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Vaccine successfully lowers cholesterol in preclinical studies

Drug Discovery World

New studies have demonstrated that Vaxxinity’s vaccine VXX-401 reproducibly lowers low-density lipoprotein cholesterol (LDL-C) in non-human primates. The results support the continued clinical development of VXX-401 as a candidate for the treatment of hypercholesterolemia and prevention of atherosclerotic cardiovascular disease. VXX-401 is a synthetic peptide vaccine designed to stimulate the immune system to produce antibodies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), whi

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Optimizing OpenFold Training for Drug Discovery

Nvidia Developer: Drug Discovery

Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep. Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep learning–based computational methods have been emerging and have shown promising results.

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Eye Ointments Sold at Walmart, CVS Recalled Due to Infection Risk

Drugs.com

TUESDAY, Feb. 27, 2024 -- Eye ointment products made in India and sold in the United States at Walmart, CVS and other retailers are being recalled due to a danger of infection.Brassica Pharma Pvt. Ltd., of Maharastra, India, said it is recalling.

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Viking data suggest obesity drug could rival Zepbound, Wegovy

BioPharma Drive: Drug Pricing

The biotech’s drug led to significant weight loss in a Phase 2 trial, causing shares to double as analysts compared results to the marks set by drugs from Eli Lilly and Novo Nordisk.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Drug limits dangerous reactions to allergy-triggering foods, Stanford Medicine-led study of kids finds

Science Daily: Pharmacology News

A drug that binds to allergy-causing antibodies can protect children from dangerous reactions to accidentally eating allergy-triggering foods, a new study found.

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2023 cancer research highlights: Drug development at its best

Drug Discovery World

Lu Rahman selects some of the year’s interesting and noteworthy advances in cancer research drug discovery and development. As always, a year within cancer drug discovery and development brings with it significant breakthroughs, and 2023 has been no exception. Figures from the Amercian Cancer Society 1 state that “a little over 1.9 million new cancer cases are expected to be diagnosed in the US in 2023”.

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What Is Measles, and How Can I Shield Myself & My Family?

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- Once thought to be a bygone disease, measles is making a comeback in the United States and globally as folks shun a safe, surefire way to prevent it: The measles vaccine. But what is measles, and how easily does it.

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A smartphone app for the self-management of Perthes’ Disease – a blog for Rare Disease Day 2024

On Medicine

What is Perthes’ disease? Perthes’ Disease is a rare condition that affects the developing femoral head (the “ball” of the “ball and socket” hip joint) of a child due to poor blood supply. In this condition, the blood supply to the femoral head is disrupted and this leads to joint deformity. The destruction typically causes the femoral head to flatten and not fit well in the acetabulum (the “socket” of the hip joint).

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Significant glacial retreat in West Antarctica began in 1940s

Science Daily: Pharmacology News

Among the vast expanse of Antarctica lies the Thwaites Glacier, the world's widest glacier measuring about 80 miles on the western edge of the continent. Despite its size, the massive landform is losing about 50 billion tons of ice more than it is receiving in snowfall, which places it in a precarious position in respect to its stability. Accelerating ice loss has been observed since the 1970s, but it is unclear when this significant melting initiated -- until now.

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Moving the needle of CAR-T beyond oncology 

Drug Discovery World

CAR-T Therapies have revolutionised the field of personalised medicine, especially in oncology. DDW’s Megan Thomas speaks with Dr Blythe Sather, Vice President and Head of Research at Tune Therapeutics, about how genetic tuning will transform the reach for CAR-T therapies, the different diseases that can benefit, and the disruptive technology making this happen.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Morgan Stanley Supercharged Its Customer Journey. Learn How at Adobe Summit 2024!

Perficient: Drug Development

Adobe Summit 2024 is right around the corner, and we’re excited to sit down with the executive director of marketing applications at Morgan Stanley Dorothy Joseph on March 27 at 11:30 A.M PST at The Grand Lux Café in The Palazzo. Perficient’s Jay Jackson, director of Adobe Digital Marketing and CDP, will host a fireside chat with Joseph about the global financial services leader’s successful journey to consolidate and optimize the Adobe Experience Platform.

