Science Daily: Pharmacology News

MAY 14, 2025

With coral reefs in crisis due to climate change, scientists have engineered a bio-ink that could help promote coral larvae settlement and restore these underwater ecosystems before it's too late.

Engineering 176

Engineering Research 176

Drug Target Review

JULY 24, 2025

With a background in neurobiology, immuno-oncology and bispecific engineering, JJ now leads the development of antibody candidates designed to go further. The main challenge was engineering a molecule that could precisely engage p95HER2 and simultaneously trigger immune activation through CD137. They are starting points.

Immune Response 52

Immune Response Engineering Cell Based Assays Therapies 52

Covalent Modifiers

JUNE 27, 2025

µM in engineered BaF3-EGFRL858R/T790M/C797S and NCI-H1975 cells, respectively, overcoming EAI045's limitation of lack in cellular potency as a single agent. Compound 4 showed potent inhibition of EGFR-driven cell proliferation with IC50 values of 0.789 µM and 1.22

Engineering 130

Engineering Therapies Drugs 130

Drug Target Review

JULY 3, 2025

Leveraging the extensive breadth of available data to identify entities and relationships across data sources, clinical research experts, therapeutic specialists, machine learning (ML) engineers and others can collectively evaluate areas of interest that may create new opportunities for the asset and a broader clinical strategy.

Drug Development 65

Drug Development Drugs Animal Testing Engineering 65

Drug Target Review

FEBRUARY 10, 2025

In just two years, CTMC has advanced eight therapies into clinical trials, harnessing genetic engineering to enhance T-cell effectiveness in the fight against cancer. Bock highlighted ongoing efforts to enhance the effectiveness of cell therapies through advanced genetic engineering to make T cells more effective in the fight against cancer.

Therapies 65

Therapies Treatment Engineering Clinical Trials 65

Broad Institute

JANUARY 6, 2025

Zhang, the James and Patricia Poitras Professor of Neuroscience at MIT and a professor of brain and cognitive sciences and biological engineering, was among nine individual recipients of the award.

Medical Schools 138

Medical Schools Engineering Science Hospitals 138

Drug Target Review

JUNE 17, 2025

When paired with AI, it can transform noisy biological complexity into structured, predictive frameworks – shifting the role of machine learning from a descriptive tool to a discovery engine. Francisco’s experience includes almost 19 years at Illumina, most recently as Vice President of Software Engineering and Embedded Systems.

RNA 72

RNA Engineering DNA Disease 72

Covalent Modifiers

APRIL 13, 2025

The strikingly different shapes of acyl cavities in TEs of known structure, including those reported here for juvenimicin, tylosin and fluvirucin biosynthesis, provide insights to facilitate TE engineering and optimization.

Engineering 147

Engineering Production Drugs 147

Drug Target Review

JULY 21, 2025

2 A raft of emerging therapeutic modalities sits at the centre of this boom, spanning advanced biologics, engineered platforms and next-generation small molecules. Molecular engineering approaches Most CNS disorders involve abnormal gene expression, and molecular engineering is one of the most powerful tools to address this issue.

Drug Development 65

Drug Development Small Molecule Drugs Therapies 65

Broad Institute

MAY 19, 2025

Tseo is joined on the paper by co-lead author Xinyi Zhang, a graduate student in the Department of Electrical Engineering and Computer Science (EECS) and the Eric and Wendy Schmidt Center at the Broad Institute; Yunhao Bai of the Broad Institute; and senior authors Fei Chen , an assistant professor at Harvard and a core institute member of the Broad (..)

Research 105

Research Engineering Science Disease 105

Science Daily: Pharmacology News

MAY 19, 2025

Recently, a team of scientists and engineers has discovered a similar phenomenon on a microscopic scale, where tiny magnetic particles driven by rotating fields spontaneously move along the edges of clusters driven by invisible 'edge currents' that follow the rules of an unexpected branch of physics.

Engineering 148

Engineering Research 148

Science Daily: Pharmacology News

JULY 20, 2025

Scientists have used DNA's self-assembling properties to engineer intricate moiré superlattices at the nanometer scale—structures that twist and layer like never before. With clever molecular “blueprints,” they’ve created customizable lattices featuring patterns such as honeycombs and squares, all with remarkable precision.

