Drugs - Drug Discovery Digest

GLP-1 Drugs Appear To Lower Cancer Risk

Drugs.com

MAY 19, 2025

MONDAY, May 19, 2025 Cutting-edge GLP-1 weight-loss drugs appear to help lower cancer risk even beyond the benefits from dropping excess pounds, a new study says.First-generation GLP-1 drugs like liraglutide (Saxenda) and exenatide (Byetta) were a.

Drugs

Bristol Myers allies with BioNTech on bispecific cancer drug

BioPharma Drive: Drug Pricing

JUNE 2, 2025

billion to co-develop a BioNTech drug that targets the proteins PD1 and VEGF, following Merck, and Pfizer into what’s become a competitive development race. The oncology giant will pay $1.5

Drugs

Novo abruptly ends obesity drug deal with Hims

BioPharma Drive: Drug Pricing

JUNE 23, 2025

The Wegovy maker says the telehealth company didn't stop selling compounded versions of the blockbuster drug after Novo resolved its shortage.

Drugs

Collaborative Drug Discovery and deepmirror Announce Collaboration for Humanitarian and Commercial Drug Discovery

Collaborative Drug

JULY 8, 2025

Collaborative Drug Discovery (CDD) , the leading provider of data management solutions for the pharmaceutical and biotechnology industries, and deepmirror , the AI drug design platform that empowers chemists to focus on more promising drug molecules, today announced a strategic partnership integrating deepmirror with CDD Vault to enhance drug discovery. (..)

Drugs

Drugs Pharmaceuticals

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Brain training game offers new hope for drug-free pain management

Science Daily: Pharmacology News

JUNE 2, 2025

A trial of an interactive game that trains people to alter their brain waves has shown promise as a treatment for nerve pain -- offering hope for a new generation of drug-free treatments.

Drugs

Drugs Treatment Trials

FDA to speed reviews for drugs supporting ‘national interests’

BioPharma Drive: Drug Pricing

JUNE 18, 2025

A new pilot program announced by FDA Commissioner Martin Makary would award vouchers that could cut drug reviews to one or two months — but only for products that meet a special criteria.

FDA

FDA Drugs Production

Combo Drug Treatment More Effective For Kidney Disease in Type 2 Diabetics

Drugs.com

JUNE 9, 2025

MONDAY, June 9, 2025 — Prompt treatment with a drug combo can effectively manage chronic kidney disease in people with type 2 diabetes, a new clinical trial shows. Patients prescribed the combination of finerenone and empagliflozin.

Treatment

Treatment Disease Clinical Trials Drugs

Drug Discovery Informatics for Big Pharma: Key Webinar Insights

Collaborative Drug

MARCH 21, 2025

Our recent Q1 2025 scientific webinar brought together industry veterans Dr. Chris Waller and Dr. Dimitris Agrafiotis to discuss the current state and future directions of drug discovery informatics in large pharmaceutical organizations led by CDD's Founder and CEO, Dr. Barry Bunin.

Drugs

Drugs Pharmaceuticals

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes.

Clinical Trials

HIV Drug, Lamivudine, Potentially Effective Against Diabetic Eye Disease

Drugs.com

JUNE 20, 2025

FRIDAY, June 20, 2025 — A cheap HIV drug might be able to help people with diabetes reverse a complication that can lead to blindness, a new small-scale study says. The drug, lamivudine, appears to improve vision that’s being threatened.

Disease

Disease Drugs

Diabetes Drug, Dapagliflozin, Effective For Fatty Liver Disease

Drugs.com

JUNE 6, 2025

FRIDAY, June 6, 2025 — A repurposed diabetes drug can be an effective tool against fatty liver disease, a new clinical trial has found. Dapagliflozin helped people reduce fat levels in their liver and avoid liver scarring that comes with the.

Disease

Disease Clinical Trials Drugs Trials

Alzheimer’s Drug, Leqembi, Can Be Safely Administered In Memory Clinics, Study Says

Drugs.com

MAY 15, 2025

THURSDAY, May 15, 2025 — The 2023 approval of the first drug shown to slow the progression of Alzheimer’s disease came with no small amount of concern from skeptics. Lecanemab (Leqembi) modestly slows Alzheimer’s by helping the.

Drugs

Drugs Disease

Agility with Complex Data Sets – Integration of Predicted and Empirical Data for Drug Discovery

Collaborative Drug

DECEMBER 6, 2024

We recently hosted an insightful webinar featuring the team from Congruence Therapeutics , who shared how they're using CDD Vault alongside their proprietary systems to manage complex drug discovery data.

