Science Daily: Pharmacology News
NOVEMBER 16, 2024
The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.
BioPharma Drive: Drug Pricing
NOVEMBER 6, 2024
Pioneers like Alnylam Pharmaceuticals have led the RNA interference field for years. Now, a crop of young biotechs is building on that foundation by taking the drugmaking technology in new directions.
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Broad Institute
NOVEMBER 21, 2024
Researchers identify source of a brain cancer’s deadly transformation By Corie Lok November 21, 2024 Breadcrumb Home Researchers identify source of a brain cancer’s deadly transformation Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations. By Wynne Parry November 21, 2024 Credit: Castro Lab, Michigan Medicine, Ann Arbor Glioma tumor cells seen under a microscope Related news Targeted drug treatment leads tumor cells to imitate vir
Drugs.com
NOVEMBER 18, 2024
MONDAY, Nov. 18, 2024 -- Drugs already taken by millions of diabetes patients appear to also help slash asthma attacks by up to 70%, new British research shows.The two drugs are metformin, one of the most widely used diabetes medications, and the.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Nvidia Developer: Drug Discovery
NOVEMBER 13, 2024
The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. This is often done in the form of a. The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. This is often done in the form of a multiple sequence alignment (MSA), and the evolutionary information retrieved from these alignments can yield insights into protein structure, function, and evolutionary history.
Perficient: Drug Development
NOVEMBER 20, 2024
Quantum computing is rapidly transitioning from theory to reality, using the principles of quantum mechanics to achieve computational power far beyond traditional computers. Imagine upgrading from a bicycle to a spaceship—quantum computers can solve complex problems at extraordinary speeds. However, this leap in computing power poses significant challenges, particularly for cybersecurity, which forms the backbone of data protection in our digital world.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
NOVEMBER 18, 2024
The agency's openness to a targeted pivotal study shows it’s still willing to consider accelerated clearance for Duchenne gene therapies despite questions about their effectiveness.
Collaborative Drug
NOVEMBER 12, 2024
Updates to ELN annotation tool, ELN insert link hotkey, auto generated sample IDs, list searching in inventory, flag outliers during imports
Drugs.com
NOVEMBER 20, 2024
WEDNESDAY, Nov. 20, 2024 -- Rates of postpartum depression have more than doubled in little over a decade among American women, a new analysis shows. While about 1 in every 10 new moms (9.4%) suffered postpartum depression in 2010, that number rose.
Chemical Biology and Drug Design
NOVEMBER 13, 2024
A series of chromone derivatives were designed and synthesized. We established a NOX4 overexpression model using the NRK-49F and identified compound 14m as highly active through the assessment of intracellular ROS levels. This investigation positions 14m as a noteworthy NOX4 inhibitor, shedding light on its regulatory role in renal fibroblasts. ABSTRACT Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) has emerged as a promising target for developing drugs to tackle renal fibrosis.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
PPD
NOVEMBER 11, 2024
It is hard to ignore some of the most pressing, long-term trends driving the push to accelerate innovation and progress in drug development. From an aging population increasing health care demand to urgent, unmet medical needs, there are clear drivers to advance safe and effective medicines to patients faster than ever. According to the United Nation’s 2024 World Population Prospects data, the global population of those 65 years old and over will grow from 0.8 billion in 2023 to 1.2 billion in 2
Science Daily: Pharmacology News
NOVEMBER 20, 2024
Researchers have discovered evidence of the oldest alphabetic writing in human history. The writing was etched onto clay cylinders discovered during a dig at an ancient Syrian city.
BioPharma Drive: Drug Pricing
NOVEMBER 15, 2024
At an event hosted by BioPharma Dive, drugmaker executives and investors discussed the importance of focus, smart spending and maintaining lines of sight to the clinic.
Quanticate
NOVEMBER 21, 2024
An efficacy endpoint in oncology is a characteristic or variable that measures how beneficial a treatment is to a patient’s feeling, function, and survival in a clinical trial. They are essential for assessing whether new cancer therapies are safe and efficacious [1]. Endpoints may serve different purposes, from evaluating survival rates to monitoring tumour size, as well as monitoring patient symptoms.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- More than a year after its advisory panel unanimously declared the drug phenylephrine to be useless against nasal congestion, the U.S. Food and Drug Administration is proposing that it be removed from common.
Chemical Biology and Drug Design
NOVEMBER 30, 2024
Seventeen new benzimidazole-hydrazone derivatives ( 4a-4r ) were designed and synthesized. Compounds 4a-4r were searched for their invitro inhibitory effects against hCA I and hCA II isozymes and IC 50 values were determined. Compound 4k , a 4-methoxyphenyl derivative, showed the most potent inhibitory activity against hCA isoenzymes. The in silico molecular docking analysis and the ability of the synthesized analogs to inhibit hCA I were also examined.
