Drug Discovery World

JULY 25, 2024

This discovery opens the door to developing new drugs that could inhibit these harmful effects, potentially slowing down or preventing the progression of certain cancers. The team also uncovered a link between certain disruptive BAP1 variants and higher levels of IGF-1, a hormone and growth factor.

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Research Drugs DNA Doctors 130

Drug Discovery World

FEBRUARY 12, 2024

million grant to engineer microbial cell factories to produce membrane proteins which will support future drug screening and sustainable chemical production. This limits the efficiency of drug screening and reduces the identification of new drugs. for drug discovery research appeared first on Drug Discovery World (DDW).

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Research Engineering Molecular Biology Protein Production 263

Drug Discovery World

MAY 28, 2024

This eBook explores the important role that imaging plays in drug discovery, and how ever-evolving technologies, combined with artificial intelligence (AI), are expanding our knowledge and advancing new therapeutics to the clinic. The use of advanced laser imaging to reveal new cancer drug targets.

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Clinical Trials Drugs Therapies Disease 130

Drug Discovery World

JUNE 27, 2024

The interview highlights their need to develop assays that are amenable to long term use to support their clients with drug development, and how bit.bio’s deterministically programmed ioMicroglia have helped them develop assays with increased physiological relevance and consistency, towards this goal.

Drug Development 130

Drug Development Disease Drugs Science 130

Drug Discovery World

JULY 19, 2024

In vivo testing validates new approach to cancer treatment In vivo testing has validated Oxford Drug Design’s potential first-in-class approach against multiple tumours, designed using its AI platform. The post This week in drug discovery (15-19 July) appeared first on Drug Discovery World (DDW).

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Drugs Therapies Treatment FDA 130

Drug Discovery World

JULY 17, 2024

A drug commonly used to treat cystic fibrosis improved outcomes for patients with severe Covid-19 pneumonia in a recent clinical trial. The drug, dornase alfa, could be used to treat other respiratory infections, according to the data from researchers at UCL, UCLH and the Francis Crick Institute.

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Clinical Trials Drugs Hospitals Trials 130

Drug Discovery World

JUNE 26, 2024

Whether you are new to drug testing or seeking to enhance your existing expertise, this eBook will serve as a valuable resource. Download ‘ Drug Stability Testing 101 ‘ now. The post New eBook: Enhance your knowledge of drug stability testing appeared first on Drug Discovery World (DDW).

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Drugs Pharmaceuticals Drug Development 130

Drug Discovery World

JULY 3, 2024

By DDW Editor Reece Armstrong The upcoming general election in the UK has placed the priorities of the country into the spotlight and the drug discovery sector should in no way be forgotten. Whatever your political leanings, the drug discovery sector in the UK must be supported if we are to compete efficiently on the global stage.

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Government Drugs Science International 147

Drug Discovery World

JUNE 27, 2024

A new Case Study is now available to download for free entitled ‘ Improving physiological relevance in neurological disease drug development. In this Case Study you will learn: How Concept Life Sciences seek to develop assays proving drug candidate efficacy with human iPSC-derived microglia.

Drug Development 130

Drug Development Disease Drugs Science 130

Drug Discovery World

JUNE 26, 2024

SPG302 has completed the Phase I safety study in healthy subjects in Australia and is currently being evaluated in ALS patients in Australia, with plans to enrol patients in the US following recent Food and Drug Administration (FDA) IND clearance. SPG302 has been granted FDA Orphan Drug Designation for the treatment of ALS.

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Drug Discovery World

JUNE 6, 2024

With the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting , taking place from 30 May to 3 June, the drug discovery announcements have been coming thick and fast, with many new cancer therapies making significant strides forward in our ability to treat the disease.

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Drug Discovery World

JULY 24, 2024

The trial was carried out at the Queen Elizabeth Hospital, Birmingham, UK, by the University of Birmingham’s Drugs, Devices, Diagnostics and Biomarkers (D3B) team. These encouraging results indicate the future potential of ILB to be the first disease-modifying drug to treat both familial and sporadic ALS with minimal side-effects.”

