Drug Target Review

MAY 23, 2025

As the biotech sector races to improve the tolerability of these revolutionary treatments, Poolbeg Pharma has a novel solution: an oral therapy, POLB 001, to block the development of CRS, by limiting inflammation without affecting the anti-cancer immune responses that are vital for effective immunotherapies.

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Alta Sciences

FEBRUARY 19, 2025

Researchers must characterize the anti-drug-antibody (ADA) response in preclinical and clinical studies and report any ADA-positive samples as a risk-based approach. These interactions may disrupt protein function, trigger immune responses, or contribute to other toxicological risks.

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Broad Institute

MAY 21, 2025

The Merkin Prize recognizes novel technologies that have improved human health and is administered by the Broad Institute, one of the worlds leading biomedical research institutes. He showed that these synthetic CAR T cells could launch an immune response when they encountered the corresponding tumor protein, called CD19.

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Drug Target Review

APRIL 7, 2025

Involved in various physiological processes, such as vision, taste, smell, immune response and neurotransmission, GPCRs are activated by various molecules including hormones, neurotransmitters and environmental stimuli, which trigger a cascade of cellular events that help regulate bodily functions.

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The Pharma Data

JUNE 25, 2025

It arises when the recipient’s immune system produces antibodies that attack the transplanted organ. Despite ongoing research and improvements in immunosuppressive therapy, there remains no FDA-approved treatment specifically for AMR , leaving clinicians with limited tools to prevent or manage the condition effectively.

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The Pharma Data

JUNE 15, 2025

This independent expert panel will aid in evaluating a new, enhanced immunosuppressive regimen meant to help ease the body’s adaptive immune response — a process suspected to contribute to the elevated liver enzyme abnormalities and related events that have been observed in a small number of patients following treatment with AAV-based gene therapy.

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Drug Target Review

NOVEMBER 7, 2024

Agonist antibodies of immune checkpoint regulators These represent a groundbreaking class of immunotherapeutic agents that mimic the natural function of endogenous ligands by binding to specific cell-surface receptors. In these conditions, the goal of therapy is typically to suppress or mitigate immune activity.

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Disease Immune Response Regulations Engineering 52

Drug Target Review

APRIL 18, 2025

He continues to detail how research has uncovered the role of various cell types in tumour development, including macrophages, fibroblasts and, more recently, senescent cells. Further investigation into the mechanism behind SenoVax revealed that CD8+ T, also known as cytotoxic T cells, are central to the immune response.

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Therapies Disease Clinical Trials Treatment 66

Codon

JUNE 5, 2025

The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. Researchers have since discovered variants of the protein with additional useful qualities. Researchers have also discovered a slew of small Cas9s — some less than half the size of the S.

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DNA RNA Clinical Trials Engineering 81

The Open Targets Blog

JANUARY 30, 2025

gget consists of a collection of modules, each enabling researchers to perform common tasks in genomics, transcriptomics, and proteomics data analysis in just one line of code without exceeding the computational capabilities of a laptop.  Was there anything particularly difficult or unexpected in the process of creating gget?

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Bioinformatics Immune Response RNA Packaging 74

Broad Institute

FEBRUARY 26, 2025

Why brain cancer is often resistant to immunotherapy By Allessandra DiCorato February 26, 2025 Breadcrumb Home Why brain cancer is often resistant to immunotherapy Researchers find four coordinated gene expression programs in immune cells from glioma tumors, including two that could lead to immunotherapy resistance.

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Immune Response Treatment RNA Clinical Trials 132

The Pharma Data

JUNE 12, 2025

An interim statistical analysis confirms that the candidate is meeting its pre-established criteria for immunogenicity — meaning it stimulates a strong and desirable immune response — in trial participants. Importantly, this is a strong indicator that the vaccine could be effective in protecting children against Shigella in the future.

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Broad Institute

JUNE 25, 2025

To better understand the biological processes at play in strictures, Broad Institute and Massachusetts General Hospital researchers analyzed individual cells from the intestinal tissue of Crohn’s disease patients, measuring gene activity and mapping the cells’ location in the tissue.

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Disease Medical Schools RNA Molecular Biology 111

BioPharma Drive: Drug Pricing

JUNE 27, 2025

For some people with leukemia, lymphoma or multiple myeloma, they can prompt powerful responses and even long-lasting remission. But their administration also comes with notable risks, including a hyperactive immune response known as CRS and neurological toxicity dubbed ICANS. Its new CEO has to figure out what’s next.

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Conversations in Drug Development Trends

OCTOBER 14, 2024

Fortunately, advances in clinical research are providing hope for better treatments and outcomes. With the support of global networks like ours at Worldwide Clinical Trials (Worldwide), autoimmune and bone health research is accelerating, providing new solutions to patients around the world.

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The Pharma Data

JUNE 12, 2025

Evidence shows that NUMELVI is at least 10-fold more selective for JAK1 than for the other JAK family members , which underpins its ability to ease pruritus without causing significant side effects related to hematopoietic dysfunction or a broad dampening of the immune response.

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PLOS: DNA Science

JUNE 12, 2025

The condition stems from a misdirected immune response to a substance – an allergen – that does not actually present a threat. To identify the gene–environment interactions behind eczema, the researchers analyzed data from 16 European studies.

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DNA Immune Response Laboratories International 61

Science Daily: Pharmacology News

APRIL 28, 2025

Scientists have uncovered why vaccines can elicit a stronger immune response if they are administered in the same arm.

