Science Daily: Pharmacology News

DECEMBER 13, 2023

In a study of historic scale, scientists have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing.

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SCIENMAG: Medicine & Health

JULY 6, 2023

In a new study, National Institutes of Health (NIH) researchers found that altered B cell function in children with mitochondrial disorders led to a weaker and less diverse antibody response to viral infections.

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Drug Discovery World

MAY 15, 2024

For example, the new vaccine does not include the SARS-CoV-1 coronavirus, which caused the 2003 SARS outbreak, yet it still induces an immune response to that virus. Multiple antigens are included in these chains, which trains the immune system to target specific regions shared across a broad range of coronaviruses.

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The Pharma Data

AUGUST 16, 2021

Better activation of innate and adaptive immune responses was achieved with CV2CoV, resulting in faster response onset, higher titers of antibodies, and stronger memory B and T cell activation as compared to the first-generation candidate, CVnCoV. “In Induction of innate immunity was investigated via specific cytokine markers.

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Drug Discovery World

MAY 2, 2024

For this study, researchers used a Covid-19 CHIM to measure what kind of immune responses stop people who have been previously infected and/or vaccinated from being infected again. The data from this COVCHIM01 study showed durable immunity post-infection/vaccination against the original Covid-19 virus.

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SCIENMAG: Medicine & Health

OCTOBER 2, 2023

Osaka, Japan – Memory B cells depend on autophagy for their survival, but the protein Rubicon is thought to hinder this process. Researchers from Osaka University have discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells.

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Drug Discovery World

JANUARY 16, 2024

This important new study will help us to see whether giving BCG more than once stimulates a stronger immune response and whether giving it by inhalation is better than giving it into the skin. People with type 2 diabetes are more likely to get TB and part of this may be because the BCG vaccine does not work as well in this group.

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The Pharma Data

SEPTEMBER 10, 2020

Pfizer-BioNTech announced Wednesday that preliminary preclinical data from mouse and macaque monkey models showed a strong immune response from its mRNA COVID-19 vaccine. . Photo by Md. Tareq Aziz Touhid.

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The Pharma Data

NOVEMBER 10, 2020

Canadian biopharmaceutical company Medicago has announced that its investigational COVID-19 vaccine generated “significant antibody and cellular immune responses” after two doses in all subjects in an early-stage clinical trial. The interim analysis from the phase 1 trial has been published online at the preprint server, medRxiv.

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Drug Discovery World

APRIL 9, 2024

A study by researchers at the UCLA Health Jonsson Comprehensive Cancer Center in the US suggests that injecting engineered dendritic cells directly into cancerous lung tumours can help promote a stronger immune response. Additionally, they observed that this therapy helped to establish a long-lasting immune response against the cancer.

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Plenge Gen

APRIL 7, 2020

Here, I focus on a specific clinical inflection point in COVID-19 disease progression – hospitalized patients early in their disease course and with signs of a maladaptive immune response, with the intervention intended to prevent disease progression and admission to the ICU. appeared first on Plenge Gen @rplenge.

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The Pharma Data

JULY 29, 2021

Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Kumquat Biosciences today announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses.

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Drug Discovery World

FEBRUARY 24, 2023

Importantly, HTI vaccines were highly immunogenic in a simpler regimen than in the previous AELIX-002 study, and the vaccine-induced responses were associated with higher time off ART, supporting the contribution of the HTI vaccines to better viral control.

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Drug Discovery World

MARCH 4, 2024

In an early phase clinical trial, a combination of antibody-based medications targeting the immune system generated promising safety data and anti-tumour activity in individuals with advanced cancer. Both medications tested in the trial support immune responses against tumour cells.

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Drugs.com

APRIL 12, 2024

FRIDAY, April 12, 2024 -- A chlamydia vaccine has triggered immune responses in an early trial, raising hopes that one day it might help curb the spread of the sexually transmitted infection (STI).There There is currently no vaccine for chlamydia, which.

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Drug Discovery World

FEBRUARY 19, 2024

At all assessed doses, RBI-4000 was well-tolerated and achieved a strong immune response, with protective virus-neutralising antibody titers above the World Health Organization (WHO)-defined immune surrogate level of protection against the rabies virus.

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Broad Institute

MARCH 20, 2024

doi: 10.1038/s41590-024-01792-2 (2024) Scientists used a microscope to visualize an immunity hub (yellow and green) in human lung tumor tissue (blue). Networks of cells are critical in mediating immune responses. How do immune cells organize within tumors to effectively eliminate cancer cells? Nature Immunology.

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Science Daily: Pharmacology News

APRIL 29, 2024

The first study of the use of microarray patches to vaccinate children has shown that the method is safe and induces strong immune responses.

