Drug Target Review

DECEMBER 9, 2024

The 2024 Nobel Prize in Chemistry was awarded to Demis Hassabis and John Jumper from Google DeepMind for developing AlphaFold2, and to David Baker from the University of Washington for his work in computational protein design. These innovations have revolutionised the understanding of protein structures using artificial intelligence. Before AlphaFold, determining 3D protein structures was complex and time-consuming, and often required the use of experimental methods like X-ray crystallography an

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Engineering International Drug Development Science 105

Science Daily: Pharmacology News

DECEMBER 4, 2024

A new study sheds light on how long humans in the Americas have had relationships with the ancestors of today's dogs -- and asks an 'existential question': What is a dog?

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BioPharma Drive: Drug Pricing

DECEMBER 4, 2024

Results from the head-to-head study showed treatment with Zepbound resulted in 47% greater relative weight loss than Wegovy, a finding that could advantage Lilly in the companies’ market competition.

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Drug Trials Trials Treatment Marketing 124

Drugs.com

DECEMBER 2, 2024

MONDAY, Dec. 2, 2024 -- A new study provides good evidence that the human papillomavirus (HPV) vaccine may be achieving its goal of slashing rates of cervical cancer.“We observed a … 62% drop in cervical cancer deaths over the last decade, likely du.

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Vaccine 114

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drug Patent Watch

DECEMBER 10, 2024

Patents play a crucial role in protecting intellectual property and fostering innovation. However, the increasing complexity of patent systems has given rise to a phenomenon known as “patent thickets.” These dense webs of overlapping patent rights can significantly impact innovation, market entry, and competition across various industries and countries.

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Licensing Licensing International Marketing 97

Chemical Biology and Drug Design

DECEMBER 5, 2024

Three pancreatic cancer-related microarray datasets (GSE183795, GSE28735, and GSE62452) were integrated. Analysis of differentially expressed genes, WGCNA, and machine learning algorithms (LASSO, XGboost, and random forest) were combined to identify genes associated with the progression of pancreatic cancer. Natural drugs, including delphinidin, which target the core genes, tripartite motif containing 16 (TRIM16), and protein regulator of cytokinesis 1 (PRC1), were then identified.

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Packaging Regulations Drugs Research 100

Science Daily: Pharmacology News

DECEMBER 4, 2024

Exposure to car exhaust from leaded gas during childhood altered the balance of mental health in the U.S. population, making generations of Americans more depressed, anxious and inattentive or hyperactive, according to researchers. They estimate that 151 million cases of psychiatric disorder over the past 75 years have resulted from American children's exposure to lead.

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Research 128

BioPharma Drive: Drug Pricing

DECEMBER 2, 2024

The ADA recommended doctors avoid prescribing unapproved, off-brand versions of drugs like Wegovy, wading into a dispute that has gripped the FDA and compounding pharmacies over the past few months.

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Compounding Pharmacies Pharmacy Doctors FDA 119

Drugs.com

DECEMBER 4, 2024

WEDNESDAY, Dec. 4, 2024 -- Zepbound, the new GLP-1 weight-loss drug from Eli Lilly & Co., has outperformed its main competitor, Wegovy, in a clinical trial funded by Lilly."Given the increased interest around obesity medications, we conducted.

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Trials Clinical Trials Drugs 111

Drug Patent Watch

DECEMBER 9, 2024

In the vast realm of pharmaceutical research and development, there’s a fascinating intersection between ancient wisdom and modern science. This intersection is where pharmacognosy meets drug patents, creating a unique landscape that shapes the future of medicine. But what exactly is pharmacognosy, and how does it relate to the complex world of drug patents?

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Drugs Drug Development Production Pharmaceuticals 87

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Chemical Biology and Drug Design

DECEMBER 5, 2024

A hybrid drug design approach was employed to develop novel leads ( 1K11K5 ). The molecules were synthesized via a multi-step synthetic approach and were assessed for their anticancer potential via cell viability studies, DMPK studies, and MERTK inhibition. Studies were corroborated by in silico studies. ABSTRACT Mer-tyrosine kinase (MERTK), a member of the AXL, TYRO3, and MERTK (TAM) family, is one of the promising targets for cancer treatment.

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Immune Response Pharmacokinetics Regulations Treatment 100

Nvidia Developer: Drug Discovery

DECEMBER 3, 2024

Antibodies have become the most prevalent class of therapeutics, primarily due to their ability to target specific antigens, enabling them to treat a wide range. Antibodies have become the most prevalent class of therapeutics, primarily due to their ability to target specific antigens, enabling them to treat a wide range of diseases, from cancer to autoimmune disorders.

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Small Molecule Disease Drugs Science 96

Science Daily: Pharmacology News

DECEMBER 2, 2024

Researchers have linked a specific type of body fat to the abnormal proteins in the brain that are hallmarks of Alzheimer's disease up to 20 years before the earliest symptoms of dementia appear, according to a new study. The researchers emphasized that lifestyle modifications targeted at reducing this fat could influence the development of Alzheimer's disease.

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Disease Research 126

BioPharma Drive: Drug Pricing

DECEMBER 3, 2024

While early and from a small trial, the findings suggest Janux’s method of “masking” T cell engagers could lead to differentiated results, some analysts said.

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Trials Drugs 115

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Clinical Trials

Drugs.com

DECEMBER 3, 2024

TUESDAY, Dec. 3, 2024 -- A newly approved immunotherapy can help adults with a difficult-to-treat form of leukemia, clinical trial results show. Aucatzyl (obecabtagene autoleucel) worked on more than three-quarters (76%) of patients with B-cell.

