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How GPCR-targeting therapies are advancing the fight against inflammatory disease

Drug Target Review

In this article, Stephan Schann, Chief Scientific Officer at Domain Therapeutics , explains why this class of drug target is so useful despite the challenges they present. DT-9046 is currently progressing through pre-IND studies, supported by a robust data package, including head-to-head benchmarks and strong patent protection.

Disease 59
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How AI and LLMs are transforming drug discovery: part 1

Drug Target Review

The challenges lie in regulated industries where governance frameworks for standard quantitative models dont necessarily apply to LLMs. The challenges lie in regulated industries where governance frameworks for standard quantitative models don’t necessarily apply to LLMs. Much of the hype and FOMO exists on the business side.

Drugs 69
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Overcoming Orphan Drug Development Challenges with Real-World Data and Evidence

PPD

This heterogeneity among small groups of patients presents substantial challenges for rare disease research, including clinical trial design, endpoint selection and the interpretation of study findings. With the new EU HTA Regulation impacting orphan medicines, navigating these pathways has become even more challenging.

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BeOne Medicines Gains CHMP Backing for BRUKINSA Tablet Formulation

The Pharma Data

By moving to tablets, BeOne estimates a reduction in bottle size by approximately 70%, which not only decreases plastic use but also facilitates more efficient packaging and transportation. This initiative is part of the company’s broader sustainability efforts aimed at reducing its environmental impact and improving supply chain efficiency.

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AZVUDINE

New Drug Approvals

SYN [link] According to the inventor’s research and understanding, at present, the synthesis of azvudine mainly includes the following methods according to different raw materials: 1. Detailed numbers are provided by Genuine in the slides and the medication package insert. [14]

RNA 62
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#ScienceSaturday: October 21, 2023

KIF1A

But what regulates the delivery of materials at these early stages? In this week’s article, researchers investigated KIF1A’s role in the delivery of synaptic building blocks, and its regulation by the lipid (fat molecule) PI(3,5)P2. From Gabrych et al.

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Article Periodic Thank You Commission unveils “one substance, one assessment” reform package

Agency IQ

Commission unveils “one substance, one assessment” reform package The Commission has long aspired to realize its one substance, one assessment concept in the EU’s chemical regulatory regime. With the publication of three proposed legal acts, this concept is one step closer to streamlining the way the bloc regulates chemicals.