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Drug Discovery World

JANUARY 12, 2024

Researchers in the US have discovered that a type of immune cell in the human body known to be important for allergy and other immune responses can also attack cancer.

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Drug Discovery World

JULY 12, 2023

However, drugs that reduce inflammation by suppressing the whole immune response also inhibit the immune cells which promote repair. The University of Edinburgh-led study tested multiple drugs in zebrafish larvae for their ability to prevent excessive inflammation during an immune response.

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Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- The nose appears to know when it comes to why children typically have milder cases of COVID-19 than seniors, a new study finds.Cells lining the inside of the nose are more likely to have a prompt immune response to COVID.

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Drug Discovery World

AUGUST 3, 2023

The vaccine demonstrated a strong immune response, and the most common side effects were mild, and self-resolved within a few days of vaccination. Decisions on which Covid-19 vaccines are deployed in the UK are taken by the Joint Committee on Vaccination and Immunisation (JCVI).

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Drug Discovery World

FEBRUARY 20, 2024

Licensing for human use Adjuvants are components of vaccines that help to enhance the magnitude, breadth, and duration of the immune response to vaccination.

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SCIENMAG: Medicine & Health

FEBRUARY 2, 2024

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in “Science Immunology.” Credit: Elijah D.

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Drug Discovery World

MAY 6, 2024

However, some B cell responses were seen across many or all tumour sites, suggesting that they are seeking out cancer cells at different sites.

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Drug Discovery World

MARCH 8, 2024

Earlier this year, Alamar launched the ARGO HT System and the NULISAseq Inflammation Panel 250 for deep profiling of immune response. In July 2022 the company announced a partnership with Abcam to further their understanding of the human proteome.

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Drug Discovery World

AUGUST 16, 2022

Known as a bivalent vaccine, Spikevax was approved following data that show it triggers a strong immune response against both Omicron (BA.1) The booster dose was also found to generate a good immune response against the Omicron sub-variants BA.4 1) and the original 2020 strain 1. . ” .

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Drug Discovery World

APRIL 11, 2024

We have noted that cancer patients can develop powerful anti-tumour immune responses that can result in complete cure of the disease and we call these patients ‘elite responders’. By understanding what triggers the adaptive immune response in “elite responders” we have identified new targets and therapeutic antibodies.

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Drug Discovery World

SEPTEMBER 15, 2023

Replicate’s srRNA technology offers the potential for more robust and durable immune responses, and improved tolerability at lower doses than existing mRNA approaches,” said Zelanna Goldberg, CMO of Replicate. “In The Phase I trial will evaluate the safety, tolerability, and immunogenicity of RBI-4000 in 84 participants in the US.

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Drug Target Review

JANUARY 23, 2024

Individualised cancer vaccines are tailored to each patient’s tumour, helping the immune system mount cancer-specific immune responses that can boost checkpoint inhibitor efficacy. Espen integrates clinical and research expertise as Director of Medical Affairs.

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addgene Blog

FEBRUARY 22, 2024

Join Abi as they explain what antibodies are, their role in the immune response, and the different antibody isotypes found in mammals. Ready to learn about antibodies? Our latest animation is here to help!

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Drug Discovery World

APRIL 12, 2024

The top stories: Genetically engineered dendritic cells enhance lung cancer therapy A study by researchers at the UCLA Health Jonsson Comprehensive Cancer Center in the US suggests that injecting engineered dendritic cells directly into cancerous lung tumours can help promote a stronger immune response.

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Drug Discovery World

DECEMBER 16, 2022

STC-15 triggers both direct cytotoxic and immune response-based efficacy mechanisms in solid tumour and leukaemia models. Storm recently presented preclinical data at the 34th EORTC-NCI-AACR and SITC meetings, demonstrating blockade of METTL3 and effects on the innate immune response. . .

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Drugs.com

SEPTEMBER 14, 2023

14, 2023 -- An oral vaccine for COVID-19 appears to produce the sort of immune response that could quickly stamp out a developing infection, according to results from a small-scale primate study. THURSDAY, Sept. Some monkeys given an experimental.

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Drug Discovery World

MARCH 30, 2023

Anupama Mishra, Pharma Analyst at GlobalData, commented: “Vaccine-based immune responses have already been explored for the development of preventive vaccines for infectious diseases, but in oncology, the stimulation of a tumour-specific immune response is a novel concept.

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Drug Target Review

MARCH 1, 2024

This antigen-spreading is critical to long-term protection because tumour often develop with inconsistent antigen expression – equipping the immune response to target many diverse tumour antigens may allow for more complete anti-tumour activity.

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BioPharma Drive: Drug Pricing

OCTOBER 24, 2023

Rampart Biosciences closed a Series A round that will fund its goal to develop more potent DNA-based medicines that avoid immune responses.

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