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Clinical Trials Trials 112

Drug Patent Watch

DECEMBER 3, 2024

In the ever-evolving landscape of pharmaceutical research and development, a revolutionary force is reshaping the way we approach drug discovery and repurposing. This force is none other than Artificial Intelligence (AI) and Machine Learning (ML).

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Drugs Pharmaceuticals Research 82

Collaborative Drug

DECEMBER 6, 2024

CDD's Holiday Poem for 2024

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Drug Target Review

DECEMBER 4, 2024

G protein-coupled receptors (GPCRs) represent a cornerstone of modern drug discovery due to their crucial role in regulating human physiology and their involvement in numerous diseases. Many of these receptors are key targets for addressing obesity and metabolic disorders. Confo Therapeutics , led by CEO Dr Cedric Ververken, is at the forefront of developing innovative GPCR-targeted therapies using its proprietary ConfoBody ® platform.

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Pharmacokinetics Small Molecule Therapies Engineering 78

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

DECEMBER 3, 2024

An average of four minutes of incidental vigorous physical activity a day could almost halve the risk of major cardiovascular events, such as heart attacks, for middle-aged women who do not engage in structured exercise, according to new research.

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Research 112

BioPharma Drive: Drug Pricing

DECEMBER 4, 2024

The company, which raised $84 million, sees validation of its GIP-blocking approach to weight loss in Amgen's recent MariTide drug data.

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Drugs 112

Drugs.com

DECEMBER 4, 2024

WEDNESDAY, Dec. 4, 2024 -- The sugar known as fructose could be a kind of rocket fuel for cancer cells, and lowering fructose intake could be one way to fight the disease, new research suggests.Fructose is already ubiquitous in American diets, due.

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Disease Research 105

Drug Patent Watch

DECEMBER 4, 2024

The pharmaceutical industry is undergoing a significant transformation with the advent of machine learning methods. These methods have the potential to revolutionize the drug discovery process by enhancing the efficiency and accuracy of identifying and developing new drug candidates.

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Drug Development Drugs Pharmaceuticals 97

Crucial Data Solutions

DECEMBER 9, 2024

December 9, 2024— Crucial Data Solutions is proud to announce that our groundbreaking innovation, TrialKit AI, has been recognized with. The post TrialKit AI: Revolutionizing Clinical Research Analytics with AI appeared first on Crucial Data Solutions.

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Clinical Research Research 59

Drug Target Review

DECEMBER 6, 2024

In drug discovery and biological research, the scientists workflow often follows a structured and iterative approach to ensure accuracy, reproducibility and scientific integrity. This article outlines the various stages of such a workflow, from hypothesis generation to data cleaning and interpretation, referencing the project workflow diagram (Figure 1).

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RNA Drugs Research Science 52

Science Daily: Pharmacology News

DECEMBER 4, 2024

New research shows that the heart has a mini-brain -- its own nervous system that controls the heartbeat. A better understanding of this system, which is much more diverse and complex than previously thought, could lead to new treatments for heart diseases.

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Treatment Disease Research 110

BioPharma Drive: Drug Pricing

DECEMBER 2, 2024

At the center of a new licensing deal is an experimental medicine, PTC518, which is currently being tested in a roughly 250-person study that should produce results next year.

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Licensing Licensing Drugs 112

Drugs.com

DECEMBER 4, 2024

WEDNESDAY, Dec. 4, 2024 -- American seniors still pay more for health care than their counterparts in most other wealthy countries do, despite coverage by Medicare, a new study finds.They are also more likely to postpone or skip needed care because.

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Drug Patent Watch

DECEMBER 3, 2024

The process of obtaining a patent for a drug invention can be complex and time-consuming. Despite the best efforts of inventors and patent attorneys, many drug patent applications are rejected by patent offices. Understanding the common reasons for these rejections is crucial for overcoming them and securing patent protection for innovative pharmaceuticals.

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Drugs Pharmaceuticals 97

Reprocell

DECEMBER 11, 2024

Inflammatory bowel disease (IBD) is rising in prevalence across the globe, as the number of individuals diagnosed with the condition has increased by 95% since 1990. 1 Despite the recent scientific advances in therapies for IBD, including ulcerative colitis and Crohns disease, there are still persistent unmet medical needs due to the complexity and chronic nature of these conditions.

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Perficient: Drug Development

DECEMBER 11, 2024

The U.S. healthcare insurance industry stands at a pivotal moment. Amid rising costs, regulatory pressures, and an increasing demand for personalized care, healthcare payers must reinvent themselves. Generative AI (GenAI) offers a transformative pathway, enabling payers to transition from reactive cost management to proactive health enablement and strategic value creation.

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Science Daily: Pharmacology News

DECEMBER 3, 2024

Scientists demonstrate how a series of extreme weather events could lead to the Arctic's first ice-free day within just a few years.

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Research 110

BioPharma Drive: Drug Pricing

DECEMBER 4, 2024

The struggling biotech company is looking to break into the lucrative hepatitis C market with the promise of an easier treatment regimen.

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Treatment Marketing Drugs 102

Drugs.com

DECEMBER 4, 2024

WEDNESDAY, Dec. 4, 2024 -- Take the stairs. Tote heavy shopping bags. Walk up that hill. Play tag with a kid or a pet.Weaving these tiny bursts of vigorous physical activity into everyday life can halve a woman’s risk of a heart attack, a new study.

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