Science Daily: Pharmacology News

JUNE 18, 2024

Tests, in mice, of a drug developed by the researchers showed that regulatory T cells can be attracted to specific body parts, boosted in number, and activated to suppress immune response and rebuild tissue.

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Treatment Immune Response Disease Clinical Trials 341

Science Daily: Pharmacology News

APRIL 3, 2025

A switch of just two weeks from a traditional African diet to a Western diet causes inflammation, reduces the immune response to pathogens, and activates processes associated with lifestyle diseases. This study highlights the significant impact of diet on the immune system and metabolism.

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Immune Response Disease 293

Science Daily: Pharmacology News

OCTOBER 24, 2024

A strain of the bacterium harbored in the children's gut microbial communities possessed a previously unknown gene capable of producing and metabolizing key molecules involved in regulating many important functions ranging from appetite, immune responses, neuronal function, and the ability of pathogenic bacteria to produce disease.

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Immune Response Regulations Disease Research 297

Science Daily: Pharmacology News

DECEMBER 19, 2024

Stitching together four molecules found in the standard flu vaccine ensures an immune response to all of them, scientists have shown.

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Vaccine Immune Response 265

Drugs.com

SEPTEMBER 14, 2023

14, 2023 -- An oral vaccine for COVID-19 appears to produce the sort of immune response that could quickly stamp out a developing infection, according to results from a small-scale primate study. THURSDAY, Sept. Some monkeys given an experimental.

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Vaccine Immune Response 299

Science Daily: Pharmacology News

APRIL 29, 2024

The first study of the use of microarray patches to vaccinate children has shown that the method is safe and induces strong immune responses.

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Vaccine Trials Immune Response 316

Drugs.com

APRIL 12, 2024

FRIDAY, April 12, 2024 -- A chlamydia vaccine has triggered immune responses in an early trial, raising hopes that one day it might help curb the spread of the sexually transmitted infection (STI).There There is currently no vaccine for chlamydia, which.

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Vaccine Trials Immune Response 290

Science Daily: Pharmacology News

MAY 15, 2025

Traditional approaches haven't worked -- largely because HIV mutates rapidly and hides key parts of itself from the immune system.

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Vaccine Trials Immune Response Clinical Trials 286

Drugs.com

OCTOBER 11, 2023

The phase 1 clinical trial showed that the product, administered nasally in two doses, delivered a significant immune response to. WEDNESDAY, Oct. 11, 2023 -- New research points to the potential of a COVID-19 vaccine delivered through the nose.

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Vaccine Trials Immune Response Clinical Trials 286

BioPharma Drive: Drug Pricing

OCTOBER 24, 2023

Rampart Biosciences closed a Series A round that will fund its goal to develop more potent DNA-based medicines that avoid immune responses.

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DNA Immune Response 272

SCIENMAG: Medicine & Health

DECEMBER 6, 2023

Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. Credit: Mike […]

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Immune Response Research 89

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

By adding synergistic self-adjuvanting properties to Covid-19 RNA vaccines, researchers showed they could significantly boost the immune response generated in mice.

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RNA Vaccine Engineering Immune Response 240

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- The nose appears to know when it comes to why children typically have milder cases of COVID-19 than seniors, a new study finds.Cells lining the inside of the nose are more likely to have a prompt immune response to COVID.

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Immune Response 246

Science Daily: Pharmacology News

OCTOBER 18, 2023

Immunotherapies, which mobilize the body's immune defenses against a cancer, have not been effective for GBM, in part because the tumor's surrounding environment is largely impenetrable to assaults from the body's immune system.

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Therapies Immune Response Research Virus 225

Chemical Biology and Drug Design

JANUARY 30, 2025

A pyrazolopyrimidine, 2-((4-methoxyphenyl)amino)-7-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile exhibits TLR7 agonistic activity and stimulates an innate immune response in RAW264.7 These findings suggest that the title compound acts as a TLR7 agonist and enhances the innate immune response. macrophages.

Immune Response 100

Immune Response Regulations Treatment Research 100

Science Daily: Pharmacology News

SEPTEMBER 29, 2023

Now, an article challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than 'clean' laboratory mice.

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Immune Response Laboratories 240

Science Daily: Pharmacology News

NOVEMBER 20, 2024

The most comprehensive map of the developing human thymus sheds light on how immune responses are built and maintained at early life, with implications for understanding and treating immunodeficiency, autoimmunity, and cancer.

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Immune Response 169

Chemical Biology and Drug Design

DECEMBER 5, 2024

It plays a key role in cancer cell survival and proliferation and regulates immune responses in cancer. ABSTRACT Mer-tyrosine kinase (MERTK), a member of the AXL, TYRO3, and MERTK (TAM) family, is one of the promising targets for cancer treatment.

Immune Response 100

Immune Response Pharmacokinetics Regulations Treatment 100

SCIENMAG: Medicine & Health

JULY 26, 2023

Key Takeaways Researchers have discovered that the NLRP11 protein plays critical roles in alerting the body to a bacterial infection and initiating an immune response against it NLRP11 is present in humans and other primates but absent in mice The discovery could enable the development of mouse models that are more similar to humans for […]

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Immune Response Research 65

Science Daily: Pharmacology News

JULY 12, 2023

The finding upends 40 years of conventional wisdom and may offer new insights into cancer, viral infections and immune responses. They hijack a little-known piece of the cell's DNA repair function to close themselves into a ring-like shape and then create a matching double strand.

