Research - Drug Discovery Digest

Does Federally Funded Research Justify A Piece Of Pharma’s Profits?

Forbes: Drug Truths

MARCH 4, 2024

The thought that all drugs arise from government funded research is a fallacy.

Research

Research Government Drugs

Cannabis and Cannabinoid Signaling: Research Gaps and Opportunities [Commentary]

ASPET

JULY 26, 2024

Meanwhile decades of research have advanced our knowledge of cannabis pharmacology and particularly of the endocannabinoid system with which the components of cannabis interact. Here we highlight the challenges of cannabis research and the gaps in our knowledge of cannabis pharmacology and of the endocannabinoid system that it targets.

Research

Research Production

Researchers devise new way to target and correct disease-related proteins

Broad Institute

JANUARY 6, 2025

Researchers at the Broad Institute of MIT and Harvard, Massachusetts General Hospital, and Harvard University took a fresh approach by building a remarkably diverse collection of molecular compounds that can be mined for those that target disease-related genetic variants in new ways.

Disease

Disease Research DNA Small Molecule

Researchers identify source of a brain cancer’s deadly transformation

Broad Institute

NOVEMBER 21, 2024

Researchers identify source of a brain cancer’s deadly transformation By Corie Lok November 21, 2024 Breadcrumb Home Researchers identify source of a brain cancer’s deadly transformation Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations.

Research

Research Medical Schools DNA Hospitals

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management.

Clinical Trials

Machine learning guides researchers to new synthetic genetic switches

Broad Institute

OCTOBER 23, 2024

Machine learning guides researchers to new synthetic genetic switches By Tom Ulrich October 23, 2024 Breadcrumb Home Machine learning guides researchers to new synthetic genetic switches A new method allows precise activation or repression of genes in specific cells and tissues. By Sarah C.P.

Research

Research DNA Laboratories Molecular Biology

Researchers make comfortable materials that generate power when worn

Science Daily: Pharmacology News

JANUARY 15, 2025

Researchers have demonstrated new wearable technologies that both generate electricity from human movement and improve the comfort of the technology for the people wearing them. The work stems from an advanced understanding of materials that increase comfort in textiles and produce electricity when they rub against another surface.

Research

Researchers map communities of single cells in metastatic breast cancers

Broad Institute

OCTOBER 30, 2024

Researchers map communities of single cells in metastatic breast cancers By Corie Lok October 30, 2024 Breadcrumb Home Researchers map communities of single cells in metastatic breast cancers The team compared different single-cell and spatial profiling methods to explore the diversity of cells in metastatic breast cancer biopsies.

Research

Research RNA Medical Schools Treatment

Researchers flip genes on and off with AI-designed DNA switches

Science Daily: Pharmacology News

OCTOBER 23, 2024

Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.

DNA

DNA Research

How artificial intelligence could automate genomics research

Science Daily: Pharmacology News

DECEMBER 2, 2024

New research suggests that large language models like GPT-4 could streamline the process of gene set enrichment, an approach what genes do and how they interact. Results bring science one step closer to automating one of the most widely used methods in genomics research.

Research

Research Science

Researchers identify previously unknown compound in drinking water

Science Daily: Pharmacology News

NOVEMBER 21, 2024

Researchers have reported the discovery of a previously unknown compound in chloraminated drinking water. Inorganic chloramines are commonly used to disinfect drinking water to safeguard public health from diseases like cholera and typhoid fever.

Research

Research Disease

Researchers develop state-of-the-art device to make artificial intelligence more energy efficient

Science Daily: Pharmacology News

JULY 26, 2024

Engineering researchers have demonstrated a state-of-the-art hardware device that could reduce energy consumption for artificial intelligent (AI) computing applications by a factor of at least 1,000.

Research

Research Engineering

A fast-moving belly flop: Researchers unveil the unique skills of cricket frogs

Science Daily: Pharmacology News

JANUARY 10, 2025

The way cricket frogs move across the surface of water has long been thought to resemble walking on water, but researchers have now discovered a different reality.

Research

'Out-of-body' research could lead to new ways to promote social harmony

Science Daily: Pharmacology News

SEPTEMBER 9, 2024

Out-of-body experiences, such as near-death experiences, can have a 'transformative' effect on people's ability to experience empathy and connect with others, new research explains.

