Chemical Biology and Drug Design

MAY 10, 2025

Although it is currently only used in veterinary therapy, carprofen proves to be a molecule with a versatile therapeutic potential for human pharmacotherapy. Moreover, the molecule is a target in the drug discovery process for the development of new bioactive compounds. ABSTRACT Carprofen, a nonsteroidal anti-inflammatory drug (NSAID) derived from propanoic acid, is known for its analgesic and antipyretic properties.

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Small Molecule Drug Development Science Therapies 100

Science Daily: Pharmacology News

MAY 12, 2025

Researchers analyzed 788 obsidian artifacts from Tenochtitlan, revealing that the Mexica (Aztec) Empire sourced this important material from at least eight different locations, including regions outside their political control. While 90% of artifacts were made from green obsidian from Sierra de Pachuca (especially for ceremonial purposes), the diversity of obsidian sources suggests sophisticated trade networks rather than just conquest-based acquisition.

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Research 154

Science Daily: Pharmacology News

MAY 7, 2025

Psychology literature has shown that curiosity tends to decline with age. Psychologists shows one type of curiosity can increase well into old age, contradicting prior research. Older adults who maintain curiosity and want to learn new things relevant to their interests may be able to offset or even prevent Alzheimer's disease. Conversely, those who show muted curiosity and disinterest may be at risk for dementia.

Disease 311

Disease Research 311

Covalent Modifiers

MAY 7, 2025

Xinyuan Wu, Jiayi Pan, Rufeng Fan, Yiwei Zhang, Chao Wang, Guoliang Wang, Jiaxiang Liu, Mengqing Cui, Jinfeng Yue, Rui Jin, Zhiqiang Duan, Mingyue Zheng, Lianghe Mei, Lu Zhou, Minjia Tan, Jing Ai, and Xiaojie Lu Journal of the American Chemical Society 2025 147 (18), 15469-15481 DOI: 10.1021/jacs.5c01712 Covalent small molecule drugs have emerged as a crucial support in precision therapy due to their high selectivity and robust potency.

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DNA Small Molecule Therapies Drugs 147

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

New Drug Approvals

MAY 9, 2025

Elacestrant (6 R )-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol FDA 1/27/2023, Orserdu WeightAverage: 458.646 Monoisotopic: 458.293328472 Chemical FormulaC 30 H 38 N 2 O 2 To treat estrogen receptor-positive, human epidermal growth factor receptor 2-negative, ESR1-mutated, advanced or metastatic breast cancer with disease

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FDA Pharmacokinetics Therapies Treatment 63

Science Daily: Pharmacology News

MAY 7, 2025

Researchers have discovered distinct roles for two dopamine receptors located on nerve cells within the portion of the brain that controls approach vs. avoidance behavior.

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Research 188

Broad Institute

MAY 7, 2025

Novo Nordisk Foundation Center for Genomic Mechanisms of Disease: Building a scientific bridge By Rose Circeo May 7, 2025 Breadcrumb Home Novo Nordisk Foundation Center for Genomic Mechanisms of Disease: Building a scientific bridge Type 2 diabetes impacts millions around the world, and yet its root cause remains a mysterya challenge the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease (NNFC) at the Broad Institute is tackling by bringing together Denmark-based and Broad scientis

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Disease Research 52

Chemical Biology and Drug Design

MAY 12, 2025

CRISPR-CAS9 is an innovative gene editing technology to precisely remove or incorporate into the gene of interest; CRISPR-CAS9 shows promising results in HIV treatment. ABSTRACT Clustered regularly interspaced short palindromic repeats (CRISPR/Cas system) is now the predominant approach for genome editing. Compared to conventional genetic editing methods, CRISPR/Cas technology offers several advantages that were previously unavailable.