Computational Chemistry

Computational Chemistry Drugs

Advancements in Antimalarial Drug Discovery and Development

Collaborative Drug

JUNE 30, 2025

Expert panel discusses malaria drug resistance, AI-driven discovery, long-acting treatments, and African research capacity. Learn about CDD's access program.

Drugs

Drugs Treatment Research

AstraZeneca drug could help keep a common breast cancer at bay

BioPharma Drive: Drug Pricing

JUNE 1, 2025

Data presented at ASCO show that swapping in the oral drug camizestrant for an older therapy helped sustain the benefit of initial treatment, potentially opening a novel step in patient care.

Drugs

Drugs Therapies Treatment

HIV Drug Potentially Effective Against Diabetic Eye Disease

Drugs.com

JUNE 20, 2025

FRIDAY, June 20, 2025 — A cheap HIV drug might be able to help people with diabetes reverse a complication that can lead to blindness, a new small-scale study says.The drug, lamivudine, appears to improve vision that’s being threatened by diabetic m.

Disease

Disease Drugs

Real-World Results For GLP-1 Drugs Underwhelm, Study Says

Drugs.com

JUNE 11, 2025

WEDNESDAY, June 11, 2025 — Real-world results for blockbuster weight-loss meds like Ozempic, Wegovy and Zepbound aren’t as impressive as those promised by the drugs’ clinical trials, a new study says. People taking such GLP-1.

Clinical Trials

Clinical Trials Drugs Trials

Prothena to lay off majority of staff; Zealand shares obesity drug data

BioPharma Drive: Drug Pricing

JUNE 20, 2025

” Elsewhere, Zealand revealed data for a dual-acting obesity drug and Biogen kicked off a new late-stage trial. Prothena will cut 63% of its workforce and evaluate a “range of business options.”

Drugs

Drugs Trials

Texas Invests $50M in Psychedelic Drug Research into Ibogaine to Treat Addiction

Drugs.com

JUNE 16, 2025

MONDAY, June 16, 2025 — Texas has moved to fund research into ibogaine, a psychedelic drug that may help treat addiction, depression, and brain injuries. Greg Abbott signed a bill last week approving $50 million in state funds for.

Drug Research

Drug Research Research Drugs

New Drug Could Quell Uncontrolled High Blood Pressure

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 An experimental drug might help people with uncontrolled high blood pressure, according to early clinical trial results.People taking lorundrostat experienced twice the decline in their systolic blood pressure than people t.

Clinical Trials

Clinical Trials Drugs Trials

Studies Address Muscle Loss Caused By GLP-1 Drugs, such as Ozempic and Zepbound

Drugs.com

JUNE 24, 2025

TUESDAY, June 24, 2025 — GLP-1 drugs like Ozempic and Zepbound are great at promoting weight loss, but they also cause folks to lose muscle along with fat. Experts are now turning their attention toward helping GLP-1 patients maintain muscle.

Drugs

Diabetes Drug Effective For Fatty Liver Disease

Drugs.com

JUNE 6, 2025

FRIDAY, June 6, 2025 — A repurposed diabetes drug can be an effective tool against fatty liver disease, a new clinical trial has found.Dapagliflozin helped people reduce fat levels in their liver and avoid liver scarring that comes with the c.

Disease

Disease Clinical Trials Drugs Trials

Abeona sells speedy drug review voucher for $155M

BioPharma Drive: Drug Pricing

MAY 12, 2025

The biotech has quickly turned a cell therapy approval into one of the more lucrative recent sales for a priority review voucher, which companies can use to fast track drug reviews.

Drugs

Drugs Therapies

Otsuka tops Vera with kidney drug data; Regenxbio sinks on Duchenne update

BioPharma Drive: Drug Pricing

JUNE 6, 2025

Elsewhere, investors scrutinized Regenxbio’s Duchenne data and a brain drug study failed. Late-stage results Otsuka presented in IgA nephropathy triggered a sell-off in Vera shares.

Drugs

Vera drug scores in closely watched study in rare kidney disease

BioPharma Drive: Drug Pricing

JUNE 2, 2025

Phase 3 results revealed Monday led shares to surge and should yield an approval application in IgA nephropathy, a competitive corner of drug research, later this year.

Disease

Disease Drugs Drug Research Research

FDA approves twice-yearly shot of Gilead drug for HIV prevention

BioPharma Drive: Drug Pricing

JUNE 18, 2025

The clearance ushers in a closely-watched launch for Gilead, which aims to show a long-acting injection can upend a market dominated by oral medicines.

