Science Daily: Pharmacology News
JULY 3, 2024
Scientists have created an anode-free sodium solid-state battery. This brings the reality of inexpensive, fast-charging, high-capacity batteries for electric vehicles and grid storage closer than ever.
BioPharma Drive: Drug Pricing
JULY 1, 2024
Study results are expected for a pair of closely watched obesity drugs, while key tests await for a high-priced AbbVie acquisition and one of 2023’s largest IPOs.
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Chemical Biology and Drug Design
JULY 5, 2024
The QSPR model accurately predicted the intestinal absorption of molecules, and the computer simulation found the mechanism of molecular structure affecting intestinal absorption. Abstract Intestinal absorption of compounds is significant in drug research and development. To evaluate this efficiently, a method combining mathematical modeling and molecular simulation was proposed, from the perspective of molecular structure.
ASPET
JULY 2, 2024
Oxidative stress, fibrosis, and inflammasome activation from AGE-RAGE interaction contribute to diabetic cardiomyopathy (DCM) formation and progression. Our study revealed the impact of β-caryophyllene (BCP) on activating CB2 receptors against diabetes complications and investigated the underlying cell signaling pathways in mice. The murine model of DCM was developed by feeding high-fat diet with streptozotocin injections.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Science Daily: Pharmacology News
JULY 1, 2024
Computer scientists have invented a camera mechanism that improves how robots see and react to the world around them. Inspired by how the human eye works, their innovative camera system mimics the tiny involuntary movements used by the eye to maintain clear and stable vision over time.
BioPharma Drive: Drug Pricing
JULY 2, 2024
The company claimed Phase 2 study results prove the therapy’s promise treating myasthenia gravis. But shares lost more than a quarter of their value amid questions about the data.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
ASPET
JULY 2, 2024
Secondary spinal cord injury (SCI) is characterized by increased cytokines and chemokines at the site of injury that have been associated with the development of neuropathic pain. Nearly 80% of SCI patients report suffering from chronic pain, which is poorly managed with available analgesics. While treatment with the FDA-approved β 2 -adrenergic receptor agonist, formoterol, improves various aspects of recovery post-SCI in vivo , its effects on cytokines, chemokines and neuropathic pain rem
Science Daily: Pharmacology News
JULY 4, 2024
Researchers have discovered several rare types of helper T cells that are associated with immune disorders such as multiple sclerosis, rheumatoid arthritis, and even asthma. The discoveries were made possible by a newly developed technology they call ReapTEC. The new T cell atlas is publicly available and should help in the development of new drug therapies for immune-mediated diseases.
BioPharma Drive: Drug Pricing
JULY 2, 2024
The drug, which Lilly will sell as Kinsunla, carries a warning for the risk of a certain kind of imaging abnormality that can be serious in rare cases.
Drugs.com
JULY 2, 2024
TUESDAY, July 2, 2024 -- Benzodiazepines do not appear to increase dementia risk, but could have subtle long-term effects on brain structure, a new study reports.Researchers found no link between use of the sedative drug and a higher risk of.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
ASPET
JULY 2, 2024
People with sickle cell disease (SCD) often experience chronic pain as well as unpredictable episodes of acute pain, which significantly affect their quality of life and life expectancy. Current treatment strategies for SCD-associated pain primarily rely on opioid analgesics, which have limited efficacy and cause serious adverse effects. Cannabis has emerged as a potential alternative, yet its efficacy remains uncertain.
Science Daily: Pharmacology News
JULY 2, 2024
Saving lives through surgery is no longer exclusive to humans. Scientists now detail how Florida carpenter ants, a common, brown species native to its namesake, selectively treat the wounded limbs of fellow nestmates -- either by wound cleaning or amputation. When experimentally testing the effectiveness of these 'treatments,' not only did they aid in recovery, but the research team found the ants' choice of care catered to the type of injury presented to them.
BioPharma Drive: Drug Pricing
JULY 3, 2024
Multibillion-dollar buyouts from Bristol Myers Squibb and Gilead could yield new drugs for brain and liver diseases, while a new cell therapy may reach market.
Drugs.com
JULY 2, 2024
TUESDAY, July 2, 2024 -- A new drug to treat Alzheimer's disease was approved by the U.S. Food and Drug Administration on Tuesday. In clinical trials, donanemab (Kisunla) modestly slowed the pace of thinking declines among patients in the early.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Perficient: Drug Development
JULY 3, 2024
In today’s digital landscape, delivering exceptional customer experiences is paramount. Salesforce OmniStudio empowers you to create engaging, personalized, and brand-consistent interactions across all touchpoints. This blog post delves into OmniStudio, exploring its capabilities, benefits, and how you can leverage it to elevate your customer journeys.
Science Daily: Pharmacology News
JULY 3, 2024
Meet Gaiasia jennyae, the swamp creature with a toilet seat-shaped head. It lived 40 million years before the first dinosaurs, and it was the top predator in its ecosystem.
BioPharma Drive: Drug Pricing
JULY 1, 2024
The Japan-based drugmaker said its U.S. partner’s “portfolio prioritization efforts” led to the termination. It will refund part of an upfront payment.
