March, 2024

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Antibody therapy shows anti-tumour activity in advanced cancer

Drug Discovery World

In an early phase clinical trial, a combination of antibody-based medications targeting the immune system generated promising safety data and anti-tumour activity in individuals with advanced cancer. Both medications tested in the trial support immune responses against tumour cells. CS1002 increases the activation and proliferation of T immune cells by binding to a T cell receptor called CTLA-4.

Therapies 289
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Early Impact Of The Inflation Reduction Act On Drug Discovery

Forbes: Drug Truths

There is another aspect of this provision of the IRA that is starting to be felt – "the small molecule penalty"

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FDA Warns of Toxic Lead in Cinnamon Products

Drugs.com

WEDNESDAY, March 6, 2024 -- The U.S. Food and Drug Administration issued a health advisory Wednesday warning consumers that six brands of ground cinnamon are tainted with lead. The FDA urged folks to throw away and not buy the following brands of.

FDA 145
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8-hour time-restricted eating linked to a 91% higher risk of cardiovascular death

Science Daily: Pharmacology News

A study of over 20,000 adults found that those who followed an 8-hour time-restricted eating schedule, a type of intermittent fasting, had a 91% higher risk of death from cardiovascular disease.

Disease 141
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Scientists generate new targeted protein degradation system that tunes a cell’s own proteins

Broad Institute

Scientists generate new targeted protein degradation system that tunes a cell’s own proteins By Leah Eisenstadt March 14, 2024 Breadcrumb Home Scientists generate new targeted protein degradation system that tunes a cell’s own proteins Researchers have engineered a compact degron tag that can be precisely edited into a cell’s genome, enabling scientists to trigger the rapid breakdown of native target proteins.

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Unlocking the potential of natural products in drug discovery

Drug Target Review

Between 2000 and 2020, approximately 30 percent of the newly introduced small molecule drugs were derived from natural products. 1 Surprisingly, however, less than one percent of the natural world’s chemical composition has been identified or studied by scientists. While plant-derived molecules (phytochemicals) have long played an essential role in drug discovery due to their diverse biological activities and chemical properties, the reliance on time-consuming and expensive screening techniques

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Amylyx ALS drug fails crucial study, putting company’s future in doubt

BioPharma Drive: Drug Pricing

The results have led Amylyx to pause promotion of Relyvrio and potentially pull it from the market in the coming weeks, a major blow to the company and ALS patients.

Marketing 135
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U.S. Mpox Cases Rising Again as Vaccinations Lag

Drugs.com

THURSDAY, March 28, 2024 -- Mpox cases are climbing again in the United States, with the number of reported infections now twice as high as they were at this time last year, new government data shows.In response, public health experts have raised.

Vaccine 134
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Two artificial intelligences talk to each other

Science Daily: Pharmacology News

Performing a new task based solely on verbal or written instructions, and then describing it to others so that they can reproduce it, is a cornerstone of human communication that still resists artificial intelligence (AI). A team has succeeded in modelling an artificial neural network capable of this cognitive prowess. After learning and performing a series of basic tasks, this AI was able to provide a linguistic description of them to a 'sister' AI, which in turn performed them.

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Spatial study of lung cancer reveals immune markers of response to immunotherapy

Broad Institute

Spatial study of lung cancer reveals immune markers of response to immunotherapy By Corie Lok March 20, 2024 Breadcrumb Home Spatial study of lung cancer reveals immune markers of response to immunotherapy Researchers visualize how immune cells are spatially organized within tumors and show that certain immune “hubs” are linked to better treatment responses.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Achieving New Heights in Healthcare Marketing With Salesforce Marketing Cloud Personalization

Perficient: Drug Development

In December 2022, the Department of Health and Human Services released a bulletin announcing additional compliance requirements for healthcare marketers when it comes to third-party trackers. The guidance lays forth expectations for how healthcare organizations collect data on activities that take place on their website and mobile apps. So, what’s the problem?

