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Metabolism of macrocyclic drugs

Metabolite Tales Blog

Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. Journal of Medicinal Chemistry 62 (21), 9418-9437. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry. Balazs et al., Drug Hunter article, June 2023. Ayushi Jain and Khalid Mumtaz, 2022.

Drugs 52
article thumbnail

Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. Journal of Medicinal Chemistry 62 (21), 9418-9437. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry. Balazs et al., Drug Hunter article, June 2023. Ayushi Jain and Khalid Mumtaz, 2022.

Drugs 52