Trending Articles

article thumbnail

This week in drug discovery (20-24 May) 

Drug Discovery World

News round-up for 20-24 May by DDW Senior Digital Content Editor Diana Spencer. The headline news this week emphasises the importance of shared expertise and collaboration, whether that be between nations, companies or research institutions, to enable the greatest advances in drug discovery. The top stories: Partners explore precision medicine approach to heart disease PlaqueTec and the Welch research group at the Babraham Institute have announced the completion of their collaboration to evaluat

Virus 130
article thumbnail

Costs, Side Effects Drive Folks to Quit New Weight-Loss Meds

Drugs.com

THURSDAY, May 23, 2024 -- Three months after starting one of the new GLP-1 weight-loss drugs, more than a quarter of patients have already quit the medications, and by a year from first use more than a third have stopped, new research shows.Reasons.

Research 124
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Trending Sources

article thumbnail

SLAS Europe reveals New Product Award finalists

Drug Discovery World

SLAS has announced the finalists for its New Product Award, with the winners to be announced at the annual conference. The SLAS 2024 Europe Conference and Exhibition is heading back to Barcelona, 27-29 May, for its fifth annual European conference. It will feature scientific sessions and keynote presentations, discussion groups, new product demonstrations and extensive exhibition access time.

article thumbnail

Scientists map networks regulating gene function in the human brain

Science Daily: Pharmacology News

A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the many regulatory elements that coordinate the brain's biological pathways and cellular functions. The research used postmortem brain tissue from over 2,500 donors to map gene regulation networks across different stages of brain development and multiple brain-related disorders.

article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

With Duchenne decision ahead, FDA’s Marks pushes for speedy gene therapy approvals

BioPharma Drive: Drug Pricing

But the head of the FDA’s CBER office didn’t tip where the agency stands on potentially broadening use of Sarepta’s Duchenne gene therapy Elevidys.

Therapies 115
article thumbnail

New patent for Ferring Pharms drug NOCDURNA

Drug Patent Watch

Annual Drug Patent Expirations for NOCDURNA Nocdurna is a drug marketed by Ferring Pharms Inc and is included in one NDA. It is available from one supplier.

Drugs 105

More Trending

article thumbnail

Stomach Paralysis Risk May Rise in People Taking Ozempic and Similar Drugs

Drugs.com

MONDAY, May 20, 2024 -- New, real-world research confirms that the blockbuster weight-loss drugs that millions of Americans have been taking to shed pounds can trigger stomach paralysis in some patients.“Although these drugs do work and should be.

Drugs 133
article thumbnail

Mental disorders may spread in young people's social networks

Science Daily: Pharmacology News

A recently completed study demonstrates that mental disorders may be transmitted between individuals within social networks. The finding was the most evident in the case of mood, anxiety and eating disorders.

121
121
article thumbnail

ASCO24: An early look at cancer drug study results

BioPharma Drive: Drug Pricing

Clinical trial abstracts posted by ASCO Thursday give a peek at anticipated datasets from Immunocore, Merck & Co., J&J and Arcus Biosciences.

article thumbnail

What are PDX-Derived Organoids (PDXOs)?

Crown Bioscience

Learn about PDX-derived organoids, including PDXO establishment and utility in a pioneering drug discovery platform combining the benefits of in vitro PDXO and highly predictive in vivo PDX models.

Drugs 98
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

CAS BioFinder Discovery Platform offers drug discovery insights

Drug Discovery World

CAS, a division of the American Chemical Society, has launched the CAS BioFinder Discovery Platform, designed to reveal novel drug discovery insights through data connections. The offering provides drug discovery scientists with the ability to explore known and predicted data, find answers to their questions, and potentially accelerate the preclinical drug discovery process.

Drugs 147
article thumbnail

1 in 9 U.S. Children Have Been Diagnosed With ADHD

Drugs.com

THURSDAY, May 23, 2024 -- About 1 in 9 American children have ever received an ADHD diagnosis, slightly more than the number of kids currently being treated for the disorder, a new study shows.About 7.1 million kids (11.4%) have ever been.

121
121
article thumbnail

'Vigorous melting' at Antarctica's Thwaites 'Doomsday' Glacier

Science Daily: Pharmacology News

Glaciologists show evidence of warm ocean water intruding kilometers beneath grounded ice at Thwaites Glacier in West Antarctica. The findings suggest that existing climate models are underestimating the impact of ocean and ice interactions in future sea level rise projections.

126
126
article thumbnail

Orna, a circular RNA specialist, acquires a buzzy startup

BioPharma Drive: Drug Pricing

After laying off staff late last year, Orna is expanding through the purchase of ReNAgade Therapeutics, which was built around technology designed to more effectively deliver RNA-based medicines.

RNA 112
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

New patent for Merck Sharp drug BELSOMRA

Drug Patent Watch

Annual Drug Patent Expirations for BELSOMRA Belsomra is a drug marketed by Merck Sharp Dohme and is included in one NDA. It is available from one supplier.

Drugs 105
article thumbnail

Peptide shows promise as therapeutic for bone loss disorders

Drug Discovery World

Birmingham researchers have shown that a naturally occurring peptide holds promise as a new therapeutic for bone loss disorders and could have advantages over existing drugs. PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) was first identified in 2015 by University of Birmingham researchers. The latest research shows for the first time that PEPITEM could be used as a novel and early clinical intervention to reverse the impact of age-related musculoskeletal diseases.

Disease 147
article thumbnail

Do Fish Oil Supplements Help or Harm the Heart?

Drugs.com

WEDNESDAY, May 22, 2024 -- Folks regularly taking fish oil supplements might not be helping their health as much as they might think, a new study suggests.Regular use of fish oil supplements could increase the risk of first-time heart disease and.

