Sat.Jan 18, 2025 - Fri.Jan 24, 2025

article thumbnail

Medicare to Negotiate Prices for 15 More Drugs, Including Ozempic

Drugs.com

WEDNESDAY, Jan. 22, 2025 -- Medicare will soon negotiate prices for 15 more drugs as part of an effort to reduce costs for seniors and people with disabilities, federal health officials announced in a news release. The negotiations, made possible.

Drugs 111
article thumbnail

Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein‐Derived Cell‐Penetrating Peptide

Chemical Biology and Drug Design

Peptidedrug conjugates (PDCs) were produced by combining a cancer selective cell-penetrating peptide (PDIP) with camptothecin (CPT). The PDCs crossed membranes and cleavable PDCs killed melanoma cells with nanomolar potency. ABSTRACT Drug targeting strategies, such as peptidedrug conjugates (PDCs), have arisen to combat the issue of off-target toxicity that is commonly associated with chemotherapeutic small molecule drugs.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

BridgeBio’s Neil Kumar on an underdog drug launch and wooing deal-hungry investors

BioPharma Drive: Drug Pricing

In an interview, the CEO discussed trying to gain support from investors hyper-focused on M&A, and competing with Pfizer and Alnylam in a closely watched commercial battle.

Drugs 141
article thumbnail

Myth busted: Healthy habits take longer than 21 days to set in

Science Daily: Pharmacology News

We're nearly one month into 2025, but if you're struggling to hold onto your New Year's resolution, stay strong, as new research shows that forming a healthy habit can take longer than you expect. Researchers found that new habits can begin forming within about two months (median of 59-66 days) but can take up to 335 days to establish.

Research 128
article thumbnail

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

article thumbnail

Certain Meds and Diet Can Reverse Type 2 Diabetes

Drugs.com

FRIDAY, Jan. 24, 2025 -- People can reverse their type 2 diabetes through a combination of calorie cutting and medication, a small clinical trial says.Overweight and obese adults caused their diabetes to go into remission by following a.

More Trending

article thumbnail

Moderna gets $590M from US government for bird flu vaccine

BioPharma Drive: Drug Pricing

Moderna has been testing an mRNA candidate for influenza viruses like the H5 and H7 strains that are seen as pandemic threats. Others, including GSK and Pfizer, are also at work on similar shots.

article thumbnail

Cycle of coral bleaching on the Great Barrier Reef now at 'catastrophic' levels

Science Daily: Pharmacology News

Marine scientists highlights the complex interplay between heat stress, disease onset and coral mortality. They found that 66 percent of the colonies were bleached by February 2024 and 80 per cent by April. By July, 44 percent of the bleached colonies had died, with some coral genera, such as Acropora, experiencing a staggering 95 percent mortality rate.

Disease 130
article thumbnail

FDA Approves Spravato Nasal Spray for Treatment-Resistant Depression

Drugs.com

WEDNESDAY, Jan. 22, 2025 -- The U.S. Food and Drug Administration has approved Spravato (esketamine) CIII nasal spray for adults living with major depressive disorder who have had an inadequate response to at least two oral antidepressants.

article thumbnail

Knowledgebase‐Driven Exploration and Experimental Verification of Simvastatin's Inhibitory Impact on P2X7/NLRP3 Inflammasome Pathway

Chemical Biology and Drug Design

A depression database was first constructed, and simvastatin was used as an input to predict potential targets using machine/deep learning methods. Interestingly, the P2X7/NLRP3 pathway was predicted as a potential target for simvastatin. Subsequent Animal experiment's results confirmed this predict. ABSTRACT Depression is a mental health disorder and is the fourth most prevalent disease.

Treatment 100
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Sara Brenner, FDA device official, named agency’s acting head

BioPharma Drive: Drug Pricing

Brenner, who has worked in the FDA’s Center for Devices and Radiological Health, will lead the agency until a permanent commissioner is confirmed.

FDA 98
article thumbnail

Neuromorphic semiconductor chip that learns and corrects itself?

Science Daily: Pharmacology News

Scientists have developed a computing chip that can learn, correct errors, and process AI tasks.

129
129
article thumbnail

Seniors Miss Out on Services With Medicare Advantage

Drugs.com

TUESDAY, Jan. 21, 2025 -- Medicare Advantage isn’t that great an advantage for seniors compared with traditional Medicare, researchers say. The privatized form of Medicare offers more supplemental benefits than traditional Medicare, including.

Research 111
article thumbnail

Antimicrobial and Antiproliferative Properties of 2‐Phenyl‐N‐(Pyridin‐2‐yl)acetamides

Chemical Biology and Drug Design

Among prepared 2-phenyl- N -(pyridin-2-yl)acetamides, we identified compounds with promising invitro antimycobacterial activity (notably compound 12 ). In comparison with the previous series, the methylene-extended linker improved antimycobacterial activity. Compound 26 was identified as a promising antiproliferative hit. ABSTRACT Infectious diseases, including bacterial, fungal, and viral, have once again gained urgency in the drug development pipeline after the recent COVID-19 pandemic.

article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

J&J joins Pfizer in detailing impact of Part D redesign

BioPharma Drive: Drug Pricing

The pharma expects a modest financial headwind this year from changes to Medicare prescription drug benefits under the Inflation Reduction Act.