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Treatment Therapies DNA RNA 100

New Drug Approvals

MAY 8, 2025

Pirtobrutinib CAS 2101700-15-4 JAYPIRCA RXC-005 LY3527727 LOXO-305 WHO 11681 WeightAverage: 479.436 Monoisotopic: 479.158052208 Chemical FormulaC 22 H 21 F 4 N 5 O 3 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(2 S )-1,1,1-trifluoropropan-2-yl]pyrazole-4-carboxamide FDA 2023, 1/27/2023, Jaypirca To treat relapsed or refractory mantle cell lymphoma in adults who have had at least two lines of systemic therapy, including a BTK inhibitor Drug Trials Snapshot Pirtobrutinib , so

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FDA Approval FDA Therapies Trials 52

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Alta Sciences

MAY 9, 2025

Evaluation in Canines of a Novel Device for Suprachoroidal Drug Delivery iianiro Fri, 05/09/2025 - 13:00 Publication Poster_Altasciences_ARVO_2025Evaluation in Canines of a Novel Device for Suprachoroidal Drug Delivery_1.

Drugs 40

Drugs 40

Science Daily: Pharmacology News

MAY 6, 2025

Biologists have discovered two previously unknown species of crocodiles, one living on the island of Cozumel and the other on the atoll of Banco Chinchorro, both off the Yucat n Peninsula. The findings challenge long-held assumptions about the American crocodile (Crocodylus acutus) and highlight the urgent need for conservation efforts, the researchers say.

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Research 284

Drugs.com

MAY 7, 2025

WEDNESDAY, May 7, 2025 The shingles vaccine has benefits that stretch beyond protecting older adults from the painful skin condition, a new study says.Folks who get the shingles jab have a 23% lower risk of health problems like stroke, heart f.

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Vaccine 255

BioPharma Drive: Drug Pricing

MAY 6, 2025

Experts say market turmoil has made it harder for buyers and sellers to agree on price, which can be an especially imposing obstacle to large acquisitions.

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Marketing 252

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Covalent Modifiers

MAY 8, 2025

Ludovica S. Sirocchi, Maximilian Scharnweber, Sarah Oberndorfer, Gabriella Siszler, Krzysztof M. Zak, Klaus Rumpel, Ralph A. Neumller, and Birgit Wilding Journal of the American Chemical Society 2025 147 (18), 15787-15795 DOI: 10.1021/jacs.5c03562 Targeted covalent inhibitors are known to be successful therapeutics used in various indications. Covalent drugs typically target cysteine, as cysteine is well suited due to its high nucleophilicity.

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Drugs 162

Alta Sciences

MAY 9, 2025

Geographic Atrophy-Like Induced Model in Nanopigs iianiro Fri, 05/09/2025 - 13:00 Publication Poster_Altasciences_ARVO_2025Geographic Atrophy-Like Induced Model in Nanopigs_0.

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Science Daily: Pharmacology News

MAY 7, 2025

People who eat more ultra processed foods like cold breakfast cereal, cookies and hot dogs are more likely to have early signs of Parkinson's disease when compared to those who eat very few ultra processed foods, according to a new study. The study does not prove that eating more ultra processed foods causes early signs of Parkinson's disease; it only shows an association.

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Disease 277

Drugs.com

MAY 7, 2025

WEDNESDAY, May 7, 2025 Stress can make it even worse for people to deal with chronic obstructive pulmonary disease, or COPD, a new study says.High levels of perceived stress are associated with a quadrupled risk of moderate or severe COPD f.

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Disease 255

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

MAY 8, 2025

Across hundreds of published papers, CBER’s new chief has argued for more stringent measures of assessing drugs for cancer and rare diseases, suggesting he might push for higher standards in the review of medicines under his division's purview.

