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Left or right arm? New research reveals why vaccination site matters for immune response

Science Daily: Pharmacology News

Scientists have uncovered why vaccines can elicit a stronger immune response if they are administered in the same arm.

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Using next-gen CRISPR tool, scientists create unprecedented molecular map of human immune response

Science Daily: Pharmacology News

In a study of historic scale, scientists have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing.

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Scientists engineer CRISPR enzymes that evade the immune system

Broad Institute

Researchers at the Broad Institute of MIT and Harvard and Cyrus Biotechnology have now engineered two CRISPR nucleases, Cas9 and Cas12, to mask them from the immune system. The team identified protein sequences on each nuclease that trigger the immune system and used computational modeling to design new versions that evade immune recognition.

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Scientists discover a cause of lupus and a possible way to reverse it

Science Daily: Pharmacology News

Scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and show that reversing this defect may potentially reverse the disease.

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A dial for tuning the immune system: Discovery sheds light on why COVID makes some sicker than others

Science Daily: Pharmacology News

Researchers have discovered a protein variant that serves as a knob for regulating the body's innate immune response. The findings could lead to new therapies for Long COVID, autoimmune disorders, and more.

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New mRNA vaccine created to prevent and treat C. difficile

Science Daily: Pharmacology News

difficile first-time infections and relapsing infections by inducing a robust immune response, promote clearance of existing C. diff bacteria from the gut, and even overcome deficits in host immunity to protect animals after infection, according to researchers. In animal models, this first mRNA-LNP C.

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Cancer vaccine shows promise for patients with stage III and IV kidney cancer

Science Daily: Pharmacology News

Researchers report that all nine patients in a clinical trial being treated for stage III or IV clear cell renal cell carcinoma (a form of kidney cancer), generated a successful anti-cancer immune response after initiation of a personalized cancer vaccine.

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