September, 2024

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Efficacy of Fluoxetine and (R,S) Ketamine in Attenuating Conditioned Fear Behaviors in Male Mice [Behavioral Pharmacology]

ASPET

Post-traumatic stress disorder (PTSD) is caused by exposure to a traumatic or stressful event. Symptoms related to this disorder include persistent re-experiencing of memories and fear generalization. Current pharmacological treatments for PTSD are insufficient, with fewer than 30% of patients reporting symptom remission. This study aims to determine the efficacy of acute ( R,S) ketamine and chronic fluoxetine (FLX) in reducing fear memory and fear generalization.

Treatment 190
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Moderate coffee and caffeine consumption is associated with lower risk of developing multiple cardiometabolic diseases, new study finds

Science Daily: Pharmacology News

Consuming moderate amounts of coffee and caffeine regularly may offer a protective effect against developing multiple cardiometabolic diseases, including type 2 diabetes, coronary heart disease and stroke, according to new research.

Disease 144
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A decade of cancer immunotherapy: Keytruda, Opdivo and the drugs that changed oncology

BioPharma Drive: Drug Pricing

Over the past 10 years, PD1-blocking medicines have transformed cancer care. But the steady expansion of their use has slowed and, despite much trying, pharmaceutical companies have largely failed to top the drugs’ successes.

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Models of Life

Codon

2024 Statistical models of organisms have existed for decades. The earliest ones relied on simple linear regression and attempted to correlate genetic variations with observable traits or disease risks — such as drug metabolization rates or cancer susceptibility. As computational power increased and machine learning techniques advanced, the models’ sophistication grew.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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New approach may yield modified messenger RNAs for treating a wide range of conditions

Broad Institute

New approach may yield modified messenger RNAs for treating a wide range of conditions By Ari Navetta September 23, 2024 Breadcrumb Home New approach may yield modified messenger RNAs for treating a wide range of conditions The LEGO framework could help scientists create mRNA therapies that last longer and require smaller doses. By Ari Navetta September 23, 2024 Credit: Natalie Velez, Broad Communications Related news Messenger RNAs with multiple “tails” could lead to more effective therapeutics

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Almost 200 Chemicals Linked to Breast Cancer Are Found in Food Packaging

Drugs.com

TUESDAY, Sept. 24, 2024 -- Food sold in shrink wrap, on cardboard trays or in paper containers might contain any of nearly 200 chemicals linked to breast cancer, a new study warns.Commonly used food packaging materials contain 189 chemicals that.

Packaging 122

More Trending

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Microscale robot folds into 3D shapes and crawls

Science Daily: Pharmacology News

Researchers have created microscale robots less than 1 millimeter in size that are printed as a 2D hexagonal 'metasheet' but, with a jolt of electricity, morph into preprogrammed 3D shapes and crawl.

Research 140
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Summit lung cancer drug shows ‘striking’ benefit over Keytruda

BioPharma Drive: Drug Pricing

Study results provide much-anticipated details to Summit’s claim earlier this year that its drug “decisively beat” Merck’s dominant immunotherapy.

Drugs 135
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Dependencies & Creep : Project Estimating (Part 2)

Perficient: Drug Development

This post is the second in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Part 2: Dependencies & Creep Coming Soon: Part 3: Assumptions & Uncertainty Part 4: The Emotional Conclusion Continuing our dive into project estimating, let’s talk about two more problem areas: dependencies and project creep. These two can turn your pristine project plan into a tangled mess.

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How is Parkinson’s disease diagnosed?

Antidote

Receiving a Parkinson’s diagnosis is a life-altering event that nearly 1 million people in the United States have experienced. Parkinson’s disease symptoms can vary from person to person. Receiving a diagnosis often requires several steps. In this blog, we’ll be sharing more details about the disease and discussing opportunities for individuals to get involved in Parkinson’s research.

Disease 114
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Polluting Puff: Asthma Inhalers Are Big Contributors to Climate Change

Drugs.com

MONDAY, Sept. 16, 2024 -- Tiny puffs from asthma inhalers could be causing big climate problems for Mother Earth, a new study warns.Each inhaler dose contains some of the most potent greenhouse gases known, and they are adding up, researchers.

