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Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

SCIENMAG: Medicine & Health

Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. Credit: Mike […]

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Lycorine Suppresses Non‐Small‐Cell Lung Cancer Progression Through Activating STING Pathway and Stimulating an Antitumor Immune Response

Chemical Biology and Drug Design

Notably, LYD also exhibited antitumor activity in LLC mice and induced an antitumor immune response. More interestingly, LYD also significantly activated the STING pathway in NSCLC, inducing CXCL10 and CCL5 expression, which may help overcome immunotherapy resistance.

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Scientist discover protein required for an effective immune response to invading bacteria

SCIENMAG: Medicine & Health

Key Takeaways Researchers have discovered that the NLRP11 protein plays critical roles in alerting the body to a bacterial infection and initiating an immune response against it NLRP11 is present in humans and other primates but absent in mice The discovery could enable the development of mouse models that are more similar to humans for […]

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Childhood cancer: Vulnerability in the immune response against metastases discovered

SCIENMAG: Medicine & Health

Scientists led by Sabine Taschner-Mandl, PhD, St. Anna Children’s Cancer Research Institute, and Nikolaus Fortelny, PhD, Paris Lodron University of Salzburg, are the first to analyze bone marrow metastases from childhood tumors of the nervous system using modern single-cell sequencing analysis.

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Scientists engineer CRISPR enzymes that evade the immune system

Broad Institute

Researchers at the Broad Institute of MIT and Harvard and Cyrus Biotechnology have now engineered two CRISPR nucleases, Cas9 and Cas12, to mask them from the immune system. The team identified protein sequences on each nuclease that trigger the immune system and used computational modeling to design new versions that evade immune recognition.

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T cells’ vital role in boosting immune responses

Drug Target Review

In the realm of immunology, researchers are constantly striving to unlock the intricate secrets of the human immune system. Among the many remarkable components that make up this complex defence network, T cells have emerged as powerful guardians, orchestrating an array of immune responses with great precision.

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Using next-gen CRISPR tool, scientists create unprecedented molecular map of human immune response

Science Daily: Pharmacology News

In a study of historic scale, scientists have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing.