

RNA 75

RNA DNA Engineering Laboratories 75

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Our machine would make proteins without using any DNA or cells. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein.

RNA 52

RNA DNA Engineering Laboratories 52

Codon

MARCH 12, 2023

Notes on Progress is a monthly roundup of papers and ideas about biology and the future. “The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. Biology is a Burrito. A new base editor to edit mitochondrial DNA.

DNA 52

DNA Engineering Therapies RNA 52

Codon

DECEMBER 17, 2023

Molecular biology, as the field came to be called 3 , pushed biology from an object of study, driven forward by gentleman scientists and precocious country clergymen, into a tool with which to solve urgent problems. Recombinant DNA technologies were invented in the 1970s. Steelman: Biotechnology is not a panacea.

Engineering 52

Engineering Molecular Biology Doctors DNA 52

Codon

AUGUST 10, 2023

Credit: Bruce Wetzel and Harry Schaefer, NCI, NIH | License Progress in biology is arguably moving faster today than at any point in the course of human history. Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. Journal of Molecular Biology (1961).

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Credit: Bruce Wetzel and Harry Schaefer, NCI, NIH | License Last edit: 13 September 2023 Progress in biology is arguably moving faster today than at any point in the course of human history. Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. Nature (2005).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Broad Institute

MAY 13, 2025

AI tool predicts potential drug targets by analyzing cell images By Corie Lok May 13, 2025 Breadcrumb Home AI tool predicts potential drug targets by analyzing cell images Researchers have developed a machine learning model that connects images of DNA structure to gene regulation.

DNA 52

DNA Drugs Regulations Molecular Biology 52

Drug Target Review

DECEMBER 12, 2024

It is a two-way street: to start, the differentiated cell (eg, skin cell) must be reverse engineered into an iPSC. Enter epigenetics Broadly speaking, epigenetics refers to the system of proteins and marks that sits atop our genome a system that modifies gene expression, guides cell differentiation, and functionally organises our DNA.

Therapies 59

Therapies DNA Molecular Biology Immune Response 59

Drug Target Review

FEBRUARY 20, 2025

Also, some young women think that in order to work in STEM, they must be good at all four elements science, technology, engineering and math which isnt the case. Sabin earned her PhD in cellular and molecular biology from the University of Pennsylvania.

Virus 52

Virus Therapies Molecular Biology Treatment 52

Codon

MAY 29, 2025

This class of drugs was engineered to mimic the body’s glucagon-like peptide-1 hormone (GLP-1), which decreases blood glucose levels by activating its receptor to signal the release of insulin. This is the step after the initial transcription of DNA into mRNA by RNA Polymerase II, the protein to which alpha amanitin binds.

Drugs 109

Drugs DNA RNA Laboratories 109

Codon

DECEMBER 1, 2024

By Matthew Cobb The Central Dogma is a linchpin for understanding how cells work, and yet it is one of the most widely misunderstood concepts in molecular biology. Many students are taught that the Central Dogma is simply “DNA → RNA → protein.”

RNA 135

RNA DNA Molecular Biology Virus 135