Wed.Jun 04, 2025

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Coffee Could Be Key To Aging Gracefully

Drugs.com

WEDNESDAY, June 4, 2025 A morning cup of coffee might do more than momentarily boost your energy and spirits.Full-test java also appears to help women age more gracefully, a new study says.Middle-aged women who regularly drank caffeinated coffee w.

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Daiichi Sankyo struck gold with ‘ADC’ cancer drugs. Its new CEO has to figure out what’s next.

BioPharma Drive: Drug Pricing

Enhertu, Datroway and other antibody-drug conjugates developed by Daiichi Sankyo have made the company a leader in a competitive field. Hiroyuki Okuzawa is working to keep it that way.

Drugs 202
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Pepto Bismol May Not Prevent Traveler’s Diarrhea, New Study Finds

Drugs.com

WEDNESDAY, June 4, 2025 Pepto Bismol is a go-to stomach remedy, but a new study suggests it might not help prevent diarrhea during international travel.The study, led by the U.S. Centers for Disease Control and Prevention (CDC), found that people.

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FDA to use new review tool on Sarepta’s gene therapy work

BioPharma Drive: Drug Pricing

The company is one of the first to receive a “platform technology designation,” which could speed the review of certain gene therapy applications it later brings to the regulator.

Therapies 201
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Troubled Kids Wait a Half-Day — Or More — In ER To Get Mental Health Care

Drugs.com

WEDNESDAY, June 4, 2025 Troubled children and teenagers are languishing hours in chaotic hospital emergency rooms, waiting for a psychiatric bed to open, a new study says.About 1 in 3 kids who go to an emergency room (ER) amid a mental health c.

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Preemptive Kidney Transplants Add No Benefit, Study Says

Drugs.com

WEDNESDAY, June 4, 2025 Folks who might need a kidney transplant in the future shouldnt rush to get one, a new study says.Patients gain no benefit from getting a donated kidney before their own kidneys deteriorate to the point that they require d.

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How to Choose the Right ELN or LIMS for Early-Stage Drug Discovery

Collaborative Drug

A practical guide to selecting the right ELN or LIMS for early-stage drug discovery, focusing on usability, structure search, and scalability.

Drugs 130
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How Does A Pregnant Woman's Weight Influence Her Child's Infection Risk?

Drugs.com

WEDNESDAY, June 4, 2025 Children born to women who are obese have a higher risk of landing in a hospital with a severe infection, a new study says.Infants under 1 year of age have a 41% increased risk of hospitalization for infection if their mom.

Hospitals 130
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Automation in Clinical Trials: AI, eConsent, and Digital Tools Driving Innovation

Quanticate

Explore how automation AI and digital tools are redefining clinical trials. Discover innovations driving faster, smarter and more ethical research.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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How Do Low-Calorie Diets Affect A Person's Mood?

Drugs.com

WEDNESDAY, June 4, 2025 Counting calories isnt simply a bummer, it might actually increase your risk of depression, a new study says.People on low-calorie diets scored higher for symptoms of depression, compared with those not dieting, res.

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Bindcraft Workshop

Broad Institute

Bindcraft Workshop By Rose Circeo June 4, 2025 Breadcrumb Home Bindcraft Workshop November 6, 2025 12:00-4:00 pm Workshop (lunch served) 4:00-5:00 pm Broad Institute museum tour Registration opens June 9. Presenter Lennart Nickel, Doctoral Assistant in the Laboratory of Protein Design & Immunoengineering at EPFL. Proteinprotein interactions are central to biological function, making their design highly relevant for therapeutic and biotechnological applications.

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High Insulin Linked To Irregular Periods

Drugs.com

WEDNESDAY, June 4, 2025 Elevated insulin levels could be causing irregular menstrual bleeding in women, a new study says.Women with excess levels of insulin are three times more likely to suffer from abnormal uterine bleeding, researchers r.

Research 130
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Beyond Animal Testing: The Rise of Organoids and AI Tools

Crown Bioscience

Revamping Test Methods: A Leap Towards Non-Animal Approaches The age-old practice of animal experiments is on the cusp of transformation. The shift is driven by a myriad of changes. Our expert guest, Professor Thomas Hartel , Chair of Evidence-Based Toxicology at Johns Hopkins Bloomberg School of Public Health provides his industry insights into new approaches drug discovery through technologies such as organoids and Artificial Intelligence (AI).

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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LatAm’s First Databricks Champion at Perficient

Perficient: Drug Development

We are thrilled to announce that Juan Cardona Ramirez has been recognized as a Databricks Partner Champion , making him the first Perficient colleague in Latin America to earn this prestigious designation. This recognition celebrates Juans deep technical expertise , consistent contributions, and commitment to innovation within the Databricks ecosystem.