Research

Every Cigarette Smoked Could Cost You 22 Minutes of Life, Research Says

Drugs.com

JANUARY 2, 2025

New research might provide all the motivation you need: Each cigarette could shorten your life by up to 22 minutes, researchers say. THURSDAY, Jan. 2, 2025 -- Considering a New Year’s resolution to quit smoking? The findings, published Dec.

Research

Researchers discover class of anti-malaria antibodies

Science Daily: Pharmacology News

JANUARY 3, 2025

Antibodies that bind to a previously untargeted portion of the malaria parasite could lead to new monoclonal antibody treatments and vaccines for malaria.

Research

Research Vaccine Treatment

Early Research Points to Possible New Parkinson's Drug

Drugs.com

DECEMBER 19, 2024

Now, researchers say they are on the trail of a potential new therapy for the disabling neurological illness.It's early research. THURSDAY, Dec. 19, 2024 -- Parkinson's is a relentless disease for which few treatments, and no real cure, exists.

Research

Research Therapies Treatment Disease

Research in 4 continents links outdoor air pollution to differences in children's brains

Science Daily: Pharmacology News

OCTOBER 1, 2024

A research team systematically analyzed 40 empirical studies, the majority of which had found that outdoor air pollution is associated with differences in children's brains. These differences include volumes of white matter, which is associated with cognitive function, connections throughout the brain and even early markers for Alzheimer's.

Research

Life from a drop of rain: New research suggests rainwater helped form the first protocell walls

Science Daily: Pharmacology News

AUGUST 21, 2024

New research shows that rainwater could have helped create a meshy wall around protocells 3.8 billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived.

RNA

RNA Research

Polymer research shows potential replacement for common superglues with a reusable and biodegradable alternative

Science Daily: Pharmacology News

JANUARY 16, 2025

Researchers have developed an adhesive polymer that is stronger than current commercially available options while also being biodegradable, tunable, and reusable. The findings show how the common, naturally occurring polymer P3HB can be chemically re-engineered for use as a strong yet sustainable bonding agent.

Research

Research Engineering

New research explores volcanic caves, advancing the search for life on Mars

Science Daily: Pharmacology News

NOVEMBER 18, 2024

Through the intricate study of lava tubes -- caves formed following volcanic eruptions when lava cools down -- an international team of researchers has uncovered clues about Earth's ancient environments that could be significant in the search for life on Mars.

Research

Research International

Vertex, startup Orna to partner on gene editing research

BioPharma Drive: Drug Pricing

JANUARY 7, 2025

The three-year partnership is another example of Vertex’s interest in improving on Casgevy, its CRISPR medicine for sickle cell and beta thalassemia.

Research

#WhyIScience Q&A: A computational biologist’s world travels have shaped her approach to research

Broad Institute

DECEMBER 11, 2024

#WhyIScience Q&A: A computational biologists world travels have shaped her approach to research By Corie Lok December 11, 2024 Breadcrumb Home #WhyIScience Q&A: A computational biologists world travels have shaped her approach to research Wolu Chukwu talks about how she brings a community-first focus to her work in cancer genetics.

Research

Research DNA Clinical Research Science

Diabetes Drug Protects Against Skin Cancer, New Research Says

Drugs.com

JANUARY 14, 2025

TUESDAY, Jan. 14, 2025 -- A popular diabetes drug can provide protection against skin cancers, a new study says.Metformin significantly reduces peoples risk of developing basal cell cancers or squamous cell cancers, the two most common skin c.

Research

Research Drugs

Memories are not only in the brain, new research finds

Science Daily: Pharmacology News

NOVEMBER 7, 2024

It's common knowledge that our brains -- and, specifically, our brain cells -- store memories.

Research

Researchers give adult zebra finches back their ability to learn new songs

Science Daily: Pharmacology News

SEPTEMBER 3, 2024

We all know the adage, 'You can't teach an old dog new tricks.' As we age, our ability to learn new skills, like mastering a foreign language or picking up a musical instrument, seems to fade. The culprit? A decline in brain plasticity - the brain's capacity to rewire itself and adapt to new challenges.

Research

Diabetes Drug, Metformin, Protects Against Skin Cancer, New Research Says

Drugs.com

JANUARY 14, 2025

TUESDAY, Jan. 14, 2025 -- A popular diabetes drug can provide protection against skin cancers, a new study says. Metformin significantly reduces people’s risk of developing basal cell cancers or squamous cell cancers, the two most common skin.

