Drug Discovery World
AUGUST 29, 2024
Neurocrine Biosciences has revealed positive top-line data for its Phase II clinical study of NBI-1117568 (NBI-‘568) in adults with schizophrenia. NBI-‘568 is the first investigational, oral, muscarinic M4 selective agonist in development for this indication. The NBI-‘568-SCZ2028 dose-finding study met its primary endpoint for the once-daily 20mg dose.
BioPharma Drive: Drug Pricing
AUGUST 29, 2024
Far fewer venture funding rounds were closed by cell and gene therapy developers over the first six months of 2024 than in prior years. Experts say there are several factors.
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National Institute on Drug Abuse: Nora's Blog
AUGUST 28, 2024
Older Black Men Are Disproportionately Affected by the Overdose Crisis mfleming Wed, 08/28/2024 - 16:08 Nora's Blog August 30, 2024 Image ©Getty Images/ xavierarnau Saturday, August 31, is International Overdose Awareness Day , when we collectively remember those who have lost their lives to drug overdose, support those who grieve those losses, and offer encouragement to those who seek recovery from addiction.
Science Daily: Pharmacology News
AUGUST 27, 2024
Crime films, action films, comedies, or documentaries? A person's favorite film genre reveals a lot about how their brain works. Fans of action films and comedies reacted very strongly to negative emotional stimuli, while participants who favored documentaries or crime films and thrillers had a significantly weaker reaction.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
AUGUST 30, 2024
News round-up for 26-30 August by DDW Senior Digital Content Editor Diana Spencer. With the launch of an international clinical trial investigating BioNTech’s mRNA lung cancer vaccine announced this week, our news highlights focus on clinical trials, including studies of a monoclonal antibody and small molecule GLP-1 agonist for obesity, and a muscarinic M4 selective agonist for schizophrenia.
Drugs.com
AUGUST 30, 2024
FRIDAY, Aug.30, 2024 -- New trials are showing how the blockbuster diabetes and weight-loss meds Ozempic and Wegovy can boost health in even more ways.These two injected drugs are versions of semaglutide. In multiple new data analyses, the drugs.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
AUGUST 28, 2024
New research explores music's impact on learning, memory, and emotions in two studies. One reveals that familiar music can enhance concentration and learning, while the other demonstrates that music with a strong emotional tone can reshape the quality of existing memories. These findings suggest that music could be used for therapeutic interventions for cognitive function, or in conditions like PTSD and depression.
Drug Discovery World
AUGUST 28, 2024
DDW’s Megan Thomas looks at a day in the life of Dr Joanne Taylor , Senior Vice President and Head of Discovery Research at Gain Therapeutics. MT: Can you provide a top line summary of your research? JT: We are developing novel small molecule, disease-modifying, allosteric regulators to treat serious diseases such as Parkinson’s disease and other dementias.
Drugs.com
AUGUST 26, 2024
MONDAY, Aug. 24, 2024 -- A type of drug used to treat Alzheimer’s disease appears to slow the progression of Lewy body dementia, the brain disease that afflicted comedian Robin Williams prior to his suicide.Cholinesterase inhibitors prevent the b.
NIOSH Science Blog: Drugs
AUGUST 30, 2024
Each Labor Day we honor workers and the role they play in building a strong and prosperous nation. Much like the first Labor Day more than a century ago, many of us mark this federal holiday with festivities such as parades or picnics. This year, as you head out to celebrate the end of summer with friends and loved ones, I urge you to take a moment to reflect on the contributions of the workers all around us.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
AUGUST 30, 2024
Facial recognition is a critical part of self-image and social interactions. In an era of advanced digital technology, we face intriguing questions about communication and identity. How does altering our facial identity affect our sense of 'self' and our interactions with others?
Drug Discovery World
AUGUST 30, 2024
Dr Nicholas Siciliano, Co-Founder of Vittoria Biotherapeutics, shares insight on the VIPER-101 trial targeting T-cell lymphoma, the company’s aim to ensure progression free survival and opportunities in this sector. MT: I understand that your lead programme is moving into the clinic, with POC human data expected in 2024. Can you elaborate on the status and the aims of your therapeutic pipeline?
Drugs.com
AUGUST 29, 2024
THURSDAY, Aug. 29, 2024 -- A migraine drug can help stop the devastating headaches in their tracks, allowing sufferers to go about their daily lives with little to no symptoms, a new clinical trial has found.People who took ubrogepant (Ubrelvy).
BioPharma Drive: Drug Pricing
AUGUST 28, 2024
Under a collaboration with NextRNA Therapeutics, Bayer will access the biotech’s platform to target long, non-coding RNA interactions with small molecule drugs.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
AUGUST 28, 2024
New research may enable potential solutions to metabolic disease by turning to evolution and to bats. 'Our study reports blood sugar levels that are the highest we have ever seen in nature -- what would be lethal, coma-inducing levels for mammals, but not for bats,' said one of the researchers. 'We are seeing a new trait we didn't know was possible.
Drug Discovery World
AUGUST 30, 2024
Twenty-three companies will benefit from a share of £12 ($15.8) million from the Innovate UK Cancer Therapeutics programme. The Cancer Therapeutics programme focuses on developing life-changing cancer treatments, including immunotherapies and vaccines. It also supports projects addressing unmet medical needs for treating childhood and young persons’ cancers.
Drugs.com
AUGUST 29, 2024
THURSDAY, Aug. 29, 2024 (HeathDay News) -- The first known U.S. cluster of cases of bird flu in humans has been recorded at two poultry facilities in Colorado, the Centers for Disease Control and Prevention (CDC) reported Thursday.The nine infected.
