Drug Discovery World

JULY 5, 2023

She will be joined by panellists Elizabeth Louie, PhD, Supervisor, Technical Applications; Xiangying Mao, PhD, Team Lead, Bioinformatics; and Crystal Richardson, PhD, Business Partnership Manager.

Virus 130

Virus Therapies Bioinformatics Packaging 130

Drug Discovery World

JUNE 29, 2023

She will be joined by panellists Elizabeth Louie, PhD, Supervisor, Technical Applications; Xiangying Mao, PhD, Team Lead, Bioinformatics; and Crystal Richardson, PhD, Business Partnership Manager.

Virus 130

Virus Therapies Bioinformatics Packaging 130

Drug Discovery World

JUNE 22, 2023

She will be joined by panellists Elizabeth Louie, PhD, Supervisor, Technical Applications; Xiangying Mao, PhD, Team Lead, Bioinformatics; and Crystal Richardson, PhD, Business Partnership Manager.

Virus 130

Virus Therapies Bioinformatics Packaging 130

Drug Discovery World

FEBRUARY 17, 2023

The drug discovery sector is feeling the love this Valentine’s week, with several new research collaborations bringing together a range of expertise and advanced bioinformatics, automation and artificial intelligence technologies to speed up the development of new treatments.

Bioinformatics 130

Bioinformatics Drugs Therapies Treatment 130

Drug Discovery World

OCTOBER 3, 2023

Andrea O’Hara, PhD, Strategic Technical Specialist, Azenta Life Sciences led the presentation and was joined by Elizabeth Louie, PhD, Supervisor, Technical Applications, Xiangying Mao, PhD, Team Lead, Bioinformatics, and Crystal Richardson, PhD, Business Partnership Manager – all Azenta Life Sciences – for the questions section.

Therapies 130

Therapies Bioinformatics Packaging Molecular Biology 130

The Open Targets Blog

OCTOBER 31, 2023

Business Analyst | Cole Devries, Lead Cloud Architect | Gayathri Radhakrishnan, Senior Quality Assurance Engineer | Hannah Stogsdill, UI Designer | Mark Cunningham, Technical Project Manager | Nahom Tesfatsion, FE Developer | Shawn Wang, Senior Backend Developer | Sowmya Karavadi, DevOps Engineer | Subhashini Jagu, NCI Federal Lead | Valentina Epishina, (..)

Bioinformatics 69

Bioinformatics Engineering FDA Clinical Trials 69

Drug Discovery World

OCTOBER 18, 2022

By utilising advanced bioinformatics and systems biology to integrate the two disciplines, Clinical Microbiomics aims to pave the way for new innovations. ? . We’re excited to engage with our network of researchers around the world to bring the?new new platform and services to work.” ? .

Bioinformatics 130

Bioinformatics Research Disease Drugs 130

Drug Discovery World

APRIL 10, 2024

Located on the campus of the University of São Paulo (USP) in a 2,000-square-meter building, the newest member of the Pasteur Network has the capacity to house some 100 scientists working in 17 laboratories, four of which are Biosafety Level Three (BSL3) facilities, as well as a bioinformatics unit and several items of multiuser equipment.

Bioinformatics 130

Bioinformatics Laboratories Government Research 130

Broad Institute

MARCH 8, 2024

Organizing Committee By Rose Circeo March 8, 2024 Breadcrumb Home Organizing Committee Sumaiya Iqbal, Co-chair Group Leader, Bioinformatics and Computational Biology, CDoT Wengong Jin, Co-chair Postdoc, Eric and Wendy Schmidt Center Holly Soutter, General Committee Member Director, Biochemistry and Biophysics, CDoT Eric Sigel, General Committee Member (..)

Bioinformatics 52

Bioinformatics Science Research Drugs 52

Broad Institute

MARCH 8, 2024

Organizing Committee By Rose Circeo March 8, 2024 Breadcrumb Home Organizing Committee Sumaiya Iqbal, Co-chair Group Leader, Bioinformatics and Computational Biology, CDoT Wengong Jin, Co-chair Postdoc, Eric and Wendy Schmidt Center Holly Soutter, General Committee Member Director, Biochemistry and Biophysics, CDoT Eric Sigel, General Committee Member (..)

Bioinformatics 52

Bioinformatics Science Research Drugs 52

Chemical Biology and Drug Design

FEBRUARY 20, 2024

Moreover, bioinformatics analysis has suggested that hsa_circRNA_103820 possesses potential peptide-coding ability. Abstract N6-methyladenosine (m6A) modification and m6A-related RNA-binding proteins (RBPs) play vital roles in various aspects of circRNA metabolism.