DNA 240

DNA Engineering 240

Drug Target Review

DECEMBER 20, 2024

Previously, Aaron was an algorithm engineer and manager of the hand tracking team at Leap Motion. Aaron Smith, Founder & Machine Learning Scientist at Unlearn Aaron Smith is a mathematician with research interests at the interface of computer vision, machine learning, physics, and geometry. Aaron received his Ph.D.

Clinical Trials 128

Clinical Trials Trials Pharmaceuticals Drug Development 128

Codon

FEBRUARY 13, 2025

Abhishaike Mahajan is a senior ML engineer at Dyno Therapeutics, a biotech startup working to create better adeno-associated viral vectors using AI. He also writes on a blog focused on the intersection of biology and AI at owlposting.com.

Small Molecule 138

Small Molecule Engineering Production DNA 138

Broad Institute

JULY 24, 2025

“This study demonstrates the power of OPS to probe the dependency of dangerous viruses like Ebola on host factors at all stages of the viral life cycle and explore new routes to improve human health,” said co-senior author Paul Blainey , a Broad core faculty member and professor in the Department of Biological Engineering at MIT.

Virus 81

Virus RNA Laboratories Drugs 81

Drug Target Review

JUNE 28, 2025

DARPins – designed ankyrin repeat proteins – are small, engineered protein scaffolds with high specificity and affinity, developed as an alternative to traditional antibodies. “I joined Molecular Partners four years ago as the Head of Preclinical Pharmacology Platforms,” she says. ” From there, things moved fast.

Science 52

Science Engineering Treatment Clinical Development 52

Drug Target Review

JUNE 6, 2025

Most are concentrating on the delivery van and not necessarily on the package,” he adds, highlighting the industry’s tendency to focus on antibody engineering while underinvesting in payload innovation. “It’s almost both worlds coming together”. And we think the package is probably equally, if not more, important.”

Small Molecule 52

Small Molecule Pharmacokinetics Packaging Drugs 52

Drug Patent Watch

JANUARY 15, 2025

Understanding Google Patents Google Patents is a search engine that allows users to search the full text of patent documents from around the world. While Google Patents is a widely used tool for searching patent information, it may not be the most effective solution for identifying drug patents.

Drugs 53

Drugs Pharmaceuticals Engineering Research 53

Drug Target Review

OCTOBER 30, 2024

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Schizophrenia risk from complex variation of complement component 4. 2016;530(7589):177-83. Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, et al. 2017;23(1):49-59. Assembling human brain organoids.

Treatment 106

Treatment Disease Clinical Trials Research 106

The Pharma Data

JUNE 22, 2025

Engineered by Chugai Pharmaceutical Co., However, NXT007 takes the science a step further with refined molecular engineering aimed at achieving enhanced efficacy, longer dosing intervals, and a more predictable bleeding protection profile.

Clinical Trials 40

Clinical Trials Therapies Treatment Trials 40

LifeSciVC

MAY 14, 2025

Microgravity crystallization, in combination with modern innovations in antibody engineering (e.g., Convenience is an increasingly common competitive lever in the biopharma industry, particularly for crowded targets. half-life extension) and formulation / delivery (e.g.,

Science 96

Science Production Research Drugs 96

Drug Target Review

APRIL 30, 2025

Zylberberg shares a notable success story involving a CAR-T therapy developer – a type of cell therapy that uses genetically engineered T-cells to fight cancer. Real-world impact The impact of Kosten Digitals AI tools is already being felt in the CGT space.

Drugs 90

Drugs Therapies Clinical Trials Trials 90

Perficient: Drug Development

MAY 27, 2025

Its templating engine, Twig, is simple and easy for beginners to use. SEO Extension Purpose: Improve your site’s visibility in search engines. Gives you control over how your content appears in search engine results and on social media. It’s simple to manage pages, media, blog entries, and plugins.

Engineering 52

Engineering Testimonials Production Marketing 52

The Pharma Data

JUNE 25, 2025

Salanersen was engineered as an advanced ASO therapeutic, building on Biogen’s experience with SPINRAZA. While the last decade has seen major breakthroughs in SMA treatment—including gene therapies like ZOLGENSMA® and ASOs like SPINRAZA—there remain substantial unmet medical needs.

Therapies 52

Therapies Trials RNA Treatment 52

Drug Target Review

JUNE 11, 2025

The lack of collaboration between biologists, chemists, engineers and data scientists represents a significant barrier. He is a senior data scientist and holds a master’s degree from Roma Tre University in computer engineering, where he also held the role of research fellow.

