Drug Target Review

DECEMBER 9, 2024

The 2024 Nobel Prize in Chemistry was awarded to Demis Hassabis and John Jumper from Google DeepMind for developing AlphaFold2, and to David Baker from the University of Washington for his work in computational protein design. These innovations have revolutionised the understanding of protein structures using artificial intelligence. Before AlphaFold, determining 3D protein structures was complex and time-consuming, and often required the use of experimental methods like X-ray crystallography an

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Drug Patent Watch

DECEMBER 11, 2024

The biopharmaceutical industry has witnessed a significant surge in the number of therapeutic molecules in development, leading to a corresponding increase in the number of contract development and manufacturing organizations (CDMOs). This growth has created a competitive landscape where pharmaceutical companies must carefully evaluate and select the right CDMO partner to ensure the success of their projects.

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Science Daily: Pharmacology News

DECEMBER 11, 2024

Researchers show that early-onset colorectal cancer (CRC) incidence rates are rising in 27 of 50 countries/territories worldwide, 20 of which have either exclusive or faster increases for early-onset disease. In 14 countries, including the United States, rates are increasing in young adults while stabilizing in those 50 years and older.

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Broad Institute

DECEMBER 11, 2024

#WhyIScience Q&A: A computational biologists world travels have shaped her approach to research By Corie Lok December 11, 2024 Breadcrumb Home #WhyIScience Q&A: A computational biologists world travels have shaped her approach to research Wolu Chukwu talks about how she brings a community-first focus to her work in cancer genetics. By Corie Lok December 11, 2024 Credit: Allison Colorado, Broad Communications Wolu Chukwu is a computational biologist studying cancer genetics at Broad.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Chemical Biology and Drug Design

DECEMBER 13, 2024

Tectorigenin could reduce the expression levels of inflammatory cytokines in both DBV-infected THP-1 cells and plasma samples of IFNAR / mice infected with DBV. ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is a severe emerging infectious disease caused by Dabie bandavirus (DBV). Tectorigenin has been demonstrated to exert anti-inflammatory effect.

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Drug Patent Watch

DECEMBER 10, 2024

The pharmaceutical industry has undergone significant changes over the past decade, with a growing trend towards outsourcing key aspects of research, development, and manufacturing to third-party vendors. This shift has led to the emergence of integrated contract development and manufacturing organizations (CDMOs), which provide end-to-end support for drug developers.

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Codon

DECEMBER 12, 2024

The creation of a “mirrored” organism could “trigger severe ecological disruptions,” according to a 300-page technical report released today. Its authors claim such organisms could quickly spread across the world, fatally infect humans, and “directly drive vulnerable plant and animal species to extinction.” The report accompanies an article in Science , also released today, entitled “Confronting Risks of Mirror Life.” But what, exactly, is a mirror

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Chemical Biology and Drug Design

DECEMBER 13, 2024

The stabilization of the G-quadruplex region in the c-Myc and Bcl-2 promoter genes by voreloxin leads to the downregulation of c-Myc and Bcl-2 expression, resulting in apoptosis of leukemia cells. ABSTRACT Overexpression of c-Myc is a key factor in the development of leukemia and other malignancies, highlighting the urgent need for novel drugs to inhibit c-Myc protein levels.

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Drug Patent Watch

DECEMBER 12, 2024

Identifying branded drugs with a low likelihood of generic entry has become a crucial strategy for companies looking to expand their product portfolio through in-licensing. This approach not only helps maintain market exclusivity but also ensures a steady revenue stream for pharmaceutical companies. In this comprehensive guide, we’ll explore the intricacies of identifying such drugs and leveraging them for successful in-licensing opportunities.

