Drug Discovery World

SEPTEMBER 11, 2024

A gene therapy developed by University of Florida scientists restored useful vision to most patients with rare condition Leber congenital amaurosis type I (LCA1) in a small trial. Patients who received the highest dose of the gene therapy saw up to a 10,000-fold improvement in their light sensitivity, were able to read more lines on an eye chart, and improved in their ability to navigate a standardised maze.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Researchers have created microscale robots less than 1 millimeter in size that are printed as a 2D hexagonal 'metasheet' but, with a jolt of electricity, morph into preprogrammed 3D shapes and crawl.

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Drug Discovery World

SEPTEMBER 11, 2024

The Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital, a neuroscience research institute based in Houston, has advanced its research capabilities with the implementation of an automation platform for human cellular model generation, maintenance, and characterisation, in collaboration with Automata Technologies.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Rapa Nui (Easter Island) with its gigantic statues and treeless landscape has fascinated researchers for centuries. A new genetic study disproves the popular theory that the Rapanui population collapsed as a result of an 'ecocide' and shows that the Rapanui admixed with Indigenous Americans centuries before Europeans arrived on the island.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Drug Discovery World

SEPTEMBER 11, 2024

Charles River Laboratories is hosting two drug discovery seminars in the UK in September. The first will be in Cambridge on 25 September covering drug discovery capabilities, with the second at the company’s Portishead, UK site covering immuno-oncology, infectious disease capabilities on 26 September. Both events are free of charge and will feature guest speakers, networking time, refreshments, equipment demos and lab tours.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- Widespread and easy access to guns is the reason behind the shockingly high rate of firearm deaths in the United States, and not any rise in mental health problems suffered by perpetrators, a new study shows.The United.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- The weight-loss drug liraglutide helped obese children lower their BMI and reach a healthier weight, researchers report.The findings, published Tuesday in the New England Journal of Medicine and presented.

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Drug Discovery World

SEPTEMBER 11, 2024

In this webinar on 30 September, from 3-4PM BST, hosted by DDW and sponsored by ApconiX, you will hear from Dr Isaac Klein, Chief Scientific Officer at Dewpoint Therapeutics, Dr Sam Clark, CEO of Terran Biosciences, and Professor Ruth Roberts, Co-founder and Director of Safety Science at ApconiX. Dr Klein shares how Dewpoint applies insights into the subcellular organisation of biochemical processes into membrane-less compartments to discover novel drug targets and revolutionary drugs for diseas

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- As fears of the consequences of an unintended pregnancy rose after Roe v. Wade was overturned in 2022, rates of surgical sterilization rose in those states most affected by the decision, new research shows. Rates of.

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Research 116

Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Since their invention in the 1920s, jungle gyms and monkey bars have become both fixtures of playgrounds and symbols of childhood injury that anxious caretakers want removed. Anthropologists mark 100 years of the iconic playground equipment by arguing that risky play exercises a biological need passed on from apes and early humans for children to independently test and expand their physical and cognitive abilities in a context in which injury is possible but avoidable.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- Contrary to a warning placed on labels for CART-T cancer therapies, use of these treatments does not appear to boost the odds for a secondary cancer later, a new study shows.Researchers at Memorial Sloan Kettering.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

It's a dogma taught in every introductory biology class: Proteins are composed of combinations of 20 different amino acids, arranged into diverse sequences like words. But researchers trying to engineer biologic molecules with new functions have long felt limited by those 20 basic building blocks and strived to develop ways of putting new building blocks -- called non-canonical amino acids -- into their proteins.

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Collaborative Drug

SEPTEMBER 11, 2024

Chemical Safety Information: When working in a lab, you must understand the risks associated with handling chemicals. CDD Vault now displays safety information obtained from PubChem as a helpful reminder. If available, you will find hazard pictograms next to the name at the top of the molecule page.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- The U.S. Food and Drug Administration announced Tuesday that it will launch an independent review into any possible effects of toxic metals found in tampons.The announcement follows the release of a study in July that.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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FDA Law Blog: Biosimilars

SEPTEMBER 11, 2024

By John W.M. Claud — Last week, FDA revised one of its two guidances relating to nitrosamines, Control of Nitrosamine Impurities in Human Drugs. Nitrosamines are impurities that can form during drug manufacturing and are considered potentially potent carcinogens. One specific kind of nitrosamines called N-nitrosamine drug substance-related impurities, or NDSRIs, are especially vexing to FDA and to industry because they mimic the structure of the specific active pharmaceutical ingredients (API),

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Neanderthal remains recently discovered in a cave in France support well-known theory of why the Neanderthals became extinct, researchers behind a new study say.

