Trending Articles

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Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors

Covalent Modifiers

Hayden A. Sharma, Michael Bielecki, Meredith A. Holm, Ty M. Thompson, Yue Yin, Jacob B. Cravatt, Timothy B. Ware, Alex Reed, Molhm Nassir, Tamara El-Hayek Ewing, Bruno Melillo, J. Fernando Bazan, Phil S. Baran, and Benjamin F. Cravatt Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.5c01944 Activity-based protein profiling (ABPP) of stereoisomerically defined sets of electrophilic compounds (stereoprobes) offers a versatile way to discover covalent ligands for proteins in native b

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Childhood exposure to bacterial toxin may be triggering colorectal cancer epidemic among the young

Science Daily: Pharmacology News

An international team has identified a potential microbial culprit behind the alarming rise in early-onset colorectal cancer: a bacterial toxin called colibactin. Scientists report that exposure to colibactin in early childhood imprints a distinct genetic signature on the DNA of colon cells -- one that may increase the risk of developing colorectal cancer before the age of 50.

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Researchers use machine learning to engineer 'bespoke enzymes' for gene editing

Science Daily: Pharmacology News

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions -- but there is always room for improvement. A new paper showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and cell therapy. In their study, authors developed a machine learning algorithm -- known as PAMmla -- that can predict the properties of about 64 million genome editing enzymes.

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Novo says it’s submitted obesity pill for FDA approval

BioPharma Drive: Drug Pricing

A spokesperson confirmed the Danish drugmaker has asked U.S. regulators to clear an oral version of its weight loss drug Wegovy two years after reporting initial Phase 3 results.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Supreme Court Case Targets Free Preventive Care Provided By The Affordable Care Act

Drugs.com

MONDAY, April 21, 2025 -- Colonoscopy for younger adults. Chest CT scans for lung cancer. Statin meds to lower cholesterol. Screening for drug addiction.More than 150 million Americans might lose no-cost access to these and other preventive care.

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More Trending

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High-fat, high-sugar diets impact cognitive function

Science Daily: Pharmacology News

New research links fatty, sugary diets to impaired brain function. The findings build on a growing body of evidence showing the negative impact of high-fat, high-sugar (HFHS) diets on cognitive ability, adding to their well-known physical effects.

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Discovery and Optimization of a Covalent AKR1C3 Inhibitor

Covalent Modifiers

R. Justin Grams, Wesley J. Wolfe, Robert J. Seal, James Veccia, and Ku-Lung Hsu Journal of Medicinal Chemistry 2025 [link] Aldo-keto reductase family 1 member C3 (AKR1C3) is a member of the AKR superfamily of enzymes that metabolize androgen, estrogen, and prostaglandin substrates that drive proliferation in hormone-dependent cancers. Interest in developing selective inhibitors has produced tool compounds for the inactivation or degradation of AKR1C3 with varying degrees of selectivity among the

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Biohaven stock slides on withdrawal of European marketing application

BioPharma Drive: Drug Pricing

The drug, being developed for a rare genetic disorder and currently under review in the U.S., is seen by some investors as critical to Biohaven’s future.

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Novavax COVID Vaccine Moves Closer to Full FDA Approval

Drugs.com

FRIDAY, April 25, 2025 Novavaxs COVID-19 vaccine could soon receive full approval from the U.S. Food and Drug Administration (FDA), the company said Wednesday.The update sent Novavaxs stock up more than 21% in early trading. It also helped ease.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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CDD Vault Update (April 2025 #3): AI+ Folding and Docking

Collaborative Drug

CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:

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Reports Document FDA Review Delays: What Drugmakers Should Know Now

FDA Law Blog: Drug Discovery

By John W.M. Claud & Michelle L. Butler Recent reductions in force (RIFs) and leadership changes at FDA are already affecting key agency functionsand as the administration plans a broader reorganization, the impact will likely grow. One area drawing increasing attention is how these changes will affect the drug development and review process. As reported by the Wall Street Journal last week , reviews of both innovative and follow-on drugs have been caught in a traffic jam, largely due to a

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Roche, answering tariff threat, pledges $50B to US drug production

BioPharma Drive: Drug Pricing

The big pharma joined several of its peers in committing to invest billions of dollars in new and expanded manufacturing facilities in the U.S.

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CDC Cancels Measles Help for Texas Schools Amid Staff Layoffs

Drugs.com

MONDAY, April 21, 2025 The U.S. Centers for Disease Control and Prevention (CDC) has canceled its plans to help Texas schools stop the rapid spread of measles. The decision came after some CDC staff involved in this years outbreak response were t.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Partnering with Eli Lilly to Empower the Biomedical Workforce

keypoint

Keystone Symposia was founded on the idea of bringing academic and industry scientists together to accelerate translational advances that cannot be achieved without their combined expertise and resources. As such, we have a long history of partnership with industry leaders with the shared goal of integrating basic science discovery and innovation into drug development efforts to yield novel and improved targeted treatment strategies.

