RNA editing: emerging from CRISPR’s shadow
BioPharma Drive: Drug Pricing
OCTOBER 22, 2024
Early study data from Wave Life Sciences suggests how editing RNA may yield viable medicines. Large and small drugmakers say such results are just the start.
Sat.Oct 19, 2024 - Fri.Oct 25, 2024
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Researchers flip genes on and off with AI-designed DNA switches
Science Daily: Pharmacology News
OCTOBER 23, 2024
Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types. Their new approach opens the possibility of controlling when and where genes are expressed in the body, for the benefit of human health and medical research, in ways never before possible.
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Machine learning guides researchers to new synthetic genetic switches
Broad Institute
OCTOBER 23, 2024
Machine learning guides researchers to new synthetic genetic switches By Tom Ulrich October 23, 2024 Breadcrumb Home Machine learning guides researchers to new synthetic genetic switches A new method allows precise activation or repression of genes in specific cells and tissues. By Sarah C.P. Williams October 23, 2024 Credit: Natalie Velez, Broad Communications, from Gosai and Castro et al 2024.
CDC Says Some People May Need Extra Dose of COVID Vaccine
Drugs.com
OCTOBER 25, 2024
FRIDAY, Oct. 25, 2024 -- Some Americans should get more than one shot of the updated COVID vaccines because their age or certain health conditions make them more vulnerable to severe infections, U.S. health officials advised this week.Six months.
From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Optimizing Drug Discovery with CUDA Graphs, Coroutines, and GPU Workflows
Nvidia Developer: Drug Discovery
OCTOBER 23, 2024
Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer. Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer technology engineer at NVIDIA, and Ellery Russell, tech lead for the Desmond engine at Schrödinger, explore advanced GPU optimization techniques designed to accelerate molecular dynamics simulati
What standing on one leg can tell you: Biological age
Science Daily: Pharmacology News
OCTOBER 23, 2024
How long a person can stand -- on one leg -- is a more telltale measure of aging than changes in strength or gait, according to new research.
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More Trending
Intellia data spark debate about CRISPR drug’s potential
BioPharma Drive: Drug Pricing
OCTOBER 24, 2024
Newly published data show the therapy reduced the rate of swelling attacks in people with hereditary angioedema, but didn't silence questions about its commercial outlook.
ChEMBL brings drug bioactivity data to the Protein Data Bank in Europe
The ChEMBL-og
OCTOBER 23, 2024
In the quest to develop new drugs, understanding the 3D structure of molecules is crucial. Resources like the Protein Data Bank in Europe (PDBe) and the Cambridge Structural Database (CSD) provide these 3D blueprints for many biological molecules. However, researchers also need to know how these molecules interact with their biological target – their bioactivity.
Plant CO2 uptake rises by nearly one third in new global estimates
Science Daily: Pharmacology News
OCTOBER 21, 2024
Plants the world over are absorbing about 31% more carbon dioxide than previously thought, according to a new assessment. The research is expected to improve Earth system simulations that scientists use to predict the future climate, and spotlights the importance of natural carbon sequestration for greenhouse gas mitigation.
Weight-Loss Surgeries Decline 25% as More Americans Turn to GLP-1 Meds
Drugs.com
OCTOBER 25, 2024
FRIDAY, Oct. 25, 2024 -- As the popularity of GLP-1 meds like Wegovy and Zepbound grows, fewer Americans are turning to weight-loss surgeries to trim their waistlines, a new report finds.Prescriptions of this GLP-1 class of diabetes and weight-loss.
How Machine Learning Drives Clinical Trial Efficiency
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Editas, changing course again, looks to partner lead CRISPR therapy
BioPharma Drive: Drug Pricing
OCTOBER 22, 2024
The gene editing company will focus on “in vivo” medicines, while seeking to license out or find a development partner for its clinical-stage treatment reni-cel.
New diagnostic approach for bacterial infections shows promise in the clinic
Broad Institute
OCTOBER 21, 2024
New diagnostic approach for bacterial infections shows promise in the clinic By Leah Eisenstadt October 21, 2024 Breadcrumb Home New diagnostic approach for bacterial infections shows promise in the clinic In a pilot study with patient samples, the technology performed as well as the current gold-standard methods, yielding accurate results within hours instead of days.
