Covalent Modifiers

APRIL 25, 2025

Hayden A. Sharma, Michael Bielecki, Meredith A. Holm, Ty M. Thompson, Yue Yin, Jacob B. Cravatt, Timothy B. Ware, Alex Reed, Molhm Nassir, Tamara El-Hayek Ewing, Bruno Melillo, J. Fernando Bazan, Phil S. Baran, and Benjamin F. Cravatt Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.5c01944 Activity-based protein profiling (ABPP) of stereoisomerically defined sets of electrophilic compounds (stereoprobes) offers a versatile way to discover covalent ligands for proteins in native b

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Science Daily: Pharmacology News

APRIL 23, 2025

An international team has identified a potential microbial culprit behind the alarming rise in early-onset colorectal cancer: a bacterial toxin called colibactin. Scientists report that exposure to colibactin in early childhood imprints a distinct genetic signature on the DNA of colon cells -- one that may increase the risk of developing colorectal cancer before the age of 50.

DNA 287

DNA International 287

Science Daily: Pharmacology News

APRIL 22, 2025

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions -- but there is always room for improvement. A new paper showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and cell therapy. In their study, authors developed a machine learning algorithm -- known as PAMmla -- that can predict the properties of about 64 million genome editing enzymes.

Engineering 165

Engineering Research Therapies 165

BioPharma Drive: Drug Pricing

APRIL 21, 2025

A spokesperson confirmed the Danish drugmaker has asked U.S. regulators to clear an oral version of its weight loss drug Wegovy two years after reporting initial Phase 3 results.

FDA Approval 350

FDA Approval FDA Regulations Drugs 350

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

Drugs.com

APRIL 21, 2025

MONDAY, April 21, 2025 -- Colonoscopy for younger adults. Chest CT scans for lung cancer. Statin meds to lower cholesterol. Screening for drug addiction.More than 150 million Americans might lose no-cost access to these and other preventive care.

Drugs 285

Drugs 285

Science Daily: Pharmacology News

APRIL 21, 2025

New research links fatty, sugary diets to impaired brain function. The findings build on a growing body of evidence showing the negative impact of high-fat, high-sugar (HFHS) diets on cognitive ability, adding to their well-known physical effects.

Research 309

Research 309

Covalent Modifiers

APRIL 25, 2025

R. Justin Grams, Wesley J. Wolfe, Robert J. Seal, James Veccia, and Ku-Lung Hsu Journal of Medicinal Chemistry 2025 [link] Aldo-keto reductase family 1 member C3 (AKR1C3) is a member of the AKR superfamily of enzymes that metabolize androgen, estrogen, and prostaglandin substrates that drive proliferation in hormone-dependent cancers. Interest in developing selective inhibitors has produced tool compounds for the inactivation or degradation of AKR1C3 with varying degrees of selectivity among the

Cell Biology 147

Cell Biology 147

BioPharma Drive: Drug Pricing

APRIL 25, 2025

The drug, being developed for a rare genetic disorder and currently under review in the U.S., is seen by some investors as critical to Biohaven’s future.

Marketing 267

Marketing Drugs 267

Drugs.com

APRIL 25, 2025

FRIDAY, April 25, 2025 Novavaxs COVID-19 vaccine could soon receive full approval from the U.S. Food and Drug Administration (FDA), the company said Wednesday.The update sent Novavaxs stock up more than 21% in early trading. It also helped ease.

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FDA Approval Vaccine FDA Drugs 278

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Collaborative Drug

APRIL 25, 2025

CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:

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FDA Law Blog: Drug Discovery

APRIL 21, 2025

By John W.M. Claud & Michelle L. Butler Recent reductions in force (RIFs) and leadership changes at FDA are already affecting key agency functionsand as the administration plans a broader reorganization, the impact will likely grow. One area drawing increasing attention is how these changes will affect the drug development and review process. As reported by the Wall Street Journal last week , reviews of both innovative and follow-on drugs have been caught in a traffic jam, largely due to a

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FDA Drug Development Drugs International 64

BioPharma Drive: Drug Pricing

APRIL 22, 2025

The big pharma joined several of its peers in committing to invest billions of dollars in new and expanded manufacturing facilities in the U.S.

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Production Drugs 256

Drugs.com

APRIL 21, 2025

MONDAY, April 21, 2025 The U.S. Centers for Disease Control and Prevention (CDC) has canceled its plans to help Texas schools stop the rapid spread of measles. The decision came after some CDC staff involved in this years outbreak response were t.

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Disease 276

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

keypoint

APRIL 22, 2025

Keystone Symposia was founded on the idea of bringing academic and industry scientists together to accelerate translational advances that cannot be achieved without their combined expertise and resources. As such, we have a long history of partnership with industry leaders with the shared goal of integrating basic science discovery and innovation into drug development efforts to yield novel and improved targeted treatment strategies.

