Drug Discovery World

JULY 26, 2024

News round-up for 22-26 July by DDW Senior Digital Content Editor Diana Spencer. There have been some interesting developments in neuroscience this week. Perhaps most note-worthy, shingles vaccines Shingrix has been shown to reduce the risk of dementia by 17%, and TikoMed’s ALS drug caused a long-term slowing of ALS progression in a Phase II trial. The top stories: Oxford centre to address global epilepsy challenges The University of Oxford is launching The Centre for Global Epilepsy to address

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Science Daily: Pharmacology News

JULY 24, 2024

A study looks at the maximum possible sizes of dinosaurs, using the carnivore, Tyrannosaurus rex, as an example. Using computer modelling, experts produced estimates that T. Rex might have been 70% heavier than what the fossil evidence suggests.

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Perficient: Drug Development

JULY 25, 2024

“Double, double toil and trouble,” is a line repeated by the witches in Macbeth as they lay out the ominous prophecies of greatness and dire consequences for the titular character. Macbeth’s ambition envisions a perfect ending though desperate actions and moral weakness ruin it. So too are the misguided actions in pursuit of perfection which can set expectations and pressure that lead to unwanted results.

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Drugs.com

JULY 23, 2024

TUESDAY, July 23, 2024 -- The boom in using GLP-1 drugs like Ozempic to treat obesity has resulted in a bust regarding the drugs’ original purpose, which was to treat type 2 diabetes, a new study finds. New prescriptions for these drugs have d.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JULY 26, 2024

Dren Bio and Novartis Pharma have entered a strategic collaboration focused on the discovery and development of therapeutic bispecific antibodies for cancer. Under the terms of the agreement, Dren Bio will receive a total upfront consideration of $150 million from Novartis, which includes a $25 million equity investment in the company. Dren Bio is also eligible to receive up to $2.85 billion in additional cash payments upon achieving certain preclinical, clinical, regulatory, and commercial mile

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Science Daily: Pharmacology News

JULY 26, 2024

Engineering researchers have demonstrated a state-of-the-art hardware device that could reduce energy consumption for artificial intelligent (AI) computing applications by a factor of at least 1,000.

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Drugs.com

JULY 25, 2024

THURSDAY, July 25, 2024 -- The bird flu is now jumping between species of mammals, a step that draws the virus closer to hopping into human beings, a new study warns.Researchers have tracked transmission of avian influenza between dairy cows in.

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Drug Discovery World

JULY 25, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers five articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: The promise and growth of cell and gene therapies No sign of stopping: The rise of cell and gene therapy Expert view: What’s next for cell and gene therapy?

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Science Daily: Pharmacology News

JULY 25, 2024

A noninvasive colorectal cancer screening test that can be done at home could reduce the risk of colorectal cancer death by 33%, according to a new study.

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BioPharma Drive: Drug Pricing

JULY 25, 2024

Some analysts described Sanofi’s pipeline of immune system therapies, which includes more than half a dozen drugs in mid- to late-stage testing, as “underappreciated” by investors, as sales of Dupixent rose over the last quarter.

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Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- Abbott has warned diabetes patients that some of its continuous blood sugar monitoring systems may need to be replaced because of inaccurate readings."Abbott has recently identified a small number of FreeStyle Libre 3.

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Drug Discovery World

JULY 25, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers five articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: The promise and growth of cell and gene therapies No sign of stopping: The rise of cell and gene therapy Expert view: What’s next for cell and gene therapy?

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Science Daily: Pharmacology News

JULY 25, 2024

An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new study. By targeting infected cells in the brain, drug may clear virus from hidden areas that have been a major challenge in HIV treatment.

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FDA Law Blog: Biosimilars

JULY 23, 2024

By Adrienne R. Lenz, Principal Medical Device Regulation Expert — For several years, FDA has requested that sponsors of drug or biologic led combination products identify essential performance requirements (EPRs) related to the device constituent in their applications. EPRs were usually requested in the context of design controls, although 21 C.F.R. § 820.30 does not use this term.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- Older people who avail themselves of the newest shingles vaccine could reap a hidden benefit: A significant drop in their odds of developing dementia. One expert applauded the new findings. "Dementia isn’t an.

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Drug Discovery World

JULY 25, 2024

Researchers at ETH Zurich in Switzerland have uncovered how colorectal cancer cells colonise the liver. The findings, by Andreas Moor in the Department of Biosystems Science and Engineering and his team, will help to develop treatments with which they hope could hinder the metastatic process. Cancer metastasises when cells from the primary tumour break off and travel via the circulatory system to other parts of the body.

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Science Daily: Pharmacology News

JULY 22, 2024

Dogs experience emotional contagion from the smell of human stress, leading them to make more 'pessimistic' choices, new research finds. Researchers tested how human stress odors affect dogs' learning and emotional state.

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Quanticate

JULY 22, 2024

Throughout the conduct of a clinical trial, ensuring patient safety and maintaining the integrity of the study are vital. This is where, Data Monitoring Committees (DMC) are used to support patient safety and integrity.

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Clinical Trials Trials 105

Drugs.com

JULY 22, 2024

MONDAY, July 22, 2024 -- Daily supplements can slow loss of vision related to late-stage “dry” age-related macular degeneration (AMD), a new study finds.The rate of dry AMD progression into a key eye region slowed by about 55% over an average three.

