Chemical Biology and Drug Design

JUNE 11, 2024

RNA sequencing (RNA-seq) and bioinformatics analyses of HCC cells were utilized to elucidate the mechanism underlying the effects of BRU in HCC. However, the exact mechanism of BRU in the treatment of hepatocellular carcinoma (HCC) remains unknown.

RNA 100

RNA Bioinformatics Treatment Therapies 100

Broad Institute

MARCH 8, 2024

Organizing Committee By Rose Circeo March 8, 2024 Breadcrumb Home Organizing Committee Sumaiya Iqbal, Co-chair Group Leader, Bioinformatics and Computational Biology, CDoT Wengong Jin, Co-chair Postdoc, Eric and Wendy Schmidt Center Holly Soutter, General Committee Member Director, Biochemistry and Biophysics, CDoT Eric Sigel, General Committee Member (..)

Bioinformatics 52

Bioinformatics Science Research Drugs 52

SCIENMAG: Medicine & Health

JULY 13, 2023

Rensselaer Polytechnic Institute’s Catherine Royer, Constellation Chair Professor of Bioinformatics and Biocomputation at the Shirley Ann Jackson, Ph.D.

Bioinformatics 87

Bioinformatics Research Science 87

Chemical Biology and Drug Design

MARCH 28, 2023

Pharmacodynamic targets of metformin were predicted using the Bioinformatics Analysis Tool for the molecular mechanism of traditional Chinese medicine (BATMAN), Drugbank, PharmMapper, SwissTargetPrediction, and TargetNet databases.

Bioinformatics 100

Bioinformatics Drugs Research 100

Chemical Biology and Drug Design

FEBRUARY 20, 2024

Moreover, bioinformatics analysis has suggested that hsa_circRNA_103820 possesses potential peptide-coding ability. Abstract N6-methyladenosine (m6A) modification and m6A-related RNA-binding proteins (RBPs) play vital roles in various aspects of circRNA metabolism.

Bioinformatics 100

Bioinformatics RNA Regulations Research 100

Practical Cheminformatics

JANUARY 16, 2024

Property Prediction Machine Learning Methods for Small Data Challenges in Molecular Science [link] Practical guidelines for the use of gradient boosting for molecular property prediction [link] Application of message passing neural networks for molecular property prediction [link] Molecular Similarity Molecular Similarity: Theory, Applications, and (..)

Targeted Protein Degradation 141

Targeted Protein Degradation Small Molecule Computational Chemistry Bioinformatics 141

Chemical Biology and Drug Design

JULY 4, 2023

Genes related to acacetin and esophageal cancer were predicted by bioinformatics analysis. In this work, esophageal squamous carcinoma cell lines were subjected to increasing doses of acacetin, and the proliferative, migrative, invasive and apoptotic phenotypes were evaluated by a series of in vitro experiments.

Bioinformatics 100

Bioinformatics Regulations Treatment Therapies 100

Drug Target Review

DECEMBER 28, 2023

Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Using powerful bioinformatics technology developed and validated with sequence data from the TRACERx study, researchers are able to identify clonal neoantigens from a patient’s unique tumour profile.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Chemical Biology and Drug Design

NOVEMBER 27, 2023

Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ. A total of 153 genes were increased, and the expression of 81 genes was decreased.

Bioinformatics 100

Bioinformatics RNA Regulations Therapies 100

Chemical Biology and Drug Design

JANUARY 5, 2024

Homeobox B7 (HOXB7) expression in CRC was analyzed and detected by bioinformatics analysis, quantitative real-time PCR or western blot. Following the treatment of 0, 1.94, 7.75, or 19.36 μM μM THA, CRC cell viability, apoptosis, migration, and invasion were evaluated by methyl tetrazolium, flow cytometry, wound-healing, and transwell assays.

Bioinformatics 100

Bioinformatics Cell Biology Treatment Research 100

Chemical Biology and Drug Design

JULY 13, 2023

Bioinformatics analysis was performed to predict the molecular targets of COP. Cell counting kit-8 (CCK-8), scratch healing assay, Transwell assay, and flow cytometry were used to detect cell growth, migration, invasion, and cell cycle progression.

Regulations 100

Regulations Bioinformatics Treatment Drugs 100

BioPharma Drive: Drug Pricing

MAY 6, 2024

Can free bioinformatics tools get the job done?

