Covalent Modifiers

APRIL 25, 2025

Hayden A. Sharma, Michael Bielecki, Meredith A. Holm, Ty M. Thompson, Yue Yin, Jacob B. Cravatt, Timothy B. Ware, Alex Reed, Molhm Nassir, Tamara El-Hayek Ewing, Bruno Melillo, J. Fernando Bazan, Phil S. Baran, and Benjamin F. Cravatt Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.5c01944 Activity-based protein profiling (ABPP) of stereoisomerically defined sets of electrophilic compounds (stereoprobes) offers a versatile way to discover covalent ligands for proteins in native b

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Science Daily: Pharmacology News

APRIL 7, 2025

What if we spend decades building advanced telescopes to search for life on other planets and come up emptyhanded? A recent study exploring what we can learn about life in the universe -- even if we don't detect signs of life or habitability. Using advanced statistical modeling, the research team sought to explore how many exoplanets scientists should observe and understand before declaring that life beyond Earth is either common or rare.

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Research 172

BioPharma Drive: Drug Pricing

APRIL 21, 2025

A spokesperson confirmed the Danish drugmaker has asked U.S. regulators to clear an oral version of its weight loss drug Wegovy two years after reporting initial Phase 3 results.

FDA Approval 350

FDA Approval FDA Regulations Drugs 350

Broad Institute

APRIL 5, 2025

David Liu receives Breakthrough Prize in Life Sciences By Corie Lok April 5, 2025 Breadcrumb Home David Liu receives Breakthrough Prize in Life Sciences Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine. By Broad Communications April 5, 2025 Credit: Casey Atkins David Liu is a core member at the Broad Institute where he is the Richard Merkin Professor and director of the Merkin Institute for Transformative Technologies in He

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Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

Drugs.com

APRIL 25, 2025

FRIDAY, April 25, 2025 Novavaxs COVID-19 vaccine could soon receive full approval from the U.S. Food and Drug Administration (FDA), the company said Wednesday.The update sent Novavaxs stock up more than 21% in early trading. It also helped ease.

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FDA Approval Vaccine FDA Drugs 278

Covalent Modifiers

APRIL 25, 2025

R. Justin Grams, Wesley J. Wolfe, Robert J. Seal, James Veccia, and Ku-Lung Hsu Journal of Medicinal Chemistry 2025 [link] Aldo-keto reductase family 1 member C3 (AKR1C3) is a member of the AKR superfamily of enzymes that metabolize androgen, estrogen, and prostaglandin substrates that drive proliferation in hormone-dependent cancers. Interest in developing selective inhibitors has produced tool compounds for the inactivation or degradation of AKR1C3 with varying degrees of selectivity among the

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Cell Biology 147

Science Daily: Pharmacology News

APRIL 22, 2025

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions -- but there is always room for improvement. A new paper showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and cell therapy. In their study, authors developed a machine learning algorithm -- known as PAMmla -- that can predict the properties of about 64 million genome editing enzymes.

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Engineering Research Therapies 165

BioPharma Drive: Drug Pricing

APRIL 8, 2025

“There will be a ChatGPT moment for biotechnology,” a bipartisan commission wrote in the new report, which calls for the U.S. to invest at least $15 billion into the sector over the next five years.

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Collaborative Drug

APRIL 25, 2025

CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

APRIL 21, 2025

MONDAY, April 21, 2025 -- Colonoscopy for younger adults. Chest CT scans for lung cancer. Statin meds to lower cholesterol. Screening for drug addiction.More than 150 million Americans might lose no-cost access to these and other preventive care.

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Drugs 285

Chemical Biology and Drug Design

APRIL 4, 2025

Isocitrate dehydrogenase (IDH) is a key metabolic enzyme that catalyzes the conversion of isocitrate to -ketoglutaric acid (-KG). At present, there are few studies on the drug resistance of mIDH1 inhibitors. Therefore, this article first summarizes terms of IDH1 function from the molecular mechanism of IDH1, the mechanism of mutation, and the metabolism of substances due to mutations.

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Small Molecule Drugs DNA Treatment 100

Covalent Modifiers

APRIL 20, 2025

Genhui Xiao, Yumeng Cui, Liangliang Zhou, Chuya Niu, Bing Wang, Jinglan Wang, Shaoyang Zhou, Miaomiao Pan, Chi Kin Chan, Yan Xia, Lan Xu, Yu Lu, Shawn Chen mLife , 2025 DOI: [link] The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens. Its role as a potential drug target for combating tuberculosis (TB) has just begun to be substantiated in drug discovery research.

Small Molecule 147

Small Molecule Drugs Research 147

Science Daily: Pharmacology News

APRIL 16, 2025

According to new research next-generation DNA sequencing (NGS) -- the same technology which is powering the development of tailor-made medicines, cancer diagnostics, infectious disease tracking, and gene research -- could become a prime target for hackers.

DNA 356

DNA Disease Research 356

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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BioPharma Drive: Drug Pricing

APRIL 25, 2025

The drug, being developed for a rare genetic disorder and currently under review in the U.S., is seen by some investors as critical to Biohaven’s future.