Paws of polar bears sustaining ice-related injuries in a warming Arctic
Science Daily: Pharmacology News
OCTOBER 22, 2024
Polar bears in some parts of the high Arctic are developing ice buildup and related injuries to their feet. The changes appear to be an unexpected consequence of climate change, related to changing conditions in a warming Arctic.
Fatal Opioid-Meth Overdoses Have Fallen in U.S. by More Than a Third
Drugs.com
OCTOBER 22, 2024
TUESDAY, Oct. 22, 2024 -- Expanded access to addiction treatment and the overdose-reversal med naloxone likely prompted a 37% reduction in OD deaths linked to opioids taken with meth or other stimulant drugs, a new study suggests.OD death rates.
Deliver Fast, Flexible Clinical Trial Insights with Spotfire
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
New JAMA Article Recommends Personal Drug Importation To Help American Patients Afford Prescription Drugs
Policy Prescription
OCTOBER 22, 2024
Harvard doctors and public health experts recommend using the website PharmacyChecker.com to find international online pharmacies to order more affordable prescription drugs for personal importation when domestic savings strategies fail. They offer this advice in a new article in the Journal of the American Medical Association. Article Review The article, Strategies to Help Patients Navigate High Prescription Drug Costs , offers very digestible and evidence-driven guidance for clinicians to bet
Using Google Patents to Find Drug Patents? Here’s 15 Reasons Why You Shouldn’t
Drug Patent Watch
OCTOBER 23, 2024
When it comes to patent searches, especially in the pharmaceutical industry, accuracy and comprehensiveness are crucial. While Google Patents is a popular tool due to its accessibility and user-friendly interface, it may not be the best resource for finding drug patents. Let’s explore why.
Bilingualism may maintain protection against Alzheimer's
Science Daily: Pharmacology News
OCTOBER 22, 2024
In a study, researchers use neuroimaging methods to examine brain resilience in regions of the brain linked to language and aging. They found that the hippocampus in bilinguals with Alzheimer's disease was noticeably larger than those who were monolingual when matched for age, education, cognitive function and memory, which suggests that there may be some form of brain maintenance related to bilingualism.
Antibiotics Reveal Links Between Gut Microbes, Parkinson's
Drugs.com
OCTOBER 25, 2024
FRIDAY, Oct. 24, 2024 -- Certain gut microbes might be linked to a person’s risk of developing Parkinson’s disease, a new study suggests.People prescribed multiple courses of penicillin antibiotics have a modestly lower risk of developing Par.
Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Pharmaceutical research on mRNA and CAR T-cell therapy in cancer: Pioneering the future of oncology
BioPharma Drive: Drug Pricing
OCTOBER 21, 2024
Immunotherapy and precision medicine show promise in better fighting cancer. What else does the research tell us?
Filing Drug Patents in Emerging Markets
Drug Patent Watch
OCTOBER 21, 2024
The pharmaceutical industry is a significant contributor to the global economy, with a substantial portion of its production costs incurred during the development stage. This makes intellectual property protection crucial for the industry’s success.
Unnoticeable electric currents could reduce skin infections
Science Daily: Pharmacology News
OCTOBER 24, 2024
Using a few zaps of electricity to the skin, researchers can stop bacterial infections without using any drugs. For the first time, researchers designed a skin patch that uses imperceptible electric currents to control microbes.
At-Home Brain Stimulation Treatment Can Safely Ease Depression
Drugs.com
OCTOBER 22, 2024
TUESDAY, Oct. 22, 2024 -- At-home brain stimulation therapy can safely and effectively treat severe to moderate depression, a new clinical trial shows.Rates of treatment response and depression remission were three times higher in people receiving.
