Chemical Biology and Drug Design

JANUARY 20, 2025

Peptidedrug conjugates (PDCs) were produced by combining a cancer selective cell-penetrating peptide (PDIP) with camptothecin (CPT). The PDCs crossed membranes and cleavable PDCs killed melanoma cells with nanomolar potency. ABSTRACT Drug targeting strategies, such as peptidedrug conjugates (PDCs), have arisen to combat the issue of off-target toxicity that is commonly associated with chemotherapeutic small molecule drugs.

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Small Molecule Drugs International Therapies 187

Broad Institute

JANUARY 14, 2025

Gene editing extends lifespan in mouse model of prion disease By Allessandra DiCorato January 14, 2025 Breadcrumb Home Gene editing extends lifespan in mouse model of prion disease A single-letter edit in DNA reduces levels of the disease-causing prion protein in the brain and could lead to a preventative, one-time treatment for the deadly neurodegenerative disorder.

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Science Daily: Pharmacology News

JANUARY 28, 2025

The study helps explain why 2023 and early 2024 saw unprecedented ocean temperatures.

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BioPharma Drive: Drug Pricing

JANUARY 30, 2025

Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.

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FDA Approval Doctors Research FDA 143

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Treatment

Nvidia Developer: Drug Discovery

JANUARY 13, 2025

Traditional computational drug discovery relies almost exclusively on highly task-specific computational models for hit identification and lead optimization. Traditional computational drug discovery relies almost exclusively on highly task-specific computational models for hit identification and lead optimization. Adapting these specialized models to new tasks requires substantial time, computational power, and expertisechallenges that grow when researchers simultaneously work across multiple ta

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Drugs Research Science 132

Chemical Biology and Drug Design

JANUARY 22, 2025

The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates. The rising incidence of these infections, coupled with increasing antifungal resistance, underscores the urgent need for novel therapeutic strategies.

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Therapies Drugs Research 100

Broad Institute

JANUARY 6, 2025

Researchers devise new way to target and correct disease-related proteins By Leah Eisenstadt January 6, 2025 Breadcrumb Home Researchers devise new way to target and correct disease-related proteins Broad scientists built a diverse library of compounds and found one that stabilizes a dysfunctional protein in Crohns disease, demonstrating their librarys potential to uncover new therapeutic strategies.

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Disease Research DNA Small Molecule 139

Science Daily: Pharmacology News

JANUARY 27, 2025

An interdisciplinary team of researchers has projected that if the rate of global CO2 emissions continues to increase and reaches a high emission scenario, sea levels would as a result very likely rise between 0.5 and 1.9 meters by 2100. The high end of this projection's range is 90 centimeters higher than the latest United Nations' global projection of 0.6 to 1.0 meters.

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Research 141

BioPharma Drive: Drug Pricing

JANUARY 23, 2025

In an interview, the CEO discussed trying to gain support from investors hyper-focused on M&A, and competing with Pfizer and Alnylam in a closely watched commercial battle.

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Drugs 141

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

FDA Law Blog: Drug Discovery

JANUARY 30, 2025

By Mark A. Tobolowsky & Charles G. Raver & James E. Valentine We recently blogged about a new December 2024 draft guidance about accelerated approval (the December 2024 draft guidance). That post largely focused on endpoints as well as the broader context for when accelerated approval is appropriate. However, as we note in that post, the design, timing of initiation, and timely conduct of confirmatory trials are also important considerations in FDAs determination of whether accelerated

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FDA Trials Disease Drugs 105

Drugs.com

JANUARY 29, 2025

WEDNESDAY, Jan. 29, 2025 -- A popular diabetes drug just got a major new approval -- and it could be a game-changer for millions of Americans at risk for kidney failure. The U.S. Food and Drug Administration (FDA) has officially approved Ozempic to.

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FDA Drugs 122

Chemical Biology and Drug Design

JANUARY 30, 2025

The remarkable therapeutic potential of luteolin against cervical cancer can be ascribed to its profound influence on amino acid and nucleotide metabolism, substantiated by the seamless integration of metabolomics, bioinformatics, and molecular docking techniques in this comprehensive investigation. ABSTRACT The incidence of cervical cancer is high among women globally.

Bioinformatics 100

Bioinformatics Treatment Therapies Research 100

Broad Institute

JANUARY 9, 2025

Scientists engineer CRISPR enzymes that evade the immune system By Allessandra DiCorato January 9, 2025 Breadcrumb Home Scientists engineer CRISPR enzymes that evade the immune system The new genome-editing tools could lead to safer, more efficient gene therapies. By Allessandra DiCorato January 9, 2025 Credit: Natalie Velez, Broad Communications Related news Researchers uncover new CRISPR-like system in animals that can edit the human genome The core components of CRISPR-based genome-editing th

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Engineering Immune Response Therapies DNA 140

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Clinical Trials

Science Daily: Pharmacology News

JANUARY 16, 2025

Increasingly common since 1980, persistent multi-year droughts will continue to advance with the warming climate, warns a new study. This publicly available forty-year global quantitative inventory seeks to inform policy regarding the environmental impact of human-induced climate change. It also detected previously 'overlooked' events.

