Drug Discovery World

SEPTEMBER 25, 2023

RNA therapeutics company SiSaf has published positive safety and efficacy data for its siRNA therapy for Autosomal Dominant Osteopetrosis 2 (ADO2). The data demonstrate that siRNA complexed with SiSaf’s silicon stabilised hybrid lipid nanoparticles (sshLNP) was able to significantly downregulate expression of an ADO2-specific mutant gene. The company says these results could have significant translational impact on bone disease therapies and open the path to human trials of it’s potentiall

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Therapies RNA Clinical Trials Disease 147

Antidote

SEPTEMBER 22, 2023

Connecting patients with clinical research opportunities is our mission here at Antidote, but often, we find that misconceptions can serve as barriers to achieving this goal. It’s important to carefully weigh the pros and cons of participating in a clinical trial but to do this effectively, it’s critical to have accurate information.

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Clinical Trials Trials Clinical Research Research 122

Drug Discovery World

SEPTEMBER 20, 2023

A new cooperative network designed to foster collaboration and boost the sharing of knowledge and expertise for the UK’s advanced therapies sector has been launched. The ‘ Scottish Advanced Therapy Medicinal Products (ATMP) and Vaccines Network ’ specifically targets researchers in the north of the UK and will coordinate events, talks from industry leaders and networking opportunities for the advanced therapies industry.

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Therapies Vaccine Drugs Science 276

Chemical Biology and Drug Design

SEPTEMBER 20, 2023

Ovarian cancer is the most lethal gynecologic cancer with recurrent or resistant disease observed in 70% of patients. We described herein the anti-cancer effect of a novel lipid vector BSV163/DOPE-mediated TRAIL gene transfection in association with cisplatin in—sensitive and—resistant ovarian cancer cells. The combined treatment successfully enhanced cisplatin cytotoxicity and helped to overcome cisplatin resistance in CR-Caov3 cells.

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Treatment Disease Research 189

Drugs.com

SEPTEMBER 22, 2023

FRIDAY, Sept. 22, 2023 -- Americans seeking out the new COVID boosters are finding themselves held back by insurance entanglements and supply delays. Some insurers have balked at covering the vaccines, with people arriving at shot appointments only.

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Vaccine 120

BioPharma Drive: Drug Pricing

SEPTEMBER 19, 2023

AIRNA is one of several biotechs to debut plans for target alpha-1 antitrypsin deficiency in recent years, with competitors such as AlveoGene, Wave Life Sciences and Arrowhead Pharmaceuticals.

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RNA Disease Pharmaceuticals Science 125

Drug Discovery World

SEPTEMBER 21, 2023

A research team from VIB-KU Leuven and the UK Dementia Research Institute has discovered how neurons die in Alzheimer’s disease, opening new pathways for potential future treatments. A new research paper published in Science illustrates how neurons initiate a programmed form of cell death, known as necroptosis, when they are exposed to amyloid plaques and tau tangles.

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Disease RNA Drugs Drug Development 254

Antidote

SEPTEMBER 21, 2023

Antidote’s podcast, Talk of the Towne , hosted by Antidote’s Senior Clinical Informatics Manager, Dr. Richard Towne, is an interview series featuring members of Antidote's partner network. During each episode, Rich and his guests take a closer look at particular therapeutic areas, the latest research developments, and specific pain points that impact the patient population.

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Research 115

Drugs.com

SEPTEMBER 22, 2023

FRIDAY, Sept. 22, 2023 -- Researchers have found a gene mutation linked to esophageal cancer, which could lead to better prevention and treatment strategies. Investigators from Case Western Reserve University in Ohio found the mutation, potentially.

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Treatment Research 119

NIOSH Science Blog: Drugs

SEPTEMBER 20, 2023

Agriculture ranks among the most hazardous industries for workers,[1] but since many farms share work and home spaces, it is also one of the few industries in which family members are also at risk for fatal and nonfatal injuries. Every day, 33 children in the United States are seriously injured in agricultural-related incidents, and every three days a child dies on a farm.[2] However, over 60% of children impacted by a farm incident were not working when the injury occurred.[3] Adult supervision

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Research 106

Perficient: Drug Development

SEPTEMBER 20, 2023

XM Cloud is a live evolving platform – the development team releases new base images almost on a weekly basis, and new features are coming to the product regularly, which gets reflected in the underlying dependencies, as well as public starter kit templates such as XM Cloud Foundation Head Starter Kit. At the same time XM Cloud professionals and enthusiasts and of course – the partners, are building their own starter kits based on publicly available templates provided by Sitecore.