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DNA Immune Response 189

SCIENMAG: Medicine & Health

JUNE 26, 2023

Scientists led by Sabine Taschner-Mandl, PhD, St. Anna Children’s Cancer Research Institute, and Nikolaus Fortelny, PhD, Paris Lodron University of Salzburg, are the first to analyze bone marrow metastases from childhood tumors of the nervous system using modern single-cell sequencing analysis.

Immune Response 89

Immune Response Research 89

Drugs.com

OCTOBER 25, 2024

25, 2024 -- Cutting certain foods from a child’s diet isn’t likely to improve their eczema symptoms, a new study finds.Eczema, also known as atopic dermatitis, results from an overactive immune response and has been linked to an inc. FRIDAY, Oct.

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Immune Response 147

The Pharma Data

OCTOBER 26, 2020

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, elicited immune responses in older coronavirus patients similar to ones generated in younger adults, lending more promise to a vaccine that’s seen as one of the leading contenders in the race to become the first approved COVID-19 vaccine. Source link.

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Immune Response Vaccine Research 52

Drug Target Review

JULY 4, 2023

In the realm of immunology, researchers are constantly striving to unlock the intricate secrets of the human immune system. Among the many remarkable components that make up this complex defence network, T cells have emerged as powerful guardians, orchestrating an array of immune responses with great precision.

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Immune Response Engineering Treatment Therapies 52

SCIENMAG: Medicine & Health

JUNE 12, 2023

Peer-reviewed / Randomised Controlled Trial / People Study of healthy US adults found that a single dose of the VLA1553 vaccine candidate was generally safe, well tolerated and provokes an immune response.

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Immune Response Vaccine Trials Disease 66

The Pharma Data

OCTOBER 22, 2020

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, currently being evaluated in phase 3 global trials, delivers a strong immune response, according to a new UK study. Source link.

Immune Response 52

Immune Response Vaccine Trials Research 52

SCIENMAG: Medicine & Health

JULY 6, 2023

In a new study, National Institutes of Health (NIH) researchers found that altered B cell function in children with mitochondrial disorders led to a weaker and less diverse antibody response to viral infections.

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Immune Response Research 85

Drugs.com

JUNE 26, 2024

WEDNESDAY, June 26, 2024 -- The COVID virus, or rather people's immune response to it, has changed and it might be prudent to wait a couple days after symptoms start before taking a COVID test, researchers report.“For For COVID, we found that if you o.

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Immune Response Virus Research 130

The Pharma Data

DECEMBER 4, 2021

The first peer-reviewed study in North America examining the timing between the first and second doses of COVID-19 mRNA vaccines shows that a longer dose interval leads to a stronger immune response. The study is funded by the Government of Canada through its COVID-19 Immunity Task Force (CITF).

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Immune Response Vaccine Hospitals Laboratories 52

The Pharma Data

AUGUST 16, 2021

Better activation of innate and adaptive immune responses was achieved with CV2CoV, resulting in faster response onset, higher titers of antibodies, and stronger memory B and T cell activation as compared to the first-generation candidate, CVnCoV. “In Induction of innate immunity was investigated via specific cytokine markers.

Immune Response 52

Immune Response Vaccine Virus RNA 52

Plenge Gen

APRIL 7, 2020

Here, I focus on a specific clinical inflection point in COVID-19 disease progression – hospitalized patients early in their disease course and with signs of a maladaptive immune response, with the intervention intended to prevent disease progression and admission to the ICU. appeared first on Plenge Gen @rplenge.

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Immune Response Disease Clinical Trials Drugs 52

Drug Patent Watch

DECEMBER 9, 2024

Additionally, the immunogenicity of biosimilars, which is the ability of the drug to trigger an immune response, can be highly variable and impact the safety and efficacy of the drug.

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Biosimilars Clinical Trials Immune Response Trials 86

The Pharma Data

SEPTEMBER 10, 2020

Pfizer-BioNTech announced Wednesday that preliminary preclinical data from mouse and macaque monkey models showed a strong immune response from its mRNA COVID-19 vaccine. . Photo by Md. Tareq Aziz Touhid.

Immune Response 52

Immune Response Vaccine RNA Research 52

Drug Discovery Today

APRIL 5, 2022

Researchers delve into the inner workings of the antibody immune response, finding key differences in the metabolism of two closely related immune cell subsets.

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Immune Response Regulations Research 113

Drug Target Review

NOVEMBER 7, 2024

Agonist antibodies of immune checkpoint regulators These represent a groundbreaking class of immunotherapeutic agents that mimic the natural function of endogenous ligands by binding to specific cell-surface receptors. In these conditions, the goal of therapy is typically to suppress or mitigate immune activity.

Disease 52

Disease Immune Response Regulations Engineering 52

The Pharma Data

JULY 29, 2021

Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Kumquat Biosciences today announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses.

Small Molecule 52

Small Molecule Immune Response Research Laboratories Laboratories 52

Drug Discovery Today

APRIL 15, 2021

176 volunteers will participate in the clinical trial the safety and immune response read-outs expected in Q2 2021 First subjects dosed with AKS-452, COVID-19 vaccine candidate in the Netherlands trial the vaccine is shelf-stable for 4 months at 25 degrees Celsius (77° Fahrenheit).

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Clinical Trials Vaccine Trials Immune Response 113