Bioinformatics 100

Bioinformatics RNA Regulations Research 100

Drug Discovery World

JUNE 14, 2023

Unlocking their secrets requires complex bioinformatic exploration. The study of health and disease through multi-omics research generates vast amounts of interconnected data.

Bioinformatics 130

Bioinformatics Research Disease Drugs 130

Drug Discovery World

JUNE 14, 2023

Unlocking their secrets requires complex bioinformatic exploration. A new Case Study is available, sponsored by Evotec. The study of health and disease through multi-omics research generates vast amounts of interconnected data.

Bioinformatics 130

Bioinformatics Research Disease Drugs 130

BioPharma Drive: Drug Pricing

MAY 6, 2024

Can free bioinformatics tools get the job done?

Bioinformatics 55

Bioinformatics 55

Drug Discovery World

SEPTEMBER 29, 2023

PandaOmics integrates multiple omics and text-based AI bioinformatics models to assess the potential of proteins as therapeutic targets.

Disease 173

Disease Bioinformatics Engineering Research 173

Practical Cheminformatics

JANUARY 16, 2024

Property Prediction Machine Learning Methods for Small Data Challenges in Molecular Science [link] Practical guidelines for the use of gradient boosting for molecular property prediction [link] Application of message passing neural networks for molecular property prediction [link] Molecular Similarity Molecular Similarity: Theory, Applications, and (..)

Targeted Protein Degradation 141

Targeted Protein Degradation Small Molecule Computational Chemistry Bioinformatics 141

Chemical Biology and Drug Design

MARCH 28, 2023

Pharmacodynamic targets of metformin were predicted using the Bioinformatics Analysis Tool for the molecular mechanism of traditional Chinese medicine (BATMAN), Drugbank, PharmMapper, SwissTargetPrediction, and TargetNet databases.

Bioinformatics 100

Bioinformatics Drugs Research 100

SCIENMAG: Medicine & Health

JULY 13, 2023

Rensselaer Polytechnic Institute’s Catherine Royer, Constellation Chair Professor of Bioinformatics and Biocomputation at the Shirley Ann Jackson, Ph.D.

Bioinformatics 87

Bioinformatics Research Science 87

Drug Target Review

DECEMBER 28, 2023

Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Using powerful bioinformatics technology developed and validated with sequence data from the TRACERx study, researchers are able to identify clonal neoantigens from a patient’s unique tumour profile.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Chemical Biology and Drug Design

JANUARY 5, 2024

Homeobox B7 (HOXB7) expression in CRC was analyzed and detected by bioinformatics analysis, quantitative real-time PCR or western blot. Following the treatment of 0, 1.94, 7.75, or 19.36 μM μM THA, CRC cell viability, apoptosis, migration, and invasion were evaluated by methyl tetrazolium, flow cytometry, wound-healing, and transwell assays.

Bioinformatics 100

Bioinformatics Cell Biology Treatment Research 100

Drug Target Review

DECEMBER 13, 2023

About the author Dr Sayoni Das SVP Bioinformatics at PrecisionLife Sayoni leads the research and development of bioinformatics pipelines that generate biological insights from PrecisionLife’s core technology and support drug discovery programmes.

Bioinformatics 145

Bioinformatics Disease Regulations Immune Response 145

Chemical Biology and Drug Design

NOVEMBER 27, 2023

Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ. A total of 153 genes were increased, and the expression of 81 genes was decreased.

Bioinformatics 100

Bioinformatics RNA Regulations Therapies 100

Chemical Biology and Drug Design

JANUARY 1, 2024

Then, Bioinformatics was applied to sort out the candidate interacting with Stachydrine as well as its expression and downstream target in BC. Abstract Considering the therapeutic efficacy of Stachydrine on breast cancer (BC), this study aims to decipher the relevant mechanism.

Bioinformatics 100

Bioinformatics Regulations Disease Research 100

Chemical Biology and Drug Design

DECEMBER 28, 2023

In present study, LINC00460 was screened out through bioinformatics analysis. The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer. However, its effect on DDP sensitivity in cervical cancer remains poorly understood. The sensitivity to DDP was investigated using an CCK8 assay.

Bioinformatics 100

Bioinformatics RNA Regulations Drugs 100

Drug Discovery World

MAY 16, 2023

NewBiologix uses next-generation sequencing (NGS)-based genome characterisation to develop a proprietary bioinformatics platform designed to improve cell line capabilities for the expression and production of ATMPs.

Production 130

Production Bioinformatics Therapies Virus 130

Chemical Biology and Drug Design

JULY 4, 2023

Genes related to acacetin and esophageal cancer were predicted by bioinformatics analysis. In this work, esophageal squamous carcinoma cell lines were subjected to increasing doses of acacetin, and the proliferative, migrative, invasive and apoptotic phenotypes were evaluated by a series of in vitro experiments.