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Identification of a Selective Cell‐Active Inhibitor of Protein Arginine Methyltransferase 5 (PRMT5) for the Treatment of Prostate Cancer by Structure‐Based Virtual Screening

Chemical Biology and Drug Design

Combining previous research, compound SJL2-1 was identified through virtual screening based on molecular docking. By reducing the expression levels of PRMT5 and AR, it exhibits anti-proliferative effects, inhibits cell migration and invasion abilities, blocks the cell cycle, and induces apoptosis in AR-sensitive prostate cancer and CRPC. ABSTRACT Protein arginine methyltransferase 5 (PRMT5) is an epigenetic-related enzyme that has been shown to be a promising target for the treatment of human ca

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Where Your Next Biotech Breakthrough Could Begin

Fierce BioTech

Where Your Next Biotech Breakthrough Could Begin In Puerto Rico, companies tap into decades of experience in scientific innovation, business-friendly incentives and public-private partnerships to push new frontiers of medicine. Join a dynamic ecosystem on the cutting-edge of biotech production and R&D. scox Wed, 06/04/2025 - 09:43 In Puerto Rico, companies tap into decades of experience in scientific innovation, business-friendly incentives and public-private partnerships to push new frontie

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Identification and Evaluation of Besifloxacin as Repurposed Antifungal Drug in Combination With Fluconazole Against Candida albicans

Chemical Biology and Drug Design

The novel repurposed antibacterial drug besifloxacin led to an 83% reduction of murine kidney fungal burden as compared to no-drug control. It showed positive synergism with a lower than MIC dose of fluconazole (0.5mg/L) proposing its use in combination therapy against Candida infections. ABSTRACT Emergence of life-threatening fungal infections like systemic candidiasis concurrently with bacterial infections and limitations of current antifungal therapies warrant the discovery of novel inhibitor

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Talk title coming soon

Broad Institute

Talk title coming soon By Nadya Karpova June 4, 2025 Talk title coming soon Lorin Crawford Microsoft Research New England (MSR) Add to calendar Talks Search - Any - Fall 2025 Spring 2025 Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

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Judge Says Transgender Inmates Must Have Access to Hormone Therapy

Drugs.com

WEDNESDAY, June 4, 2025 A federal judge has ruled that transgender inmates in U.S. prisons must continue getting medical care, including hormone therapy and gender-affirming accommodations.The decision blocks parts of an executive order signed by.

Therapies 147
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Talk title coming soon

Broad Institute

Talk title coming soon By Nadya Karpova June 4, 2025 Talk title coming soon Martin Steinegger Seoul National University Sooyoung Cha Seoul National University Add to calendar Talks Search - Any - Fall 2025 Spring 2025 Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

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Proinflammatory Foods Tied to Higher Risk of Death in Colon Cancer Patients

Drugs.com

WEDNESDAY, June 4, 2025 — What you eat after a colon cancer diagnosis could do more than affect your energy or digestion — it might impact your chance of survival. Researchers looked at more than 1,600 patients with stage 3 colon.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Talk title coming soon

Broad Institute

Talk title coming soon By Nadya Karpova June 4, 2025 Talk title coming soon Gamze Gursoy Columbia University Add to calendar Talks Search - Any - Fall 2025 Spring 2025 Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

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The MAHA Assessment’s Implications: Drugs (Part One)

FDA Law Blog: Biosimilars

By Mark A. Tobolowsky & Ricardo Carvajal Among other things, EO 14212 established the Make America Healthy Again (MAHA) Commission (with HHS Secretary Kennedy as its Chair) and tasked it with a tall order: submission to the President of an Assessment that tackled 10(!) complex public health issues within 100(!) days. Perhaps it was inevitable that the Commission would turn to AI for help, as seems to have been the case in light of media reports that the Assessment as originally published in

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Talk title coming soon

Broad Institute

Talk title coming soon By Nadya Karpova June 4, 2025 Talk title coming soon Kexin Huang Stanford University Add to calendar Talks Search - Any - Fall 2025 Spring 2025 Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

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A Naturally Derived Glycosylated Oleanolic Acid Derivative Suppresses NF‐κB Translocation and Induces Intrinsic Apoptosis in Lung Adenocarcinoma Cells

Chemical Biology and Drug Design

The derivative F4B1 exhibits significant anticancer activity by specifically inducing apoptosis in lung cancer cells. Mechanistically, it inhibits NF-kappa-B translocation into the nucleus, thereby attenuating the expression of c-Myc and cyclin D1. Additionally, the derivative triggers a cascade of caspase activation, further promoting apoptotic cell death.

Treatment 100
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Talk title coming soon

Broad Institute

Talk title coming soon By Nadya Karpova June 4, 2025 Talk title coming soon Jacob Schreiber UMass Medical School Add to calendar Talks Search - Any - Fall 2025 Spring 2025 Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

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Regeneron makes obesity push; Atai, Alto ink brain drug deals

BioPharma Drive: Drug Pricing

Regeneron licensed a weight loss drug and revealed study data for a pair of muscle-preserving medicines. Elsewhere, two neuroscience biotechs cut deals and Bluebird officially went private.

Licensing 157
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Talk title coming soon

Broad Institute

Talk title coming soon By Nadya Karpova June 4, 2025 Talk title coming soon Jingyi Jessica Li UCLA Pan Liu UCLA Add to calendar Talks Search - Any - Fall 2025 Spring 2025 Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

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Lilly partners with Camurus in search of a long-lasting obesity drug

BioPharma Drive: Drug Pricing

The deal, which could be worth up to $870 million overall, will give Lilly access to a delivery technology that may help extend the durability of up to four of its weight-loss medicines.

Drugs 157