Drug Discovery World
MARCH 4, 2024
In an early phase clinical trial, a combination of antibody-based medications targeting the immune system generated promising safety data and anti-tumour activity in individuals with advanced cancer. Both medications tested in the trial support immune responses against tumour cells. CS1002 increases the activation and proliferation of T immune cells by binding to a T cell receptor called CTLA-4.
Forbes: Drug Truths
MARCH 6, 2024
There is another aspect of this provision of the IRA that is starting to be felt – "the small molecule penalty"
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Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- The U.S. Food and Drug Administration issued a health advisory Wednesday warning consumers that six brands of ground cinnamon are tainted with lead. The FDA urged folks to throw away and not buy the following brands of.
Science Daily: Pharmacology News
MARCH 20, 2024
A study of over 20,000 adults found that those who followed an 8-hour time-restricted eating schedule, a type of intermittent fasting, had a 91% higher risk of death from cardiovascular disease.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Broad Institute
MARCH 14, 2024
Scientists generate new targeted protein degradation system that tunes a cell’s own proteins By Leah Eisenstadt March 14, 2024 Breadcrumb Home Scientists generate new targeted protein degradation system that tunes a cell’s own proteins Researchers have engineered a compact degron tag that can be precisely edited into a cell’s genome, enabling scientists to trigger the rapid breakdown of native target proteins.
BioPharma Drive: Drug Pricing
MARCH 8, 2024
The results have led Amylyx to pause promotion of Relyvrio and potentially pull it from the market in the coming weeks, a major blow to the company and ALS patients.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drug Target Review
MARCH 28, 2024
Between 2000 and 2020, approximately 30 percent of the newly introduced small molecule drugs were derived from natural products. 1 Surprisingly, however, less than one percent of the natural world’s chemical composition has been identified or studied by scientists. While plant-derived molecules (phytochemicals) have long played an essential role in drug discovery due to their diverse biological activities and chemical properties, the reliance on time-consuming and expensive screening techniques
Drugs.com
MARCH 18, 2024
MONDAY, March 18, 2024 -- As millions of Americans prepare to travel abroad this summer and measles outbreaks increase worldwide, the U.S. Centers for Disease Control and Prevention has tightened its guidance on how travelers should handle the.
Science Daily: Pharmacology News
MARCH 18, 2024
Performing a new task based solely on verbal or written instructions, and then describing it to others so that they can reproduce it, is a cornerstone of human communication that still resists artificial intelligence (AI). A team has succeeded in modelling an artificial neural network capable of this cognitive prowess. After learning and performing a series of basic tasks, this AI was able to provide a linguistic description of them to a 'sister' AI, which in turn performed them.
Broad Institute
MARCH 20, 2024
Spatial study of lung cancer reveals immune markers of response to immunotherapy By Corie Lok March 20, 2024 Breadcrumb Home Spatial study of lung cancer reveals immune markers of response to immunotherapy Researchers visualize how immune cells are spatially organized within tumors and show that certain immune “hubs” are linked to better treatment responses.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
MARCH 14, 2024
Rezdiffra’s clearance is a turning point in the fight against the liver disease. But its sales potential is unclear, and competition could emerge from popular weight loss drugs.
Perficient: Drug Development
MARCH 6, 2024
In December 2022, the Department of Health and Human Services released a bulletin announcing additional compliance requirements for healthcare marketers when it comes to third-party trackers. The guidance lays forth expectations for how healthcare organizations collect data on activities that take place on their website and mobile apps. So, what’s the problem?
Antidote
MARCH 12, 2024
For many people, participating in a research study presents an interesting opportunity with many benefits to volunteering. While there are many types of clinical research, all with distinct goals and timelines, trial volunteers will follow a similar path when taking part. Read on to learn more about the process.
Drugs.com
MARCH 29, 2024
FRIDAY, March 29, 2024 -- Some pain-relieving skin products contain potentially harmful doses of the numbing agent lidocaine and should be avoided, the U.S. Food and Drug Administration warns.These creams, gels, sprays and soaps are marketed for.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
MARCH 22, 2024
How much time do planets have to form from a swirling disk of gas and dust around a star? A new study gives scientists a better idea of how our own solar system came to be.
Broad Institute
MARCH 8, 2024
Study reveals genetic clusters that may explain differences in type 2 diabetes risk By Corie Lok March 8, 2024 Breadcrumb Home Study reveals genetic clusters that may explain differences in type 2 diabetes risk The clusters point to a range of biological processes that likely contribute to the development of type 2 diabetes. By Brandon Chase, Massachusetts General Hospital Communications March 8, 2024 Related content Largest and most diverse genome-wide association study of type 2 diabetes revea
BioPharma Drive: Drug Pricing
MARCH 11, 2024
Publicly traded companies raised nearly $10 billion in follow-on stock offerings in January and February, a financing surge that’s driving a “sector recovery,” the investment bank said.
