Drug Patent Watch

DECEMBER 9, 2024

Additionally, the immunogenicity of biosimilars, which is the ability of the drug to trigger an immune response, can be highly variable and impact the safety and efficacy of the drug.

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Biosimilars Clinical Trials Immune Response Trials 89

Drug Target Review

JUNE 16, 2025

Moreover, GPCRs have a complex pharmacology, with each acting as a kind of signalling hub for an array of downstream signals, in contrast to simpler receptors which are generally responsible for one signal.

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Disease Therapies Small Molecule Immune Response 59

Drug Target Review

NOVEMBER 11, 2024

This is partly because cancer cells are shrewd and often develop ways to evade immune detection. An important puzzle to solve is how to mount a good immune response in types of cancer with poor T-cell infiltration, or deficiencies in T-cell priming, and associated unresponsiveness to established immunotherapies.

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Immune Response Treatment International Doctors 52

Drug Target Review

MAY 23, 2025

As the biotech sector races to improve the tolerability of these revolutionary treatments, Poolbeg Pharma has a novel solution: an oral therapy, POLB 001, to block the development of CRS, by limiting inflammation without affecting the anti-cancer immune responses that are vital for effective immunotherapies.

Immune Response 52

Immune Response Therapies Treatment Clinical Trials 52

Alta Sciences

FEBRUARY 19, 2025

These interactions may disrupt protein function, trigger immune responses, or contribute to other toxicological risks. to ligands or linkers) may elicit immune responses. Immunogenicity: While oligonucleotides are typically non-immunogenic, modifications or conjugations (e.g.,

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Drug Development Clinical Pharmacology Immune Response Drugs 52

Drug Target Review

JULY 18, 2025

These CCR8+ Tregs are known to suppress immune responses in the tumour microenvironment (TME), allowing cancers to grow unchecked. “DT-7012 DT-7012: targeting Tregs where it matters most DT-7012 is Domain’s Treg depleting anti-CCR8 monoclonal antibody designed to deplete tumour-infiltrating regulatory T cells (Tregs).

Medical Chemistry 52

Medical Chemistry Small Molecule Therapies Clinical Development 52

Broad Institute

MAY 21, 2025

He showed that these synthetic CAR T cells could launch an immune response when they encountered the corresponding tumor protein, called CD19. That ability to stick around, which is critical for attacking cancer over time, was another turning point.

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Therapies FDA Approval Engineering Immune Response 119

keypoint

JULY 17, 2025

She works in the Institute of Virology, where she characterizes HIV-specific T cell responses in people living with HIV, and endometrial immune responses in the context of infectious diseases and infertility. Andrew is a postdoctoral scholar at the UCSF Gladstone Institutes, where she studies HIV in the lab of Dr. Nadia Roan.

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Immune Response Disease Therapies Research 94

Conversations in Drug Development Trends

OCTOBER 14, 2024

Scientists now use cutting-edge techniques, including biological therapies that target specific immune system components and precision medicine approaches that personalize treatment plans based on a patient’s genetic profile.

Research 52

Research Clinical Trials Therapies Immune Response 52

SugarCone Biotech

MARCH 24, 2025

These agents simultaneously bind to a tumor-associated protein on cancer cells and the CD3 protein on T-cells, facilitating a targeted anti-cancer immune response. Today, however, we turn to the TCE therapeutic class. Both explanations are plausible, but the relevant clinical data are limited.

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Immune Response Therapies Treatment Disease 64

The Pharma Data

JUNE 15, 2025

This independent expert panel will aid in evaluating a new, enhanced immunosuppressive regimen meant to help ease the body’s adaptive immune response — a process suspected to contribute to the elevated liver enzyme abnormalities and related events that have been observed in a small number of patients following treatment with AAV-based gene therapy.

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Immune Response Regulations Therapies Disease 40

Drug Target Review

APRIL 7, 2025

Involved in various physiological processes, such as vision, taste, smell, immune response and neurotransmission, GPCRs are activated by various molecules including hormones, neurotransmitters and environmental stimuli, which trigger a cascade of cellular events that help regulate bodily functions.