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Science Daily: Pharmacology News

DECEMBER 13, 2024

A new study points to why, and how, Io became the most volcanic body in the solar system.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Perficient: Drug Development

DECEMBER 13, 2024

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Chemical Biology and Drug Design

DECEMBER 12, 2024

Compounds 7h and 7 in HTB-9 and compounds 7a and 7 in HT-29 cell line demonstrated most cytotoxic activity among all compounds. These compounds expectedly increased apoptosis, activated caspase 3/7, and inhibited migration in both cell lines compared to controls. As a remarkable result, a greater apoptotic index was observed in HT-29 cells treated with compound 7 than those of cisplatin-treated cells.

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Drug Patent Watch

DECEMBER 9, 2024

In the vast realm of pharmaceutical research and development, there’s a fascinating intersection between ancient wisdom and modern science. This intersection is where pharmacognosy meets drug patents, creating a unique landscape that shapes the future of medicine. But what exactly is pharmacognosy, and how does it relate to the complex world of drug patents?

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Drugs Drug Development Pharmaceuticals Production 97

Science Daily: Pharmacology News

DECEMBER 12, 2024

Neanderthal genes make up 1-2% of the genomes of non-Africans. Scientists analyzed the lengths of regions of Neanderthal DNA in 58 ancient Eurasian genomes of early modern humans and determined that the introgressed genes result from interbreeding between Homo sapiens and Neanderthals about 47,000 years ago, over a single, extended period of about 7,000 years.

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Clinical Trials

Drug Channels

DECEMBER 13, 2024

This week, Im rerunning some popular posts while I prepare for todays Drug Channels Outlook 2025 live video webinar. (If you sign up before 12 p.m. ET, you can attend the live event.) Click here to see the original post. The econowonks at the Centers for Medicare & Medicaid Services (CMS) recently released the latest projections for U.S. spending on healthcare.

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Chemical Biology and Drug Design

DECEMBER 12, 2024

This diagram illustrates the proposed mechanism by which Schisandrin A (SchA) affects hepatocellular carcinoma (HCC) cells. SchA induces reactive oxygen species (ROS) generation in mitochondria, leading to oxidative stress and mitochondrial dysfunction. This cascade activates AMP-activated protein kinase (AMPK), which inhibits the mTOR pathway, resulting in decreased cell proliferation and increased apoptosis.

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Protein Expression DNA Regulations Research 100

Drug Patent Watch

DECEMBER 10, 2024

India has long been recognized as a significant player in the global pharmaceutical industry, particularly in the production of generic drugs. The country’s pharmaceutical sector has experienced substantial growth over the years, driven by both domestic and international demand for affordable and high-quality medicines. This article delves into India’s growing importance in generic drug API manufacturing, highlighting the key factors contributing to its success and the challenges it

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Science Daily: Pharmacology News

DECEMBER 12, 2024

A research team has developed an ultra-thin, flexible film that could power next-generation wearable devices using body heat, eliminating the need for batteries.

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Clinical Trials

Drugs.com

DECEMBER 13, 2024

FRIDAY, Dec. 13, 2024 -- Beans, peas and lentils take center stage in newly proposed changes to dietary guidelines for Americans. In a report released this week by an advisory committee to the Agriculture Department, experts suggest that the.

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Chemical Biology and Drug Design

DECEMBER 12, 2024

The inhibitory profile of triaminopyrimidines was expanded and low nM IC 50 alky and aryl variants of CK-1-41 were discovered. Docking supported previous work indicating allosteric inhibition of caspase-1. Analogs with electrophilic warheads were created and inhibited caspase-1 in a partially reversible, time-dependent manner with experimental and docking results supporting allostery.

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Drug Patent Watch

DECEMBER 9, 2024

Biosimilars have faced significant challenges in their analytical characterization. This process involves a comprehensive analysis of the biosimilar’s molecular structure, biological activity, and other quality characteristics to demonstrate similarity to the reference product. The emphasis on analytical and functional testing through sophisticated technology is crucial in overcoming these challenges.

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Science Daily: Pharmacology News

DECEMBER 11, 2024

A new class of magnetism called altermagnetism has been imaged for the first time in a new study. The findings could lead to the development of new magnetic memory devices with the potential to increase operation speeds of up to a thousand times.

