Drug Discovery World

JULY 26, 2024

News round-up for 22-26 July by DDW Senior Digital Content Editor Diana Spencer. There have been some interesting developments in neuroscience this week. Perhaps most note-worthy, shingles vaccines Shingrix has been shown to reduce the risk of dementia by 17%, and TikoMed’s ALS drug caused a long-term slowing of ALS progression in a Phase II trial. The top stories: Oxford centre to address global epilepsy challenges The University of Oxford is launching The Centre for Global Epilepsy to address

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Perficient: Drug Development

JULY 25, 2024

“Double, double toil and trouble,” is a line repeated by the witches in Macbeth as they lay out the ominous prophecies of greatness and dire consequences for the titular character. Macbeth’s ambition envisions a perfect ending though desperate actions and moral weakness ruin it. So too are the misguided actions in pursuit of perfection which can set expectations and pressure that lead to unwanted results.

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Science Daily: Pharmacology News

JULY 22, 2024

Large language models may pass medical exams with flying colors but using them for diagnoses would currently be grossly negligent. Medical chatbots make hasty diagnoses, do not adhere to guidelines, and would put patients' lives at risk. A team has systematically investigated whether this form of artificial intelligence (AI) would be suitable for everyday clinical practice.

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Drugs.com

JULY 24, 2024

WEDNESDAY, July 24, 2024 -- Misuse of illicit prescription drugs is falling dramatically among U.S. high school students, a new study says.The percentage of seniors who say they’ve misused prescription drugs in the past year has dropped to 2% in 2.

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Drugs 114

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

BioPharma Drive: Drug Pricing

JULY 22, 2024

The company plans to start a late-stage study next year, after a smaller trial found its drug offered “robust and consistent” benefits on communication, cognition and motor function.

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Drugs Trials 117

Drug Discovery World

JULY 26, 2024

Dren Bio and Novartis Pharma have entered a strategic collaboration focused on the discovery and development of therapeutic bispecific antibodies for cancer. Under the terms of the agreement, Dren Bio will receive a total upfront consideration of $150 million from Novartis, which includes a $25 million equity investment in the company. Dren Bio is also eligible to receive up to $2.85 billion in additional cash payments upon achieving certain preclinical, clinical, regulatory, and commercial mile

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Science Daily: Pharmacology News

JULY 22, 2024

Dogs experience emotional contagion from the smell of human stress, leading them to make more 'pessimistic' choices, new research finds. Researchers tested how human stress odors affect dogs' learning and emotional state.

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Research 124

Drugs.com

JULY 23, 2024

TUESDAY, July 23, 2024 -- The boom in using GLP-1 drugs like Ozempic to treat obesity has resulted in a bust regarding the drugs’ original purpose, which was to treat type 2 diabetes, a new study finds. New prescriptions for these drugs have d.

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Drugs 114

Drug Patent Watch

JULY 24, 2024

In the high-stakes world of pharmaceutical innovation, drafting detailed drug patent claims is a critical process that can make or break a company’s future.

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Drug Discovery World

JULY 25, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers five articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: The promise and growth of cell and gene therapies No sign of stopping: The rise of cell and gene therapy Expert view: What’s next for cell and gene therapy?

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

JULY 22, 2024

Private biotech company acquisitions are on their fastest pace in years, a trend some in the industry say is driven by the abundance of mature, but not yet public, drug startups.

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Marketing Drugs 101

Science Daily: Pharmacology News

JULY 25, 2024

An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new study. By targeting infected cells in the brain, drug may clear virus from hidden areas that have been a major challenge in HIV treatment.

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Drugs.com

JULY 24, 2024

WEDNESDAY, July 24, 2024 -- Hospitals and clinical laboratories across the United States are facing a critical shortage of bottles used to culture blood samples, federal health officials report.Without the ability to culture blood, patients might.

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Laboratories Hospitals 108

Drug Patent Watch

JULY 24, 2024

As patents expire on blockbuster biologic drugs, manufacturers are increasingly employing a controversial tactic known as “product hopping” to maintain […] Source

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Production Marketing Drugs 97

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Discovery World

JULY 25, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers five articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: The promise and growth of cell and gene therapies No sign of stopping: The rise of cell and gene therapy Expert view: What’s next for cell and gene therapy?

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DrugBank

JULY 24, 2024

In the constantly evolving field of drug discovery, the term “undruggable” refers to proteins and targets in the body that, until recently, were considered impossible to treat with traditional drugs. Thanks to emerging technologies and innovative pharmacological tools, we’re expanding our "drug discovery toolbox" and finding ways to tackle these tough targets.

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Science Daily: Pharmacology News

JULY 24, 2024

Researchers have discovered a novel pain control pathway that links the cingulate cortex in the front of the brain, through the pons region of the brainstem, to cerebellum in the back of the brain.