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Production 104

addgene Blog

SEPTEMBER 21, 2023

Fighting with antibodies to produce immunohistochemistry images that are crisp, bright, and lacking in non-specific staining can be a challenge in the best of cases. But it can be particularly challenging when your only antibody option is from the same species as your tissue samples. The bad news: this situation is hard to avoid if your model system is a mouse, given the wealth of commercially available mouse monoclonal antibodies.

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Drugs.com

SEPTEMBER 22, 2023

FRIDAY, Sept. 22, 2023 – New research suggests some newer diabetes treatments may not be as beneficial for Black patients, after earlier drug trials included small numbers of non-white people. Whether the medications -- called sodium-glucose.

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Drug Trials Drugs Treatment Trials 119

BioPharma Drive: Drug Pricing

SEPTEMBER 20, 2023

Targeted protein degradation has emerged as one of the more competitive areas of pharmaceutical research in recent years as scientists develop new ways to reach difficult-to-drug targets.

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Targeted Protein Degradation Drugs Pharmaceuticals Research 104

Drug Discovery World

SEPTEMBER 25, 2023

Download this exclusive DDW eReport to learn more about: The global market for synthetic biology: its potential and where innovative drug development is taking place Analysis of regional markets and the key players within the synthetic biology sector How advances in the synthetic biology field are impacting drug discovery – from hit finding and lead generation onwards The way synthetic gene constructs are being used in drug discovery From vaccines to cell-based therapies, what the future h

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Drugs Drug Development Vaccine Therapies 130

Perficient: Drug Development

SEPTEMBER 20, 2023

Dependency injection (DI) is a technique for achieving loose coupling between objects and their dependencies. Rather than creating classes of classes or using static references to perform their actions, most classes declare their depending on a constructor. Sitecore uses Construction injection and Sitecore implementation is based on Microsoft.Extensions.DependencyInjection.

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FDA Law Blog: Biosimilars

SEPTEMBER 19, 2023

By Sara W. Koblitz & Kurt R. Karst — Listing patent information in the Orange Book is a matter of judgment, but that judgment call is about to get a bit more scrutiny. On the heels of its powerful (and unprecedented) amicus brief in Paragraph IV litigation between Jazz and Avadel concerning a patent covering a Risk Evaluation and Mitigation Strategy (“REMS”) listed in the Orange Book, the Federal Trade Commission (“FTC”) is gearing up to tackle anticompetitive Orange Book listing practices.

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FDA Drugs FDA Approval Biosimilars 105

Drugs.com

SEPTEMBER 22, 2023

FRIDAY, Sept. 22, 2023 -- Kraft Heinz said it is recalling over 83,000 packs of its Kraft Singles American processed cheese slices because of a packaging defect in the plastic that wraps the cheese slices. A temporary issue developed on one of the.

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Packaging 115

BioPharma Drive: Drug Pricing

SEPTEMBER 19, 2023

Pharmacy benefit manager lobby PCMA and drugmaker lobby PhRMA pointed fingers over problems in the prescription supply chain during the House committee's second hearing on the PBM industry.

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Pharmacy Drugs 104

Drug Discovery World

SEPTEMBER 25, 2023

Enrolment in a Phase I trial of a new investigational universal influenza vaccine candidate has begun at the National Institutes of Health’s Clinical Center in Bethesda, Maryland, US. The trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH, and will evaluate the investigational vaccine for safety and its ability to elicit an immune response.

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Vaccine Trials Clinical Trials Virus 130

KIF1A

SEPTEMBER 23, 2023

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors During the COVID-19 epidemic many of us experienced how devastating shipping disruptions were; industri

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Disease Regulations Research Science 88

Science Daily: Pharmacology News

SEPTEMBER 21, 2023

Reducing CO2 levels in the atmosphere will take more than cutting emissions -- we will also need to capture and store the excessive volumes of already-emitted carbon. A team of plant scientists argue that arid lands such as deserts could be one answer to the carbon-capture problem.

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Drugs.com

SEPTEMBER 20, 2023

WEDNESDAY, Sept. 20, 2023 -- Cardiac rehabilitation is a key part of recovery from a heart attack, helping to prevent another, perhaps more severe one. About 800,000 people in the United States have a heart attack every year, about one-quarter of.

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Drug Channels

SEPTEMBER 22, 2023

Today’s guest post comes from Kristina Crockett, VP of Product Management at CoverMyMeds. Kristina shares the story of a patient who cut pills in half to extend her prescriptions. Unfortunately, this patient didn’t know about manufacturer affordability programs. In this article, Kristina reviews how brands can help patients make connections that address medication affordability challenges, whether at the prescriber’s office, the pharmacy, or at home.