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Drugs.com

DECEMBER 13, 2024

FRIDAY, Dec. 13, 2024 -- The ancient Japanese practice of reiki "energy healing" might help some cancer patients deal with the pain that can come with infusion therapies, new research shows. "Outpatients receiving reiki during infusion reported.

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Drug Target Review

DECEMBER 13, 2024

Lung cancer is the most commonly diagnosed cancer worldwide, representing 12.4 percent of all cases. It is also the leading cause of cancer-related deaths, accounting for 18.7 percent of total cancer fatalities. 1 Lung cancer is primarily classified into two types based on histological examination: Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC).

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Chemical Biology and Drug Design

DECEMBER 9, 2024

EXPRESSION OF CONCERN: Y. Liu, D. Cheng, M. Ge, and W. Lin, The Truncated Human Telomeric Sequence Forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution, Chemical Biology & Drug Design 88, no. 1 (2016): 122-128, [link]. This Expression of Concern is for the above article, published online on 12 February 2016, in Wiley Online Library ( [link] ), and has been issued by agreement between the journal Editor-in-Chief, Roberta Melander; and John Wiley

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Science Daily: Pharmacology News

DECEMBER 11, 2024

A new study highlights a hidden challenge of using AI in medical imaging research -- the phenomenon of highly accurate yet potentially misleading results known as 'shortcut learning.' The researchers analyzed thousands of knee X-rays and found that AI models can 'predict' unrelated and implausible traits such as whether patients abstained from eating refried beans or beer.

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Drugs.com

DECEMBER 13, 2024

FRIDAY, Dec. 13, 2024 -- It's a decision no woman wants to have to make, but new research shows that young breast cancer patients with high-risk genes may be able to prevent their cancer from returning if they have their breasts or ovaries.

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Drug Patent Watch

DECEMBER 12, 2024

The pharmaceutical industry relies heavily on Contract Development and Manufacturing Organizations (CDMOs) to outsource various stages of drug development and manufacturing. With the increasing complexity of drug development and the need for efficient, cost-effective solutions, selecting the right CDMO is crucial. Evaluating CDMO performance is a critical step in this process, ensuring that the chosen partner can meet the required standards and deliver high-quality products.

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Chemical Biology and Drug Design

DECEMBER 11, 2024

The review discusses the systemic development of selective inhibitors for Mtb -DHFR as antitubercular agents and their designing strategies. The study also explores and compiles the latest patents and clinical trial data into a single platform to help develop selective Mtb -DHFR inhibitors for effective tuberculosis treatment. ABSTRACT Tuberculosis (TB) is an obstinate and infectious disease requiring a relatively longer treatment duration than other bacterial infections.

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Science Daily: Pharmacology News

DECEMBER 11, 2024

Scientists' findings in mice could translate into a radical, needle-free vaccination approach that would also eliminate reactions including fever, swelling and pain.

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Drugs.com

DECEMBER 13, 2024

FRIDAY, Dec. 13, 2024 -- Have you been boozing more often than usual? A new blood test might be able to tell if you’re damaging your liver from too many beers, margaritas or belts of scotch, researchers report. A blood-borne byproduct of.

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Drug Patent Watch

DECEMBER 10, 2024

Patents play a crucial role in protecting intellectual property and fostering innovation. However, the increasing complexity of patent systems has given rise to a phenomenon known as “patent thickets.” These dense webs of overlapping patent rights can significantly impact innovation, market entry, and competition across various industries and countries.

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The ChEMBL-og

DECEMBER 12, 2024

Use your well-deserved Christmas holidays to spend time with your loved ones and explore the new release of ChEMBL 35! This fresh release comes with a wealth of new data sets and some new data sources as well. Examples include a total of 14 datasets deposited by by the ASAP ( AI-driven Structure-enabled Antiviral Platform) project, a new NTD data se t by Aberystwyth University on anti-schistosome activity, nine new chemical probe data sets, and seven new data sets for the Chemogenomic library of

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