Thu.Dec 05, 2024

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Tyrannosaur teeth discovered in Bexhill-on-Sea, England

Science Daily: Pharmacology News

Research has revealed that several groups of meat-eating dinosaur stalked the Bexhill-on-Sea region of coastal East Sussex 135 million years ago.

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Prevention Outpaced Treatment Advances in Saving Lives From Major Cancers

Drugs.com

THURSDAY, Dec. 5, 2024 -- “An ounce of prevention is worth a pound of cure,” founding father Benjamin Franklin once said.That’s definitely true of cancer, a new study has found.Cancer prevention and screening has saved more people from five types of.

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TRIM16 and PRC1 Are Involved in Pancreatic Cancer Progression and Targeted by Delphinidin

Chemical Biology and Drug Design

Three pancreatic cancer-related microarray datasets (GSE183795, GSE28735, and GSE62452) were integrated. Analysis of differentially expressed genes, WGCNA, and machine learning algorithms (LASSO, XGboost, and random forest) were combined to identify genes associated with the progression of pancreatic cancer. Natural drugs, including delphinidin, which target the core genes, tripartite motif containing 16 (TRIM16), and protein regulator of cytokinesis 1 (PRC1), were then identified.

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'Broken' Sleep Could Be Hallmark of Obesity-Linked Liver Disease

Drugs.com

THURSDAY, Dec. 5, 2024 -- Fatty liver disease may contribute to fragmented sleep patterns, robbing already sick people of good rest, a new study finds.These folks woke up more often in the night, and then lay awake longer waiting for slumber to.

Disease 98
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Design and Development of Novel Hybrids Based on Pyrrolo[2,1‐f][1,2,4]Triazine and 1‐(Methylpiperidin‐4‐yl) Aniline–Based Analogs: Exploring the Utility as Anticancer Agents via MERTK Inhibition

Chemical Biology and Drug Design

A hybrid drug design approach was employed to develop novel leads ( 1K11K5 ). The molecules were synthesized via a multi-step synthetic approach and were assessed for their anticancer potential via cell viability studies, DMPK studies, and MERTK inhibition. Studies were corroborated by in silico studies. ABSTRACT Mer-tyrosine kinase (MERTK), a member of the AXL, TYRO3, and MERTK (TAM) family, is one of the promising targets for cancer treatment.

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Dark Chocolate Could Help You Ward Off Type 2 Diabetes

Drugs.com

THURSDAY, Dec. 5, 2024 -- The choice may be bittersweet, but the evidence is clear: New research shows that dark chocolate can lower a person’s risk of type 2 diabetes.People who ate at least five servings of dark chocolate a week had a 21% lower r.

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California Farm Expands Raw Milk Recall After Bird Flu Virus Found in More Samples

Drugs.com

THURSDAY, Dec. 5, 2024 -- A California dairy farm has expanded a recall of its raw milk and cream after state health officials discovered bird flu virus in more milk samples.In a notice posted Tuesday, Fresno-based Raw Farm LLC said it has now.

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GSK taps a startup for shot at Alzheimer’s drug

BioPharma Drive: Drug Pricing

The collaboration deal, which could be worth hundreds of millions of dollars, is a “pivotal moment” for Muna Therapeutics, a startup that launched less than four years ago.

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America's Rural Hospitals Are Shutting Down Maternity Wards

Drugs.com

THURSDAY, Dec. 5, 2024 -- Hospitals across America are shuttering their obstetric units, and the issue is most acute for women served by rural hospitals, a new study finds.By 2022, a majority (52%) of rural U.S. hospitals no longer had any.

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Nuvig pulls in $161M to make better immune drugs

BioPharma Drive: Drug Pricing

The company is developing treatments to rebalance, rather than suppress, immune function in people with inflammatory conditions, starting with an antibody near Phase 2 testing.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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'Game of Roulette': Flying With Food Allergies Brings Stress, Danger

Drugs.com

THURSDAY, Dec. 5, 2024 -- Holiday travel is always stressful, but particularly so for people with food allergies.Airlines don’t always honor requests to protect the health of people with food allergies during flights, a new study published Dec. 5 i.

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Atlas XIV And Reflections On The VC Math Problem

LifeSciVC

Today we announced the closing of Atlas Venture Fund XIV , a $450M investment vehicle focused exclusively on early stage biotech investing. With the closing of Fund XIV, we’re privileged to be able to continue backing innovative new biotech companies for another fund cycle, reinforcing our science-first and seed-led venture creation model for novel therapeutics – and delivering on our mission of doing well by doing good.

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Prenatal Blood Tests for Baby Are Spotting Cancers in Moms-to-Be

Drugs.com

FRIDAY, Dec. 6, 2024 -- Could a prenatal blood test designed to find abnormalities in a fetus also detect hidden cancer in the mom-to-be? A new study says yes: Scientists report they discovered cancer in nearly half (48%) of expecting mothers with.

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Understanding the Lifecycle of Generic Drugs: From Development to Market Impact

Drug Patent Watch

In the ever-evolving landscape of healthcare, generic drugs play a crucial role in providing affordable and accessible medication to millions of people worldwide. But have you ever wondered about the journey these drugs take from conception to your local pharmacy shelf?

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Most Young People With Long COVID Recover Within 2 Years

Drugs.com

THURSDAY, Dec. 5, 2024 -- Most children and teenagers can shake long COVID within a couple of a years, a new, reassuring study finds.About 70% of children and teens diagnosed with long COVID recover from the disorder within 24 months of their.