Trials 130

Trials Disease Hospitals Clinical Trials 130

Drug Discovery World

JUNE 24, 2024

Drugs developed to treat HIV and AIDS are being trialled for the first time in patients with multiple brain tumours. The RETREAT clinical trial, led by Professor Oliver Hanemann and funded by the Children’s Tumour Foundation, will expand on research which showed the repurposed drugs reduced tumour growth and survival in the tumours.

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Clinical Trials Trials Drugs DNA 147

Drug Discovery World

JULY 23, 2024

The UK Medicines and Healthcare products Regulatory Agency (MHRA) has approved the first generic raltegravir drug to treat adult and paediatric HIV patients who weigh at least 40kg. The drug is a generic version of Merck’s Isentress and is manufactured by Lupin Healthcare and Zentiva Pharma.

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Regulations Licensing Licensing Drugs 130

Drug Discovery World

MAY 10, 2024

Nutrient research reveals pathway for treating brain disorders Dr Rosemary Cater, a University of Queensland (UQ) researcher, has found molecular doorways that could be used to help deliver drugs into the brain to treat neurological disorders. The post This week in drug discovery (6-10 May) appeared first on Drug Discovery World (DDW).

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Drug Discovery World

JANUARY 25, 2024

The US Food and Drug Administration (FDA) has granted Orphan Drug Designation to Pleco Therapeutics’s lead compound PTX-252 for the treatment of acute myeloid leukaemia (AML). The post Novel leukaemia drug receives FDA Orphan Drug Designation appeared first on Drug Discovery World (DDW).

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Drug Discovery World

JULY 18, 2024

The US Food and Drug Administration (FDA) has granted Fast Track designation to Sumitomo Pharma’s DSP-5336 for relapsed or refractory acute myeloid leukaemia (AML). The drug is intended for patients with a KMT2A rearrangement, also known as, mixed lineage leukaemia rearrangement (MLLr) or nucleophosmin mutation (NPM1m).

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Small Molecule FDA Drugs Therapies 130

Drug Discovery World

MAY 23, 2024

CAS, a division of the American Chemical Society, has launched the CAS BioFinder Discovery Platform, designed to reveal novel drug discovery insights through data connections. CAS leveraged Chemotargets CLARITY as the technological foundation for the CAS BioFinder predictive capabilities and analytics.

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Drugs Science Research Disease 147

Drug Discovery World

MAY 28, 2024

A new eBook is now available for download entitled ‘Using imaging in drug discovery’. The growth will in part by driven by an increase in the use of imaging modalities in drug research and development. The growth will in part by driven by an increase in the use of imaging modalities in drug research and development.

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Drugs Clinical Trials Marketing Disease 130

Drug Discovery World

JUNE 20, 2024

Read More: UK research partners team up to accelerate MND drug discovery Drug trial targets the blood brain barrier In April, Axoltis Pharma received authorisation from ANSM, the French agency for the safety of health products, to launch the SEALS study for ALS, the most common form of MND.

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Clinical Trials Drugs Disease Trials 162

Science Daily: Pharmacology News

JULY 25, 2024

An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new study. By targeting infected cells in the brain, drug may clear virus from hidden areas that have been a major challenge in HIV treatment.

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Virus Drugs Treatment 101

Drugs.com

JULY 15, 2024

MONDAY, July 15, 2024 -- An experimental drug appears to help women deal with stress incontinence, clinical trial data show.The drug, for now dubbed TAS-303, reduced the frequency of leaks related to stress incontinence by about 58%, compared with.

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Clinical Trials Trials Drugs 111

Drug Patent Watch

JULY 24, 2024

In the high-stakes world of pharmaceuticals, generic drugs have become the unsung heroes of healthcare accessibility. These cost-effective alternatives to […] Source

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BioPharma Drive: Drug Pricing

JULY 2, 2024

The drug, which Lilly will sell as Kinsunla, carries a warning for the risk of a certain kind of imaging abnormality that can be serious in rare cases.