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High-tech sticker can identify real human emotions

Science Daily: Pharmacology News

Saying one thing while feeling another is part of being human, but bottling up emotions can have serious psychological consequences like anxiety or panic attacks. To help health care providers tell the difference, a team has created a stretchable, rechargeable sticker that can detect real emotions -- by measuring things like skin temperature and heart rate -- even when users put on a brave face.

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Inavolisib

New Drug Approvals

Inavolisib WeightAverage: 407.378 Monoisotopic: 407.140510438 Chemical FormulaC 18 H 19 F 2 N 5 O 4 GDC-0077 CAS 2060571-02-8 GDC0077 RG6114 WHO 11204 GDC 0077 GDC-0077 RG-6114 RG6114 RO-7113755 RO7113755 FDA APPROVED, 10/10/2024, Itovebi , To treat locally advanced or metastatic breast cancer Drug Trials Snapshot (2 S )-2-[[2-[(4 S )-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide (2S)-2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazoli

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Merck takes $200M tariff hit, trimming its gross profits

BioPharma Drive: Drug Pricing

The drugmaker absorbed additional tariff-related costs in the first quarter, but has taken steps to lower the financial impact it’ll have for the rest of the year and beyond.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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HHS Announces Plans to Pay Moderna $176 Million for mRNA Flu Vaccine

Drugs.com

FRIDAY, April 25, 2025 -- On Tuesday, the U.S. Department of Health and Human Services announced that the government will invest $176 million in Moderna to expedite the creation of a pandemic influenza vaccine, according to a report from the.

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Can a CDMO be patient-centric?

Fierce BioTech

Can a CDMO be patient-centric? This paper outlines our vision for empowering patients, demonstrating how a CDMO can play a pivotal role in the advancement of patient-friendly drug delivery systems. We highlight the importance of flexibility and adaptability in manufacturing processes, illustrating how these qualities are essential for bringing innovative solutions to life. sdees Mon, 04/28/2025 - 14:12 This paper outlines our vision for empowering patients, demonstrating how a CDMO can play a pi

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By 15 months, infants begin to learn new words for objects, even those they've never seen

Science Daily: Pharmacology News

A new study by developmental scientists offers the first evidence that infants as young as 15 months can identify an object they have learned about from listening to language -- even if the object remains hidden.

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Daily Routines That Help Manage Parkinson’s Symptoms

Antidote

Hearing the words You have Parkinsons disease can feel life-changing but having a consistent daily routine can make a big difference in how you feel, move, and think throughout the day. Creating structure not only supports your physical health but also boosts mental well-being and helps you stay more in control.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Etiome, a new Flagship startup, looks to catch disease before it strikes

BioPharma Drive: Drug Pricing

The biotech is using AI and a trove of health data to better understand why certain conditions progress and intervene beforehand with a targeted medication.

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Microplastics Could Be Contributing To Clogged Arteries

Drugs.com

WEDNESDAY, April 23, 2025 Microplastics could be contributing to clogged arteries, increasing peoples risk of heart attack or stroke, a new study says.Fatty plaques in neck arteries can contain more than 50 times as much microplastics as are fou.

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We've Moved

Practical Cheminformatics

After more than eight years on Blogger, I've decided to move Practical Cheminformatics to a new location. Formatting posts on Blogger has always been a struggle, and I'd prefer to be able to write posts in markdown. This site will remain as an archive for previous posts, but all new content will be posted under the "Blog" link on my website [link].

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The eukaryotic cell emerged as an evolutionary algorithmic phase transition

Science Daily: Pharmacology News

An international collaboration has published groundbreaking research, shedding light on the most significant increase in complexity in the history of life's evolution on Earth: the origin of the eukaryotic cell.

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When Should You Consider Drug Product Development Services?

DS in Pharmatics

Navigating the complexities of drug development demands more than internal resources. From overcoming technical hurdles and avoiding costly or inappropriate development paths to meeting regulatory standards, every stagediscovery to marketpresents unique challenges. At key moments, companies must recognize when external expertise isn't just helpful but crucial.

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Caribou, in reversal, scraps autoimmune cell therapy and cuts staff

BioPharma Drive: Drug Pricing

The CRISPR company is laying off about a third of its employees and stopping work on an experimental lupus treatment in a bid to focus resources on a pair of cancer cell therapies.

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Cutting-Edge Cancer Treatment, CAR T-Cell Therapy, Isn't Known By Most Americans

Drugs.com

MONDAY, April 21, 2025 -- Chris Vogelsang has had a long and terrible fight with cancer. Fourteen years ago, the 70-year-old man was first diagnosed with an aggressive form of lymphoma. His cancer has since returned twice, fighting against several.

Therapies 257
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From Gut Feelings to Granular Insights: PLD in Action

Fierce BioTech

From Gut Feelings to Granular Insights: PLD in Action pesurya Wed, 04/23/2025 - 11:13 Wed, 06/04/2025 - 13:00 Resource Type Webinar Seth Chaney When it comes to connecting with healthcare providers (HCPs), smart marketers know that data is their best friend. And Physician-Level Data (PLD) is the MVP of campaign insights. PLD gives you the granular, inside scoop on HCP behavior, so you can easily see whats working, whats missing the mark, and optimize your strategy in real time.