Molecular mechanisms underlying amyloid beta peptide mediated upregulation of vascular cell adhesion molecule-1 in Alzheimer's disease. [Cellular and Molecular]
ASPET
OCTOBER 25, 2024
Amyloid beta (Aβ) deposition and neurofibrillary tangles are widely considered as the primary pathological hallmarks of familial and sporadic forms of Alzheimer's disease (AD). However, cerebrovascular inflammation, which is prevalent in 70% of AD patients is emerging as another core feature of AD pathology. In addition, activation of inflammatory signaling pathways have been observed in AD patients; specifically, cerebrovascular inflammation was found to be augmented in Alzheimer's patient
Prioritizing Patient Centricity in Generic Drug Development
Drug Patent Watch
OCTOBER 23, 2024
The pharmaceutical industry has faced significant challenges in recent years, including the loss of patents, increased regulatory scrutiny, and rising research and development costs. Amidst these challenges, the concept of patient centricity has gained prominence as a key strategy for improving the drug development process and enhancing patient outcomes.
Popular diabetes and weight-loss drug may reduce risk of Alzheimer's disease
Science Daily: Pharmacology News
OCTOBER 24, 2024
Researchers have found that semaglutide may lower the risk of Alzheimer's disease in people with type 2 diabetes (T2D).
U.S. Infant Deaths Rose After Fall of Roe v. Wade
Drugs.com
OCTOBER 21, 2024
MONDAY, Oct. 21, 2024 -- The United States experienced a small but significant rise in infant deaths in the months following the U.S. Supreme Court's decision overturned Roe v. Wade, a new study shows.The Dobbs ruling, handed down in July of 2022.
Dopamine D1-Like Receptor-Mediated Insurmountable Blockade of the Reinforcing Effects of Cocaine in Rats [Behavioral Pharmacology]
ASPET
OCTOBER 23, 2024
Previous studies indicated differing effects of dopamine D 1 -like and D 2 -like receptor (D 1 R and D 2 R, respectively) agonists on cocaine self-administration. Leftward shifts by D 2 R agonists in the cocaine self-administration dose-effect function contrast with decreases by D 1 R agonists in maximal cocaine self-administration without rightward or leftward displacement.
Harnessing the power of upstream platform integration to accelerate biopharma innovation
BioPharma Drive: Drug Pricing
OCTOBER 21, 2024
Learn how Syngene’s integrated strategy can enhance your mAb production capabilities.
Gut bacteria transfer genes to disable weapons of their competitors
Science Daily: Pharmacology News
OCTOBER 24, 2024
New research shows that a large, ubiquitous mobile genetic element changes the antagonistic weaponry of Bacteroides fragilis, a common bacterium of the human gut.
Doctors More Likely to Order 'Opioids Only' for Black Patients After Surgery
Drugs.com
OCTOBER 21, 2024
MONDAY, Oct. 21, 2024 -- After Black patients undergo a surgery, they are much more likely than their white peers to receive only an opioid for post-op pain relief, rather than a more nuanced combo of analgesics, a new study finds.So-called.
Clinical Development of the GluN2B-selective NMDA Receptor Inhibitor NP10679 for the Treatment of Neurologic Deficit after Subarachnoid Hemorrhage [Neuropharmacology]
ASPET
OCTOBER 23, 2024
Aneurysmal subarachnoid hemorrhage (aSAH) may be associated with cerebral vasospasm, which can lead to delayed cerebral ischemia, infarction, and worsened functional outcomes. The delayed nature of cerebral ischemia secondary to SAH-related vasculopathy presents a window of opportunity for the evaluation of well-tolerated neuroprotective agents administered soon after ictus.
Carl Sailer on AI, market trends, and strategic planning in biotech
Fierce BioTech
OCTOBER 21, 2024
Carl Sailer is Vice President of Full Service Solutions at Syneos Health®, a leading fully integrated biopharmaceutical solutions organization providing clinical development and commercialization s | In this conversation with Fierce Biotech, we explore the ever-evolving biotech landscape. Chiefly, Sailer highlights the transformative impact of AI and machine learning in drug development, a trend which, he believes, can potentially double approval rates while reducing costs and time-to-market.
What happened when a meteorite the size of four Mount Everests hit Earth?
Science Daily: Pharmacology News
OCTOBER 21, 2024
Scientists paint a compelling picture of what happened the day the S2 meteorite crashed into Earth 3.26 billion years ago.
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