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FDA Drugs 135

Crown Bioscience

JUNE 6, 2024

In a significant development, the US Food and Drug Administration’s (FDA) Center for Drug Evaluation and Research (CDER) approved 55 new drugs in 2023.

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FDA Approval FDA Drugs Research 105

BioPharma Drive: Drug Pricing

JULY 22, 2024

The company plans to start a late-stage study next year, after a smaller trial found its drug offered “robust and consistent” benefits on communication, cognition and motor function.

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Drugs Trials 117

Drugs.com

JULY 2, 2024

TUESDAY, July 2, 2024 -- A new drug to treat Alzheimer's disease was approved by the U.S. Food and Drug Administration on Tuesday. In clinical trials, donanemab (Kisunla) modestly slowed the pace of thinking declines among patients in the early.

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FDA Approval FDA Clinical Trials Drugs 116

Broad Institute

JULY 17, 2024

Still, more than 90 percent of drug candidates fail in clinical trials, with even more that never make it to the clinical stage. Many drugs fail because they simply aren’t safe. Seal began this work after wondering if more toxicology insights could be gleaned from a drug candidate’s chemical structure.

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Pharmacokinetics Molecular Biology Drugs FDA 80

Drug Patent Watch

JULY 9, 2024

To find low-competition generic drug opportunities, focus on drugs with limited competition due to small patient populations, complex formulations, or […] Source

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Drugs 104

Drug Patent Watch

JUNE 27, 2024

Introduction Patent portfolios are critical assets for pharmaceutical companies, providing market exclusivity and protecting revenue streams for drug products. Effective management of drug patent portfolios requires strategic planning, ongoing evaluation, and adaptation to the evolving pharmaceutical landscape.

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Pharmaceutical Companies Drugs Pharmaceuticals Production 105

Drugs.com

JULY 2, 2024

TUESDAY, July 2, 2024 -- A new drug to treat Alzheimer's disease was approved by the U.S. Food and Drug Administration on Tuesday.In clinical trials, donanemab (Kisunla) modestly slowed the pace of thinking declines among patients in the early.

FDA Approval 105

FDA Approval FDA Clinical Trials Drugs 105

Drug Patent Watch

JULY 25, 2024

The generic drug market has been significantly impacted by the COVID-19 pandemic, with both challenges and opportunities arising from the crisis. As the world continues to recover…

Marketing 90

Marketing Drugs 90

Drugs.com

JULY 18, 2024

THURSDAY, July 18, 2024 -- A new monoclonal antibody treatment called Kesimpta (ofatumumab) appears to improve on an older drug in pushing multiple sclerosis (MS) into remission, a new trial shows.Funded by Kesimpta's maker, Novartis, the trial.

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Trials Drugs Treatment 116

Drug Patent Watch

APRIL 23, 2024

Drug repurposing, or identifying new therapeutic uses for existing drugs, is gaining significant momentum as a promising approach to accelerate drug development and reduce costs. This book chapter provides a… Source

Drugs 111

Drugs Drug Development 111

Drugs.com

JULY 15, 2024

MONDAY, July 15, 2024 -- Some diabetes drugs appear to lower the risk that people with type 2 diabetes will develop dementia or Alzheimer’s disease, a new evidence review says.The risk of dementia and Alzheimer’s is significantly lower in patients t.

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Drugs Disease 97

Drugs.com

JUNE 11, 2024

Food and Drug Administration advisory panel voted unanimously on Monday to recommend that the benefits of a new drug for Alzheimer's outweigh its harms, which can include brain swelling and bleeding. TUESDAY, June 11, 2024 -- A U.S. Eli Lilly's.

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FDA Drugs 110

DrugBank

JULY 24, 2024

In the constantly evolving field of drug discovery, the term “undruggable” refers to proteins and targets in the body that, until recently, were considered impossible to treat with traditional drugs. Peptides and peptidomimetics, for instance, mimic natural peptides and can target specific proteins with high precision.

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Small Molecule Clinical Trials Drugs Therapies 84