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Pharmacy Drugs Production 91

Drug Discovery World

SEPTEMBER 25, 2023

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. As we approach another autumn/winter season in the northern hemisphere, Covid-19 vaccines are once again making the headlines, but in the last week we have also reported on vaccine trials for a number of other conditions, including Nipah virus, rabies and lung cancer.

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Vaccine Virus Drugs Trials 130

PPD

SEPTEMBER 19, 2023

During the drug development process, companies have a choice of different approaches based on their development plan requirements. In order to access patients as early as possible, some integrate a drug-to-drug interaction (DDI), food effect or patient arm with a single ascending dose/multiple ascending dose (SAD/MAD) study, potentially providing early signals of efficacy in the patient population.

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Clinical Trials Drug Development Pharmacokinetics Clinical Development 98

Science Daily: Pharmacology News

SEPTEMBER 22, 2023

Even without a central brain, jellyfish can learn from past experiences like humans, mice, and flies, scientists report for the first time. They trained Caribbean box jellyfish (Tripedalia cystophora) to learn to spot and dodge obstacles. The study challenges previous notions that advanced learning requires a centralized brain and sheds light on the evolutionary roots of learning and memory.

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Drugs.com

SEPTEMBER 20, 2023

WEDNESDAY, Sept. 20, 2023 -- Another diabetes drug maker is taking legal action against businesses in several states, alleging that they’re “fraudulently claiming” that their compounded products are the same as its medication.

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Drugs Production 119

addgene Blog

SEPTEMBER 19, 2023

You’ve designed the perfect experiment – controls, conditions, and everything in between – now all you need are some of your favorite proteins purified to carry out your plan. With a little thoughtful planning, affinity tags can make protein purification a cinch. Types of affinity tags, the proteins they work best attached to, and the species they are compatible with are all reviewed here.

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Drug Discovery World

SEPTEMBER 25, 2023

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. As we approach another autumn/winter season in the northern hemisphere, Covid-19 vaccines are once again making the headlines, but in the last week we have also reported on vaccine trials for a number of other conditions, including Nipah virus, rabies and lung cancer.

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Vaccine Drugs Virus Trials 130

Antidote

SEPTEMBER 25, 2023

Clinical trials are how researchers advance their knowledge about potential new treatments, including medications, medical devices, and lifestyle interventions. Clinical trials are divided into phases , each with a distinct duration, purpose, and number of volunteers needed. Before any new treatment becomes available on the market, it must go through this process, as required by the FDA.

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Clinical Trials Trials FDA Treatment 71

biobide

SEPTEMBER 22, 2023

Zebrafish ( Danio rerio ) has been used as a New Alternative Model (NAM) for the last 40 years. This organism conserves approximately 70% of gene homology with humans, in addition to having the benefit of possessing fast development, high fecundity, feasible maintenance, and ease of manipulation. This NAM complies with the 3Rs principle (Replacement, Reduction and Refinement), since it is possible to perform multiple assays on embryos.

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Drugs 83

Drugs.com

SEPTEMBER 22, 2023

FRIDAY, Sept. 22, 2023 – About 500,000 children and families have had their Medicaid reinstated after some states erroneously purged them because of a systems issue, the U.S. Centers for Medicare and Medicaid (CMS) said Thursday. The agency had.

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Science Daily: Pharmacology News

SEPTEMBER 21, 2023

A team has developed a shape-changing smart speaker, which uses self-deploying microphones to divide rooms into speech zones and track the positions of individual speakers.

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Drug Discovery World

SEPTEMBER 25, 2023

Hosted by DDW and sponsored by Azenta, ‘What are some of the biggest challenges related to the delivery of RNA therapeutics?’ will be free to attend on 27 September at 7am PST | 10am ET | 3PM BST | 4PM CET. Join this free roundtable to learn about challenges related to the delivery of RNA therapeutics and some of factors advancing research in this field.

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RNA Disease Drugs Research 130

Drug Target Review

SEPTEMBER 22, 2023

Organoid technologies are becoming an invaluable solution for preclinical research, with the ability to augment the development of personalised medicine, drug discovery and gene therapies. These 3D cultured structures that are derived from healthy individuals or patients’ cells, such as human pluripotent stem cells (hPSCs) 1 or adult stem cells (ADSCs) 2 are changing the paradigm of scientific understanding.

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Clinical Research Research Drug Development Drugs 81

The Open Targets Blog

SEPTEMBER 21, 2023

David Hulcoop, previously Strategy and Operations Director for the consortium, starts as Executive Director of Open Targets in October 2023. We found out more about how his background in industry motivated him to work on the problem of target selection at Open Targets, and the challenges of bridging disciplines and ways of working across industry and academia.

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Drugs Disease Small Molecule Clinical Trials 83