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Fragment Screening Drugs Biophysical Assays Small Molecule 52

The Pharma Data

JUNE 25, 2025

The compound is being studied as a next-generation precision immunotherapy , offering the potential to more effectively preserve transplanted organs by modulating specific immune responses rather than broadly suppressing the immune system.

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FDA FDA Approval Therapies Drugs 40

Alta Sciences

JULY 7, 2025

One important aspect of toxicity studies is determining whether the drug produces undesired immune effects. The focus is to ensure that the drug does not have any potential to induce an excessive immune response, particularly cytokine storm, which can lead to severe adverse effects and impede clinical development.

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Immune Response Drugs Therapies Drug Development 52

Drug Target Review

NOVEMBER 7, 2024

Agonist antibodies of immune checkpoint regulators These represent a groundbreaking class of immunotherapeutic agents that mimic the natural function of endogenous ligands by binding to specific cell-surface receptors. In these conditions, the goal of therapy is typically to suppress or mitigate immune activity.

Disease 52

Disease Immune Response Regulations Engineering 52

Drug Target Review

APRIL 18, 2025

Further investigation into the mechanism behind SenoVax revealed that CD8+ T, also known as cytotoxic T cells, are central to the immune response. The therapeutic effects of SenoVax in the lung model seem to be dependent on the type of T cell called CD8+ T cells.

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Therapies Disease Clinical Trials Treatment 66

The Pharma Data

JUNE 15, 2025

Elevidys utilizes adeno-associated virus vector technology, which is a powerful delivery platform but carries inherent risks related to the delivery process and the patient’s own immune response.

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Regulations Clinical Trials Trials Treatment 40

The Pharma Data

JUNE 9, 2025

Unlike traditional vaccines, Beyfortus does not require activation of the infant’s immune system to be effective. Instead, the monoclonal antibody immediately delivers passive immunity, offering rapid protection without the need for multiple doses or a waiting period for an immune response to develop.

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Virus Hospitals Vaccine Immune Response 40

Codon

NOVEMBER 3, 2024

If present before vaccination, memory immune cells primed to destroy the environmental relatives might cross-react with and neutralize the BCG strain before it has a chance to set up an immune response against itself and M. tuberculosis. A Peace Corps Volunteer administers the BCG vaccine to a six-year-old Korean boy.

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Vaccine Trials Therapies Treatment 113

Codon

JUNE 5, 2025

The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. Traditional approaches to this problem involve the use of viral vectors , which run the risk of triggering immune responses in patients. Collectively, these repeat-protospacer regions are known as CRISPR arrays.

DNA 81

DNA RNA Clinical Trials Engineering 81

Broad Institute

FEBRUARY 26, 2025

New findings from researchers at the Broad Institute of MIT and Harvard and the Dana-Farber Cancer Institute (DFCI) could help make immunotherapies for brain cancer more effective.

Immune Response 132

Immune Response Treatment RNA Clinical Trials 132

Drug Target Review

DECEMBER 4, 2024

The MC4R-based ConfoGen was used to immunize llamas, resulting in an immune response that generated a highly diverse panel of MC4R-specific agonists. Identification of the agonistic VHHs was accomplished using an immunogen known as a ConfoGen , which comprises a ConfoBody-stabilized chimeric version of the target GPCR.

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Small Molecule Pharmacokinetics Therapies Immune Response 123

The Open Targets Blog

JANUARY 30, 2025

For example, to find drugs associated with the human IL13 gene (Ensembl ID ENSG00000169194*), a cytokine that plays an important role in allergic inflammation and immune response to parasite infection, you can use: # Install gget !pip

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Bioinformatics Immune Response RNA Packaging 76

The Pharma Data

JUNE 12, 2025

An interim statistical analysis confirms that the candidate is meeting its pre-established criteria for immunogenicity — meaning it stimulates a strong and desirable immune response — in trial participants. Importantly, this is a strong indicator that the vaccine could be effective in protecting children against Shigella in the future.