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Research 115

Drugs.com

JULY 22, 2024

MONDAY, July 22, 2024 -- Daily supplements can slow loss of vision related to late-stage “dry” age-related macular degeneration (AMD), a new study finds.The rate of dry AMD progression into a key eye region slowed by about 55% over an average three.

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Drug Patent Watch

JULY 21, 2024

The Patent Trial and Appeal Board (PTAB) is a crucial component of the United States Patent and Trademark Office (USPTO), established in 2012 by the Leahy-Smith America Invents Act (AIA).

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Trials 98

Drug Discovery World

JULY 25, 2024

Researchers at ETH Zurich in Switzerland have uncovered how colorectal cancer cells colonise the liver. The findings, by Andreas Moor in the Department of Biosystems Science and Engineering and his team, will help to develop treatments with which they hope could hinder the metastatic process. Cancer metastasises when cells from the primary tumour break off and travel via the circulatory system to other parts of the body.

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Collaborative Drug

JULY 25, 2024

Inventory Search Interface: The new CDD Vault Inventory tab can be enabled by the CDD Support Team. If you wish to enable this tab in your vault please have your vault administrator contact support@collaborativedrug.com.

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Science Daily: Pharmacology News

JULY 23, 2024

Butterflies and moths collect so much static electricity whilst in flight, that pollen grains from flowers can be pulled by static electricity across air gaps of several millimeters or centimeters.

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Drugs.com

JULY 23, 2024

TUESDAY, July 23, 2024 -- A single drop of blood might be able to predict the onset of dozens of diseases, a new study claims.Analysis of the protein “signatures” in a droplet of blood can predict 67 diseases, including blood cancers, degenerative n.

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Disease 111

Drug Patent Watch

JULY 25, 2024

The generic drug market has been significantly impacted by the COVID-19 pandemic, with both challenges and opportunities arising from the crisis.

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Marketing Drugs 90

Drug Discovery World

JULY 25, 2024

UK researchers have mapped the exact variants in a gene that dramatically increase a person’s risk of developing cancer, paving the way for targeted treatment across diverse populations. Over 5,000 genetic variants that enable certain cancers to thrive were identified, along with a potential therapeutic target to treat or even prevent these cancers from developing.

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BioPharma Drive: Drug Pricing

JULY 22, 2024

Serum-based glycoproteins demonstrate success in predicting immune checkpoint inhibitor therapy outcomes.

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Therapies 111

Science Daily: Pharmacology News

JULY 24, 2024

A new study provides evidence that a spillover of avian influenza from birds to dairy cattle across several U.S. states has now led to mammal-to-mammal transmission -- between cows and from cows to cats and a raccoon.

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Drugs.com

JULY 24, 2024

WEDNESDAY, July 24, 2024 -- As marijuana loses much of its stigma and laws around its use relax, Americans are increasingly consuming it medically and recreationally.Americans with diabetes are no exception, a new study finds. The number of adults.

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Drug Patent Watch

JULY 24, 2024

In the high-stakes world of pharmaceuticals, generic drugs have become the unsung heroes of healthcare accessibility.

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Drug Discovery World

JULY 25, 2024

The future is looking rosy for the biotechnology sector. Diana Spencer takes a world-tour of some of the key centres of innovation. According to data analysts Precedence Research, the global biotechnology market was estimated at $1.38 trillion in 2023 and is expected to be worth around $4.25 trillion by 2033, growing at an impressive CAGR of 11.8% 1.

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addgene Blog

JULY 25, 2024

An enzyme-linked immunosorbent assay (ELISA) is a versatile method used to quantify the level of target antigen in a sample. While Engvall et al. originally developed the ELISA assay to measure antibody levels, scientists have since adapted it for a host of different proteins and small molecules from a variety of sample types (Engvall 1971). Scientists value ELISAs for their accuracy, specificity, and sensitivity (a good ELISA can detect picogram quantities of the target!

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Science Daily: Pharmacology News

JULY 25, 2024

Over the last century, a once-deadly mosquito-borne virus has evolved so that it no longer sickens humans. New research shows that changes in the virus's ability to target human cells paralleled the decline in illness and death. The findings offer important lessons in virology that may help guide better preparedness for future outbreaks of other viral diseases.

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Drugs.com

JULY 24, 2024

WEDNESDAY, July 24, 2024 -- Online retail giants like Amazon have made it easier for people to buy what they want when they want it, but that convenience comes at a cost to people’s health, a new study says.Huge warehouses that support online s.

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BioPharma Drive: Drug Pricing

JULY 26, 2024

Eisai plans to appeal the EMA’s negative recommendation, hoping to break into a market analysts expect could eventually bring billions of dollars in sales for the Alzheimer’s drug.

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