Chemical Biology and Drug Design

FEBRUARY 6, 2025

Analysis of prevalence of ring, nonring, sp 3 -, and sp 2 -hybridized oxygen in approved drugs. For the first time, analysis of distribution of different types of oxygen from center of mass of a molecule. ABSTRACT Despite advancements in molecular design rules and understanding biochemical processes, the field of drug design and discovery seeks to minimize the number and duration of synthesis-testing cycles to convert lead compounds into drug candidates.

FDA Approval 100

FDA Approval FDA Small Molecule Pharmacokinetics 100

Covalent Modifiers

FEBRUARY 6, 2025

Merve Demir,*, Laura Koepping, Ya Li, Lynn Fujimoto, Andrey Bobkov, Jianhua Zhao, Taro Hitosugi, Eduard Sergienko Structure, 2024 [link] Mitochondrial creatine kinases (MtCKs) are key players in maintaining energy homeostasis in cells that work with cytosolic creatine kinases for energy transport from mitochondria to cytoplasm. The inhibition of breast cancer growth by cyclocreatine targeting CKs indicates dependence of cancer cells on the energy shuttle for cell growth and survival.

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Science Daily: Pharmacology News

FEBRUARY 4, 2025

New assessment warns area the size of the USA will become too hot during extreme heat events for even healthy young humans to maintain a safe body temperature if we hit 2 degrees Celsuis above preindustrial levels. For those aged over 60, the same 2 degree rise would see more than a third of the planet's land mass cross this critical 'overheating' threshold.

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BioPharma Drive: Drug Pricing

FEBRUARY 3, 2025

The small, Ireland-based company GH Research said its inhaled version of mebufotenin — a molecular cousin to psilocybin — was fast and effective in a treatment-resistant depression trial.

Trials 292

Trials Treatment Research 292

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

FEBRUARY 5, 2025

WEDNESDAY, Feb. 5, 2025 -- The U.S. Food and Drug Administration has approved Susvimo (ranibizumab) 100 mg/mL for treating diabetic macular edema.Susvimo is the first and only FDA-approved treatment shown to maintain vision in people with diabetic.

FDA Approval 288

FDA Approval FDA Treatment Drugs 288

Science Daily: Pharmacology News

FEBRUARY 6, 2025

Researchers have unveiled the precise brain mechanisms that enable animals to overcome instinctive fears. The study in mice could have implications for developing therapeutics for fear-related disorders such as phobias, anxiety and post-traumatic stress disorder (PTSD).

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Research 327

BioPharma Drive: Drug Pricing

FEBRUARY 6, 2025

The biotech is evaluating several cystic fibrosis medicines that could either work alongside Vertex’s top-selling Trikafta or be used in new, multi-drug combinations.

Drugs 284

Drugs 284

Drugs.com

FEBRUARY 3, 2025

MONDAY, Feb. 3, 2025 -- A common drug used to prevent migraines might have an additional benefit -- protecting women against stroke. Women taking the beta blocker propranolol to ward off migraines have a lower risk of strokes caused by blood clots.

Drugs 285

Drugs 285

Collaborative Drug

FEBRUARY 7, 2025

Vault Snack #28 - Averting the Sample Apocalypse!

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

FEBRUARY 4, 2025

A daily intake of one gram of omega-3s can slow down biological aging by up to four months, according to an analysis of clinical data from the international DO-HEALTH study. For the first time, epigenetic clocks were used to measure the aging process.

International 323

International 323

BioPharma Drive: Drug Pricing

FEBRUARY 3, 2025

The results could sway U.S. regulators to convert Braftovi’s accelerated clearance in colorectal tumors into a full approval — boosting an oncology portfolio Pfizer is looking to for revenue growth.

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Regulations Drugs 284

Drugs.com

FEBRUARY 6, 2025

THURSDAY, Feb. 6, 2025 -- The U.S. Food and Drug Administration has approved Onapgo (apomorphine hydrochloride) injection as the first and only subcutaneous apomorphine infusion device for the treatment of motor fluctuations in patients with.

FDA Approval 277

FDA Approval Disease FDA Treatment 277

Quanticate

FEBRUARY 7, 2025

Learn about the proportional odds assumption in clinical trials, its importance in ordinal regression, and key considerations for statistical analysis.

Clinical Trials 98

Clinical Trials Trials 98

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

FEBRUARY 5, 2025

Boosting communication between the spinal nerves and the muscles using the spinal cord stimulation reverses spinal muscle atrophy (SMA) progression and could be applied to other motoneuron diseases, including ALS.