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Product lifecycle management: why it matters for the In Vitro Diagnostics industry

Tecan

By David Keller Developing an effective product lifecycle management (LCM) process is no longer just a ‘nice to have’ for manufacturers in the medical and diagnostics equipment industry, but an essential ‘must have’ to ensure long-term business growth. From managing the total cost of ownership (TCO) to accomplishing product updates without disruptions in regulatory compliance, a holistic view of product LCM during new product development can help you to increase operational efficiency and mainta

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CTE Rates Rise Year-by-Year in Pro Hockey Players

Drugs.com

THURSDAY, Dec. 5, 2024. Hockey players’ chances of developing concussion-related brain injury increase with every year they spend on the ice, a new study finds. The odds of having chronic traumatic encephalopathy (CTE) increase among hockey.

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Multi-Omics and its Application in Personalised Medicine Studies

Quanticate

Advances in multi-omics are driving significant breakthroughs in biomedical research. By integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics, researchers can achieve a comprehensive view of complex biological processes. This in turn is aiding personalised disease prevention, diagnosis, and treatment​. However, handling and interpreting vast, heterogeneous data present unique challenges, requiring advanced computational methods and data integration techniques.

Disease 52
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Product lifecycle management: why it matters for the In Vitro Diagnostics industry

Tecan

By David Keller Developing an effective product lifecycle management (LCM) process is no longer just a ‘nice to have’ for manufacturers in the medical and diagnostics equipment industry, but an essential ‘must have’ to ensure long-term business growth. From managing the total cost of ownership (TCO) to accomplishing product updates without disruptions in regulatory compliance, a holistic view of product LCM during new product development can help you to increase operational efficiency and mainta

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New insights into the role of viral capsids in gene therapy safety

Drug Target Review

Viral vectors have been crucial in transforming the gene therapy landscape due to their natural ability to infect cells. Among them, adeno-associated viruses (AAVs) stand out due to their small size, high efficiency in gene delivery, low immunogenicity, and potential for customisable tissue targeting, making them the leading tool in gene expression research. 1 In 2017, the US Food and Drug Administration (FDA) approved the first AAV-based gene replacement therapy (Luxturna), for Leber congenital

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Pre-Approval Inspection (PAI) Readiness is Easy, Isn't It?

thought leadership

Facing a  pending filing and subsequent PAI  can feel overwhelming, no matter if you are a young firm or an established company. You're balancing the excitement of bringing a new product to market with the reality of limited resources. For many companies, regardless of size and tenure, the culmination of fund raising, planning, and execution has led you to this – the need for a solid filing and a successful inspection.

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Streamlining Test Automation with Page Object Model (POM) in PyTest and Selenium

Perficient: Drug Development

In our previous discussion about utilizing PyTest with Selenium, we laid the groundwork for automated testing in web applications. Now, let’s enhance that foundation by exploring the Page Object Model (POM), a design pattern that improves the organization of your code and boosts your tests’ maintainability. What is the Page Object Model (POM)?

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Weight Loss Brings Americans Big Health Care Savings

Drugs.com

THURSDAY, Dec. 5, 2024 -- The advent of GLP-1 weight-loss medications such as Wegovy and Zepbound has spurred debate as to whether the drugs' cost should be covered by Medicare, Medicaid and private insurers. Late last month, the Biden.

Drugs 105
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Mastering SFMC Automation Studio: Activities, Capabilities, and Journey Integration

Perficient: Drug Development

In todays fast-paced marketing landscape, efficiency is key. Salesforce Marketing Cloud (SFMC) Automation Studio enables businesses to automate complex workflows, reduce manual effort, and deliver personalized experiences at scale. With its wide range of activities and integration capabilities, Automation Studio is a powerhouse for marketers aiming to streamline operations and achieve optimal results.

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Mystery Illness Kills Dozens in Congo

Drugs.com

THURSDAY, Dec. 5, 2024 -- Health officials in the Democratic Republic of Congo are racing to try to identify the cause of a mysterious, flu-like illness that has sickened 376 people and left 79 dead in that country.In a alert posted on the social.

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Harnessing the Power of SFMC Social Studio

Perficient: Drug Development

In a world dominated by social media, businesses need to stay connected with their audience and remain ahead of trends. Salesforce Marketing Cloud Social Studio serves as an all-encompassing social media management platform, empowering marketers, customer service teams, and brand managers to manage, engage, and analyze their social media presence effectively.

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Recent changes to Search Reports and Curves Module

Collaborative Drug

Inventory Link in Search Reports: As mentioned in a previous release , a summary of sample inventory information can be shown in a search report table on the Explore Data tab to quickly see a snapshot of the remaining samples and total amounts. Summaries are available at the molecule and batch levels. To display the field, click “Customize your report” and select “Inventory Summary” from the list of Molecule and Batch Fields.

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Regenerative Biology of the Female Reproductive Tract

keypoint

The Keystone Symposia on Regenerative Biology of the Female Reproductive System will cover mechanisms of regeneration, fertility, gynecologic conditions, reproductive tract cancers, and more, capturing the breadth of this expanding field while acknowledging that much of this work is long overdue.

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How Managers Can Spot and Prevent Burnout Before It Starts

Perficient: Drug Development

In today’s fast-paced work environment, it’s easy to fall into the trap of pushing for results. But as leaders, we need to adopt a different mindset—one that views work as a marathon, not a sprint. While sprints can bring immediate wins, they’re unsustainable in the long run, often leading to team burnout. It’s our responsibility to ensure that our teams are not only productive but also healthy and balanced.