Science Daily: Pharmacology News

MAY 14, 2025

With coral reefs in crisis due to climate change, scientists have engineered a bio-ink that could help promote coral larvae settlement and restore these underwater ecosystems before it's too late.

Engineering 185

Engineering Research 185

Covalent Modifiers

JUNE 27, 2025

µM in engineered BaF3-EGFRL858R/T790M/C797S and NCI-H1975 cells, respectively, overcoming EAI045's limitation of lack in cellular potency as a single agent. Compound 4 showed potent inhibition of EGFR-driven cell proliferation with IC50 values of 0.789 µM and 1.22

Engineering 130

Engineering Therapies Drugs 130

Drug Target Review

JULY 3, 2025

Leveraging the extensive breadth of available data to identify entities and relationships across data sources, clinical research experts, therapeutic specialists, machine learning (ML) engineers and others can collectively evaluate areas of interest that may create new opportunities for the asset and a broader clinical strategy.

Drug Development 64

Drug Development Drugs Animal Testing Engineering 64

Drug Target Review

JUNE 17, 2025

When paired with AI, it can transform noisy biological complexity into structured, predictive frameworks – shifting the role of machine learning from a descriptive tool to a discovery engine. Francisco’s experience includes almost 19 years at Illumina, most recently as Vice President of Software Engineering and Embedded Systems.

RNA 71

RNA Engineering DNA Disease 71

Broad Institute

JANUARY 6, 2025

Zhang, the James and Patricia Poitras Professor of Neuroscience at MIT and a professor of brain and cognitive sciences and biological engineering, was among nine individual recipients of the award.

Medical Schools 138

Medical Schools Engineering Science Hospitals 138

Drug Target Review

FEBRUARY 10, 2025

In just two years, CTMC has advanced eight therapies into clinical trials, harnessing genetic engineering to enhance T-cell effectiveness in the fight against cancer. Bock highlighted ongoing efforts to enhance the effectiveness of cell therapies through advanced genetic engineering to make T cells more effective in the fight against cancer.

Therapies 64

Therapies Treatment Engineering Clinical Trials 64

Covalent Modifiers

APRIL 13, 2025

The strikingly different shapes of acyl cavities in TEs of known structure, including those reported here for juvenimicin, tylosin and fluvirucin biosynthesis, provide insights to facilitate TE engineering and optimization.

Engineering 147

Engineering Production Drugs 147

Broad Institute

MAY 19, 2025

Tseo is joined on the paper by co-lead author Xinyi Zhang, a graduate student in the Department of Electrical Engineering and Computer Science (EECS) and the Eric and Wendy Schmidt Center at the Broad Institute; Yunhao Bai of the Broad Institute; and senior authors Fei Chen , an assistant professor at Harvard and a core institute member of the Broad (..)

Research 105

Research Engineering Science Disease 105

Science Daily: Pharmacology News

MAY 19, 2025

Recently, a team of scientists and engineers has discovered a similar phenomenon on a microscopic scale, where tiny magnetic particles driven by rotating fields spontaneously move along the edges of clusters driven by invisible 'edge currents' that follow the rules of an unexpected branch of physics.

Engineering 147

Engineering Research 147

Drug Target Review

DECEMBER 20, 2024

Previously, Aaron was an algorithm engineer and manager of the hand tracking team at Leap Motion. Aaron Smith, Founder & Machine Learning Scientist at Unlearn Aaron Smith is a mathematician with research interests at the interface of computer vision, machine learning, physics, and geometry. Aaron received his Ph.D.

Clinical Trials 128

Clinical Trials Trials Pharmaceuticals Drug Development 128

Codon

FEBRUARY 13, 2025

Abhishaike Mahajan is a senior ML engineer at Dyno Therapeutics, a biotech startup working to create better adeno-associated viral vectors using AI. He also writes on a blog focused on the intersection of biology and AI at owlposting.com.

Small Molecule 138

Small Molecule Engineering Production DNA 138

Drug Target Review

JUNE 28, 2025

DARPins – designed ankyrin repeat proteins – are small, engineered protein scaffolds with high specificity and affinity, developed as an alternative to traditional antibodies. “I joined Molecular Partners four years ago as the Head of Preclinical Pharmacology Platforms,” she says. ” From there, things moved fast.