Drugs 93
article thumbnail

Researchers make breakthrough in bioprinting functional human heart tissue

Science Daily: Pharmacology News

Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development. The breakthrough science focused on replicating heart tissues, bringing research closer to generating functional, bioprinted organs, which would have broad applications in disease modelling, drug screening and regenerative medicine.

Research 125
article thumbnail

Ketamine Use Is on the Rise in U.S.

Drugs.com

MONDAY, Jan. 20, 2025 -- Many more Americans are turning to ketamine for kicks, a new study reports.Recreational use of the anesthetic drug among U.S. adults increased 40% between 2021 and 2022, researchers say.That follows a nearly 82% increase in.

Research 111
article thumbnail

The role of biosimilars in reducing out-of-pocket costs for patients

Drug Patent Watch

Breaking Down Barriers to Affordable Healthcare: The Power of Biosimilars As we navigate the complex landscape of modern healthcare, one thing is clear: the cost of prescription medications is a significant burden for many patients. The rising cost of brand-name medications has left millions of people struggling to afford the treatments they need to manage their conditions.

article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

From Lab Bench to Leadership: Transitioning into Management as a PhD

addgene Blog

One of the most pivotal decisions many PhDs face when transitioning from academia to industry is whether to stay hands-on in the lab or pivot to a managerial role. For those contemplating the leap into management, the journey can be as exciting as it is challenging.

Science 87
article thumbnail

Drug candidate eliminates breast cancer tumors in mice in a single dose

Science Daily: Pharmacology News

Despite significant therapeutic advances, breast cancer remains a leading cause of cancer-related death in women. Treatment typically involves surgery and follow-up hormone therapy, but late effects of these treatments include osteoporosis, sexual dysfunction and blood clots. Now, researchers have created a novel treatment that eliminated small breast tumors and significantly shrank large tumors in mice in a single dose, without problematic side effects.

Treatment 115
article thumbnail

Bird Flu Outbreak Forces Culling of 100,000 Ducks, Threatening Last Duck Farm in Long Island

Drugs.com

FRIDAY, Jan. 24, 2025 -- The last duck farm on New York's Long Island is facing an uncertain future after a bird flu outbreak forced the culling of nearly 100,000 ducks. The highly contagious H5N1 avian flu, otherwise known as bird flu, was.

105
105
article thumbnail

J&J oncology sales grow, but shares slide on outlook

BioPharma Drive: Drug Pricing

CEO Joaquin Duato said the company is positioned for sustained growth in coming years even as competition batters Stelara, one of its top-sellers.

83
article thumbnail

Continuous Innovation with WorldwideEdge™ — A World of a Difference in Bioanalytic Operations

Conversations in Drug Development Trends

Jayaprakash Kotha, MBBS, PhD, ASCP (SH), Vice President, Bioanalytical Laboratory Satish Kumar, MBB, Head of Process Improvement Continuous Innovation is a Cornerstone of Bioanalysis Approximately 80% of drugs that begin the research process fail to reach approval. What is one contributing factor that sets the 20% that do apart from the rest? Rigorous procedures to ensure that drugs are effective and safe.

article thumbnail

New study reveals how a 'non-industrialized' style diet can reduce risk of chronic disease

Science Daily: Pharmacology News

Researchers have found that a newly developed diet inspired by the eating habits of non-industrialized societies can significantly reduce the risk of a number of chronic diseases -- and are to share recipes with the public.

Disease 121
article thumbnail

Popular GLP-1 Drugs Are Shaping Health Beyond Weight Loss & Diabetes

Drugs.com

TUESDAY, Jan. 21, 2025 -- Popular GLP-1 medications for weight loss and diabetes may have unexpected benefits for reducing risks for conditions such as substance abuse, psychosis, infections and even dementia. But these drugs also come with risks.

Drugs 105
article thumbnail

Novo shares climb on early data for dual-acting obesity drug

BioPharma Drive: Drug Pricing

An experimental drug called amycretin showed signs it could be more potent than Eli Lilly’s rival Zepbound, though analysts cautioned certain aspects of the study may have inflated its performance.

Drugs 70
article thumbnail

Patient Content Marketing 2.0: Leverage AI for efficient content creation, personalized delivery, and measurable outcomes

Fierce BioTech

Patient Content Marketing 2.0: Leverage AI for efficient content creation, personalized delivery, and measurable outcomes dwunderlin Fri, 01/24/2025 - 16:27 Thu, 04/17/2025 - 11:00 Resource Type Webinar William Grambley Paul ONeill In an era defined by technological innovation, artificial intelligence (AI) is reshaping the landscape of pharmaceutical marketing.

article thumbnail

Antibiotics, vaccinations and anti-inflammatory medication linked to reduced risk of dementia

Science Daily: Pharmacology News

Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals.

Vaccine 123
article thumbnail

Premature Aging in Brains of Sickle Cell Patients

Drugs.com

FRIDAY, Jan. 24, 2025 -- People with sickle cell disease often struggle with memory, focus, learning and problem solving, setting them back in school and the workplace.That could be because their brains are older than expected for their age, a new.

Disease 102
article thumbnail

Ascentage prices first biotech IPO of 2025, raising $126M

BioPharma Drive: Drug Pricing

The China-based cancer drug developer’s offering will fund testing of medicines for several blood malignancies — one of which is part of an alliance with Takeda.

article thumbnail

Polygenic risk scores: method development and application

Broad Institute

Polygenic risk scores: method development and application By Rose Circeo January 23, 2025 Breadcrumb Home Polygenic risk scores: method development and application The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of core concepts and practical tu