FDA Approval

FDA Approval FDA Marketing Drugs

Rival GLP-1 Weight-Loss Drug, Ecnoglutide, Emerges From China

Drugs.com

JUNE 24, 2025

TUESDAY, June 24, 2025 — A new Chinese-developed GLP-1 weight loss drug could prove a new competitor to blockbuster drugs Ozempic/Wegovy and Zepbound, clinical trial results show. Ecnoglutide helped people lose between 9% to 13% of their body.

Clinical Trials

Clinical Trials Drugs Trials

FDA Plans to Use AI to Speed Up Drug and Food Safety Reviews

Drugs.com

JUNE 11, 2025

Food and Drug Administration (FDA) says it plans to use artificial intelligence (AI) to help speed the approval of new drugs and medical devices. WEDNESDAY, June 11, 2025 — The U.S. That's one of several priorities federal officials detailed.

FDA

FDA Drugs

Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein‐Derived Cell‐Penetrating Peptide

Chemical Biology and Drug Design

JANUARY 20, 2025

ABSTRACT Drug targeting strategies, such as peptidedrug conjugates (PDCs), have arisen to combat the issue of off-target toxicity that is commonly associated with chemotherapeutic small molecule drugs. The PDCs crossed membranes and cleavable PDCs killed melanoma cells with nanomolar potency.

Small Molecule

Small Molecule Drugs International Therapies

PTC stock slides on new data for Huntington’s drug

BioPharma Drive: Drug Pricing

MAY 5, 2025

While updated study results confirmed the drug lowers a target protein, the therapy's effect on clinical outcomes was less clear-cut.

Drugs

Drugs Therapies

Insmed surges on lung drug data; Recursion cuts staff

BioPharma Drive: Drug Pricing

JUNE 11, 2025

Insmed shares rocketed on results for a pulmonary arterial hypertension drug that exceeded Wall Street expectations. Elsewhere, Recursion is laying off 20% of its workforce and Gilead halted several HIV studies.

Drugs

Targeted Covalent Modification Strategies for Drugging the Undruggable Targets

Covalent Modifiers

JANUARY 9, 2025

4c00745 The term undruggable refers to proteins or other biological targets that have been historically challenging to target with conventional drugs or therapeutic strategies because of their structural, functional, or dynamic properties. Thus, investigating methods to achieve such drugging is an important challenge in medicinal chemistry.

Drugs

Drugs Therapies Treatment Disease

Chasing rivals, Nuvalent to seek approval of targeted lung cancer drug

BioPharma Drive: Drug Pricing

JUNE 24, 2025

New study results position Nuvalent to bring forward what it claims is a differentiated treatment for ROS1-positive lung cancer, a crowded indication with uncertain sales potential.

Treatment

Treatment Drugs

After delay, Kalvista wins FDA OK for drug to treat rare swelling disorder

BioPharma Drive: Drug Pricing

JULY 7, 2025

The company had blamed FDA "resource constraints" for the delay, while a rival drug for hereditary angioedema received an on-time approval.

FDA

FDA Drugs

GSK to buy liver disease drug for $1.2B

BioPharma Drive: Drug Pricing

MAY 14, 2025

The new acquisition from Boston Pharmaceuticals adds to a wave of dealmaking undertaken by GSK to build its liver disease franchise.

Disease

Disease Pharmaceuticals Drugs

Drug Effective Against Early Migraine Symptoms

Drugs.com

MAY 14, 2025

WEDNESDAY, May 14, 2025 -- Migraines dont just cause headaches.These attacks often are accompanied by symptoms like light and sound sensitivity, nausea, neck pain and dizziness.Whats more, those non-headache symptoms tend to crop up before a ful.

Drugs

Advancing Covalent Ligand and Drug Discovery beyond Cysteine

Covalent Modifiers

JUNE 5, 2025

5c00001 Targeting intractable proteins remains a key challenge in drug discovery, as these proteins often lack well-defined binding pockets or possess shallow surfaces not readily addressed by traditional drug design. Justin Grams, and Ku-Lung Hsu Chemical Reviews 2025 DOI: 10.1021/acs.chemrev.5c00001

Drugs

Daiichi Sankyo struck gold with ‘ADC’ cancer drugs. Its new CEO has to figure out what’s next.

BioPharma Drive: Drug Pricing

JUNE 4, 2025

Enhertu, Datroway and other antibody-drug conjugates developed by Daiichi Sankyo have made the company a leader in a competitive field. Hiroyuki Okuzawa is working to keep it that way.

Drugs

Experimental Drug Lorundrostat Could Quell Uncontrolled High Blood Pressure

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 — An experimental drug might help people with uncontrolled high blood pressure, according to early clinical trial results. People taking lorundrostat experienced twice the decline in their systolic blood pressure than.