Drugs.com
JULY 1, 2024
MONDAY, July 1, 2024 -- You're getting heart surgery, but your surgeon notices a new anomaly that perhaps could be fixed at the same time.That's more likely to happen if you're a man than a woman, new studies find.The findings came as little.
Quanticate
JULY 5, 2024
Good Clinical Practice (GCP) affects a variety of entities, including sponsors, contract research organisations (CROs), and investigator sites. It’s essential for maintaining ethical standards, high-quality outcomes and facilitating global standardisation, enabling multi-center and multinational studies, thereby streamlining the development and approval process for new medical treatments, and maintaining public trust in clinical research.
Science Daily: Pharmacology News
JULY 1, 2024
Two samples from Mars together deliver clear evidence of the origin of Martian organic material. The study presents solid evidence for a prediction made over a decade ago that could be key to understanding how organic molecules, the foundation of life, were first formed here on Earth.
BioPharma Drive: Drug Pricing
JULY 2, 2024
BARDA will provide Moderna with $176 million to advance late-stage testing of an H5 influenza shot, as health officials monitor animal outbreaks.
Drugs.com
JULY 2, 2024
TUESDAY, July 2, 2024 -- Most people addicted to opioids and their loved ones are unaware that their primary care doctor can prescribe a medication to treat the disorder, a new nationwide survey reveals."We've made great strides in making it easier.
addgene Blog
JULY 2, 2024
CRISPR is a sleek acronym for a real mouthful of a phrase: Clustered Regularly Interspaced Short Palindromic Repeats. That contrast of simplicity and complexity is reflected in the biology, too. CRISPR is an elegant bacterial immune system and an efficient gene editing tool… but boy does it have a lot of parts! If you’re still a bit confused by CRISPR acronyms, this post is for you.
Science Daily: Pharmacology News
JUNE 30, 2024
The desert moss Syntrichia caninervis is a promising candidate for Mars colonization thanks to its extreme ability to tolerate harsh conditions lethal to most life forms. The moss is well known for its ability to tolerate drought conditions, but researchers now report that it can also survive freezing temperatures as low as 196 C, high levels of gamma radiation, and simulated Martian conditions involving these three stressors combined.
BioPharma Drive: Drug Pricing
JULY 1, 2024
Under an arrangement with Radionetics, Lilly will have rights to acquire the San Diego biotechnology company for $1 billion.
Drugs.com
JULY 1, 2024
MONDAY, July 1, 2024 -- All Diamond Shruumz edibles have been recalled after the company found high levels of a mushroom toxin in them that may have sickened 39 people in 20 states.The recall includes Diamond Shruumz cones, chocolate bars and.
Covalent Modifiers
JULY 5, 2024
Nie, D.Y., Tabor, J.R., Li, J. et al. Nat Chem Biol (2024). [link] Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins for proteasomal degradation. Here we describe a TPD strategy involving the recruitment of FBXO22 to induce degradation of the histone methyltransferase and oncogene NSD2.
Science Daily: Pharmacology News
JULY 2, 2024
When it comes to managing blood sugar levels, most people think about counting carbs. But new research shows that, for some, it may be just as important to consider the proteins and fats in their diet. The study is the first large-scale comparison of how different people produce insulin in response to each of the three macronutrients: carbohydrates (glucose), proteins (amino acids) and fats (fatty acids).
Drug Patent Watch
JULY 1, 2024
Lipitor’s marketing strategy underwent a significant evolution as generic competition emerged, employing aggressive tactics to retain market share and brand […] Source
Drugs.com
JULY 2, 2024
TUESDAY, July 2, 2024 -- U.S. health officials announced Tuesday that the federal government will pay Moderna $176 million to speed development of a pandemic flu vaccine based on mRNA technology.Such a vaccine could be used to treat bird flu in.
Covalent Modifiers
JUNE 29, 2024
Cai, G., Bao, Y., Li, Q. et al. Commun Chem 7 , 144 (2024). [link] Serine–arginine (SR) proteins are splicing factors that play essential roles in both constitutive and alternative pre-mRNA splicing. Phosphorylation of their C-terminal RS domains by SR protein kinases (SRPKs) regulates their localization and diverse cellular activities. Dysregulation of phosphorylation has been implicated in many human diseases, including cancers.
Science Daily: Pharmacology News
JULY 1, 2024
With a new surgical intervention and neuroprosthetic interface, researchers restored a natural walking gait in people with amputations below the knee. Seven patients were able to walk faster, avoid obstacles, and climb stairs more naturally than people with a traditional amputation.
Drug Target Review
JULY 3, 2024
Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? My journey into STEM began at a young age. It was fuelled by my fascination with how the world operates and a deep desire to comprehend scientific phenomena. From high school onwards I chose to pursue studies in science; this passion has guided me throughout my academic journey.
Drugs.com
JULY 1, 2024
MONDAY, July 1, 2024 (HealthDay news) -- A 14-year study of testicular cancer survivors suggests that a chemotherapy drug could greatly raise patients' long-term odds for hearing loss. The drug in question, cisplatin, has been a mainstay of cancer.
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