Regulations 100

Regulations Bioinformatics Treatment Therapies 100

Crown Bioscience

JANUARY 9, 2024

We have published our study on " SynAI " in the journal " Bioinformatics Advances " (November 2023). I am excited to share with you a significant advancement in the field of cancer research, the culmination of recent efforts by my team and me.

Bioinformatics 52

Bioinformatics Drugs Treatment Research 52

Chemical Biology and Drug Design

JULY 13, 2023

Bioinformatics analysis was performed to predict the molecular targets of COP. Cell counting kit-8 (CCK-8), scratch healing assay, Transwell assay, and flow cytometry were used to detect cell growth, migration, invasion, and cell cycle progression.

Regulations 100

Regulations Bioinformatics Treatment Drugs 100

Chemical Biology and Drug Design

FEBRUARY 7, 2024

We assessed the effect of HSYA and NF-κB signaling pathway-related genes by bioinformatics analysis and conducted molecular docking to assess the interaction of HSYA with a combined protein residue molecule ligand. Western blot was employed to investigate NF-κB transcription factors in chondrocyte metabolism.

Bioinformatics 100

Bioinformatics Production Treatment Disease 100

SCIENMAG: Medicine & Health

JULY 6, 2023

EMBL’s European Bioinformatics Institute (EMBL-EBI) has launched the Pathogens Portal – an online platform that enables researchers, clinicians, and policymakers to access the most comprehensive collection of biomolecular data about pathogens.

Bioinformatics 69

Bioinformatics Research 69

Drug Discovery World

AUGUST 29, 2022

Dr Navar holds a PhD in Medicine from Leiden University, and an MSc in Bioinformatics and Artificial Intelligence from Brunel University. . He has over 12 years of experience in the healthcare sector and is the author of over 30 peer-reviewed scientific articles.

Bioinformatics 130

Bioinformatics Biosimilars Drugs Science 130

Chemical Biology and Drug Design

AUGUST 20, 2023

Bioinformatics analysis predicted cathepsin B (CTSB) as a target of hederagenin to modulate NOD-like receptor (NLR) pathway. NLRP3 inhibitor MCC950 attenuated HG-induced fibrosis of renal cells, and its activator nigericin reversed the suppressive effect of hederagenin on HG-induced fibrosis.

Bioinformatics 100

Bioinformatics Protein Expression Research 100

Broad Institute

OCTOBER 27, 2023

Machine Learning in Drug Discovery Symposium 2023 | Opening Remarks By Rose Circeo October 27, 2023 Breadcrumb Home Machine Learning in Drug Discovery Symposium 2023 | Opening Remarks Sumaiya Iqbal Group Leader Bioinformatics and Computational Biology Group Center for the Development of Therapeutics Broad Institute Alex Burgin Senior Director Center (..)

Bioinformatics 52

Bioinformatics Drugs 52

SCIENMAG: Medicine & Health

SEPTEMBER 14, 2023

Led by researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), Cold Spring Harbor Laboratory (CSHL), and the Massachusetts Institute of Technology (MIT), the work focuses on understanding why some tumours fail to respond to immune checkpoint blockade (ICB) […]

Bioinformatics 52

Bioinformatics Laboratories Research 52

Chemical Biology and Drug Design

AUGUST 9, 2023

Bioinformatics and functional analyses indicated that these proteins were predominantly involved in protein synthesis and translation. Our investigation indicated that plumbagin markedly inhibited the LoVo cells proliferation, and induced the apoptosis in LoVo cells, simultaneously induced G0/G1 phase cell cycle arrest.

Bioinformatics 100

Bioinformatics Protein Expression Treatment Research 100

The Open Targets Blog

OCTOBER 24, 2023

Amir Feizi is the Director of Bioinformatics at OMass Therapeutics, a spinout from Professor Dame Carol Robinson’s Laboratory at the University of Oxford. Their work was recently published in Bioinformatics. We chat with him about otargen, and the importance of sharing open-source resources within the bioinformatics community.

Bioinformatics 65

Bioinformatics Packaging Pharmaceutical Companies Pharma Companies 65

Chemical Biology and Drug Design

JUNE 21, 2023

Hsa-miR-503-5p expression in LUAD and the target gene downstream of hsa-miR-503-5p was predicted by bioinformatics analysis. Abstract The study aimed to assess the role of hsa-miR-503-5p in cisplatin resistance and angiogenesis in LUAD and its underlying mechanisms.

Regulations 100

Regulations Protein Expression Bioinformatics Drugs 100