Bioinformatics 57

Bioinformatics 57

SCIENMAG: Medicine & Health

JULY 6, 2023

EMBL’s European Bioinformatics Institute (EMBL-EBI) has launched the Pathogens Portal – an online platform that enables researchers, clinicians, and policymakers to access the most comprehensive collection of biomolecular data about pathogens.

Bioinformatics 69

Bioinformatics Research 69

Crown Bioscience

JANUARY 9, 2024

We have published our study on " SynAI " in the journal " Bioinformatics Advances " (November 2023). I am excited to share with you a significant advancement in the field of cancer research, the culmination of recent efforts by my team and me.

Bioinformatics 52

Bioinformatics Drugs Treatment Research 52

Chemical Biology and Drug Design

JANUARY 1, 2024

Then, Bioinformatics was applied to sort out the candidate interacting with Stachydrine as well as its expression and downstream target in BC. Abstract Considering the therapeutic efficacy of Stachydrine on breast cancer (BC), this study aims to decipher the relevant mechanism.

Bioinformatics 100

Bioinformatics Regulations Disease Research 100

Chemical Biology and Drug Design

DECEMBER 28, 2023

In present study, LINC00460 was screened out through bioinformatics analysis. The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer. However, its effect on DDP sensitivity in cervical cancer remains poorly understood. The sensitivity to DDP was investigated using an CCK8 assay.

Bioinformatics 100

Bioinformatics RNA Regulations Drugs 100

Broad Institute

OCTOBER 27, 2023

Machine Learning in Drug Discovery Symposium 2023 | Opening Remarks By Rose Circeo October 27, 2023 Breadcrumb Home Machine Learning in Drug Discovery Symposium 2023 | Opening Remarks Sumaiya Iqbal Group Leader Bioinformatics and Computational Biology Group Center for the Development of Therapeutics Broad Institute Alex Burgin Senior Director Center (..)

Bioinformatics 52

Bioinformatics Drugs 52

SCIENMAG: Medicine & Health

SEPTEMBER 14, 2023

Led by researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), Cold Spring Harbor Laboratory (CSHL), and the Massachusetts Institute of Technology (MIT), the work focuses on understanding why some tumours fail to respond to immune checkpoint blockade (ICB) […]

Bioinformatics 52

Bioinformatics Laboratories Research 52

Chemical Biology and Drug Design

AUGUST 20, 2023

Bioinformatics analysis predicted cathepsin B (CTSB) as a target of hederagenin to modulate NOD-like receptor (NLR) pathway. NLRP3 inhibitor MCC950 attenuated HG-induced fibrosis of renal cells, and its activator nigericin reversed the suppressive effect of hederagenin on HG-induced fibrosis.

Bioinformatics 100

Bioinformatics Protein Expression Research 100

Chemical Biology and Drug Design

FEBRUARY 7, 2024

We assessed the effect of HSYA and NF-κB signaling pathway-related genes by bioinformatics analysis and conducted molecular docking to assess the interaction of HSYA with a combined protein residue molecule ligand. Western blot was employed to investigate NF-κB transcription factors in chondrocyte metabolism.

Bioinformatics 100

Bioinformatics Treatment Production Disease 100

Chemical Biology and Drug Design

AUGUST 9, 2023

Bioinformatics and functional analyses indicated that these proteins were predominantly involved in protein synthesis and translation. Our investigation indicated that plumbagin markedly inhibited the LoVo cells proliferation, and induced the apoptosis in LoVo cells, simultaneously induced G0/G1 phase cell cycle arrest.

Bioinformatics 100

Bioinformatics Protein Expression Treatment Research 100

ASPET

JANUARY 23, 2024

Proteomic and bioinformatic analyses demonstrated an increased number of differentially expressed proteins with clozapine that were enriched in pathways related to inflammation, myeloid cell chemotaxis, wounding, transforming growth factor (TGF)-β signaling, and negative regulation of stimuli response.

Immune Response 100

Immune Response Bioinformatics Regulations Drugs 100

Chemical Biology and Drug Design

JUNE 21, 2023

Hsa-miR-503-5p expression in LUAD and the target gene downstream of hsa-miR-503-5p was predicted by bioinformatics analysis. Abstract The study aimed to assess the role of hsa-miR-503-5p in cisplatin resistance and angiogenesis in LUAD and its underlying mechanisms.

Regulations 100

Regulations Protein Expression Bioinformatics Drugs 100

Drug Target Review

AUGUST 11, 2023

1 The study reveals a novel bioinformatic approach and tool that holds the potential to empower researchers in designing vaccines capable of inducing a stronger immune response. Since December 2019, SARS-CoV-2 (COVID-19) infection has become a worldwide urgent public health concern.

