2024, Fragment Screening and Small Molecule

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2024

Fragment Screening

Small Molecule

Advancements in hit identification for membrane protein drug discovery

Drug Target Review

APRIL 7, 2025

Advancements in screening technologies for small-molecule drug discovery including cellular assays, computational screening, and biophysics-based methods enhanced by structural biology breakthroughs have improved screening hit rates and facilitated the identification of drug candidates for previously undruggable targets.

Fragment Screening

Fragment Screening Drugs Biophysical Assays Small Molecule

Open-source Electrophilic Fragment Screening Platform to Identify Chemical Starting Points for UCHL1 Covalent Inhibitors

Covalent Modifiers

DECEMBER 3, 2024

Marto SLAS Discovery, 2024 [link] Target-based screening of covalent fragment libraries with mass spectrometry has emerged as a powerful strategy to identify chemical starting points for small molecule inhibitors or find new binding pockets on proteins of interest. Buhrlage, Jarrod A.

Fragment Screening

Fragment Screening Compound Screening Small Molecule Drugs

Drug Discovery Digest

Advancements in hit identification for membrane protein drug discovery

Open-source Electrophilic Fragment Screening Platform to Identify Chemical Starting Points for UCHL1 Covalent Inhibitors

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