Disease 308

Disease 308

BioPharma Drive: Drug Pricing

FEBRUARY 3, 2025

China is now a dealmaking hot spot for firms seeking next-generation innovation. What will 2025 hold?

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Drugs.com

FEBRUARY 7, 2025

FRIDAY, Feb. 7, 2025 -- The Texas Department of State Health Services (DSHS) is reporting an outbreak of measles in Gaines County.All cases have been identified among unvaccinated school-aged children who are residents of Gaines County. Symptom.

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Advarra

FEBRUARY 6, 2025

The beginning of a new semester brings a fresh crop of aspiring researchers to institutions each fall and spring. Students learn how to navigate post-secondary education and gain knowledge around effective research methods, both practical and intangible. Student researchers, along with early career researchers (collectively referred to here as new researchers), begin to experience responsible conduct of research principles firsthand.

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Research Regulations 52

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

FEBRUARY 5, 2025

There's a 26 per cent annual chance that space rocket junk will re-enter the atmosphere and pass through a busy flight area, according to a recent study. While the chance of debris hitting an aircraft is very low, the research highlights that the potential for uncontrolled space rocket junk to disrupt flights and create additional costs for airlines and passengers is not.

Research 304

Research 304

BioPharma Drive: Drug Pricing

FEBRUARY 6, 2025

Cobenfy, the main asset acquired through Bristol Myers’ $14 billion purchase of Karuna, had $10 million in sales in the fourth quarter and is around 1,000 prescriptions weekly by late January.

Drugs 251

Drugs 251

Drugs.com

FEBRUARY 5, 2025

WEDNESDAY, Feb. 5, 2025 -- Hopes that GLP-1 drugs such as Ozempic and Wegovy could help slow Parkinson's disease have taken an hit.A new study found that a drug in the same class called exenatide, marketed as Byetta, had no effect on slowing the.

Drugs 276

Drugs Disease Marketing 276

Fierce BioTech

FEBRUARY 5, 2025

AI in Action: Delivering Results in HCP Engagement dwunderlin Wed, 02/05/2025 - 14:16 Thu, 03/20/2025 - 11:00 Resource Type Webinar Matt Lehmann Adam Cahill AI is no longer a noveltyit's an expectation. As stakeholders demand evidence of real-world impact, the focus is shifting from the tools themselves to the tangible results they deliver. Join us for a dynamic discussion on how predictive sales intelligence and omnichannel strategies are transforming healthcare professional (HCP) engagement by

Science 52

Science 52

Science Daily: Pharmacology News

FEBRUARY 3, 2025

Ever notice how much more tempting it is to pick up fast food for dinner after being stuck in traffic? It's not just you. New research shows that traffic delays significantly increase visits to fast food restaurants, leading to unhealthier eating for millions each year.

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Research 305

BioPharma Drive: Drug Pricing

FEBRUARY 3, 2025

While the virus hasn’t made a sustained leap into humans, vaccines and treatments are being developed ahead of an outbreak.

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Virus Vaccine Treatment 241

Drugs.com

FEBRUARY 7, 2025

FRIDAY, Feb. 7, 2025 -- Add surgical tweaks to fix so-called "Ozempic face" to the list of top trending cosmetic procedures, as tallied by the American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS). The group's annual survey of its.

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Advarra

FEBRUARY 4, 2025

At a busy research site, a clinical trial is ready to launch but its stuck in limbo over a single paragraph in the informed consent form (ICF). The issue? Language relating to the potential cost of participation. One sites language on what they will pay for differs from anothers, and the contradictory wording needs to be reviewed and agreed to by the sponsor before the IRB can proceed.

Clinical Trials 52

Clinical Trials Trials Compliance Therapies 52

Science Daily: Pharmacology News

FEBRUARY 5, 2025

In a milestone that brings quantum computing tangibly closer to large-scale practical use, scientists have demonstrated the first instance of distributed quantum computing. Using a photonic network interface, they successfully linked two separate quantum processors to form a single, fully connected quantum computer, paving the way to tackling computational challenges previously out of reach.

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BioPharma Drive: Drug Pricing

FEBRUARY 7, 2025

“There is not a single member of AAM who has not raised concerns about the tariff situation,” said the CEO of the generic drug lobby Association for Accessible Medicines.

Drugs 229

Drugs 229