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The plant virus that trains your immune system to kill cancer

Science Daily: Pharmacology News

Unlike other plant viruses, the cowpea mosaic virus (CPMV) can awaken the human immune system and transform it into a cancer-fighting powerhouse, without infecting human cells.

Virus 269
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One shot to stop HIV: MIT's bold vaccine breakthrough

Science Daily: Pharmacology News

Researchers from MIT and Scripps have unveiled a promising new HIV vaccine approach that generates a powerful immune response with just one dose. By combining two immune-boosting adjuvants alum and SMNP the vaccine lingers in lymph nodes for nearly a month, encouraging the body to produce a vast array of antibodies.

Vaccine 229
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Scientists engineer CRISPR enzymes that evade the immune system

Broad Institute

Researchers at the Broad Institute of MIT and Harvard and Cyrus Biotechnology have now engineered two CRISPR nucleases, Cas9 and Cas12, to mask them from the immune system. The team identified protein sequences on each nuclease that trigger the immune system and used computational modeling to design new versions that evade immune recognition.

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Designing antibodies to think before they bind

Drug Target Review

By designing the antibody to activate CD137 only in the presence of p95HER2, the team created a more controlled immune response and reduced the risk of off-target effects. This approach not only reduces the risk of CRS but also changes how immune engagement is defined.

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The future of CNS drug development: signs of real progress

Drug Target Review

Due to off-target effects, tissue accumulation and immune responses, ASOs face significant challenges, especially for preclinical safety assessments. However, they face challenges in surviving the hostile CNS environment, integrating into existing neural circuits and avoiding immune responses; but they are rich in potential.

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Design and Development of Novel Hybrids Based on Pyrrolo[2,1‐f][1,2,4]Triazine and 1‐(Methylpiperidin‐4‐yl) Aniline–Based Analogs: Exploring the Utility as Anticancer Agents via MERTK Inhibition

Chemical Biology and Drug Design

It plays a key role in cancer cell survival and proliferation and regulates immune responses in cancer. ABSTRACT Mer-tyrosine kinase (MERTK), a member of the AXL, TYRO3, and MERTK (TAM) family, is one of the promising targets for cancer treatment.

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Design, Synthesis, and Biological Evaluation of Aryl Pyrazolopyrimidines as Toll‐Like Receptor 7 Agonists

Chemical Biology and Drug Design

A pyrazolopyrimidine, 2-((4-methoxyphenyl)amino)-7-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile exhibits TLR7 agonistic activity and stimulates an innate immune response in RAW264.7 These findings suggest that the title compound acts as a TLR7 agonist and enhances the innate immune response. macrophages.