July, 2024

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Evotec and Pfizer collaborate on metabolic and infectious diseases

Drug Discovery World

Evotec and Pfizer have entered into a multi-year research collaboration, initially focused on early discovery research for metabolic and infectious diseases. The research will be carried out at Evotec’s sites in France, including Campus Curie in Toulouse with capabilities spanning high throughput screening, in vitro and in vivo biology, proteomics and metabolomics.

Disease 278
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Prime editing efficiently corrects cystic fibrosis mutation in human lung cells

Broad Institute

Prime editing efficiently corrects cystic fibrosis mutation in human lung cells By Allessandra DiCorato July 10, 2024 Breadcrumb Home Prime editing efficiently corrects cystic fibrosis mutation in human lung cells The approach targets the most common genetic cause of the disease and could enable a one-time treatment as effective as existing daily therapies.

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Ant insights lead to robot navigation breakthrough

Science Daily: Pharmacology News

Have you ever wondered how insects are able to go so far beyond their home and still find their way? The answer to this question is not only relevant to biology but also to making the AI for tiny, autonomous robots. Drone-researchers felt inspired by biological findings on how ants visually recognize their environment and combine it with counting their steps in order to get safely back home.

Research 134
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Artiva prices $167M IPO, riding optimism for autoimmune cell therapy

BioPharma Drive: Drug Pricing

The offering comes days after the publication of a paper showing what analysts said was early proof that “off-the-shelf” cell therapies can treat inflammatory diseases.

Therapies 127
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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The Curse of Perfection – Toil and Trouble

Perficient: Drug Development

“Double, double toil and trouble,” is a line repeated by the witches in Macbeth as they lay out the ominous prophecies of greatness and dire consequences for the titular character. Macbeth’s ambition envisions a perfect ending though desperate actions and moral weakness ruin it. So too are the misguided actions in pursuit of perfection which can set expectations and pressure that lead to unwanted results.

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Big Drop in U.S. Kids, Teens Misusing Prescription Meds

Drugs.com

WEDNESDAY, July 24, 2024 -- Misuse of illicit prescription drugs is falling dramatically among U.S. high school students, a new study says.The percentage of seniors who say they’ve misused prescription drugs in the past year has dropped to 2% in 2.

Drugs 114

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How to get into a clinical trial? Understanding inclusion and exclusion criteria

Antidote

When determining which clinical trial is the right fit , many factors must be considered. The site location, the number of required visits, and the length of the study are all important considerations, but before any of this, it is vital to consider the study's inclusion and exclusion criteria.

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Are AI-chatbots suitable for hospitals?

Science Daily: Pharmacology News

Large language models may pass medical exams with flying colors but using them for diagnoses would currently be grossly negligent. Medical chatbots make hasty diagnoses, do not adhere to guidelines, and would put patients' lives at risk. A team has systematically investigated whether this form of artificial intelligence (AI) would be suitable for everyday clinical practice.

Hospitals 125
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Revolution Medicines firms up Phase 3 trial plans with latest cancer drug data

BioPharma Drive: Drug Pricing

Updated results show the biotech's RAS inhibitor shrank pancreatic tumors in 20% to 25% of study participants, but with high rates of side effects like rash and nausea.

Trials 126
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How to Configure ServiceNow Knowledge Articles for Microsoft Graph Connector

Perficient: Drug Development

If you use ServiceNow as your knowledge management platform, you might want to make your knowledge articles searchable and accessible from Microsoft Search. Microsoft Search is a unified search experience that helps you find what you need across your organization, including files, sites, people, and more. By connecting your ServiceNow knowledge articles to Microsoft Search, you can enable your users to find and request them directly from the Microsoft 365 apps.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Study Finds Big Shift in Who's Using GLP-1 Meds Like Ozempic

Drugs.com

TUESDAY, July 23, 2024 -- The boom in using GLP-1 drugs like Ozempic to treat obesity has resulted in a bust regarding the drugs’ original purpose, which was to treat type 2 diabetes, a new study finds. New prescriptions for these drugs have d.

