Drug Discovery World

FEBRUARY 12, 2024

DDW’s Megan Thomas spoke to experts from the drug discovery industry about their predictions on what 2024 holds for our sector. This is part of a series of predictions based on different themes. Here, experts weigh in on the impact of artificial intelligence (AI), machine learning (ML) and automation in the sector. Updesh Dosanjh, Practice Leader for Pharmacovigilance Technology Solutions, IQVIA “In 2024, the traditional pain points of the pharmacovigilance (PV) space will not disappear.

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Broad Institute

JULY 10, 2024

Prime editing efficiently corrects cystic fibrosis mutation in human lung cells By Allessandra DiCorato July 10, 2024 Breadcrumb Home Prime editing efficiently corrects cystic fibrosis mutation in human lung cells The approach targets the most common genetic cause of the disease and could enable a one-time treatment as effective as existing daily therapies.

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Science Daily: Pharmacology News

JULY 17, 2024

Have you ever wondered how insects are able to go so far beyond their home and still find their way? The answer to this question is not only relevant to biology but also to making the AI for tiny, autonomous robots. Drone-researchers felt inspired by biological findings on how ants visually recognize their environment and combine it with counting their steps in order to get safely back home.

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BioPharma Drive: Drug Pricing

JUNE 27, 2024

A growing cohort of biotechs, from Biohaven to Neurocrine to Jazz, hope research on ion channels will bring them new drugs and big business — much like it has done for Vertex.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

MARCH 6, 2024

WEDNESDAY, March 6, 2024 -- The U.S. Food and Drug Administration issued a health advisory Wednesday warning consumers that six brands of ground cinnamon are tainted with lead. The FDA urged folks to throw away and not buy the following brands of.

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National Institute on Drug Abuse: Nora's Blog

FEBRUARY 1, 2024

50 years after founding, NIDA urges following science to move beyond stigma area Thu, 02/01/2024 - 11:20 Nora's Blog February 1, 2024 Image NIDA Image In 2024, NIDA celebrates its 50th anniversary. On May 14, 1974, an act of Congress established the National Institute on Drug Abuse (NIDA), and since then NIDA has led the world in funding and conducting research on drug use and addiction.

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Perficient: Drug Development

JULY 25, 2024

“Double, double toil and trouble,” is a line repeated by the witches in Macbeth as they lay out the ominous prophecies of greatness and dire consequences for the titular character. Macbeth’s ambition envisions a perfect ending though desperate actions and moral weakness ruin it. So too are the misguided actions in pursuit of perfection which can set expectations and pressure that lead to unwanted results.

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LifeSciVC

JANUARY 16, 2024

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Just in time for new years’ reflections and resolutions, this year’s JPM felt like a refreshing burst of enthusiasm for a sector that has seen its challenges in 2022 and 2023 but also some green shoots. 2023 was a stellar year for M&A, comeback stories, burgeoning “hot” spaces, and for re-learning the basics of belt-tightening and careful capital allocation.

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Nvidia Developer: Drug Discovery

FEBRUARY 28, 2024

Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep. Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep learning–based computational methods have been emerging and have shown promising results.

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Practical Cheminformatics

JANUARY 16, 2024

Following up on Part I and Part II, the third post in this series is a collection of review articles published in 2023 that I found helpful.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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DrugBaron

FEBRUARY 16, 2024

“There is more than one way to skin a cat” is a rather gruesome British idiom, but its sentiment surely applies to running a successful pharmaceutical portfolio. It is now more than a decade since Francesco De Rubertis, together with Kevin Johnson and Michele Olier, coined the term “asset-centric” investing to describe the approach to portfolio creation that still underpins the strategy at Medicxi.

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Broad Institute

JUNE 14, 2024

Some CRISPR screens may be missing cancer drug targets By Allessandra DiCorato June 14, 2024 Breadcrumb Home Some CRISPR screens may be missing cancer drug targets Current CRISPR guides don’t work equally well in cells from people of all ancestries, which could lead to false negative results. By Allessandra DiCorato June 14, 2024 Credit: Ricardo Job-Reese, Broad Communications CRISPR/Cas9 gene editing has made possible a multitude of biomedical experiments including studies that systematically t

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Science Daily: Pharmacology News

JULY 3, 2024

Scientists have created an anode-free sodium solid-state battery. This brings the reality of inexpensive, fast-charging, high-capacity batteries for electric vehicles and grid storage closer than ever.

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BioPharma Drive: Drug Pricing

JUNE 17, 2024

One expert described trial results presented at EULAR last week as “unprecedented.” But reports of relapses in some patients drew questions about the therapies’ ultimate potential.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 -- Clostridioides difficile (C. difficile) is a leading cause of illness and death, especially for frail and hospitalized Americans. Now, a new study suggests that the leading antibiotic used to fight it, vancomycin, may be.

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Codon

JULY 14, 2024

Dr. Keith Neeves gives a history of blood transfusions and explains why it will be difficult to scale up the creation of synthetic blood for Issue 03 of Asimov Press. We are mostly blood. Of the 36 trillion cells in the human body, 32 trillion are blood cells. These blood cells synchronize the delivery of oxygen to every tissue in your body, fight pathogens, and heal wounds.