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Drug Discovery World

JULY 25, 2024

UK researchers have mapped the exact variants in a gene that dramatically increase a person’s risk of developing cancer, paving the way for targeted treatment across diverse populations. Over 5,000 genetic variants that enable certain cancers to thrive were identified, along with a potential therapeutic target to treat or even prevent these cancers from developing.

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Science Daily: Pharmacology News

JULY 25, 2024

Engineers discovered that when the aluminum in soda cans is purified and mixed with seawater, the solution produces hydrogen -- which can power an engine or fuel cell without generating carbon emissions. The reaction can be sped up by adding caffeine.

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Drug Patent Watch

JULY 21, 2024

The Patent Trial and Appeal Board (PTAB) is a crucial component of the United States Patent and Trademark Office (USPTO), established in 2012 by the Leahy-Smith America Invents Act (AIA).

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Drugs.com

JULY 25, 2024

THURSDAY, July 25, 2025 -- Synthetic antibiotics that attack bacteria in two directions at once could be the solution for combatting antimicrobial-resistant bugs, a new study claims.These dual-action antibiotics, called macrolones, disrupt.

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Drug Discovery World

JULY 25, 2024

The future is looking rosy for the biotechnology sector. Diana Spencer takes a world-tour of some of the key centres of innovation. According to data analysts Precedence Research, the global biotechnology market was estimated at $1.38 trillion in 2023 and is expected to be worth around $4.25 trillion by 2033, growing at an impressive CAGR of 11.8% 1.

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Science Daily: Pharmacology News

JULY 22, 2024

When people are having a conversation, they rapidly take turns speaking and sometimes even interrupt. Now, researchers who have collected the largest ever dataset of chimpanzee 'conversations' have found that they communicate back and forth using gestures following the same rapid-fire pattern.

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Broad Institute

JULY 23, 2024

#WhyIScience Q&A: A mechanical engineer builds microscopes to give new spatial views of cells and tissues By Leah Eisenstadt July 23, 2024 Breadcrumb Home #WhyIScience Q&A: A mechanical engineer builds microscopes to give new spatial views of cells and tissues Lindsey Erion-Barner describes her efforts to develop and share innovative tools in the Spatial Technology Platform By Leah Eisenstadt July 23, 2024 Credit: Allison Colorado, Broad Communications Lindsey Erion-Barner develops and shares

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Drugs.com

JULY 22, 2024

MONDAY, July 22, 2024 -- At least 28 people have been hospitalized and two have died in a multi-state outbreak of listeria linked to deli meat, U.S. health officials warned.In an investigation notice posted Friday, the U.S. Centers for Disease.

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Drug Discovery World

JULY 25, 2024

Abiologics, a Flagship Pioneering company, has launched to develop a new class of supranatural and programmable medicines called Synteins. Synteins are computationally-generated and synthesised with novel building blocks, potentially providing treatments across a wide range of diseases. Flagship has initially committed $50 million to advance the company’s platform and develop a diverse pipeline of medicines, with an initial focus on oncology and immunology indications.

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Science Daily: Pharmacology News

JULY 22, 2024

In a finding that opens the door to the development of targeted therapies for various muscle disorders, newly published research identifies key mechanisms of skeletal muscle regeneration and growth of muscles following resistance exercise.

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Perficient: Drug Development

JULY 26, 2024

Perficient is thrilled to announce that Amarender Peddamalku has been awarded the prestigious “Most Valuable Professional” (MVP) status in Business Applications by Microsoft for the second time. This achievement is especially significant, highlighting his continued excellence and commitment to the Microsoft community. Amarender Peddamalku serves as the Microsoft Modern Work practice lead and digital transformation leader at Perficient.

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Drugs.com

JULY 24, 2024

WEDNESDAY, July 24, 2024 -- Misuse of illicit prescription drugs is falling dramatically among U.S. high school students, a new study says.The percentage of seniors who say they’ve misused prescription drugs in the past year has dropped to 2% in 2.

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Drug Discovery World

JULY 24, 2024

SynaptixBio and Evotec have announced they are extending their partnership to find further candidate drugs to treat H-ABC, the most severe form of TUBB4A leukodystrophy. The drug research was originally carried out by the Children’s Hospital of Philadelphia (CHOP), the world’s leading centre for leukodystrophy research, under a sponsored research agreement.

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Science Daily: Pharmacology News

JULY 26, 2024

New therapy uses synthetic nanofibers to mimic the natural signaling of a protein that is crucial for cartilage formation and maintenance. Researchers found that intensifying the motion of molecules within the nanofibers led to more components needed for regeneration. After just four hours, the treatment activated the gene expression necessary to generate cartilage.

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National Institute on Drug Abuse: Nora's Blog

JULY 22, 2024

To address the fentanyl crisis, greater access to methadone Is needed area Mon, 07/22/2024 - 12:43 Nora's Blog July 29, 2024 By Nora D. Volkow, National Institute on Drug Abuse Image ©Getty images/ seb_ra Over the past several years, the increasing prevalence of fentanyl in the drug supply has created an unprecedented overdose death rate and other devastating consequences.

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