Drugs 114
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The Effects the ICH E6(R3) Updates Will Have on Good Clinical Practice

Quanticate

Good Clinical Practice (GCP) affects a variety of entities, including sponsors, contract research organisations (CROs), and investigator sites. It’s essential for maintaining ethical standards, high-quality outcomes and facilitating global standardisation, enabling multi-center and multinational studies, thereby streamlining the development and approval process for new medical treatments, and maintaining public trust in clinical research.

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What is the medical definition of obesity?

Antidote

Obesity, a condition that impacts 2 out of 5 adults in the United States , has become a significant health concern, both due to the impacts it has on individuals with the condition and the effect it can have on the overall medical system. It is estimated that obesity is responsible for nearly $1.73 billion in excess treatment costs annually, compounded by the fact that individuals with obesity are far more likely to have other conditions such as hypertension, diabetes, and osteoarthritis.

Treatment 111
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A breakthrough in inexpensive, clean, fast-charging batteries

Science Daily: Pharmacology News

Scientists have created an anode-free sodium solid-state battery. This brings the reality of inexpensive, fast-charging, high-capacity batteries for electric vehicles and grid storage closer than ever.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Ionis plots next steps for Angelman drug Biogen passed on

BioPharma Drive: Drug Pricing

The company plans to start a late-stage study next year, after a smaller trial found its drug offered “robust and consistent” benefits on communication, cognition and motor function.

Drugs 117
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Meet the Flower Designer Who Built a Laboratory In His Home

Codon

In a quiet New York town, an amateur scientist has constructed a fully equipped research laboratory in which to advance plant biology research. Sebastian Cocioba wears the word “amateur” as a badge of honor. He’s an educator, molecular florist, and founder at Binomica Labs , a small biology research group focusing on providing an alternative to “exposure-driven and marketing-centric research.” Earlier this year, we sent a photographer to Sebastian’s home labor

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Daily Supplements May Slow 'Dry' Form of Macular Degeneration

Drugs.com

MONDAY, July 22, 2024 -- Daily supplements can slow loss of vision related to late-stage “dry” age-related macular degeneration (AMD), a new study finds.The rate of dry AMD progression into a key eye region slowed by about 55% over an average three.

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Supercharge Customer Journeys with Salesforce OmniStudio

Perficient: Drug Development

In today’s digital landscape, delivering exceptional customer experiences is paramount. Salesforce OmniStudio empowers you to create engaging, personalized, and brand-consistent interactions across all touchpoints. This blog post delves into OmniStudio, exploring its capabilities, benefits, and how you can leverage it to elevate your customer journeys.

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Drafting Detailed Drug Patent Claims: The Art and Science of Pharmaceutical IP Protection

Drug Patent Watch

In the high-stakes world of pharmaceutical innovation, drafting detailed drug patent claims is a critical process that can make or break a company’s future.

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Smell of human stress affects dogs' emotions leading them to make more pessimistic choices

Science Daily: Pharmacology News

Dogs experience emotional contagion from the smell of human stress, leading them to make more 'pessimistic' choices, new research finds. Researchers tested how human stress odors affect dogs' learning and emotional state.

Research 124
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10 clinical trials to watch in the second half of 2024

BioPharma Drive: Drug Pricing

Study results are expected for a pair of closely watched obesity drugs, while key tests await for a high-priced AbbVie acquisition and one of 2023’s largest IPOs.

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New Viral Vectors - Summer 2024

addgene Blog

What's new in Addgene's ready-to-use viral vectors repository? Quite a bit! In this post, we'll share the 20 additions we've made to our viral vectors repository since March.

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FLiRTy Summer: All You Need to Know About the Latest COVID Variants

Drugs.com

SUNDAY, July 21, 2024 -- As yet another batch of variants fuel a COVID surge this summer, one expert offers advice on how to navigate the threat.“We've seen a bit of a seasonal pattern emerge, where we've had an uptick in COVID in the summer and t.

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How MMR-deficient colorectal cancers regulate their growth

Drug Target Review

For the first time, scientists at UCL and University Medical Center Utrecht have observed bowel cancer cells’ ability to regulate their growth using a genetic on-off switch to increase their likelihood of survival. These results could pave the way for personalised cancer medicine, determining how aggressive a patient’s cancer is, and selecting the most effective therapeutics.

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Understanding the Patent Trial and Appeal Board (PTAB) – A Comprehensive Overview

Drug Patent Watch

The Patent Trial and Appeal Board (PTAB) is a crucial component of the United States Patent and Trademark Office (USPTO), established in 2012 by the Leahy-Smith America Invents Act (AIA).

Trials 98
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New and improved camera inspired by the human eye

Science Daily: Pharmacology News

Computer scientists have invented a camera mechanism that improves how robots see and react to the world around them. Inspired by how the human eye works, their innovative camera system mimics the tiny involuntary movements used by the eye to maintain clear and stable vision over time.

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Pfizer thinks it found its obesity pill

BioPharma Drive: Drug Pricing

Far behind companies like Novo and Eli Lilly, Pfizer hopes the version of the drug, danuglipron, that it’s chosen to advance can break into the ultra-lucrative market for weight-loss medicines.

Marketing 124
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InMed’s INM-901 Demonstrates Potential as a Multi-factorial Approach to Treating Alzheimer’s Disease

Fierce BioTech

InMed’s INM-901 Demonstrates Potential as a Multi-factorial Approach to Treating Alzheimer’s Disease jpiatt Fri, 07/19/2024 - 09:56

Disease 99
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Predicting Myriad Diseases From a Single Drop of Blood

Drugs.com

TUESDAY, July 23, 2024 -- A single drop of blood might be able to predict the onset of dozens of diseases, a new study claims.Analysis of the protein “signatures” in a droplet of blood can predict 67 diseases, including blood cancers, degenerative n.

Disease 111
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Where's the Synthetic Blood?

Codon

Dr. Keith Neeves gives a history of blood transfusions and explains why it will be difficult to scale up the creation of synthetic blood for Issue 03 of Asimov Press. We are mostly blood. Of the 36 trillion cells in the human body, 32 trillion are blood cells. These blood cells synchronize the delivery of oxygen to every tissue in your body, fight pathogens, and heal wounds.

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Biologic Product Hopping: Innovation or Market Manipulation?

Drug Patent Watch

As patents expire on blockbuster biologic drugs, manufacturers are increasingly employing a controversial tactic known as “product hopping” to maintain […] Source

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A new twist on artificial 'muscles' for safer, softer robots

Science Daily: Pharmacology News

Engineers have developed a new soft, flexible device that makes robots move by expanding and contracting -- just like a human muscle. To demonstrate their new device, called an actuator, the researchers used it to create a cylindrical, worm-like soft robot and an artificial bicep. In experiments, the cylindrical soft robot navigated the tight, hairpin curves of a narrow pipe-like environment, and the bicep was able to lift a 500-gram weight 5,000 times in a row without failing.

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Cartesian data add to progress, questions for CAR-T in autoimmune disease

BioPharma Drive: Drug Pricing

The company claimed Phase 2 study results prove the therapy’s promise treating myasthenia gravis. But shares lost more than a quarter of their value amid questions about the data.

Disease 124
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Women in STEM with Juliet Williams

Drug Target Review

What inspired you to pursue a career in STEM and can you tell us about how your career journey unfolded? An early introduction to STEM in the classroom sparked my passion for biology and I’m grateful for the exposure to different scientific concepts and contexts at a young age. I wanted to make a tangible impact on the world through biology and was drawn to the challenge of scientific discovery, which led me to pursue a career in the biotech/pharma industry.