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BioPharma Drive: Drug Pricing

JANUARY 16, 2025

Pharma dealmaking for drugs invented in China is putting pressure on U.S. biotechs to compete harder, according to investors and executives interviewed by BioPharma Dive at the J.P. Morgan Healthcare Conference.

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Drugs 144

Science Daily: Pharmacology News

JANUARY 9, 2025

Construction materials such as concrete and plastic have the potential to lock away billions of tons of carbon dioxide, according to a new study by civil engineers and earth systems scientists. The study shows that combined with steps to decarbonize the economy, storing CO2 in buildings could help the world achieve goals for reducing greenhouse gas emissions.

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Engineering 145

Science Daily: Pharmacology News

JANUARY 15, 2025

The Atlantic Meridional Overturning Circulation (AMOC) has not slowed down since the mid-20th century based on the North Atlantic air-sea heat fluxes over that time. This finding contrasts with studies that have estimated a decline in the AMOC, likely because previous studies rely on sea surface temperature measurements to understand how the AMOC has changed.

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Clinical Trials

BioPharma Drive: Drug Pricing

JANUARY 8, 2025

The regulator is requiring labeling that warns of Guillan-Barré syndrome, although it said data don’t prove a causal link and affirmed the shots’ benefit outweighs their risks.

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FDA Regulations 141

Broad Institute

JANUARY 6, 2025

Feng Zhang awarded the National Medal of Technology and Innovation By Corie Lok January 6, 2025 Breadcrumb Home Feng Zhang awarded the National Medal of Technology and Innovation Zhang and 22 other individuals received the USs highest honors for science and technology. By Broad Communications January 6, 2025 Credit: Ryan K. Morris Feng Zhang receives the National Medal of Technology and Innovation at the White House from Arati Prabhakar (left), director of the White House Office of Science and T

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Medical Schools Engineering Science Hospitals 138

Science Daily: Pharmacology News

JANUARY 1, 2025

Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans -- including those causing flu, COVID, whooping cough and tuberculosis.

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Virus Disease Research 142

BioPharma Drive: Drug Pricing

JANUARY 28, 2025

The startup says its specially constructed RNAi therapies can get deep into brain tissue, yielding new ways to treat neurological conditions like Huntington’s.

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Therapies Drugs 133

Science Daily: Pharmacology News

JANUARY 13, 2025

Researchers have developed a drastically smaller and more energy efficient method of creating coveted photon pairs that influence each other from any distance. The technology could transform computing, telecommunications, and sensing.

Engineering 138

Engineering Research 138

Science Daily: Pharmacology News

JANUARY 31, 2025

In a comprehensive systematic review and meta-analysis, researchers have taken a deep dive into the effects of cold-water immersion on health and wellbeing. Analyzing data from 11 studies with 3177 participants, researchers found that cold-water immersion may lower stress, improve sleep quality, and boost quality of life.

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Research 129

BioPharma Drive: Drug Pricing

JANUARY 31, 2025

After decades of research, Vertex Pharmaceuticals now has an approved pain medication. Can one of the world’s most powerful biotechs contend with a healthcare system that’s long favored opioids?

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Pharmaceuticals Research Drugs 127

Science Daily: Pharmacology News

JANUARY 2, 2025

A research team has developed a method for extracting gold from electronics waste, then using the recovered precious metal as a catalyst for converting carbon dioxide (CO2), a greenhouse gas, to organic materials.

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Research 137

Science Daily: Pharmacology News

JANUARY 15, 2025

New proteins not found in nature have now been designed to counteract certain highly poisonous components of snake venom. The deep learning, computational methods for developing these toxin-neutralizing proteins offer hope for creating safer, more cost-effective and more readily available therapeutics than those currently in use. Each year more than 2 million people suffer snakebites.

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Science Daily: Pharmacology News

JANUARY 3, 2025

Scientists recently discovered that the giant 'conveyer belt' currents that push star-forged material out of our galaxy and pull it back in can also transport carbon atoms. That means that a good deal of the carbon here on Earth, including the carbon in our bodies, likely left the galaxy at some point!

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Science Daily: Pharmacology News

JANUARY 21, 2025

Marine scientists highlights the complex interplay between heat stress, disease onset and coral mortality. They found that 66 percent of the colonies were bleached by February 2024 and 80 per cent by April. By July, 44 percent of the bleached colonies had died, with some coral genera, such as Acropora, experiencing a staggering 95 percent mortality rate.

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Disease 130

Science Daily: Pharmacology News

JANUARY 24, 2025

We're nearly one month into 2025, but if you're struggling to hold onto your New Year's resolution, stay strong, as new research shows that forming a healthy habit can take longer than you expect. Researchers found that new habits can begin forming within about two months (median of 59-66 days) but can take up to 335 days to establish.

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Research 128

Science Daily: Pharmacology News

JANUARY 17, 2025

Astrophysicists have imaged a large number of exocomet belts around nearby stars, and the tiny pebbles within them. The crystal-clear images show light being emitted from these millimeter-sized pebbles within the belts that orbit 74 nearby stars of a wide variety of ages -- from those that are just emerging from birth to those in more mature systems like our own Solar System.

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