Perficient: Drug Development
AUGUST 28, 2024
This post is the first in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Coming Soon: Part 2: Dependencies & Creep Part 3: Assumptions & Uncertainty Part 4: The Emotional Conclusion Estimating is a precarious business – part science, a lot of guesswork, and a bit of psychic magic! The goal is to forecast the effort, time, and cost of a project with enough accuracy to avoid disaster.
Science Daily: Pharmacology News
AUGUST 26, 2024
An international team of paleontologists has found matching sets of Early Cretaceous dinosaur footprints on what are now two different continents.
Drug Discovery World
AUGUST 29, 2024
Diana Spencer reviews the latest high-throughput screening technologies used for drug discovery and how they can accelerate therapeutics to the clinic. High-throughput screening (HTS) utilises robotics and automation to allow testing of large numbers of chemical and/or biological compounds for a specific biological target. HTS compatible cellular assays Robert G Lowery PhD, President & CEO at BellBrook Labs, comments: “AI and virtual screening are increasing the diversity of targets in drug
BioPharma Drive: Drug Pricing
AUGUST 27, 2024
The platform is similar in concept to a service launched this year by Eli Lilly, and aims to give consumers easier access to Pfizer’s migraine, COVID-19 and flu treatments.
Drug Patent Watch
AUGUST 29, 2024
Ensuring that a generic drug meets FDA standards is crucial for maintaining the high quality and efficacy of medications. The FDA’s Office of Generic Drugs (OGD) plays a vital role in this process by following a rigorous review process to ensure that generic medications meet the same standards as their brand-name counterparts. The FDA’s review process for generic drugs involves several key steps.
Science Daily: Pharmacology News
AUGUST 30, 2024
Researchers have uncovered a surprising genetic mechanism that influences the vibrant and complex patterns on butterfly wings. The team discovered that an RNA molecule, rather than a protein as previously thought, plays a pivotal role in determining the distribution of black pigment on butterfly wings.
Drug Discovery World
AUGUST 29, 2024
The benefits of Alzheimer’s drug lecanemab (Leqembi) are too small to justify the cost of providing the treatment to NHS patients, the UK regulator has ruled. This was the decision by the National Institute for Health and Care Excellence (NICE) in draft guidance on the drug. Lecanemab is for slowing progression in mild cognitive impairment or mild dementia due to Alzheimer’s disease (AD) in adults.
BioPharma Drive: Drug Pricing
AUGUST 28, 2024
Despite “positive” results, shares of the biotech slid by 20%. Analysts cautioned that Neurocrine shouldn’t get “the benefit of the doubt” with its data.
Drugs.com
AUGUST 30, 2024
FRIDAY, Aug. 30, 2024 -- Senior residential homes are breeding grounds for antibiotic-resistant bacteria, due to overprescription of antibiotics, a new study says.Stool samples provided by Australian senior home residents contained bacteria with a.
Science Daily: Pharmacology News
AUGUST 27, 2024
Women diagnosed with breast cancer who had regular screening mammograms every year were less likely to have late-stage cancer and had higher overall survival than those who received screening every other year or less often, according to new research.
Drug Discovery World
AUGUST 28, 2024
Pfizer has expanded its strategic partnership with Flagship Pioneering, adding two new research programmes with Flagship-founded Quotient Therapeutics. Under the collaboration, the companies will analyse somatic mutations that occur in diseased patient tissue to inform the discovery and development of therapies for cardiovascular and renal diseases.
BioPharma Drive: Drug Pricing
AUGUST 29, 2024
The trial setbacks for Merck’s best-selling drug, which faces patent expiration in 2028, are a blow to the company’s plans for further indication expansion.
Drugs.com
AUGUST 30, 2024
FRIDAY, Aug. 30, 2024 -- In some people, new-onset depression may stem from the same buildup of toxic plaques in the brain that have long been linked to Alzheimer's disease, according to a new study."Our findings provide additional support for.
Science Daily: Pharmacology News
AUGUST 28, 2024
Bacterial cells can 'remember' brief, temporary changes to their bodies and immediate surroundings, a new study has found. And, although these changes are not encoded in the cell's genetics, the cell still passes memories of them to its offspring -- for multiple generations.
Drug Discovery World
AUGUST 28, 2024
Therapeutics companies developing immunotherapies, mRNA vaccines and anti-inflammatory therapies have been chosen to receive funding from Innovate UK Biomedical Catalyst. In total, thirty projects will receive a share of £17.8 ($23.5) million from Biomedical Catalyst, Innovate UK’s flagship grant funding mechanism. Biomedical Catalyst was created to help small and medium-sized businesses test and develop innovative health and care solutions across health and life sciences, including therapeutics
Perficient: Drug Development
AUGUST 28, 2024
Perficient continues to make strategic investments to grow our global footprint. This is great for our clients because we span time zones, cultures and capabilities. However, it can present a challenge fostering a cohesive company culture and opportunities for colleagues to connect. That is why Perficient invests in its people by supporting Employee Resource Groups (ERGs), Special Interest Groups (SIGs), and Innovation Groups (IGs).
Drugs.com
AUGUST 30, 2024
FRIDAY, Aug. 30, 2024 -- A new, tougher rule on the sale of tobacco products will require retailers to check the IDs of any buyers under the age of 30, the U.S. Food and Drug Administration announced Thursday.The final rule, which will go into.
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