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Licensing Licensing Vaccine Clinical Trials 40

Broad Institute

JUNE 25, 2025

The team thinks these cells and the collagen they produce could be responsible for making the stricture that contracts intestinal tissue. The team also uncovered neurons associated with Crohn’s that were embedded deep in the organ and had been difficult to detect previously with single-cell methods or in biopsy samples.

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Disease Medical Schools RNA Molecular Biology 111

PLOS: DNA Science

JULY 24, 2025

Although they got some meds to dampen their immune response to up the odds of the transplant taking, they didn’t get radiation or busulfan. A Trio of Brave Kids The three trial participants, all under 10, were of different racial/ethnic backgrounds and had different mutations.

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Treatment DNA Clinical Trials Trials 52

BioPharma Drive: Drug Pricing

JUNE 27, 2025

For some people with leukemia, lymphoma or multiple myeloma, they can prompt powerful responses and even long-lasting remission. But their administration also comes with notable risks, including a hyperactive immune response known as CRS and neurological toxicity dubbed ICANS.

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Therapies FDA Treatment Licensing 178

Perficient: Drug Development

APRIL 15, 2025

This pattern may relate to differences in immune response, organ-specific vulnerability, or patterns of healthcare utilization. Differential Immune Response: Women with Long COVID typically show higher levels of IL-6 compared to men, particularly those with central sensitization phenotypes.

Immune Response 52

Immune Response Treatment Therapies Research 52

Conversations in Drug Development Trends

OCTOBER 14, 2024

Scientists now use cutting-edge techniques, including biological therapies that target specific immune system components and precision medicine approaches that personalize treatment plans based on a patient’s genetic profile.

Research 59

Research Clinical Trials Therapies Immune Response 59

The Pharma Data

JUNE 12, 2025

Evidence shows that NUMELVI is at least 10-fold more selective for JAK1 than for the other JAK family members , which underpins its ability to ease pruritus without causing significant side effects related to hematopoietic dysfunction or a broad dampening of the immune response.

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Vaccine Immune Response Treatment Disease 40

PLOS: DNA Science

JUNE 12, 2025

The condition stems from a misdirected immune response to a substance – an allergen – that does not actually present a threat. About 100 million adults and 100 million children worldwide have the red, flaky, itchy skin of the most common form of eczema, atopic dermatitis, according to the NIH.

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DNA Immune Response Laboratories International 61

Science Daily: Pharmacology News

APRIL 28, 2025

Scientists have uncovered why vaccines can elicit a stronger immune response if they are administered in the same arm.

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Immune Response Vaccine Research 161

Science Daily: Pharmacology News

DECEMBER 13, 2023

In a study of historic scale, scientists have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing.

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Immune Response Government Disease Drugs 212

Science Daily: Pharmacology News

JULY 10, 2024

Scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and show that reversing this defect may potentially reverse the disease.

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Immune Response Disease 325

Drugs.com

SEPTEMBER 14, 2023

14, 2023 -- An oral vaccine for COVID-19 appears to produce the sort of immune response that could quickly stamp out a developing infection, according to results from a small-scale primate study. THURSDAY, Sept. Some monkeys given an experimental.

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Vaccine Immune Response 298

Science Daily: Pharmacology News

OCTOBER 17, 2024

difficile first-time infections and relapsing infections by inducing a robust immune response, promote clearance of existing C. diff bacteria from the gut, and even overcome deficits in host immunity to protect animals after infection, according to researchers. In animal models, this first mRNA-LNP C.

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Vaccine Immune Response Clinical Trials Trials 293

Drugs.com

APRIL 12, 2024

FRIDAY, April 12, 2024 -- A chlamydia vaccine has triggered immune responses in an early trial, raising hopes that one day it might help curb the spread of the sexually transmitted infection (STI).There There is currently no vaccine for chlamydia, which.

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Vaccine Trials Immune Response 289