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Research 111

Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- It’s natural for a parent to want to protect their children and keep them from harm.But sometimes this understandable desire crosses over into “helicopter parenting,” an overbearing need to be part of a child’s every dec.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Neuroscientists have revealed how sensory input is transformed into motor action across multiple brain regions in mice. The research shows that decision-making is a global process across the brain that is coordinated by learning. The findings could aid artificial intelligence research by providing insights into how to design more distributed neural networks.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- In the two years since the March of Dimes' last report on the state of U.S. maternity care, more than 100 hospitals nationwide have shuttered their obstetric units, leaving more new moms with literally "Nowhere to Go".

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Hospitals 98

Science Daily: Pharmacology News

SEPTEMBER 11, 2024

The team first looked at variation in data from genetic sequencing of 106,973 post-menopausal female participants in the UK Biobank study. Researchers focused on rare types of genetic changes which cause a loss of the protein, and investigated their effect on the timing of menopause. The genetic changes studied are all rare in the population, however their influence on menopause is five times greater than the impact of any previously identified common genetic variant.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- Weekly insulin shots can help control both type 1 and type 2 diabetes as well as daily injections do, a pair of clinical trials have found.A new class of insulin called efsitora alfa has been designed to require.

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keypoint

SEPTEMBER 11, 2024

By Shannon Weiman In 2023 we launched a new initiative to add health equity programming to select meetings to raise awareness for health disparities in various fields and initiate discussions on how to rectify these health inequities through scientific research and discovery. These messages are of critical importance to the global research community, so we are releasing the audio recordings of these Health Equity Forums open access, to inform broader audiences about these issues and inspire them

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Outdoor light at night could be a significant risk factor in Alzheimer's disease, according to new research from Rush.

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Disease Research 119

keypoint

SEPTEMBER 11, 2024

Checkout Health Equity highlights, climate & sustainability conferences, emerging topics & more from Keystone Symposia in our September 2024 Keypoint Newsletter.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Researchers have demonstrated that bluestreak cleaner wrasse (Labroides dimidiatus) checked their body size in a mirror before choosing whether to attack fish that were slightly larger or smaller than themselves, saying it was the first time for a non-human animal to be demonstrated to possess some mental states that are elements of private self-awareness.

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Drug Patent Watch

SEPTEMBER 11, 2024

The pharmaceutical industry has witnessed significant advancements in recent years, particularly in the realm of nanotechnology. This innovative field has revolutionized the way drugs are developed, manufactured, and delivered to patients.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Researchers designed an energy-efficient device that produces drinking water from seawater using an evaporation process driven largely by the sun.

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keypoint

SEPTEMBER 11, 2024

In June we wrapped up our 2024 conference season, aligning with the academic calendar. Altogether we hosted 52 conferences across North America, Europe and Asia, serving nearly 9,000 participants and providing financial aid to over 500 students, post-docs, underrepresented scientists and scientists from low- and middle-income countries. Find out more about our attendees below and see what they are saying about Keystone Symposia!

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Newborns who had an atypical pattern of metabolites were more than 14 times as likely to die of sudden infant death syndrome (SIDS), compared to infants who had more typical metabolic patterns, according to a new study. Metabolites are molecules produced by the body's various chemical reactions. Researchers found that infants who died of SIDS had a specific pattern of metabolites compared to infants who lived to their first year.

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BioPharma Drive: Drug Pricing

SEPTEMBER 11, 2024

Data from an early trial of the therapy fell short of the company’s “threshold to warrant additional capital investment,” an executive said.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Astronomers have captured images of a star other than the Sun in enough detail to track the motion of bubbling gas on its surface. The images of the star, R Doradus, were obtained in July and August 2023. They show giant, hot bubbles of gas, 75 times the size of the Sun, appearing on the surface and sinking back into the star's interior faster than expected.

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keypoint

SEPTEMBER 11, 2024

By Heather Gerhart Keystone Symposia’s flagship Fellows Program is now accepting applications for the Class of 2025! This unique, cutting-edge, life science Fellowship is designed to support the career development of postdoctoral and early-career scientists from underrepresented and other disadvantaged backgrounds who are engaged in biological or biomedical sciences research.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

The earliest humans to settle the Great Lakes region likely returned to a campsite in southwest Michigan for several years in a row, according to a new study.

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BioPharma Drive: Drug Pricing

SEPTEMBER 11, 2024

Following an FDA rejection last year, the drugmakers plan to resubmit their application for an expanded approval of Dupixent in chronic spontaneous urticaria.

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