Drug Patent Watch
NOVEMBER 20, 2024
Generic drug development is a complex process that involves rigorous scientific research and regulatory assessments. The U.S. Food and Drug Administration (FDA) plays a crucial role in ensuring the quality and efficacy of generic drugs through various programs and guidelines.
Science Daily: Pharmacology News
NOVEMBER 15, 2024
More time spent sitting, reclining or lying down during the day may increase the risk of cardiovascular disease (CVD) and death, according to a new study. More than roughly 10-and-a-half hours of sedentary behavior per day was significantly linked with future heart failure (HF) and cardiovascular (CV) death, even among people meeting recommended levels of exercise.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
NOVEMBER 11, 2024
Negative drug results cost AbbVie billions of dollars in market value and convinced analysts that Bristol Myers had placed a better bet in buying Karuna Therapeutics.
Science Daily: Pharmacology News
NOVEMBER 27, 2024
A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report. Dubbed the NanoGripper, the nanorobotic hand also could be programmed to interact with other viruses or to recognize cell surface markers for targeted drug delivery, such as for cancer treatment.
Science Daily: Pharmacology News
NOVEMBER 7, 2024
It's common knowledge that our brains -- and, specifically, our brain cells -- store memories. But a team of scientists has discovered that cells from other parts of the body also perform a memory function, opening new pathways for understanding how memory works and creating the potential to enhance learning and to treat memory-related afflictions.
Science Daily: Pharmacology News
NOVEMBER 12, 2024
Researchers have developed PanoRadar, a new tool to give robots superhuman vision by transforming simple radio waves into detailed, 3D views of the environment.
Science Daily: Pharmacology News
NOVEMBER 22, 2024
New research has uncovered what may be the oldest direct evidence of ancient hot water activity on Mars, revealing the planet may have been habitable at some point in its past.
Science Daily: Pharmacology News
NOVEMBER 21, 2024
Researchers have reported the discovery of a previously unknown compound in chloraminated drinking water. Inorganic chloramines are commonly used to disinfect drinking water to safeguard public health from diseases like cholera and typhoid fever.
Science Daily: Pharmacology News
NOVEMBER 20, 2024
A recently published meta-analysis reveals an advantage in sports-related information processing compared to non-athletes. The data consisted of 21 studies involving a total of 1455 participants. Athletes had better working memory than non-athletes and this advantage was further enhanced when athletes were compared to sedentary people.
Science Daily: Pharmacology News
NOVEMBER 6, 2024
Older people who are sleepy during the day or lack enthusiasm for activities due to sleep issues may be more likely to develop a syndrome that can lead to dementia, according to a new study.
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2024
Howard Chang will take over as chief scientific officer and senior VP of research as the biotech searches for more ways to overcome the looming loss of exclusivity for some of its top-selling medicines.
Science Daily: Pharmacology News
NOVEMBER 27, 2024
Recent results from a recent clinical trial indicate that a twice-yearly injection of Lenacapavir offers an overall 96% reduced risk of acquiring HIV. This makes Lenacapavir significantly more effective than the standard daily oral PrEP (pre-exposure prophylaxis).
Science Daily: Pharmacology News
NOVEMBER 13, 2024
How much land, water, and other resources does our lifestyle require? And how can we adapt this lifestyle to stay within the limits of what the Earth can give? A new article tackles these questions.
Science Daily: Pharmacology News
NOVEMBER 7, 2024
Researchers have developed an innovative technique to search for black hole light echoes. Their novel method, which will make it easier for the mass and the spin of black holes to be measured, represents a major step forward, since it operates independently of many of the other ways in which scientists have probed these parameters in the past.
Science Daily: Pharmacology News
NOVEMBER 8, 2024
When people have an audience watching them, it can change their performance for better or worse. Now, researchers have found that chimpanzees' performance on computer tasks is influenced by the number of people watching them. The findings suggest that this 'audience effect' predates the development of reputation-based human societies, the researchers say.
Science Daily: Pharmacology News
NOVEMBER 6, 2024
New research suggests that adding a small amount of physical activity -- such as uphill walking or stair-climbing -- into your day may help to lower blood pressure.
Science Daily: Pharmacology News
NOVEMBER 16, 2024
Some of the first human beings to arrive in Tasmania, over 41,000 years ago, used fire to shape and manage the landscape, about 2,000 years earlier than previously thought.
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