Disease 122
article thumbnail

Brain 'assembloids' mimic human blood-brain barrier

Science Daily: Pharmacology News

Major advance promises to accelerate the understanding and improved treatment of a wide range of brain disorders, including stroke, cerebral vascular disorders, brain cancer, Alzheimer's disease, Huntington disease, Parkinson's disease, and other neurodegenerative conditions.

Disease 125
article thumbnail

Certain menopausal hormone therapy could raise ovarian cancer risk, study finds

BioPharma Drive: Drug Pricing

The findings, from two trials involving tens of thousands of women, could influence guidelines around the use of hormonal treatment for menopausal symptoms.

Therapies 112
article thumbnail

Tips for Writing a Good Cover Letter

addgene Blog

If you are job searching, you may be wondering if you need to go to the effort of writing a cover letter. After all, they’re less common than they were ten years ago, and it does take a bit of time to craft one. We still think they're useful, so we've updated our cover letter blog post to help you write the best one possible!

Science 98
article thumbnail

Discover how organoids bridge the gap between the lab and clinic

Drug Discovery World

Developing new drugs is a complex and often lengthy process. A major roadblock lies in the limitations of traditional preclinical models, which often fail to accurately represent the intricate biology of human patients. Join DDW for a free event on 18 June, 3PM BST to learn more about how patient-derived organoids are revolutionising drug discovery.

article thumbnail

Shared Fentanyl Pipe Residue a New Overdose Danger

Drugs.com

THURSDAY, May 23, 2024 -- San Francisco researchers report that smoking has now replaced injections as the most common way of ingesting illicit fentanyl.That switch has created a potentially deadly new danger, however, as fentanyl residues slowly.

Research 115
article thumbnail

Cement recycling method could help solve one of the world's biggest climate challenges

Science Daily: Pharmacology News

Researchers have developed a method to produce very low emission concrete at scale -- an innovation that could be transformative in the transition to net zero. The method, which the researchers say is 'an absolute miracle', uses the electrically-powered arc furnaces used for steel recycling to simultaneously recycle cement, the carbon-hungry component of concrete.

Research 119
article thumbnail

Therapies designed to dismantle cancer’s escape mechanisms show promise for patients

BioPharma Drive: Drug Pricing

Hear from IO Biotech CEO Dr. Mai-Britt Zocca about the potential of therapeutic vaccines to strip the defenses used by cancer cells to keep the immune system at bay.

Therapies 109
article thumbnail

Boiling It Down: Conveying Complexity For Decision-makers

LifeSciVC

By Ankit Mahadevia, former CEO of Spero Therapeutics, as part of the From The Trenches feature of LifeSciVC Drug development is complex. So is running a business. Sometimes, the work of doing both can make your head spin. In my career as a CEO and Board Chair, I’ve found that one of the most important things a team can do is convey this complexity clearly and efficiently when it’s time to decide.

article thumbnail

Test predicts obesity patients’ response to Ozempic

Drug Discovery World

A new study has demonstrated the clinical utility of a machine-learning gene risk score biomarker to predict patient response to Ozempic (semaglutide) and reduce variability. The study ‘Performance of a Machine-Learning Gene Risk Score Biomarker on Predicting Response to Semaglutide’ was led by the Mayo Clinic and presented at Digestive Disease Week 2024.

Science 147
article thumbnail

Stroke Rates Are Rising, Especially Among the Young

Drugs.com

THURSDAY, May 23, 2024 -- The rate at which Americans under the age of 65 suffered a stroke rose by about 15% between 2011 and 2022, new government data shows.That was true even among the young: The rate of stroke jumped 14.6% among people ages 18.

article thumbnail

Birth of universe's earliest galaxies observed for first time

Science Daily: Pharmacology News

Researchers have now seen the formation of three of the earliest galaxies in the universe, more than 13 billion years ago. The sensational discovery contributes important knowledge about the universe.

Research 115
article thumbnail

AstraZeneca sets sights on $80B in revenue by 2030

BioPharma Drive: Drug Pricing

The U.K. pharma expects to launch 20 new drugs by then, among them complex medicines for cancer as well as treatments for weight loss.

Treatment 112
article thumbnail

Hot Plasmids Spring 2024

addgene Blog

Every few months we highlight some of the new plasmids, antibodies, and viral preps in our repository through our Hot Plasmids articles.

78
article thumbnail

New DDW Highlights podcast: 21 May 2024

Drug Discovery World

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. From a weight loss drug that prevents heart attacks and a gene therapy that restores hearing, to a vaccine that can treat viruses that don’t exist yet, our chosen news stories this week all represent potential breakthroughs in their respective fields.

Virus 147
article thumbnail

Use of GLP-1 Meds Have Risen 7-Fold Among Young Americans

Drugs.com

WEDNESDAY, May 22, 2024 -- The number of American teens and young adults who've been prescribed one of the new GLP-1 weight-loss drugs soared nearly seven-fold between 2020 and 2023, a new report finds. That's compared to an overall decline of.

Drugs 115
article thumbnail

Foraging ants navigate more efficiently when given energy-drink-like doses of caffeine

Science Daily: Pharmacology News

Ants who receive a caffeine-laced sugary reward become more efficient at navigating back to the reward's location compared to ants that only receive sugar. Caffeinated ants move toward the reward via a more direct path but do not increase their speed, suggesting that caffeine improved their ability to learn. The study was conducted on Argentine ants (Linepithema humile), a globally invasive species, and the researchers say that incorporating caffeine into ant baits could aid efforts to control t

Research 114
article thumbnail

AltruBio lands up to $225M after shift to immune drug research

BioPharma Drive: Drug Pricing

Since pivoting from oncology, the startup has raised close to $300 million and advanced an ulcerative colitis drug into mid-stage testing.