Marketing 122
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Vector Space Biosciences: Leading Innovation in Space Medicine with AI

DrugBank

Space biosciences are on the verge of becoming one of the largest total addressable markets to ever exist, opening up vast opportunities for economic growth and scientific discovery.  In the realm of space exploration, one critical yet often overlooked aspect is the impact of space conditions on human health. The goal of sending humans to space for increasingly longer periods of time is contingent on our ability to ensure astronauts' health.

DNA 117
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Madrigal wins FDA approval of first drug for MASH

BioPharma Drive: Drug Pricing

Rezdiffra’s clearance is a turning point in the fight against the liver disease. But its sales potential is unclear, and competition could emerge from popular weight loss drugs.

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Measles Outbreaks Have CDC Tweaking Travel Guidelines

Drugs.com

MONDAY, March 18, 2024 -- As millions of Americans prepare to travel abroad this summer and measles outbreaks increase worldwide, the U.S. Centers for Disease Control and Prevention has tightened its guidance on how travelers should handle the.

Disease 124
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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James Webb Space Telescope captures the end of planet formation

Science Daily: Pharmacology News

How much time do planets have to form from a swirling disk of gas and dust around a star? A new study gives scientists a better idea of how our own solar system came to be.

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Study reveals genetic clusters that may explain differences in type 2 diabetes risk

Broad Institute

Study reveals genetic clusters that may explain differences in type 2 diabetes risk By Corie Lok March 8, 2024 Breadcrumb Home Study reveals genetic clusters that may explain differences in type 2 diabetes risk The clusters point to a range of biological processes that likely contribute to the development of type 2 diabetes. By Brandon Chase, Massachusetts General Hospital Communications March 8, 2024 Related content Largest and most diverse genome-wide association study of type 2 diabetes revea

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What do volunteers for research studies do after finding a trial?

Antidote

For many people, participating in a research study presents an interesting opportunity with many benefits to volunteering. While there are many types of clinical research, all with distinct goals and timelines, trial volunteers will follow a similar path when taking part. Read on to learn more about the process.

Trials 119
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It’s Time To Update Your Data Lake Ingestion Strategy

Perficient: Drug Development

If you built your data lake in the last 5-7 years, you probably are ingesting data into the data lake using many batch jobs that ingest and update data in the data lake. There is nothing wrong with what you did, but data technology has continued to move forward and in my opinion, the time has come to change your data lake ingestion strategy to reduce the number of high-latency batch jobs and move toward primarily using real-time change data capture (CDC).

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Biotech stock fundings headed for best quarter in 3 years, Jefferies says

BioPharma Drive: Drug Pricing

Publicly traded companies raised nearly $10 billion in follow-on stock offerings in January and February, a financing surge that’s driving a “sector recovery,” the investment bank said.

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High-Strength Lidocaine Skin Creams Can Cause Seizures, Heart Trouble, FDA Warns

Drugs.com

FRIDAY, March 29, 2024 -- Some pain-relieving skin products contain potentially harmful doses of the numbing agent lidocaine and should be avoided, the U.S. Food and Drug Administration warns.These creams, gels, sprays and soaps are marketed for.

FDA 119
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Robot, can you say 'cheese'?

Science Daily: Pharmacology News

What would you do if you walked up to a robot with a human-like head and it smiled at you first? You'd likely smile back and perhaps feel the two of you were genuinely interacting. But how does a robot know how to do this? Or a better question, how does it know to get you to smile back?

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#WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers

Broad Institute

#WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers By Leah Eisenstadt March 25, 2024 Breadcrumb Home #WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers Alex Navarro draws from her scientific and personal experiences to guide young researchers toward their professional goals in the Broad’s post-baccalaureate program.

Science 111
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Antidote anecdotes: A conversation with an MS care partner

Antidote

MS is a chronic disease that is estimated to impact over a million Americans. The condition causes damage to the body’s central nervous system, leading to numbness, memory problems, sight issues, and difficulties with coordination.

