Sat.Mar 01, 2025 - Fri.Mar 07, 2025

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Can We Control Field-Level Security from Apex?

Perficient: Drug Development

Imagine you are building a Salesforce application and must ensure that users can only access specific fields based on their profiles or permission sets. You might wonder: can we control field-level security (FLS) from Apex? Explore this topic and understand the possibilities, challenges, and best practices. Understanding Field-Level Security in Salesforce Before we explore Apex, let’s first understand how Salesforce manages field-level security (FLS).

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Novel stem cell therapy repairs 'irreversible' corneal damage in clinical trial

Science Daily: Pharmacology News

Results from a phase 1/2 clinical trial of a novel stem cell treatment for cornea injuries found 14 patients treated and tracked for 18 months had a more than 90% success rate at restoring the cornea's surface and improvements in vision. The procedure, called CALEC (cultivated autologous limbal epithelial cells) involves taking stem cells from a healthy eye, expanding it into a graft over several weeks, then transplanting it into a patient's damaged eye.

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Orally Bioavailable and Site-Selective Covalent STING Inhibitor Derived from a Macrocyclic Marine Diterpenoid

Covalent Modifiers

Guang-Hao Niu, Wan-Chi Hsiao, Po-Hsun Lee, Li-Guo Zheng, Yu-Shao Yang, Wei-Cheng Huang, Chih-Chien Hsieh, Tai-Yu Chiu, Jing-Ya Wang, Ching-Ping Chen, Chen-Lung Huang, May-Su You, Yi-Ping Kuo, Chien-Ming Wang, Zhi-Hong Wen, Guann-Yi Yu, Chiung-Tong Chen, Ya-Hui Chi, Chun-Wei Tung, Shu-Ching Hsu, Teng-Kuang Yeh, Ping-Jyun Sung, Mingzi M. Zhang, and Lun Kelvin Tsou Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.4c02665 Pharmacological inhibition of the cGAS-STING-controlled innate im

Disease 130
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GLP-1 Drugs Improve Outlook For Kidney Transplants

Drugs.com

THURSDAY, March 6, 2025 -- GLP-1 drugs like Ozempic can help kidney transplant patients avoid organ failure and live longer, a new study suggests.The drugs help manage patients type 2 diabetes and promote weight loss, both of which improve the c.

Drugs 297
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Identification of Potent Leucine‐Rich Repeat Kinase 2 Inhibitors by Virtual Screening and Biological Evaluation

Chemical Biology and Drug Design

We reported a virtual screening workflow combining docking and MD simulations to achieve eight compounds for further enzymatic assay and ADMET profile prediction. The results indicated a candidate 2 with IC 50 values of 2.396 and 5.996M against LRRK2 and LRRK2 G2019S, respectively, implying the reliability of this approach. ABSTRACT Parkinson's disease (PD) is the second most common neurodegenerative disease but has limited medications.

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Morita–Baylis–Hillman Adduct Chemistry as a Tool for the Design of Lysine-Targeted Covalent Ligands

Covalent Modifiers

Marco Paolino, Giusy Tassone, Paolo Governa, Mario Saletti, Matteo Lami, Riccardo Carletti, Filippo Sacchetta, Cecilia Pozzi, Maurizio Orlandini, Fabrizio Manetti, Massimo Olivucci, and Andrea Cappelli ACS Medicinal Chemistry Letters 2025 DOI: 10.1021/acsmedchemlett.4c00479 The use of Targeted Covalent Inhibitors (TCIs) is an expanding strategy for the development of innovative drugs.

Drugs 100
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Florida Seeks Patient Prescription Data

Drugs.com

THURSDAY, March 6, 2025 -- Florida’s insurance regulator is demanding detailed prescription data on millions of patients, raising alarms over patient privacy. In January, the Florida Office of Insurance Regulation asked pharmacy benefit.

Pharmacy 288
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Biotech startup pulls in $187M to make ‘multi-payload’ ADCs

BioPharma Drive: Drug Pricing

Callio Therapeutics is launching with an ADC technology and programs licensed from Singapore-based antibody drug developer Hummingbird Bioscience.

Licensing 250
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Heat from the sun affects seismic activity on Earth

Science Daily: Pharmacology News

Researchers explore the likelihood that Earth's climate, as affected by solar heat, plays a role in seismic activity. Using mathematical and computational methods, they analyzed earthquake data alongside solar activity records and surface temperatures on Earth and observed that when they included Earth surface temperatures into their model, the forecasting became more accurate, especially for shallow earthquakes.

Research 278
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Fused and Substituted Piperazines as Anticancer Agents: A Review

Chemical Biology and Drug Design

Synthesis, structureactivity relationship, targets, and anticancer activity of fused and substituted piperazines. ABSTRACT Cancer is an abnormal and uncontrolled proliferation of normal cells. The availability of safer anticancer drugs with exceptional selectivity for healthy cells and great efficacy against various cancer forms continues to be a significant obstacle.

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Injectable Drug, Xolair, Resolves Dangerous Food Allergies In One-Third Of Kids

Drugs.com

MONDAY, March 3, 2025 -- More than a third of food-allergic kids were able to eat full servings of their trigger foods after treatment with an injectable asthma drug, new clinical trial findings report. In all, 36% of children treated with.

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Roche launches new Boston center; NIH centralizes peer review

BioPharma Drive: Drug Pricing

The Swiss pharma will base cardiometabolic drug research at the new Allston site. Elsewhere, AskBio advanced a gene therapy and Pfizer hired a scientist well versed in GLP-1 science.