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Immune Response Vaccine Research 160

Science Daily: Pharmacology News

OCTOBER 17, 2024

difficile first-time infections and relapsing infections by inducing a robust immune response, promote clearance of existing C. diff bacteria from the gut, and even overcome deficits in host immunity to protect animals after infection, according to researchers. In animal models, this first mRNA-LNP C.

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Vaccine Immune Response Clinical Trials Trials 298

Science Daily: Pharmacology News

OCTOBER 18, 2023

Immunotherapies, which mobilize the body's immune defenses against a cancer, have not been effective for GBM, in part because the tumor's surrounding environment is largely impenetrable to assaults from the body's immune system.

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Therapies Immune Response Research Virus 203

Drugs.com

OCTOBER 11, 2023

11, 2023 -- New research points to the potential of a COVID-19 vaccine delivered through the nose. The phase 1 clinical trial showed that the product, administered nasally in two doses, delivered a significant immune response to. WEDNESDAY, Oct.

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SCIENMAG: Medicine & Health

DECEMBER 6, 2023

Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. Credit: Mike […]

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Immune Response Research 89

Science Daily: Pharmacology News

JUNE 18, 2024

These cells shut down inflammation and repair the collateral damage to cells caused after our immune system has responded to injury or illness. Current anti-inflammatory drugs used for this purpose suppress the body's whole immune system, making patients more vulnerable to infection.

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Treatment Immune Response Disease Clinical Trials 316

Science Daily: Pharmacology News

DECEMBER 12, 2024

Researchers have discovered a protein variant that serves as a knob for regulating the body's innate immune response. The findings could lead to new therapies for Long COVID, autoimmune disorders, and more.

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Immune Response Regulations Therapies Research 236

Science Daily: Pharmacology News

FEBRUARY 5, 2025

Researchers report that all nine patients in a clinical trial being treated for stage III or IV clear cell renal cell carcinoma (a form of kidney cancer), generated a successful anti-cancer immune response after initiation of a personalized cancer vaccine.

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Science Daily: Pharmacology News

OCTOBER 24, 2024

Researchers discovered potentially far-reaching effects of a particular gut bacterium that was linked to better growth in Bangladeshi children receiving a therapeutic food designed to nurture healthy gut microbes.

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Immune Response Regulations Disease Research 232

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

By adding synergistic self-adjuvanting properties to Covid-19 RNA vaccines, researchers showed they could significantly boost the immune response generated in mice.

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RNA Vaccine Engineering Immune Response 221

SCIENMAG: Medicine & Health

JULY 6, 2023

In a new study, National Institutes of Health (NIH) researchers found that altered B cell function in children with mitochondrial disorders led to a weaker and less diverse antibody response to viral infections.

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Immune Response Research 85

SCIENMAG: Medicine & Health

JULY 26, 2023

Key Takeaways Researchers have discovered that the NLRP11 protein plays critical roles in alerting the body to a bacterial infection and initiating an immune response against it NLRP11 is present in humans and other primates but absent in mice The discovery could enable the development of mouse models that are more similar to humans for […]

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Immune Response Research 65

SCIENMAG: Medicine & Health

JUNE 26, 2023

Anna Children’s Cancer Research Institute, and Nikolaus Fortelny, PhD, Paris Lodron University of Salzburg, are the first to analyze bone marrow metastases from childhood tumors of the nervous system using modern single-cell sequencing analysis. Scientists led by Sabine Taschner-Mandl, PhD, St.

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Drug Target Review

JULY 4, 2023

In the realm of immunology, researchers are constantly striving to unlock the intricate secrets of the human immune system. Among the many remarkable components that make up this complex defence network, T cells have emerged as powerful guardians, orchestrating an array of immune responses with great precision.

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Immune Response Engineering Treatment Therapies 52

The Pharma Data

OCTOBER 26, 2020

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, elicited immune responses in older coronavirus patients similar to ones generated in younger adults, lending more promise to a vaccine that’s seen as one of the leading contenders in the race to become the first approved COVID-19 vaccine. Source link.

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Immune Response Vaccine Research 52

Drugs.com

JUNE 26, 2024

WEDNESDAY, June 26, 2024 -- The COVID virus, or rather people's immune response to it, has changed and it might be prudent to wait a couple days after symptoms start before taking a COVID test, researchers report.“For For COVID, we found that if you o.

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The Pharma Data

OCTOBER 22, 2020

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, currently being evaluated in phase 3 global trials, delivers a strong immune response, according to a new UK study. Source link.

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Immune Response Vaccine Trials Research 52

The Pharma Data

DECEMBER 4, 2021

The first peer-reviewed study in North America examining the timing between the first and second doses of COVID-19 mRNA vaccines shows that a longer dose interval leads to a stronger immune response. The study is funded by the Government of Canada through its COVID-19 Immunity Task Force (CITF).

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Drug Discovery Today

APRIL 5, 2022

Researchers delve into the inner workings of the antibody immune response, finding key differences in the metabolism of two closely related immune cell subsets.

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Plenge Gen

APRIL 7, 2020

Here, I focus on a specific clinical inflection point in COVID-19 disease progression – hospitalized patients early in their disease course and with signs of a maladaptive immune response, with the intervention intended to prevent disease progression and admission to the ICU. appeared first on Plenge Gen @rplenge.

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