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Say Goodbye to PFAS Chemicals in Food Packaging: FDA

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- PFAS "forever" chemicals, increasingly linked to health risks, will no longer be added to food packaging handled by American consumers, the U.S. Food and Drug Administration announced Wednesday."Grease-proofing materials.

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Live from SCOPE 2024: Talk of the Towne featuring Rare Patient Voice

Antidote

We’re here with Antidote’s tenth installment of Talk of the Towne, and it’s a very special one! We recently attended SCOPE 2024, where we met up with our partners at Rare Patient Voice and recorded our first Talk of the Towne episode live and in person.

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Barriers against Antarctic ice melt disappearing at the double

Science Daily: Pharmacology News

Undersea anchors of ice that help prevent Antarctica's land ice from slipping into the ocean are shrinking at more than twice the rate compared with 50 years ago, research shows. More than a third of these frozen moorings, known as pinning points, have decreased in size since the turn of the century, experts say. Further deterioration of pinning points, which hold in place the floating ice sheets that fortify Antarctica's land ice, would accelerate the continent's contribution to rising sea leve

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Sustainability in the Lab: A Step-by-Step Guide

Drug Discovery World

Download this guide to gain insights on the steps you can take to achieve a more sustainable lab without compromising quality or performance. Learn about: Conducting an assessment Choosing the right equipment Conserving water and reducing waste Engaging and educating your team The post Sustainability in the Lab: A Step-by-Step Guide appeared first on Drug Discovery World (DDW).

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Sedentary behavior increases mortality risk

SCIENMAG: Medicine & Health

Based on decades-long observations of centenarians, author Dan Buettner (Blue Zones) conjectures that people live longer when they get up and move around after sitting for twenty minutes. Now, a rigorous new study published in the Journal of the American Heart Association (JAHA) has data showing that older women who sat for 11.

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Treating Crohn's Sooner, More Aggressively Greatly Improves Outcomes: Study

Drugs.com

MONDAY, Feb. 26, 2024 -- In a finding that suggests sooner is better than later, a new trial shows that giving advanced treatment early to Crohn’s patients can dramatically improve their gut health.About 80% of those who got therapy with an.

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Joining a clinical trial: Helpful hints for discussions with loved ones

Antidote

Individuals living with an illness are likely well-versed in the art of discussing difficult topics with their family and friends. However, for those who are considering taking part in a clinical trial, there may be extra questions to consider when sharing their intent to enroll.

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Cost-Cut Without Compromise: Navigating Excipient Switching in Pharma

Drug Patent Watch

Switching pharmaceutical excipients, the inactive components used in drug formulations, can have significant implications for both production costs and market appeal. These components, while not contributing directly to the therapeutic… The post Cost-Cut Without Compromise: Navigating Excipient Switching in Pharma appeared first on DrugPatentWatch - Make Better Decisions.

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Improve sustainability without compromising on quality

Drug Discovery World

A new Feature Note is now available entitled ‘ Sustainability in the Lab: A Step-by-Step Guide ‘, brought to you by PHCbi. Download the guide to gain insights on the steps you can take to achieve a more sustainable lab without compromising quality or performance. Learn about: Conducting an assessment Choosing the right equipment Conserving water and reducing waste Engaging and educating your team Download for free now.

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Aorta recognised as an independent organ for the first time

SCIENMAG: Medicine & Health

Heart, lungs, brain, aorta: elevated to the highest league as an organ Credit: Medical Center – University of Freiburg / Britt Schilling Heart, lungs, brain, aorta: elevated to the highest league as an organ “Recognising the aorta as an organ puts it on a par with the heart, lungs or brain.

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Your Brain Feels Better When Music Is Live, Not Recorded: Study

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- Live musical performances speak to the soul, stimulating the brain in ways more powerful than listening to a recorded tune does, new research finds.“Our study showed that pleasant and unpleasant emotions performed as.