Marketing 267

Marketing Drugs 267

Collaborative Drug

APRIL 18, 2025

CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:

Pharmacokinetics 247

Pharmacokinetics 247

Drugs.com

APRIL 25, 2025

FRIDAY, April 25, 2025 -- On Tuesday, the U.S. Department of Health and Human Services announced that the government will invest $176 million in Moderna to expedite the creation of a pandemic influenza vaccine, according to a report from the.

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Vaccine Government 270

Chemical Biology and Drug Design

APRIL 2, 2025

A multi-objective optimization algorithm incorporating the strategies of dynamic semi-parameter adaptation updating, gradient enhancement, and population size reduction is adopted to solve the problem of protein-ligand docking. ABSTRACT Molecular docking, which simulates the binding pose of a drug molecule to target proteins and predicts the binding affinity, is an important computational tool in structure-based drug discovery.

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Drugs Research 100

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Covalent Modifiers

APRIL 13, 2025

Tyler M. McCullough, Vishakha Choudhary, David L. Akey, Meredith A. Skiba, Steffen M. Bernard, Jeffrey D. Kittendorf, Jennifer J. Schmidt, David H. Sherman, and Janet L. Smith ACS Catalysis 2024 14 (16), 12551-12563 DOI: 10.1021/acscatal.4c03637 Emerging antibiotic resistance requires continual improvement in the arsenal of antimicrobial drugs, especially the critical macrolide antibiotics.

Engineering 147

Engineering Production Drugs 147

Science Daily: Pharmacology News

APRIL 16, 2025

A study suggests that Homo sapiens may have benefited from the use of ochre and tailored clothing during a period of increased UV light 41,000 years ago, during the Laschamps excursion.

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BioPharma Drive: Drug Pricing

APRIL 11, 2025

The initiative, which will start with monoclonal antibodies, is the first big regulatory shift from the FDA since Martin Makary was sworn in.

Animal Testing 284

Animal Testing FDA Drugs 284

New Drug Approvals

APRIL 11, 2025

Fitusiran 1711.0g/mol, C 78 H 139 N 11 O 30 FDA APPROVED 3/28/2025, Qfitlia , To prevent or reduce the frequency of bleeding episodes in hemophilia A or B Press Release CAS 1499251-18-1 EX-A12034 DA-53206 N-[1,3-Bis[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]propan-2-yl]-12-[(2R,4R)-4

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Clinical Trials FDA FDA Approval Trials 107

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Clinical Trials

Drugs.com

APRIL 15, 2025

TUESDAY, April 15, 2025 — A newly approved antibiotic to treat urinary tract infections may also help fight drug-resistant gonorrhea, a new study shows. The medication, called gepotidacin, sold under the brand name Blujepa, could become the.

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Drugs 287

Collaborative Drug

APRIL 10, 2025

CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:

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Covalent Modifiers

APRIL 12, 2025

Pasquale A. Morese, Ayaz Ahmad, Mathew P. Martin, Richard A. Noble, Sara Pintar, Lan Z. Wang, Shangze Xu, Andrew Lister, Richard A. Ward, Agnieszka K. Bronowska, Martin E. M. Noble, Hannah L. Stewart & Michael J. Waring Commun Chem 8 , 111 (2025). [link] The discovery of targeted covalent inhibitors is of increasing importance in drug discovery.

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Drugs 130

Science Daily: Pharmacology News

APRIL 9, 2025

Investigators have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations. The system can be formulated completely as RNA, dramatically simplifying delivery logistics compared to traditional systems that use both RNA and DNA. By inserting an entire gene, the tool offers a one-and-done approach that overcomes hurdles from CRISPR gene editing technology -- which is programmed to correct individual mutations -- offerin

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RNA DNA Disease Therapies 334

BioPharma Drive: Drug Pricing

APRIL 7, 2025

HELP committee chair Bill Cassidy, R-La., had invited Kennedy to testify April 10 on the sweeping layoffs of federal health workers Kennedy ordered last month. A hearing could still take place later.

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Drug Target Review

APRIL 7, 2025

As our understanding of the underlying biology of disease grows more sophisticated, emerging therapies operate on increasingly complex biopathological systems and mechanisms. Advanced strategies and tools are being implemented to establish the safety and efficacy of new therapeutic modalities, with the development of new biomarkers becoming one of the most relevant approaches for enhancing the precision and utility of early-stage studies.

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Clinical Development Clinical Trials Clinical Pharmacology Trials 69

Drugs.com

APRIL 21, 2025

MONDAY, April 21, 2025 The U.S. Centers for Disease Control and Prevention (CDC) has canceled its plans to help Texas schools stop the rapid spread of measles. The decision came after some CDC staff involved in this years outbreak response were t.

Disease 276

Disease 276

Covalent Modifiers

APRIL 13, 2025

Waldmann H, Zhang R, liu J, Gasper R, Janning P. ChemRxiv. 2025 doi:10.26434/chemrxiv-2025-70x40. [link] For targeted covalent protein modification at low reactivity aspartates and glutamates, new methods are in high demand. Inspired by the HaloTag technology we have developed a new technique which employs a reaction between chloroalkane-functionalised ligands and a specific glutamate residue.

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