Broad Institute

AUGUST 16, 2023

Nuclear DNA influences variation in mitochondrial DNA By Allessandra DiCorato August 16, 2023 Breadcrumb Home Nuclear DNA influences variation in mitochondrial DNA Whole genomes from hundreds of thousands of people reveal new complexity in how the nuclear and mitochondrial genomes interact, which may influence how cells produce energy.

DNA 98

DNA Molecular Biology Disease Regulations 98

Science Daily: Pharmacology News

AUGUST 16, 2024

To better understand the timing of this replacement, researchers sequenced mitochondrial DNA from archaeological dogs. Previous scientific studies have indicated that North American dog lineages were replaced with European ones between 1492 and the present day.

DNA 124

DNA Research 124

Science Daily: Pharmacology News

JANUARY 19, 2024

The science team designed a turbine engineered from DNA that is powered by hydrodynamic flow inside a nanopore, a nanometer-sized hole in a membrane of solid-state silicon nitride. Scientists have created a working nanoscale electomotor.

DNA 120

DNA Engineering Science Research 120

Science Daily: Pharmacology News

MAY 22, 2024

New research has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.

DNA 125

DNA Research 125

Science Daily: Pharmacology News

AUGUST 29, 2024

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

DNA 120

DNA Research Treatment Disease 120

Science Daily: Pharmacology News

AUGUST 1, 2024

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies.

DNA 119

DNA 119

Science Daily: Pharmacology News

NOVEMBER 27, 2024

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.

DNA 118

DNA Virus Treatment Research 118

Chemical Biology and Drug Design

JANUARY 29, 2024

MGMT mRNA expression was significantly increased in CD138+ myeloma cells compared with their matched CD138-nontumorigenic cells and inhibition of MGMT by its specific inhibitor lomeguatrib in MM cells reduced DNA repair, cell viability, and S phase entry and increased DNA damage and apoptosis.

DNA 100

DNA Treatment Disease Research 100

PLOS: DNA Science

DECEMBER 14, 2023

“Meet Invisible Woods: a clean, refreshing scent revived from extinct flower DNA ,” beneath an image of “origin flower” Wendlandia angustifolia. • compare the DNA sequence to similar genes in other species. • tweak a lab-made copy of the DNA sequence using clues from other plant species.

DNA 119

DNA Production Science Disease 119

PLOS: DNA Science

AUGUST 17, 2023

The Maui firestorm was so vast and fast that most identification of human remains will come from bits of persisting DNA from mitochondria. MtDNA in Forensics and Genealogy Mitochondrial DNA (mtDNA) is used in forensics to match the tiniest bits of human remains to families. Mitochondrial DNA is also far more abundant than nuclear DNA.

DNA 96

DNA Disease Science Research 96

Science Daily: Pharmacology News

NOVEMBER 19, 2024

Leveraging a unique statistical analysis and applying it to ancient DNA extracted from human skeletal remains, a team of researchers has revealed new insights into how ancient Europeans adapted to their environments over 7,000 years of European history.

DNA 112

DNA Research 112

Science Daily: Pharmacology News

JANUARY 20, 2025

Over half of our genomes consists of thousands of remnants of ancient viral DNA, known as transposable elements, which are widespread across the tree of life. Once dismissed as the 'dark side' of the genome, researchers have now revealed their crucial role in early embryo development.

DNA 84

DNA Research 84

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Ancient DNA has provided spectacular insights into human history, particularly in Europe and Asia, where researchers have reconstructed the genomes of thousands of people.

DNA 112

DNA Research 112

BioPharma Drive: Drug Pricing

APRIL 15, 2024

Learn about why access to robust biomarkers such as cfHPV-DNA is pivotal in determining eligibility, assessing treatment response and detecting recurrence early to improve patient outcomes.

DNA 103

DNA Treatment 103

Drug Discovery Today

MAY 25, 2023

The Facility will have capacity that exceeds today’s global plasmid DNA demand and can enable commercialisation of genetic medicines. Transformation of Grade II-listed Victorian waterworks on the River Thames in Hampton, London.

DNA 113

DNA Drugs 113

Science Daily: Pharmacology News

MARCH 28, 2024

New DNA sequencing technologies have identified the historical remains of George Washington's grandnephews, Samuel Walter Washington and George Steptoe Washington Jr., and their mother, Lucy Payne Washington, from unmarked, fragmentary bones left at the Harewood family cemetery in Charles Town, West Virginia, in the mid-1800s.

DNA 122

DNA 122

Science Daily: Pharmacology News

FEBRUARY 20, 2024

By analysing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.

DNA 94

DNA International Research 94

Chemical Biology and Drug Design

AUGUST 6, 2023

Radiotherapy induced DNA damage in rat lymphocytes. DNA damage was significantly reduced by 4 mg/kg/day Astaxanthin for 7 days. Astaxanthin may be a promising agent against radiotherapy induced DNA damage. Abstract Astaxanthin, a carotenoid pigment, is believed to be effective in the repair of DNA damage.