Disease 116
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Perficient Included in Forrester’s The Adobe Services Landscape

Perficient: Drug Development

In a dynamic digital landscape, choosing the right provider among the Adobe services landscape is paramount for businesses seeking to maximize their Adobe investments. The selection process can be daunting with a diverse set of providers that vary by size, type of offering, geography, and business scenario differentiation. So where do marketing leaders start?

Marketing 115
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Madrigal, FDA approval in hand, outlines plan to sell MASH drug

BioPharma Drive: Drug Pricing

The company expects initial uptake of Rezdiffra, which costs $47,400 per year, to be slow as doctors and insurers establish the protocols needed to find patients eligible for treatment.

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CDC Warns of Spike in Bacterial Illness That Can Cause Meningitis

Drugs.com

FRIDAY, March 29, 2024 -- There has been a troubling rise in cases of a rare bacterial illness that can cause meningitis, U.S. health officials warned Thursday.In an alert issued to doctors, the U.S. Centers for Disease Control and Prevention said.

Doctors 119
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Persian plateau unveiled as crucial hub for early human migration out of Africa

Science Daily: Pharmacology News

A new study combining genetic, palaeoecological, and archaeological evidence has unveiled the Persian Plateau as a pivotal geographic location serving as a hub for Homo sapiens during the early stages of their migration out of Africa. It highlights the period between 70,000 to 45,000 years ago when human populations did not uniformly spread across Eurasia, leaving a gap in our understanding of their whereabouts during this time frame.

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Women in STEM with Delphine Guyon-Gellin

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? DGG: I started my journey in STEM as a strategic consultant with various global pharmaceutical groups, working to solve specific strategic questions and being fully focused on one critical topic for a short time. After 10 years of supporting other teams, I wanted to become a full-time member and focus on using my analytic skills on a specific story that I believed in.

Vaccine 110
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7 things to know about multiple sclerosis

Antidote

Receiving a multiple sclerosis (MS) diagnosis can feel overwhelming and isolating for many. MS is a neurodegenerative disease that often involves challenging symptoms — but knowing what to expect and what resources are available can help.

Disease 116
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Why You Want To Use Looker Studio For Data Visualization on BigQuery

Perficient: Drug Development

If you have built or are building a Data Lake on the Google Cloud Platform (GCP) and BigQuery you already know that BigQuery is a fully managed enterprise data warehouse that helps you manage and analyze your data with built-in features like machine learning, geospatial analysis, and business intelligence. BigQuery’s serverless architecture lets you use SQL queries to answer your organization’s biggest questions with zero infrastructure management.

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After surprise trial failure, ALS doctors brace for one less treatment option

BioPharma Drive: Drug Pricing

Physicians are preparing for tough conversations with patients on Amylyx Pharmaceuticals’ drug, Relyvrio, while holding out hope it still may help some with the disease.

Doctors 120
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Carcinogen Benzene Can Form in Some Acne Treatments: Report

Drugs.com

THURSDAY, March 7, 2024 -- Some acne treatments may may banish blemishes but carry hidden dangers: A new report reveals high levels of the carcinogen benzene can form in products that contain the zit-fighting ingredient benzoyl peroxide.According.

Treatment 122
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Risk factors for faster aging in the brain revealed in new study

Science Daily: Pharmacology News

Researchers have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.

Research 128
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Ubiquitous pyrogens and 3D cancer models

Drug Target Review

A collaboration between the University of Twente in the Netherlands and Rousselot has revealed the dynamics between biomaterial purity and the fidelity of 3D cancer models. Their joint study illuminated the profound impact of endotoxins on the accuracy and efficacy of these models, marking a significant breakthrough in cancer research. Through experimentation, contrasting research-grade gelatine, inherently infused with endotoxins, with an ultra-low endotoxin-level gelatine, they revealed that t