Research 119
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Scientists identify a unique combination of bacterial strains that could treat antibiotic-resistant gut infections

Broad Institute

Scientists identify a unique combination of bacterial strains that could treat antibiotic-resistant gut infections By Allessandra DiCorato September 18, 2024 Breadcrumb Home Scientists identify a unique combination of bacterial strains that could treat antibiotic-resistant gut infections The microbes control the growth of harmful bacteria in mice, promoting a healthier intestinal microbiome.

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New AI can ID brain patterns related to specific behavior

Science Daily: Pharmacology News

Scientists have developed a new AI algorithm that can separate brain patterns related to a particular behavior. This work promises to improve brain-computer interfaces and aid with the discovery of new brain patterns.

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Bristol Myers schizophrenia drug, the first of its kind, approved by FDA

BioPharma Drive: Drug Pricing

In testing, Cobenfy eased schizophrenia symptoms without some of the disruptive side effects typical of existing drugs. The results have been met with excitement, as well as caution.

FDA 132
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Women in STEM with Kristina Torfgard

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I am a pharmacist by training and continued with a PhD in Clinical Pharmacology. However, my goal was all the time to work with drug development in the pharma industry, so I moved on and started that journey in 1992 when I took on a role as Clinical Research Manager at AstraHässle, a mid-size Swedish pharma company.

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Commercial interests contribute to drug use and addiction

National Institute on Drug Abuse: Nora's Blog

Commercial interests contribute to drug use and addiction mfleming Wed, 09/25/2024 - 15:00 Nora's Blog September 26, 2024 Image ©Getty Images/ PeopleImages Biomedical sciences are bringing increased focus to social determinants of health, which the World Health Organization (WHO) defines as “the conditions in which people are born, grow, work, live, and age, the systems put in place to deal with illness, and the wider set of forces and systems shaping the conditions of daily life.” 1 Very often,

Drugs 109
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Ozempic Could Curb Progression of Diabetes-Linked Liver Disease

Drugs.com

MONDAY, Sept. 16, 2024 -- Fatty liver disease linked to diabetes and obesity can easily progress to liver cirrhosis, but new research suggests that GLP-1 medicines like Ozempic can help stop that. In a new decades-long study, veterans with diabetes.

Disease 119
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CDD Vault Update (September 2024)

Collaborative Drug

Chemical Safety Information: When working in a lab, you must understand the risks associated with handling chemicals. CDD Vault now displays safety information obtained from PubChem as a helpful reminder. If available, you will find hazard pictograms next to the name at the top of the molecule page.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Travel could be the best defense against aging

Science Daily: Pharmacology News

Forget about retinol night creams, researchers believe travel could be the best way to defy premature aging. An interdisciplinary study has applied the theory of entropy to tourism, finding that travel could have positive health benefits, including slowing down the signs of aging.

Research 138
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Three biotechs raise $700M in rare burst of IPO activity

BioPharma Drive: Drug Pricing

The offerings by Bicara, Zenas and MBX give a glimpse into what industry insiders describe as a backlog of mature startups waiting for the right opportunity to test public markets.

Marketing 131
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Streamlining Marketing Success: The Benefits for Optimizely One with Perficient

Perficient: Drug Development

As an Optimizely expert, I eagerly anticipate this time of year due to the exciting Optimizely events happening worldwide. These include Opticon, the main conference for customers, the Optimizely OMVP Summit, a developer meetup, and the Optimizely Hackathon. During these events, we learn about new product releases and discover innovative ways to drive success for our customers.

Marketing 109
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Looking beyond traditional oncogenic pathways to break cancer resistance

Drug Target Review

Targeted cancer therapies and treatment resistance mechanisms Targeted cancer therapies such as epidermal growth factor receptor (EGFR), Kirsten rat sarcoma virus (KRAS), or V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) inhibitors have made a significant positive impact in the treatment of solid tumours, specifically for patients exhibiting oncogenic mutations.

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It's High Number of Guns, Not Mental Health Crises, That Drives U.S. Gun Deaths: Study

Drugs.com

WEDNESDAY, Sept. 11, 2024 -- Widespread and easy access to guns is the reason behind the shockingly high rate of firearm deaths in the United States, and not any rise in mental health problems suffered by perpetrators, a new study shows.The United.