Drug Development 82

Drug Development Science Treatment Drugs 82

Science Daily: Pharmacology News

APRIL 21, 2025

Saying one thing while feeling another is part of being human, but bottling up emotions can have serious psychological consequences like anxiety or panic attacks. To help health care providers tell the difference, a team has created a stretchable, rechargeable sticker that can detect real emotions -- by measuring things like skin temperature and heart rate -- even when users put on a brave face.

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New Drug Approvals

APRIL 25, 2025

Inavolisib WeightAverage: 407.378 Monoisotopic: 407.140510438 Chemical FormulaC 18 H 19 F 2 N 5 O 4 GDC-0077 CAS 2060571-02-8 GDC0077 RG6114 WHO 11204 GDC 0077 GDC-0077 RG-6114 RG6114 RO-7113755 RO7113755 FDA APPROVED, 10/10/2024, Itovebi , To treat locally advanced or metastatic breast cancer Drug Trials Snapshot (2 S )-2-[[2-[(4 S )-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide (2S)-2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazoli

FDA 57

FDA FDA Approval Therapies Trials 57

BioPharma Drive: Drug Pricing

APRIL 24, 2025

The drugmaker absorbed additional tariff-related costs in the first quarter, but has taken steps to lower the financial impact it’ll have for the rest of the year and beyond.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

APRIL 25, 2025

FRIDAY, April 25, 2025 -- On Tuesday, the U.S. Department of Health and Human Services announced that the government will invest $176 million in Moderna to expedite the creation of a pandemic influenza vaccine, according to a report from the.

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Vaccine Government 270

Fierce BioTech

APRIL 28, 2025

Can a CDMO be patient-centric? This paper outlines our vision for empowering patients, demonstrating how a CDMO can play a pivotal role in the advancement of patient-friendly drug delivery systems. We highlight the importance of flexibility and adaptability in manufacturing processes, illustrating how these qualities are essential for bringing innovative solutions to life. sdees Mon, 04/28/2025 - 14:12 This paper outlines our vision for empowering patients, demonstrating how a CDMO can play a pi

Drugs 52

Drugs 52

Science Daily: Pharmacology News

APRIL 23, 2025

A new study by developmental scientists offers the first evidence that infants as young as 15 months can identify an object they have learned about from listening to language -- even if the object remains hidden.

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Antidote

APRIL 28, 2025

Hearing the words You have Parkinsons disease can feel life-changing but having a consistent daily routine can make a big difference in how you feel, move, and think throughout the day. Creating structure not only supports your physical health but also boosts mental well-being and helps you stay more in control.

Disease 52

Disease 52

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

APRIL 24, 2025

The biotech is using AI and a trove of health data to better understand why certain conditions progress and intervene beforehand with a targeted medication.

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Disease 185

Drugs.com

APRIL 23, 2025

WEDNESDAY, April 23, 2025 Microplastics could be contributing to clogged arteries, increasing peoples risk of heart attack or stroke, a new study says.Fatty plaques in neck arteries can contain more than 50 times as much microplastics as are fou.

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Practical Cheminformatics

APRIL 26, 2025

After more than eight years on Blogger, I've decided to move Practical Cheminformatics to a new location. Formatting posts on Blogger has always been a struggle, and I'd prefer to be able to write posts in markdown. This site will remain as an archive for previous posts, but all new content will be posted under the "Blog" link on my website [link].

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Science Daily: Pharmacology News

APRIL 21, 2025

An international collaboration has published groundbreaking research, shedding light on the most significant increase in complexity in the history of life's evolution on Earth: the origin of the eukaryotic cell.

International 259

International Research 259

DS in Pharmatics

APRIL 25, 2025

Navigating the complexities of drug development demands more than internal resources. From overcoming technical hurdles and avoiding costly or inappropriate development paths to meeting regulatory standards, every stagediscovery to marketpresents unique challenges. At key moments, companies must recognize when external expertise isn't just helpful but crucial.

Production 52

Production Drugs International Drug Development 52

BioPharma Drive: Drug Pricing

APRIL 25, 2025

The CRISPR company is laying off about a third of its employees and stopping work on an experimental lupus treatment in a bid to focus resources on a pair of cancer cell therapies.

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Therapies Treatment 184

Drugs.com

APRIL 21, 2025

MONDAY, April 21, 2025 -- Chris Vogelsang has had a long and terrible fight with cancer. Fourteen years ago, the 70-year-old man was first diagnosed with an aggressive form of lymphoma. His cancer has since returned twice, fighting against several.

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Therapies Treatment 257

Fierce BioTech

APRIL 23, 2025

From Gut Feelings to Granular Insights: PLD in Action pesurya Wed, 04/23/2025 - 11:13 Wed, 06/04/2025 - 13:00 Resource Type Webinar Seth Chaney When it comes to connecting with healthcare providers (HCPs), smart marketers know that data is their best friend. And Physician-Level Data (PLD) is the MVP of campaign insights. PLD gives you the granular, inside scoop on HCP behavior, so you can easily see whats working, whats missing the mark, and optimize your strategy in real time.

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Marketing 52