Clinical Trials

Clinical Trials Drugs Trials

Clash Of Drugs Impedes Lung Cancer Treatment, Lowers Survival

Drugs.com

JULY 8, 2025

TUESDAY, July 7, 2025 — Two drugs used in lung cancer treatment appear to be tripping over each other, reducing patients’ chances for a cure, a new study says.Corticosteroids are commonly prescribed to alleviate cancer-related symptoms in patients w.

Treatment

Treatment Drugs

After rejections, AbbVie secures approval for Parkinson’s drug

BioPharma Drive: Drug Pricing

OCTOBER 17, 2024

Vyalev’s clearance is the second victory for AbbVie in Parkinson’s this year, following an April readout for a drug acquired through its Cerevel buyout.

Drugs

Reproductive health startup raises $65M for infertility drugs

BioPharma Drive: Drug Pricing

MAY 21, 2025

Founded in 2021, ReproNovo has licensed rights to two drugs from Mereo BioPharma and ObsEva that it thinks could address fertility issues in men and women.

Licensing

Licensing Licensing Drugs

Top Scientific Data Platforms for AI-Driven Drug Discovery: What to Look For

Collaborative Drug

JUNE 11, 2025

Compare top scientific data platforms for AI-driven drug discovery. Evaluate CDD Vault, Dotmatics, Benchling & more for chemistry and biologics workflows.

Drugs

GLP-1 Drugs Appear To Lower Cancer Risk

Bristol Myers allies with BioNTech on bispecific cancer drug

Trending Sources

Novo abruptly ends obesity drug deal with Hims

Collaborative Drug Discovery and deepmirror Announce Collaboration for Humanitarian and Commercial Drug Discovery

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Brain training game offers new hope for drug-free pain management

FDA to speed reviews for drugs supporting ‘national interests’

Combo Drug Treatment More Effective For Kidney Disease in Type 2 Diabetics

Drug Discovery Informatics for Big Pharma: Key Webinar Insights

Bridging Innovation & Patient Care: The Growing Role of AI

HIV Drug, Lamivudine, Potentially Effective Against Diabetic Eye Disease

Diabetes Drug, Dapagliflozin, Effective For Fatty Liver Disease

Alzheimer’s Drug, Leqembi, Can Be Safely Administered In Memory Clinics, Study Says

Agility with Complex Data Sets – Integration of Predicted and Empirical Data for Drug Discovery

Advancements in Antimalarial Drug Discovery and Development

AstraZeneca drug could help keep a common breast cancer at bay

HIV Drug Potentially Effective Against Diabetic Eye Disease

Real-World Results For GLP-1 Drugs Underwhelm, Study Says

Prothena to lay off majority of staff; Zealand shares obesity drug data

Texas Invests $50M in Psychedelic Drug Research into Ibogaine to Treat Addiction

New Drug Could Quell Uncontrolled High Blood Pressure

Studies Address Muscle Loss Caused By GLP-1 Drugs, such as Ozempic and Zepbound

Diabetes Drug Effective For Fatty Liver Disease

Abeona sells speedy drug review voucher for $155M

Otsuka tops Vera with kidney drug data; Regenxbio sinks on Duchenne update

Vera drug scores in closely watched study in rare kidney disease

FDA approves twice-yearly shot of Gilead drug for HIV prevention

Rival GLP-1 Weight-Loss Drug, Ecnoglutide, Emerges From China

FDA Plans to Use AI to Speed Up Drug and Food Safety Reviews

Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein‐Derived Cell‐Penetrating Peptide

PTC stock slides on new data for Huntington’s drug

Insmed surges on lung drug data; Recursion cuts staff

Targeted Covalent Modification Strategies for Drugging the Undruggable Targets

Chasing rivals, Nuvalent to seek approval of targeted lung cancer drug

After delay, Kalvista wins FDA OK for drug to treat rare swelling disorder

GSK to buy liver disease drug for $1.2B

Drug Effective Against Early Migraine Symptoms

Advancing Covalent Ligand and Drug Discovery beyond Cysteine

Daiichi Sankyo struck gold with ‘ADC’ cancer drugs. Its new CEO has to figure out what’s next.

Experimental Drug Lorundrostat Could Quell Uncontrolled High Blood Pressure

Clash Of Drugs Impedes Lung Cancer Treatment, Lowers Survival

After rejections, AbbVie secures approval for Parkinson’s drug

Reproductive health startup raises $65M for infertility drugs

Top Scientific Data Platforms for AI-Driven Drug Discovery: What to Look For

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