DNA 100

DNA Research 100

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

An international consortium of scientists is using an unprecedentedly large database of canine DNA to take an unbiased look at how our furry friends evolved into the various breeds we know and love.

DNA 97

DNA International 97

Drug Target Review

JANUARY 10, 2024

There is extensive crosstalk between the DNA damage response (DDR) and innate immune pathways. Both are a focus for exciting new small-molecule drug therapeutics that target cancers and autoimmune disorders.

DNA 104

DNA Biochemical Assays Small Molecule Drugs 104

Science Daily: Pharmacology News

SEPTEMBER 27, 2023

Scientists were able to fabricate a pure form of glass and coat specialized pieces of DNA with it to create a material that was not only stronger than steel, but incredibly lightweight.

DNA 92

DNA 92

Chemical Biology and Drug Design

FEBRUARY 26, 2024

The mechanism research revealed that cinnamaldehyde activated the Nrf2 pathway to attenuate lipid peroxidation and repair DNA damage to protect cardiomyocytes from ischemia/reperfusion injury in the OGD/R-induced H9C2 cardiomyocyte model. The severity of DNA damage was assessed by tail moment (TM) values using alkaline comet assay.

DNA 100

DNA Treatment Disease Research 100

BioPharma Drive: Drug Pricing

OCTOBER 24, 2023

Rampart Biosciences closed a Series A round that will fund its goal to develop more potent DNA-based medicines that avoid immune responses.

DNA 107

DNA Immune Response 107

Science Daily: Pharmacology News

JANUARY 15, 2025

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that the damage has multiple chances to generate harmful mutations, which can lead to cancer.

DNA 65

DNA Research 65

Science Daily: Pharmacology News

APRIL 24, 2024

A research team has discovered that cancer, one of the leading causes of death worldwide, can be caused entirely by epigenetic changes, in other words, changes that contribute to how gene expression is regulated, and partly explain why, despite an identical genome, an individual develops very different cells (neurons, skin cells, etc.).

DNA 117

DNA Regulations Research 117

ASPET

NOVEMBER 17, 2023

SM cytotoxicity emerges, in part, through DNA alkylation and double-strand breaks (DSBs). Because DSBs can naturally be repaired by DNA damage response pathways with low efficiency, we hypothesized that enhancing the HR pathway could pose a novel approach to mitigate SM injury.

DNA 100

DNA Treatment Drugs Research 100

Broad Institute

JANUARY 14, 2025

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent. In 2018, Liu, who works on the same floor as Minikel and Vallabh at Broad, approached them and proposed a collaboration.

Disease 144

Disease DNA Protein Production Treatment 144

ASPET

JUNE 30, 2023

Significance Statement Drugs that target cellular DNA damage repair pathways are now being used as new ways to maximise the effect of multimodality treatments such as radiotherapy. Here, we develop a mathematical model to investigate the effects of ceralasertib and olaparib, two drugs that target DNA damage response pathways.

DNA 100

DNA Therapies Government Treatment 100

Broad Institute

JANUARY 6, 2025

Also featured are the FKBP12 binding motif (light blue triangle), the DNA barcode (red double helix), and the combinatorial library element (red hexagon). Related groups Xavier lab Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits and diseases.

Disease 139

Disease Research DNA Small Molecule 139

Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Rapa Nui (Easter Island) with its gigantic statues and treeless landscape has fascinated researchers for centuries. A new genetic study disproves the popular theory that the Rapanui population collapsed as a result of an 'ecocide' and shows that the Rapanui admixed with Indigenous Americans centuries before Europeans arrived on the island.

DNA 130

DNA Research 130

Science Daily: Pharmacology News

DECEMBER 7, 2023

Despite the Roman Empire's extensive military and cultural influence on the nearby Balkan peninsula, a DNA analysis of individuals who lived in the region between 1 and 1000 CE found no genetic evidence of Iron Age Italian ancestry.

DNA 87

DNA 87

ASPET

JUNE 22, 2023

Clinical trials assessing the impact of Radiotherapy (RT) in combination with inhibitors of the DNA Damage Response Pathway (DDRi) and/or immune checkpoint blockade are currently ongoing. The model was fitted to datasets which assessed the impact of RT in combination with the DNA Protein Kinase inhibitor (DNAPKi) - AZD7648.

DNA 100

DNA Clinical Trials International Trials 100

Science Daily: Pharmacology News

JULY 11, 2024

An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample.

DNA 125

DNA International Research 125

Broad Institute

JANUARY 18, 2024

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

DNA 133

DNA Engineering Science Disease 133

Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 -- New research suggests that switching from smoking to vaping won't prevent some dangerous changes to a person's genome.A new study conducted in young adults shows similar cancer-linked gene changes in both vapers and.

DNA 97

DNA Research 97

Science Daily: Pharmacology News

AUGUST 20, 2024

A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA.

Government 127

Government DNA Regulations Disease 127

Broad Institute

JUNE 28, 2023

By Leah Eisenstadt June 28, 2023 Credit: Courtesy of the Zhang lab Cryo-EM map of a Fanzor protein in complex with ωRNA and its target DNA. They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells.

RNA 139

RNA DNA Research Engineering 139