Research

Research Drugs

Quantum research breakthrough uses synthetic dimensions to efficiently process quantum information

Science Daily: Pharmacology News

OCTOBER 17, 2024

A new study opens the door to cutting-edge solutions that could contribute to the realization of a system capable of processing quantum information in a simple yet powerful way. The work presents a method for manipulating the photonic states of light in a never-before-seen way, offering greater control over the evolution of photon propagation.

Research

Brain research: Study shows what your favorite film genres reveal about your brain

Science Daily: Pharmacology News

AUGUST 27, 2024

Crime films, action films, comedies, or documentaries? A person's favorite film genre reveals a lot about how their brain works. Fans of action films and comedies reacted very strongly to negative emotional stimuli, while participants who favored documentaries or crime films and thrillers had a significantly weaker reaction.

Research

Galapagos, after research struggles, will split in two and revamp Gilead deal

BioPharma Drive: Drug Pricing

JANUARY 8, 2025

Alongside plans to spin out a new company, the Belgian drugmaker said it will cut some 300 positions, or about 40% of its current workforce.

Research

Do parents really have a favorite child? Here's what new research says

Science Daily: Pharmacology News

JANUARY 16, 2025

A new study found that younger siblings generally receive more favorable treatment from parents. Meanwhile, older siblings are often granted more autonomy, and parents are less controlling towards them as they grow up.

Research

Research Treatment

Key players in brain aging: New research identifies age-related damage on a cellular level

Science Daily: Pharmacology News

JANUARY 1, 2025

Scientists have identified the molecular changes that occur in the brains of aging mice and located a hot spot where much of that damage is centralized. The cells in the area are also connected with metabolism, suggesting a connection between diet and brain health.

Research

Why our biological clock ticks: Research reconciles major theories of aging

Science Daily: Pharmacology News

JANUARY 21, 2025

Researchers have revealed that these theories may not be so different after all. Two major theories of aging both involve DNA, but in very different ways.

Research

Research DNA

New research unlocks jaw-dropping evolution of lizards and snakes

Science Daily: Pharmacology News

DECEMBER 11, 2024

A groundbreaking study has shed light on how lizards and snakes -- the most diverse group of land vertebrates with nearly 12,000 species -- have evolved remarkably varied jaw shapes, driving their extraordinary ecological success.

Research

Researchers discover new third class of magnetism that could transform digital devices

Science Daily: Pharmacology News

DECEMBER 11, 2024

A new class of magnetism called altermagnetism has been imaged for the first time in a new study. The findings could lead to the development of new magnetic memory devices with the potential to increase operation speeds of up to a thousand times.

Research

Could Olumiant Be A New Way to Treat Sjögren’s Disease? Researchers Are Hopeful

Drugs.com

DECEMBER 20, 2024

FRIDAY, Dec. 20, 2024 -- An existing drug might be able to treat an autoimmune disorder that causes dry eye, dry mouth, fatigue and muscle or joint pain. Baricitinib (Olumiant), a drug currently used to treat rheumatoid arthritis, appears to.

Disease

Disease Research Drugs

Tune raises $175M for hepatitis B medicine, epigenetic research

BioPharma Drive: Drug Pricing

JANUARY 12, 2025

The biotech plans to use the funding to advance clinical testing of an epigenetic silencing therapy it hopes could treat chronic hepatitis B infections.

Research

Research Therapies

Pioneering research exposes huge loss of glaciers in one of the fastest-warming places on Earth

Science Daily: Pharmacology News

JANUARY 16, 2025

A new study has revealed the alarming extent glaciers have shrunk over the past 40 years in a global warming hotspot -- and the biggest retreat has occurred in recent years.

Research

A New Way to Treat Sjögren’s Disease? Researchers Are Hopeful

Drugs.com

DECEMBER 20, 2024

FRIDAY, Dec. 20, 2024 -- An existing drug might be able to treat an autoimmune disorder that causes dry eye, dry mouth, fatigue and muscle or joint pain.Baricitinib (Olumiant), a drug currently used to treat rheumatoid arthritis, appears to.

Disease

Disease Research Drugs

Researchers deal a blow to theory that Venus once had liquid water on its surface

Science Daily: Pharmacology News

DECEMBER 2, 2024

A team of astronomers has found that Venus has never been habitable, despite decades of speculation that our closest planetary neighbor was once much more like Earth than it is today.

