Trending Articles

article thumbnail

AI-Designed Enzymes

Codon

One of the ultimate aims of protein design has long been to build entirely new enzymes — proteins that perform specific chemical reactions — from scratch. These molecular machines power various cellular processes, from converting sugar into energy to switching genes on and off. Both Cas9 and hydrolases (widely used in the dairy and laundry industries) are also enzymes.

article thumbnail

Boosting evolution: How humans unintentionally altered the skulls of pigs

Science Daily: Pharmacology News

Short snouts and a flat profile -- within a span of 100 years, humans have significantly changed the shape of the skulls of German domestic pigs. This is likely down to new breeding practices introduced at the beginning of the 20th century. The researchers analyzed 3D scans of 135 skulls of wild boars and domestic pigs from the early 20th and 21st centuries.

Research 117
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Analyzing Oxygen Atom Distribution in FDA‐Approved Drugs to Enhance Drug Discovery Strategies

Chemical Biology and Drug Design

Analysis of prevalence of ring, nonring, sp 3 -, and sp 2 -hybridized oxygen in approved drugs. For the first time, analysis of distribution of different types of oxygen from center of mass of a molecule. ABSTRACT Despite advancements in molecular design rules and understanding biochemical processes, the field of drug design and discovery seeks to minimize the number and duration of synthesis-testing cycles to convert lead compounds into drug candidates.

article thumbnail

Vertex challenger Sionna prices $191M IPO

BioPharma Drive: Drug Pricing

The biotech is evaluating several cystic fibrosis medicines that could either work alongside Vertex’s top-selling Trikafta or be used in new, multi-drug combinations.

Drugs 113
article thumbnail

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

article thumbnail

Can GLP-1 Meds Harm Your Eyes?

Drugs.com

MONDAY, Feb. 10, 2025 -- Yes, rare cases of vision issues have arisen in people taking popular GLP-1 weight loss drugs, but the jury's out on whether the medications caused the eye trouble, according to a new small study.The study reviewed the.

Drugs 113

More Trending

article thumbnail

The Assumption of Proportional Odds in Clinical Trials

Quanticate

Learn about the proportional odds assumption in clinical trials, its importance in ordinal regression, and key considerations for statistical analysis.

article thumbnail

Site-Specific Molecular Glues for the 14-3-3/Tau pS214 ProteinProtein Interaction via Reversible Covalent Imine Tethering

Covalent Modifiers

DOI Ansgar Oberheide, Maxime van den Oetelaar, Jakob Scheele, Jan Borggrfe, Semmy Engelen, Michael Sattler, Christian Ottmann, Peter Cossar and Luc Brunsveld RSC Med Chem 2025 [link] Protein-protein interactions (PPIs) are key regulators of various cellular processes. Modulating PPIs with small molecules has gained increasing attention in drug discovery, particularly targeting the 14-3-3 protein family, which interacts with several hundred client proteins and plays a central role in cellular net

article thumbnail

Bristol Myers gives first peek at closely watched launch of schizophrenia drug

BioPharma Drive: Drug Pricing

Cobenfy, the main asset acquired through Bristol Myers’ $14 billion purchase of Karuna, had $10 million in sales in the fourth quarter and is around 1,000 prescriptions weekly by late January.

Drugs 100
article thumbnail

UNAIDS Warns HIV Infections Could Skyrocket Without U.S. Funding

Drugs.com

MONDAY, Feb. 10, 2025 -- The head of the United Nations AIDS agency (UNAIDS) is warning that a major spike in HIV infections and deaths could occur if the U.S. follows through on freezing foreign aid for HIV programs.UNAIDS Executive Director.

110
110
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Eating gradually increasing doses of peanut butter enables children with high-threshold allergy to safely consume peanuts, study suggests

Science Daily: Pharmacology News

Findings suggest a safe, inexpensive, and effective pathway for allergists to treat children who already tolerate at least half a peanut.

114
114
article thumbnail

New cell therapy model accelerates cancer treatment development

Drug Target Review

In the rapidly advancing field of cell therapies, Dr Jason Bock has emerged as a leader, known for his innovative approach to optimising the development process. With over 25 years of experience in therapeutics, Bock has played a pivotal role in shaping the future of cell therapies, particularly through his work at CTMC. In a recent conversation, he shared his vision for transforming the development and commercialisation of novel cell therapies, focusing on cutting-edge approaches like tumour in

article thumbnail

Structural Basis for Substrate Binding, Catalysis and Inhibition of Breast Cancer Target Mitochondrial Creatine Kinase by Covalent Inhibitor via Cryo-EM

Covalent Modifiers

Merve Demir,*, Laura Koepping, Ya Li, Lynn Fujimoto, Andrey Bobkov, Jianhua Zhao, Taro Hitosugi, Eduard Sergienko Structure, 2024 [link] Mitochondrial creatine kinases (MtCKs) are key players in maintaining energy homeostasis in cells that work with cytosolic creatine kinases for energy transport from mitochondria to cytoplasm. The inhibition of breast cancer growth by cyclocreatine targeting CKs indicates dependence of cancer cells on the energy shuttle for cell growth and survival.

59
article thumbnail

AbbVie, Pfizer gain FDA OK for novel antibiotic

BioPharma Drive: Drug Pricing

The drug is cleared to treat complicated intra-abdominal infections, including those caused by tough-to-control, gram-negative bacteria.