Science 52

Science Engineering Treatment Clinical Development 52

Drug Target Review

JUNE 6, 2025

Most are concentrating on the delivery van and not necessarily on the package,” he adds, highlighting the industry’s tendency to focus on antibody engineering while underinvesting in payload innovation. “It’s almost both worlds coming together”. And we think the package is probably equally, if not more, important.”

Small Molecule 52

Small Molecule Pharmacokinetics Packaging Drugs 52

Drug Patent Watch

JANUARY 15, 2025

Understanding Google Patents Google Patents is a search engine that allows users to search the full text of patent documents from around the world. While Google Patents is a widely used tool for searching patent information, it may not be the most effective solution for identifying drug patents.

Drugs 53

Drugs Pharmaceuticals Engineering Research 53

Drug Target Review

OCTOBER 30, 2024

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Schizophrenia risk from complex variation of complement component 4. 2016;530(7589):177-83. Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, et al. 2017;23(1):49-59. Assembling human brain organoids.

Treatment 105

Treatment Disease Clinical Trials Research 105

The Pharma Data

JUNE 22, 2025

Engineered by Chugai Pharmaceutical Co., However, NXT007 takes the science a step further with refined molecular engineering aimed at achieving enhanced efficacy, longer dosing intervals, and a more predictable bleeding protection profile.

Clinical Trials 40

Clinical Trials Therapies Treatment Trials 40

LifeSciVC

MAY 14, 2025

Microgravity crystallization, in combination with modern innovations in antibody engineering (e.g., Convenience is an increasingly common competitive lever in the biopharma industry, particularly for crowded targets. half-life extension) and formulation / delivery (e.g.,

Science 96

Science Production Research Drugs 96

The Pharma Data

JUNE 25, 2025

Salanersen was engineered as an advanced ASO therapeutic, building on Biogen’s experience with SPINRAZA. While the last decade has seen major breakthroughs in SMA treatment—including gene therapies like ZOLGENSMA® and ASOs like SPINRAZA—there remain substantial unmet medical needs.

Therapies 52

Therapies Trials RNA Treatment 52

Drug Target Review

APRIL 30, 2025

Zylberberg shares a notable success story involving a CAR-T therapy developer – a type of cell therapy that uses genetically engineered T-cells to fight cancer. Real-world impact The impact of Kosten Digitals AI tools is already being felt in the CGT space.

Drugs 90

Drugs Therapies Clinical Trials Trials 90

Perficient: Drug Development

MAY 27, 2025

Its templating engine, Twig, is simple and easy for beginners to use. SEO Extension Purpose: Improve your site’s visibility in search engines. Gives you control over how your content appears in search engine results and on social media. It’s simple to manage pages, media, blog entries, and plugins.

Engineering 52

Engineering Testimonials Production Marketing 52

Drug Target Review

JUNE 11, 2025

The lack of collaboration between biologists, chemists, engineers and data scientists represents a significant barrier. He is a senior data scientist and holds a master’s degree from Roma Tre University in computer engineering, where he also held the role of research fellow.

Drugs 64

Drugs Clinical Trials Drug Development Pharmaceuticals 64

The Pharma Data

JUNE 18, 2025

A Next-Generation Antibody-Drug Conjugate Targeting B7-H3 Ifinatamab deruxtecan is a potential first-in-class antibody-drug conjugate (ADC) specifically engineered to target B7-H3 , a surface protein overexpressed in many solid tumors, including prostate cancer.

Trials 40

Trials Therapies Clinical Trials Treatment 40

Drug Target Review

JUNE 19, 2025

Atwood’s message is clear: lab automation is no longer just for the elite few with seven-figure budgets and teams of engineers. For applications such as protein engineering, drug response prediction or synthetic pathway optimisation, high-quality datasets are essential. It is becoming a necessity – and an accessible one.

Analytical Chemistry 52

Analytical Chemistry Engineering Science Government 52

Drug Target Review

JULY 8, 2025

ABBV-514 was engineered to selectively deplete CCR8+ Tregs, a subset with high tumour infiltration and suppressive capacity, without broadly compromising immune function. “Unleashing anti-tumour immunity by depleting Tregs is a promising therapeutic approach.”