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Breakthrough in clean energy: Palladium nanosheets pave way for affordable hydrogen

Science Daily: Pharmacology News

Hydrogen energy is widely recognized as a sustainable source for the future, but its large-scale production still relies on expensive and scarce platinum-based catalysts. In order to address this challenge, researchers have developed Bis(diimino)palladium coordination nanosheets (PdDI), a novel two-dimensional electrocatalyst that effectively facilitates the hydrogen evolution reactions while minimizing the use of precious metals like platinum, paving the way for affordable hydrogen production.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Vault Snack #29 – New Curve Fits for Plotting and Analysing Assay Data in CDD Vault

Collaborative Drug

Hello, CDD users, and Happy 2025! As we get started with this new year, CDD Support thought we would highlight the CDD Vault Curves feature set.

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CDC Sends Experts to Texas as Measles Outbreak Grows

Drugs.com

WEDNESDAY, March 5, 2025 -- A measles outbreak in Texas has grown to 159 cases, and now the U.S. Centers for Disease Control and Prevention (CDC) has sent a team to help local health officials respond.The CDC announced the plan on X, explaining.

Disease 278
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Vertex’s new pain drug gets first coverage nod from major insurer

BioPharma Drive: Drug Pricing

Optum, the pharmacy benefit manager owned by UnitedHealth Group, placed Journavx on some of its commercial formularies in an interim decision while a formal review continues.

Pharmacy 227
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Paralyzed man moves robotic arm with his thoughts

Science Daily: Pharmacology News

Researchers have enabled a man who is paralyzed to control a robotic arm through a device that relays signals from his brain to a computer. He was able to grasp, move and drop objects just by imagining himself performing the actions.

Research 338
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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The Importance of International R&D Collaborations in Generic Drug Development

Drug Patent Watch

Breaking Down Barriers: The Power of Global Research Collaborations in Generic Drug Development As the world grapples with the complexities of healthcare, one thing is clear: the need for innovative solutions has never been more pressing. In the realm of generic drug development, international research collaborations are emerging as a game-changer. By pooling resources, expertise, and knowledge, researchers from around the globe can accelerate the discovery of life-saving treatments and make the

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Continuous Glucose Monitors Can Overestimate Blood Sugar Levels, Study Finds

Drugs.com

TUESDAY, March 4, 2025 -- Continuous blood glucose monitors have been promoted as potentially life-changing for people with diabetes -- allowing real-time updates on blood sugar levels without the need for repeated finger pricks.But a new.

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Blocking PD-1 and VEGF: The bispecific cancer drugs that could best Keytruda

BioPharma Drive: Drug Pricing

Striking study results last year indicated a new type of medicine may improve on Merck’s dominant immunotherapy, spurring a wave of research practically overnight.

Drugs 201
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World's critical food crops at imminent risk from rising temperatures

Science Daily: Pharmacology News

A new study offers a more precise picture of exactly where and how warming will affect our ability to grow food.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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PBM Industry Update: Trends, Challenges, and What's Ahead (NEW Live Video Webinar)

Drug Channels

Dr. Adam J. Fein, president of Drug Channels Institute (DCI) and the author of Drug Channels , invites you to join him for DCIs new live video webinar: PBM Industry Update: Trends, Challenges, and What's Ahead This event will be broadcast live on Friday, April 4, 2025, from 12:00 p.m. to 1:30 p.m. ET This page describes the event and explains how to purchase a registration.

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NSAIDs Linked To Lower Dementia Risk

Drugs.com

WEDNESDAY, March 5, 2025 -- Over-the-counter drugs like aspirin or ibuprofen might help protect against dementia, a new study suggests.These NSAIDs (non-steroidal anti-inflammatory drugs) might help protect the brain by quelling inflammation that.

Drugs 264
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AbbVie gets into obesity with $350M deal for once-weekly shot

BioPharma Drive: Drug Pricing

A licensing deal with Denmark’s Gubra gives the immunology giant control of an experimental therapy that could compete with drugs from Novo Nordisk, Eli Lilly and Zealand.

Licensing 199
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Researchers create gel that can self-heal like human skin

Science Daily: Pharmacology News

Until now, artificial gels have either managed to replicate high stiffness or natural skin's self-healing properties, but not both. Now, a team of researchers has developed a hydrogel with a unique structure that overcomes earlier limitations, opening the door to applications such as drug delivery, wound healing, soft robotics sensors and artificial skin.

Research 329
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Novel Bispecific therapies in oncology

SugarCone Biotech

Lemmings We wrote recently about the lemming phenomena with respect to the bispecific modality combining VEGF pathway inhibition plus PD-1 pathway inhibition. Our hope is not all the lemmings dive off the cliff, however we are not optimistic. This does not mean that VEGF pathway inhibition should not be exploited this is obvious based on the synergy seen when approved VEGF pathway inhibitors are administered alongside approved PD-1 pathway inhibitors.

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Patients Devastated When Docs Dismiss Autoimmune Ailments As Psychosomatic

Drugs.com

MONDAY, March 3, 2025 -- A patient with multiple autoimmune diseases can remember the exact moment a doctor tore their heart out.One doctor told me I was making myself feel pain, and I still cant forget those words, the patient remembered. Tell.

Doctors 264
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Nimbus swaps CEOs and turns to new leader for ‘next chapter’

BioPharma Drive: Drug Pricing

CBO Abbas Kazimi will replace longtime CEO Jeb Keiper as part of a planned leadership transition at the unorthodox drug startup.

Drugs 167
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Feeling is believing: Bionic hand 'knows' what it's touching, grasps like a human

Science Daily: Pharmacology News

Engineers have developed a pioneering prosthetic hand that can grip plush toys, water bottles, and other everyday objects like a human, carefully conforming and adjusting its grasp to avoid damaging or mishandling whatever it holds.