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Research FDA Disease Drugs 249

Collaborative Drug

MAY 13, 2025

Drug Discovery Industry Roundup with Barry Bunin April 8th, 2025

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Drugs 130

Chemical Biology and Drug Design

MAY 10, 2025

ART inhibits the resistance of RCC cells to sunitinib by promoting the ubiquitination of PAX6 through upregulation of TRIM24 expression. ABSTRACT This research aims to elucidate the mechanistic role of artesunate (ART) in enhancing the sensitivity of renal cell carcinoma (RCC) to sunitinib. To establish sunitinib-resistant RCC cell lines (786-O R and Caki-1 R), cells were treated with different concentrations of sunitinib and ART.

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DNA Research Drugs 100

Drugs.com

MAY 12, 2025

MONDAY, May 12, 2025 A new study has found that people taking Eli Lillys obesity drug Zepbound lost almost 50% more weight than those using Novo Nordisks Wegovy.The study published May 11 in the New England Journal of Medicine followed 751 p.

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Drugs 252

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

MAY 6, 2025

A vocal opponent of his predecessor Peter Marks, Vinay Prasad will now lead the office tasked with reviewing some genetic medicines, adding more uncertainty to an already struggling field of research.

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Therapies FDA Research 204

Quanticate

MAY 9, 2025

Gene therapy offers a one-off treatment that tackles the underlying mutation causing an illness or medical condition. By using adeno-associated virus (AAV) vectors to deliver a functional copy of the faulty gene to liver cells, patients begin producing their own clotting factoreither factor VIII for hemophilia A or factor IX for hemophilia B. Human gene therapy clinical trials show promising results of durable factor expression s and far fewer bleeds within these patient groups.

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Clinical Trials Therapies Trials Virus 98

Chemical Biology and Drug Design

MAY 10, 2025

This review explores the latest advancements in dual COX-2/5-LOX inhibitors, highlighting their potential as effective anti-inflammatory agents with improved safety profiles compared to traditional NSAIDs. ABSTRACT Chronic pain and inflammation are widespread clinical issues that significantly affect patients' quality of life and are often associated with serious conditions such as arthritis, cancer, and cardiovascular disease.

Drugs 100

Drugs Disease Therapies Treatment 100

Science Daily: Pharmacology News

MAY 7, 2025

Engineers have invented a sponge-like device that captures water from thin air and then releases it in a cup using the sun's energy, even in low humidity where other technologies such as fog harvesting and radiative cooling have struggled. The water-from-air device remained effective across a broad range of humidity levels (30 -- 90%) and temperatures (5 -- 55 degrees Celsius).

Engineering 154

Engineering 154

Drugs.com

MAY 9, 2025

FRIDAY, May 9, 2025 The U.S. Food and Drug Administration (FDA) is warning consumers and tattoo artists that two tattoo inks have tested positive for harmful bacteria and could lead to serious infections.The affected products are:Sacred Tattoo I.

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FDA Production Drugs 250

BioPharma Drive: Drug Pricing

MAY 8, 2025

The startup’s first prospect is a heart medicine that works differently than the hypertrophic cardiomyopathy drugs developed by Bristol Myers and Cytokinetics.

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Drugs Drug Development 183

Broad Institute

MAY 12, 2025

#WhyIScience Q&A: A systems biologist uses AI to understand how the genome controls cell fate By Allessandra DiCorato May 12, 2025 Breadcrumb Home #WhyIScience Q&A: A systems biologist uses AI to understand how the genome controls cell fate Bo Xia leads a lab that uses machine learning to learn about fundamental biological processes in human health and disease.

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DNA Regulations Cell Biology Disease 78

Chemical Biology and Drug Design

MAY 6, 2025

Further bromination of methoxy quinoline furnished novel polyfunctionalized quinoline derivatives. Additionally, nitration of dibromoquinoline gave 5-nitrated quinoline. Their significant anticancer activities were determined and also supported by in silico studies. ABSTRACT In this study, we synthesized and characterized novel brominated methoxyquinolines ( 7 and 11 ) and nitrated bromoquinoline ( 17 ) derivatives with potential antiproliferative activity against cancer cell lines.

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DNA Drugs Research 100