Therapies 52

Therapies Science Drug Development Treatment 52

The Pharma Data

JULY 2, 2025

HK), a leading global Contract Research, Development, and Manufacturing Organization (CRDMO), has announced the official launch of WuXiHigh™ 2.0 , a next-generation, high-throughput formulation development platform specifically engineered for high-concentration biologics. WuXi Biologics Launches WuXiHigh™ 2.0

FDA Approval 40

FDA Approval Packaging Production FDA 40

Broad Institute

JUNE 24, 2025

Doctors took donor T cells and performed three precise base edits on them, engineering them to attack leukemia cells while leaving healthy cells alone. Indeed, in 2022 Alyssa Tapley became the first human to receive a base-edited therapeutic, treating her life-threatening T-cell leukemia that had not responded to other treatments.

Treatment 133

Treatment Disease DNA Clinical Trials 133

The Pharma Data

JUNE 18, 2025

The company is harnessing these rapidly evolving technologies to engineer a new generation of gene-editing tools capable of achieving unmatched precision. Neoclease stands at the intersection of artificial intelligence and synthetic biology.

Science 40

Science Therapies Disease Treatment 40

The Pharma Data

JUNE 18, 2025

She emphasized that Alnylam’s innovation engine has been delivering consistently, with multiple new drug approvals, strong Phase 3 clinical outcomes, and a growing clinical-stage pipeline. This momentum, she noted, requires even more synergy between the research and development functions.

RNA 40

RNA Clinical Development Science Disease 40

Broad Institute

JANUARY 13, 2025

Broads software engineering team and the large computational and biological scientists who are part of the Broad research community will be active contributors to the platform, with a continued commitment to open science and sharing reproducible techniques and insights.

Science 130

Science Research Engineering Government 130

The Pharma Data

JUNE 20, 2025

Beyond the clear clinical benefits demonstrated thus far, zimislecel represents a broader shift in the therapeutic landscape — one that leverages regenerative medicine, cellular engineering, and stem cell science to solve previously intractable medical challenges.

Therapies 40

Therapies Treatment Trials Production 40

Perficient: Drug Development

MARCH 25, 2025

They unify Finance, Engineering, and Product teams around shared goals, fostering a mindset where cost efficiency and value creation go hand in hand. Are Finance, Product, and Engineering collaborating on goals, reporting, and forecasting? How mature are our tagging, cost allocation, and mapping practices?

Engineering 52

Engineering Production Licensing Licensing 52

Drug Target Review

JUNE 2, 2025

His journey began in the early stages of his career, initially working with small molecules as a chemical engineer in development and manufacturing. This partnership blends Lonzas manufacturing expertise with BigHats machine-learning platform for antibody engineering. BigHat is a very interesting company.

Small Molecule 52

Small Molecule Engineering Therapies Drugs 52

SugarCone Biotech

JUNE 19, 2025

These are the patient’s own T cells that are engineered to express a binder to directly attack DLL3-positive cells. Second we see the appearance of bispecific ADC programs in the preclinical space – this will be problematic given the toxicity associated with DLL3 itself, before adding a second target. Finally, let’s look a CAR-T cells.

Therapies 78

Therapies Clinical Trials Treatment Clinical Development 78

Perficient: Drug Development

APRIL 7, 2025

Metadata contention in Unity Catalog can occur in high-throughput Databricks environments, slowing down user queries and impacting performance across the platform. Our Finops strategy shifts left on performance. However, we have found scenarios where clients are still experiencing query slowdowns intermittently and even on optimized queries.

Government 52

Government Production Engineering 52

Science Daily: Pharmacology News

MAY 22, 2025

Engineers developed a membrane that filters the components of crude oil by their molecular size, an advance that could dramatically reduce the amount of energy needed for crude oil fractionation.

Engineering 152

Engineering 152

Drug Target Review

MAY 21, 2025

By transforming trusted community infrastructure into engines of innovation, Vitalant is set to redefine what accessibility and excellence look like in the age of cell and gene therapy. I think blood centres offer the ideal environment to support and drive this innovation.

Therapies 52

Therapies Hospitals Production Treatment 52

The Pharma Data

JUNE 24, 2025

Unlike earlier attempts to inhibit individual mutations such as KRAS G12C, daraxonrasib is engineered to have broader inhibitory activity across multiple RAS mutations. Daraxonrasib, Revolution’s most advanced candidate, is a RAS(ON) multi-selective inhibitor designed to selectively target a subset of RAS-driven cancers.

Clinical Development 40

Clinical Development Packaging Therapies Treatment 40