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CDD Vault Update (September 2024 #3) - Release Notes

Collaborative Drug

New Default ELN Editor: The new ELN editor that had been pre-released for testing is now the default editor for all newly created entries. You can continue to edit entries created with the previous editor, but new features will only be available in the new editor. Existing entries that are duplicated will continue to use the old editor. We recommend copying contents over to a new entry and taking advantage of the new templates feature.

Treatment 104
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Fungus-controlled robots tap into the unique power of nature

Science Daily: Pharmacology News

In creating a pair of new robots, researchers cultivated an unlikely component, one found on the forest floor: fungal mycelia. By harnessing mycelia's innate electrical signals, the researchers discovered a new way of controlling 'biohybrid' robots that can potentially react to their environment better than their purely synthetic counterparts.

Research 137
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ArsenalBio raises $325M in one of the year’s largest biotech funding rounds

BioPharma Drive: Drug Pricing

The funding comes amid a slowdown in venture investment for gene and cell therapy startups, and will support development of multiple solid tumor programs.

Therapies 131
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Powering the Future: Key Highlights from PPCC24 and What’s Next for Power Platform

Perficient: Drug Development

The energy was electric last week as thousands of attendees invaded MGM Grand along the Las Vegas Strip for the 3rd Annual Power Platform Community Conference (PPCC24). From groundbreaking announcements to new features unveiled during keynotes from Microsoft’s Charles Lamanna, Corporate Vice President of Business Industry and Copilot, and Jeff Teper, President of Apps and Platforms, PPCC24 offered an electrifying three days of innovation and collaboration.

Hospitals 105
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Revised Final Guidance on Nitrosamines Offers New Recommendations for Assessment and Control

FDA Law Blog: Biosimilars

By John W.M. Claud — Last week, FDA revised one of its two guidances relating to nitrosamines, Control of Nitrosamine Impurities in Human Drugs. Nitrosamines are impurities that can form during drug manufacturing and are considered potentially potent carcinogens. One specific kind of nitrosamines called N-nitrosamine drug substance-related impurities, or NDSRIs, are especially vexing to FDA and to industry because they mimic the structure of the specific active pharmaceutical ingredients (API),

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Twice-Yearly Injection Cuts HIV Risk by 96%, But Will Cost Cut Access?

Drugs.com

THURSDAY, Sept. 12, 2024 -- It could be a real breakthrough for people at risk for HIV infection: A shot given every six months that reduces their risk by a whopping 96%.That's according to new trial results released Thursday by Gilead Sciences.

Science 119
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BRAIN at 10: A View from the National Institute on Drug Abuse

National Institute on Drug Abuse: Nora's Blog

BRAIN at 10: A View from the National Institute on Drug Abuse mfleming Wed, 09/25/2024 - 19:31 Nora's Blog October 1, 2024 By Nora Volkow, MD, Director, and Rita Valentino, Ph.D., Director, Division of Neuroscience and Behavior, NIDA This blog was originally posted on the The BRAIN Blog. The BRAIN Initiative is marking a milestone—10 years of& advancing neuroscience and neurotechnology research by funding innovative projects.

Drugs 103
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The collapse of bat populations led to more than a thousand infant deaths

Science Daily: Pharmacology News

A new study shows that when communities experienced the near death of entire insect-eating bat populations, farmers increased their use of pesticides. This in turn increased the infant mortality rate.

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Can the Fed’s rate cut change biotech’s ‘new normal’?

BioPharma Drive: Drug Pricing

Industry insiders hope the Fed’s decision to cut rates for the first time in years will boost biotech investment. But the long-awaited move won’t cure all that ails the sector, others cautioned.

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Content Hub: Data Model Simplified

Perficient: Drug Development

Sitecore Content Hub is a world-class platform for centralizing and managing content across various channels. It helps businesses organize and streamline often chaotic, messy content operations. It does this by providing an architecture or schema for content and its interconnections. A schema defines how different types of assets are structured, organized, related to each other.

Marketing 105