FDA 100
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Texas County Reports Measles Outbreak Among Unvaccinated Children

Drugs.com

FRIDAY, Feb. 7, 2025 -- The Texas Department of State Health Services (DSHS) is reporting an outbreak of measles in Gaines County.All cases have been identified among unvaccinated school-aged children who are residents of Gaines County. Symptom.

109
109
article thumbnail

Physician's medical decisions benefit from chatbot, study suggests

Science Daily: Pharmacology News

A study showed that chatbots alone outperformed doctors when making nuanced clinical decisions, but when supported by artificial intelligence, doctors performed as well as the chatbots.

Doctors 113
article thumbnail

Vault Snack #28 - Averting the Sample Apocalypse!

Collaborative Drug

Vault Snack #28 - Averting the Sample Apocalypse!

60
article thumbnail

Covalent-Allosteric Inhibitors: Do We Get the Best of Both Worlds?

Covalent Modifiers

Hui Tao, Bo Yang, Atena Farhangian, Ke Xu, Tongtong Li, Zhong-Yin Zhang, and Jianing Li Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.4c02760 Covalent-allosteric inhibitors (CAIs) may achieve the best of both worlds: increased potency, long-lasting effects, and reduced drug resistance typical of covalent ligands, along with enhanced specificity and decreased toxicity inherent in allosteric modulators.

Drugs 59
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Axsome secures top drug’s future with Teva patent settlement

BioPharma Drive: Drug Pricing

Shares in the brain drug developer rose by more than 20% Monday on news of the deal, which will forestall Teva's generic copy of Auvelity from entering the U.S. market until at least 2038.

article thumbnail

'Ozempic Face' and Other Top Trends in Plastic Surgery

Drugs.com

FRIDAY, Feb. 7, 2025 -- Add surgical tweaks to fix so-called "Ozempic face" to the list of top trending cosmetic procedures, as tallied by the American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS). The group's annual survey of its.

107
107
article thumbnail

Truly autonomous AI is on the horizon

Science Daily: Pharmacology News

Researchers have developed a new AI algorithm, called Torque Clustering, that significantly improves how AI systems independently learn and uncover patterns in data, without human guidance.

Research 112
article thumbnail

Remix vs. Next.js: A Comprehensive Look at Modern React Frameworks

Perficient: Drug Development

In the ever-evolving landscape of web development, choosing the right framework can significantly impact the performance and user experience of your applications. Two of the most prominent frameworks in the React ecosystem today areRemixandNext.js. Both are designed to enhance web development efficiency and performance, but they cater to different needs and use cases.

article thumbnail

Drug Discovery Industry Roundup with Barry Bunin — February 12th, 2025

Collaborative Drug

Drug Discovery Industry Roundup with Barry Bunin February 10th, 2025

Drugs 59
article thumbnail

Novartis pays $925M to reel in a startup it helped launch

BioPharma Drive: Drug Pricing

The acquisition of Anthos Therapeutics could be worth up to $3.1 billion and returns to Novartis a blood thinner it licensed to the Blackstone-backed startup six years ago.

article thumbnail

FDA Approves Wearable Infusion Device for Advanced Parkinson Disease

Drugs.com

THURSDAY, Feb. 6, 2025 -- The U.S. Food and Drug Administration has approved Onapgo (apomorphine hydrochloride) injection as the first and only subcutaneous apomorphine infusion device for the treatment of motor fluctuations in patients with.

article thumbnail

Euclid discovers a stunning Einstein ring

Science Daily: Pharmacology News

Euclid, the European Space Agency's dark Universe detective, has made an astonishing discovery -- right in our cosmic backyard.

111
111
article thumbnail

How FSP Solutions Support Risk-Based Methodologies and Tech Innovation in Clinical Operations

PPD

Biopharmaceutical, biotech and medical device developers can choose from a range of options to support effective clinical operations across critical functions such as clinical monitoring, site management, clinical oversight, support services and site engagement. In the past, these developers mostly used in-house resources for their clinical monitoring and site management capabilities, whereas today they often prefer functional service provider (FSP) or full-service outsourcing (FSO) models, or a

article thumbnail

Streamlining the Generic Drug Supply Chain: Best Practices

Drug Patent Watch

Streamlining the Generic Drug Supply Chain: Best Practices to Improve Efficiency and Patient Access As the generic drug industry continues to grow, it's becoming increasingly clear that the traditional supply chain model is no longer sustainable. With the rise of complex generics, regulatory pressures, and increasing demand for affordable medicines, it's time to rethink the way we approach the generic drug supply chain.

Drugs 52
article thumbnail

Bristol Myers, bracing for key patent losses, deepens cost-cutting plan

BioPharma Drive: Drug Pricing

The pharmaceutical company plans to cut $2 billion in annual expenses by the end of 2027 through “operational efficiencies across multiple areas of the business,” its CFO told analysts on a conference call.

article thumbnail

Possible Listeria Contamination Prompts Recall of 2 Million Baked Goods

Drugs.com

MONDAY, Feb. 10, 2025 -- About 2 million baked goods have been recalled over concerns of potential contamination with Listeria monocytogenes, according to federal safety regulators.The recall went into effect on Jan. 7, 2025, and was upgraded on.

104
104
article thumbnail

Soft tissue from a 183 million-year-old Jurassic plesiosaur analyzed

Science Daily: Pharmacology News

Researchers have analyzed the soft tissue from a fossilized plesiosaur for the first time. The results show that the long-necked marine reptile had both smooth and scaly skin. This was likely so it could both swim rapidly and move along rough seabeds.

Research 108