Drugs 65

Drugs Clinical Trials Drug Development Pharmaceuticals 65

Drug Target Review

DECEMBER 9, 2024

Its applications include studying disease pathology to develop targeted therapeutics, visualising enzymes that can decompose plastics, and engineering solutions to antibiotic resistance, among many others. Further, trade secrets offer no protection against independent discovery or reverse engineering by competitors.

Engineering 106

Engineering International Drug Development Science 106

The Pharma Data

JUNE 18, 2025

A Next-Generation Antibody-Drug Conjugate Targeting B7-H3 Ifinatamab deruxtecan is a potential first-in-class antibody-drug conjugate (ADC) specifically engineered to target B7-H3 , a surface protein overexpressed in many solid tumors, including prostate cancer.

Trials 40

Trials Therapies Clinical Trials Treatment 40

Broad Institute

MAY 21, 2025

The idea of genetically instructing T cells to specifically eliminate cancer cells was born in the 1980s, but it would take 20 years to bring it to patients, said Sadelain, who left MSKCC last year to become the Herbert and Florence Irving Professor of Medicine and director of the Columbia Initiative in Cell Engineering and Therapy.

Therapies 119

Therapies FDA Approval Engineering Immune Response 119

Drug Target Review

JULY 8, 2025

ABBV-514 was engineered to selectively deplete CCR8+ Tregs, a subset with high tumour infiltration and suppressive capacity, without broadly compromising immune function. “Unleashing anti-tumour immunity by depleting Tregs is a promising therapeutic approach.”

Therapies 52

Therapies Science Drug Development Treatment 52

The Pharma Data

JULY 2, 2025

HK), a leading global Contract Research, Development, and Manufacturing Organization (CRDMO), has announced the official launch of WuXiHigh™ 2.0 , a next-generation, high-throughput formulation development platform specifically engineered for high-concentration biologics. WuXi Biologics Launches WuXiHigh™ 2.0

FDA Approval 40

FDA Approval Packaging Production FDA 40

Broad Institute

JANUARY 14, 2025

Building on previous work by the vector-engineering lab of Ben Deverman at the Broad, the team developed a pair of adeno-associated viruses (AAVs) to package and deliver the base-editing machinery to brain cells. But the researchers needed to deliver the base editors to the brain.

Disease 144

Disease DNA Protein Production Treatment 144

Broad Institute

JUNE 24, 2025

Doctors took donor T cells and performed three precise base edits on them, engineering them to attack leukemia cells while leaving healthy cells alone. Indeed, in 2022 Alyssa Tapley became the first human to receive a base-edited therapeutic, treating her life-threatening T-cell leukemia that had not responded to other treatments.

Treatment 133

Treatment Disease DNA Clinical Trials 133

Reprocell

OCTOBER 31, 2024

Welcome to our new blog series on a REPROCELL 3D tissue engineering platform powered by Alvetex® technology.

Engineering 59

Engineering Production Research Drugs 59

Broad Institute

JANUARY 13, 2025

Broads software engineering team and the large computational and biological scientists who are part of the Broad research community will be active contributors to the platform, with a continued commitment to open science and sharing reproducible techniques and insights.

Science 130

Science Research Engineering Government 130

The Open Targets Blog

JULY 17, 2025

Nick Ren is an engineer with a lot of experience working alongside geneticists. The query shown is from an initial chat without any prior prompt engineering or setup required." " Was there anything unexpected or particularly difficult? The hardest part is deciding which query patterns to expose as tools.

Engineering 52

Engineering Research Drugs 52

Drug Target Review

DECEMBER 16, 2024

At the time, in India, we typically had two major career choices, engineering or medicine. With artificial intelligence, the pace of change is exciting for STEM, whether in medicine, engineering, space, or technology. I opted for medicine due to my love for biological sciences.

Medical Schools 52

Medical Schools Clinical Research Drug Development Trials 52

The Pharma Data

JUNE 20, 2025

Beyond the clear clinical benefits demonstrated thus far, zimislecel represents a broader shift in the therapeutic landscape — one that leverages regenerative medicine, cellular engineering, and stem cell science to solve previously intractable medical challenges.

Therapies 40

Therapies Treatment Trials Production 40