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Drug Discovery World

JULY 18, 2024

Scientists have discovered that ‘switching off’ protein interleukin 11 (IL-11) can significantly increase the healthy lifespan of mice by almost 25%. The scientists at the Medical Research Council Laboratory of Medical Science (MRC LMS) and Imperial College London, working with colleagues at Duke-NUS Medical School in Singapore, created mice that had the gene producing IL-11 deleted.

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Broad Institute

JUNE 18, 2024

Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus. By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips an

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Science Daily: Pharmacology News

JULY 1, 2024

Computer scientists have invented a camera mechanism that improves how robots see and react to the world around them. Inspired by how the human eye works, their innovative camera system mimics the tiny involuntary movements used by the eye to maintain clear and stable vision over time.

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Science Daily: Pharmacology News

JULY 22, 2024

Large language models may pass medical exams with flying colors but using them for diagnoses would currently be grossly negligent. Medical chatbots make hasty diagnoses, do not adhere to guidelines, and would put patients' lives at risk. A team has systematically investigated whether this form of artificial intelligence (AI) would be suitable for everyday clinical practice.

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BioPharma Drive: Drug Pricing

JULY 18, 2024

The offering comes days after the publication of a paper showing what analysts said was early proof that “off-the-shelf” cell therapies can treat inflammatory diseases.

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Science Daily: Pharmacology News

MAY 15, 2024

It's one thing to dream up a quantum internet that could send hacker-proof information around the world via photons superimposed in different quantum states. It's quite another to physically show it's possible. That's exactly what physicists have done, using existing Boston-area telecommunication fiber, in a demonstration of the world's longest fiber distance between two quantum memory nodes to date.

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Science Daily: Pharmacology News

JUNE 4, 2024

Have you ever wished you could understand what your dog is trying to say to you? Researchers are exploring the possibilities of AI, developing tools that can identify whether a dog's bark conveys playfulness or aggression.

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Science Daily: Pharmacology News

JULY 10, 2024

Engineers have developed a new soft, flexible device that makes robots move by expanding and contracting -- just like a human muscle. To demonstrate their new device, called an actuator, the researchers used it to create a cylindrical, worm-like soft robot and an artificial bicep. In experiments, the cylindrical soft robot navigated the tight, hairpin curves of a narrow pipe-like environment, and the bicep was able to lift a 500-gram weight 5,000 times in a row without failing.

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Broad Institute

APRIL 2, 2024

Scientists link certain gut bacteria to lower heart disease risk By Allessandra DiCorato April 2, 2024 Breadcrumb Home Scientists link certain gut bacteria to lower heart disease risk Study finds several species of cholesterol-metabolizing bacteria in people with lower cholesterol levels. By Allessandra DiCorato April 2, 2024 Credit: Ahmed Mohamed Rod-shaped Oscillibacter sp. bacteria take up fluorescently labeled cholesterol (here shown in green).

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Science Daily: Pharmacology News

APRIL 11, 2024

New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.

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Science Daily: Pharmacology News

JULY 22, 2024

Dogs experience emotional contagion from the smell of human stress, leading them to make more 'pessimistic' choices, new research finds. Researchers tested how human stress odors affect dogs' learning and emotional state.

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Science Daily: Pharmacology News

MAY 6, 2024

About 79% of clinical trial participants experienced measurable improvement after receiving experimental, CRISPR-based gene editing that is designed to fix a rare form of blindness, according to a new article.

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Science Daily: Pharmacology News

JULY 8, 2024

You look up into the clear blue sky and see something you can't quite identify. Is it a balloon? A plane? A UFO? You're curious, right? A research team has for the first time witnessed what is happening in the human brain when feelings of curiosity like this arise. The scientists revealed brain areas that appear to assess the degree of uncertainty in visually ambiguous situations, giving rise to subjective feelings of curiosity.

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BioPharma Drive: Drug Pricing

MAY 16, 2024

The biotech, tentatively named Hercules CM Newco, has rights to three incretin drugs discovered by Jiangsu Hengrui Pharmaceuticals, two of which are in clinical testing.

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Science Daily: Pharmacology News

JULY 3, 2024

Meet Gaiasia jennyae, the swamp creature with a toilet seat-shaped head. It lived 40 million years before the first dinosaurs, and it was the top predator in its ecosystem.

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Science Daily: Pharmacology News

FEBRUARY 8, 2024

Researchers have uncovered the first direct evidence that the West Antarctic Ice Sheet shrunk suddenly and dramatically at the end of the Last Ice Age, around eight thousand years ago. The evidence, contained within an ice core, shows that in one location the ice sheet thinned by 450 meters -- that's more than the height of the Empire State Building -- in just under 200 years.

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Science Daily: Pharmacology News

MAY 1, 2024

The health benefits of exercise are well known but new research shows that the body's response to exercise is more complex and far-reaching than previously thought. In a study on rats, a team of scientists has found that physical activity causes many cellular and molecular changes in all 19 of the organs they studied in the animals.

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BioPharma Drive: Drug Pricing

JUNE 21, 2024

Peter Marks’ decision to override the objections of agency staff and broaden use of Elevidys could have a “lasting impact” on gene therapy as well as the FDA, one analyst wrote.

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