Research

Evaluating the potential for psilocybin as a treatment for post-traumatic stress disorder [Minireview]

ASPET

SEPTEMBER 16, 2024

Recent work demonstrating the psychoplastogenic effects of psychedelics has reinvigorated research to examine their therapeutic potential in psychiatric conditions. Psilocybin, one psychedelic found in the Psilocybe genus of mushrooms, has exhibited promising antidepressant and anxiolytic effects in preclinical and clinical studies.

Treatment

Treatment Research

Hydrogels can play Pong by 'remembering' previous patterns of electrical simulation

Science Daily: Pharmacology News

AUGUST 22, 2024

Non-living hydrogels can play the video game Pong and improve their gameplay with more experience, researchers report. With practice, the hydrogel's accuracy improved by up to 10%, resulting in longer rallies.

Research

Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

Science Daily: Pharmacology News

JANUARY 3, 2025

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests. Researchers drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank.

Disease

Disease Research

Scientists engineer CRISPR enzymes that evade the immune system

Broad Institute

JANUARY 9, 2025

Researchers at the Broad Institute of MIT and Harvard and Cyrus Biotechnology have now engineered two CRISPR nucleases, Cas9 and Cas12, to mask them from the immune system. The study was led by Feng Zhang , a core institute member at the Broad and an Investigator at the McGovern Institute for Brain Research at MIT.

Engineering

Engineering Immune Response Therapies DNA

Does Federally Funded Research Justify A Piece Of Pharma’s Profits?

Cannabis and Cannabinoid Signaling: Research Gaps and Opportunities [Commentary]

Trending Sources

Researchers devise new way to target and correct disease-related proteins

Researchers identify source of a brain cancer’s deadly transformation

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Machine learning guides researchers to new synthetic genetic switches

Researchers make comfortable materials that generate power when worn

Researchers map communities of single cells in metastatic breast cancers

Researchers flip genes on and off with AI-designed DNA switches

How artificial intelligence could automate genomics research

Researchers identify previously unknown compound in drinking water

Researchers develop state-of-the-art device to make artificial intelligence more energy efficient

A fast-moving belly flop: Researchers unveil the unique skills of cricket frogs

'Out-of-body' research could lead to new ways to promote social harmony

Every Cigarette Smoked Could Cost You 22 Minutes of Life, Research Says

Researchers discover class of anti-malaria antibodies

Early Research Points to Possible New Parkinson's Drug

Research in 4 continents links outdoor air pollution to differences in children's brains

Life from a drop of rain: New research suggests rainwater helped form the first protocell walls

Polymer research shows potential replacement for common superglues with a reusable and biodegradable alternative

New research explores volcanic caves, advancing the search for life on Mars

Vertex, startup Orna to partner on gene editing research

#WhyIScience Q&A: A computational biologist’s world travels have shaped her approach to research

Diabetes Drug Protects Against Skin Cancer, New Research Says

Memories are not only in the brain, new research finds

Researchers give adult zebra finches back their ability to learn new songs

Diabetes Drug, Metformin, Protects Against Skin Cancer, New Research Says

Quantum research breakthrough uses synthetic dimensions to efficiently process quantum information

Brain research: Study shows what your favorite film genres reveal about your brain

Galapagos, after research struggles, will split in two and revamp Gilead deal

Do parents really have a favorite child? Here's what new research says

Key players in brain aging: New research identifies age-related damage on a cellular level

Why our biological clock ticks: Research reconciles major theories of aging

New research unlocks jaw-dropping evolution of lizards and snakes

Researchers discover new third class of magnetism that could transform digital devices

Could Olumiant Be A New Way to Treat Sjögren’s Disease? Researchers Are Hopeful

Tune raises $175M for hepatitis B medicine, epigenetic research

Pioneering research exposes huge loss of glaciers in one of the fastest-warming places on Earth

A New Way to Treat Sjögren’s Disease? Researchers Are Hopeful

Researchers deal a blow to theory that Venus once had liquid water on its surface

Evaluating the potential for psilocybin as a treatment for post-traumatic stress disorder [Minireview]

Hydrogels can play Pong by 'remembering' previous patterns of electrical simulation

Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

Scientists engineer CRISPR enzymes that evade the immune system

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