KIF1A
MARCH 2, 2024
#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research SPARKing New Insight Into Autism Across the Lifespan When I was growing up, autism was still unfamiliar to many; people may had heard the term but families often had to educate themselves, their
DrugBank
MARCH 28, 2024
Space biosciences are on the verge of becoming one of the largest total addressable markets to ever exist, opening up vast opportunities for economic growth and scientific discovery. In the realm of space exploration, one critical yet often overlooked aspect is the impact of space conditions on human health. The goal of sending humans to space for increasingly longer periods of time is contingent on our ability to ensure astronauts' health.
Drugs.com
MARCH 7, 2024
THURSDAY, March 7, 2024 -- Some acne treatments may may banish blemishes but carry hidden dangers: A new report reveals high levels of the carcinogen benzene can form in products that contain the zit-fighting ingredient benzoyl peroxide.According.
Science Daily: Pharmacology News
MARCH 27, 2024
What would you do if you walked up to a robot with a human-like head and it smiled at you first? You'd likely smile back and perhaps feel the two of you were genuinely interacting. But how does a robot know how to do this? Or a better question, how does it know to get you to smile back?
Antidote
MARCH 27, 2024
MS is a chronic disease that is estimated to impact over a million Americans. The condition causes damage to the body’s central nervous system, leading to numbness, memory problems, sight issues, and difficulties with coordination.
BioPharma Drive: Drug Pricing
MARCH 15, 2024
The company expects initial uptake of Rezdiffra, which costs $47,400 per year, to be slow as doctors and insurers establish the protocols needed to find patients eligible for treatment.
Perficient: Drug Development
MARCH 5, 2024
If you built your data lake in the last 5-7 years, you probably are ingesting data into the data lake using many batch jobs that ingest and update data in the data lake. There is nothing wrong with what you did, but data technology has continued to move forward and in my opinion, the time has come to change your data lake ingestion strategy to reduce the number of high-latency batch jobs and move toward primarily using real-time change data capture (CDC).
Broad Institute
MARCH 25, 2024
#WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers By Leah Eisenstadt March 25, 2024 Breadcrumb Home #WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers Alex Navarro draws from her scientific and personal experiences to guide young researchers toward their professional goals in the Broad’s post-baccalaureate program.
Drugs.com
MARCH 25, 2024
MONDAY, March 25, 2024 -- Drugmaker Eli Lilly & Co is announcing a temporary shortage of two of its insulin products."The 10 mL [millilter] vials of Humalog® and Insulin Lispro Injection are or will be temporarily out of stock at wholesalers.
Science Daily: Pharmacology News
MARCH 1, 2024
In a recent study, 151 human participants were pitted against ChatGPT-4 in three tests designed to measure divergent thinking, which is considered to be an indicator of creative thought.
Antidote
MARCH 14, 2024
Receiving a multiple sclerosis (MS) diagnosis can feel overwhelming and isolating for many. MS is a neurodegenerative disease that often involves challenging symptoms — but knowing what to expect and what resources are available can help.
BioPharma Drive: Drug Pricing
MARCH 12, 2024
Physicians are preparing for tough conversations with patients on Amylyx Pharmaceuticals’ drug, Relyvrio, while holding out hope it still may help some with the disease.
Perficient: Drug Development
MARCH 1, 2024
In a dynamic digital landscape, choosing the right provider among the Adobe services landscape is paramount for businesses seeking to maximize their Adobe investments. The selection process can be daunting with a diverse set of providers that vary by size, type of offering, geography, and business scenario differentiation. So where do marketing leaders start?
Drug Target Review
MARCH 11, 2024
A collaboration between the University of Twente in the Netherlands and Rousselot has revealed the dynamics between biomaterial purity and the fidelity of 3D cancer models. Their joint study illuminated the profound impact of endotoxins on the accuracy and efficacy of these models, marking a significant breakthrough in cancer research. Through experimentation, contrasting research-grade gelatine, inherently infused with endotoxins, with an ultra-low endotoxin-level gelatine, they revealed that t
Drugs.com
MARCH 29, 2024
FRIDAY, March 29, 2024 -- There has been a troubling rise in cases of a rare bacterial illness that can cause meningitis, U.S. health officials warned Thursday.In an alert issued to doctors, the U.S. Centers for Disease Control and Prevention said.
Science Daily: Pharmacology News
MARCH 25, 2024
A new study combining genetic, palaeoecological, and archaeological evidence has unveiled the Persian Plateau as a pivotal geographic location serving as a hub for Homo sapiens during the early stages of their migration out of Africa. It highlights the period between 70,000 to 45,000 years ago when human populations did not uniformly spread across Eurasia, leaving a gap in our understanding of their whereabouts during this time frame.
KIF1A
MARCH 9, 2024
#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. Meet our Guest Bloggers! This spring we’ve been quite fortunate to be joined by 6 Master’s students from Columbia University, who have been contributing to our creation of community resources as part of the
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