Research 105
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Obesity drug from Boehringer, Zealand succeeds in MASH trial

BioPharma Drive: Drug Pricing

Zealand shares rose by more than one-third on the data, which provide further evidence so-called incretin drugs could help treat people with the liver disease.

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Cannabis use linked to increase in heart attack and stroke risk

Science Daily: Pharmacology News

More frequent use of cannabis was associated with higher odds of adverse cardiovascular outcomes, finds new study.

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Study undermines mechanism-based discovery, says CureLab founder

Drug Discovery World

CureLab Oncology’s DNA vaccine Elenagen, in combination with chemotherapy, has demonstrated promising clinical results against triple-negative ovarian cancer. The study shows that disease progression was significantly delayed in a group of stage III and IV platinum-resistant ovarian cancer (PROC) patients who received gemcitabine in combination with Elenagen, compared to the group who received gemcitabine alone.

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New study links placental oxygen levels to fetal brain development

SCIENMAG: Medicine & Health

A new study shows oxygenation levels in the placenta, formed during the last three months of fetal development, are an important predictor of cortical growth (development of the outermost layer of the brain or cerebral cortex) and is likely a predictor of childhood cognition and behaviour.

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What Is Chronic Sinusitis, and How Is it Treated?

Drugs.com

TUESDAY, Feb. 27, 2024 -- Stuffy, sneezing, miserable: folks plagued by chronic sinusitis know the feeling all too well.Experts at University of Cincinnati Health say it's also an all-too-common affliction, affecting an estimated 14.6% of.

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Rare Disease Day: Understanding the power of diagnosis and connection

Antidote

Rare Disease Day, typically observed on February 28th, will be celebrated this year on February 29th! Rare Disease Day is an awareness holiday intended to generate change for the 300 million people who are diagnosed with a rare disease worldwide, as well as their families and caregivers.

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BioMarin preaches patience amid slow sales for hemophilia gene therapy

BioPharma Drive: Drug Pricing

The company earned only $3.5 million last year from its Roctavian treatment, far below the $50 million to $150 million range it had forecast eight months ago.

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Minerva value plummets following FDA rejection of roluperidone

Drug Discovery World

The stock market value of Minerva Biosciences has dropped nearly 60%, following the US Food and Drug administration (FDA) decision not to approve roluperidone for symptoms of schizophrenia. The company received a ‘Complete Response Letter’ from the FDA highlighting the clinical deficiencies in its new drug application (NDA). Although one study (MIN-101C03) demonstrated statistical significance on the primary efficacy endpoint, the FDA argued that it is insufficient on its own to establish substa

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Determine stroke risk at an early stage using tear fluid, mitochondria and AI-based data

SCIENMAG: Medicine & Health

Every year, over 100 million people worldwide suffer a stroke. Ischemic strokes (cerebral infarction) are the most common, but they can also occur “silently” and therefore often go undetected. This can result in serious illnesses such as dementia, depression or even suicide. In order to determine the risk of stroke at an early stage, Prof.

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Cyberattack Stalls Prescription Dispensing at UnitedHealth

Drugs.com

TUESDAY, Feb. 2, 2024 -- For nearly a week, prescription drug orders have been disrupted at thousands of pharmacies as the largest health insurer in the United States tries to fully restore services following a cyberattack. The security breach was.

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Astronomers discover heavy elements after bright gamma-ray burst from neutron star merger

Science Daily: Pharmacology News

An international team of astronomers obtained observational evidence for the creation of rare heavy elements in the aftermath of a cataclysmic explosion triggered by the merger of two neutron stars.

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Women in Stem with Dr Amber D. Van Laar

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? From a very young age, I was drawn to science and medicine. My interest in the field of STEM sharpened when, in my early teens, I had the chance to work in a neuro-oncology lab. This early exposure to bench science had a long-lasting impact. It propelled me to continue lab work during my undergraduate training, my medical training, and to an academic appointment in the Movement Disorders Div