Vaccine 98

Vaccine Immune Response Bioinformatics Virus 98

SCIENMAG: Medicine & Health

JULY 24, 2023

In this study, the authors proposed and tested a new bioinformatic approach and tool that allows researchers to […]

Vaccine 60

Vaccine Bioinformatics Immune Response Virus 60

Chemical Biology and Drug Design

MARCH 14, 2023

The bioinformatics website, dual luciferase reporter assay, and quantitative real-time polymerase chain reaction were applied to analyze the network among EVO, lncRNA, miR-152-3p, and mRNA. Abstract Evodiamine (EVO) has been demonstrated to promote apoptosis of ovarian cancer cells, and upregulate miR-152-3p level in colorectal cancer.

Regulations 100

Regulations Bioinformatics Drugs Research 100

SCIENMAG: Medicine & Health

AUGUST 7, 2023

” This project advances property-controlled molecule generation.

Bioinformatics 71

Bioinformatics Research Science 71

Broad Institute

AUGUST 7, 2024

At the Broad, he directs the Cancer Genome Computational Analysis Group , and he is a professor of pathology at Harvard Medical School and director of bioinformatics at Massachusetts General Hospital. Gad Getz is one of the world’s leaders in cancer genomics and has pioneered widely used tools for analyzing cancer genomes.

Medical Schools 90

Medical Schools Hospitals Bioinformatics Vaccine 90

Drug Target Review

JULY 12, 2023

Using our bioinformatics expertise, we then map those profiles onto a large database of patient data – the AACR Project GENIE database – to translationally predict which tumour types are likely to be most responsive to monotherapy or combination therapy to our drug candidate.

Biochemical Assays 98

Biochemical Assays Treatment Bioinformatics Disease 98

Fierce BioTech

OCTOBER 26, 2023

They turned to Oracle Cloud Infrastructure to quickly deploy, optimize, and scale a bioinformatics pipeline for predicting protein structures in drug discovery efforts, as well as accelerate the adoption of a next-generation archive storage technology.

DNA 52

DNA Bioinformatics Engineering Science 52

Drug Target Review

JUNE 13, 2024

Study co-senior investigator Dr Aristotelis Tsirigos is a professor in the Departments of Pathology and Medicine at NYU Grossman School of Medicine and Perlmutter Cancer Center, where he also is co-director of precision medicine and director of its Applied Bioinformatics Laboratories.

Bioinformatics 45

Bioinformatics Disease Laboratories Hospitals 45

Broad Institute

NOVEMBER 15, 2023

However, inferring the strain-level composition of the gut microbiome from metagenomic sequencing data remains a challenging bioinformatic problem.

Bioinformatics 52

Bioinformatics 52

Drug Target Review

MARCH 19, 2024

Murray has used his expertise in bioinformatics to establish an internationally recognised laboratory specialising in complex trait genomics. Murray is also leading the HMRI Precision Medicine Research Program and is the CEO of PolygenRx.

Laboratories 106

Laboratories Bioinformatics International Research Laboratories 106

The Open Targets Blog

AUGUST 13, 2024

Building and Sustaining I have huge admiration for the incredible teams at EMBL’s European Bioinformatics Institute and beyond who build and sustain knowledge resources for the community. I am really excited about bringing this to life with the team and where it will take us.

Bioinformatics 72

Bioinformatics Disease Treatment Drugs 72

Drug Target Review

MAY 24, 2024

5 Several major technology areas are not included above, such as cheminformatics and bioinformatics. For those looking to learn the basics of data quality, a good start is the 7 C’s framework. These are foundational to drug discovery and will be discussed in future articles.

RNA 59

RNA DNA Bioinformatics Science 59

Broad Institute

SEPTEMBER 30, 2024

BM: During COVID, there was an exponential increase in the need to analyze pathogen genomic data in public health settings quickly, locally, and often without deep bioinformatics capacity. Terra was one of the few systems that was available and ready to meet the moment.

Bioinformatics 101

Bioinformatics Disease Engineering Virus 101

Drug Target Review

JULY 24, 2023

The first identification was based on a bioinformatic analysis. Other than essential cellular processes are likely occurring in the apicoplast compartment. How did the researchers identify a nuclear-encoded apicoplast RNA polymerase σ subunit in the study?

RNA 98

RNA Regulations Bioinformatics Laboratories 98