Targeted Protein Degradation Related Topics 
Covalent Modifiers
JUNE 25, 2025
2025 , 147 , 25 , 21512–21525 [link] Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy for treating various diseases. However, current small molecule degraders predominantly rely on a limited set of E3 ubiquitin ligases, such as CRBN and VHL, which restricts their applications.
Covalent Modifiers
NOVEMBER 7, 2024
Nowak Annual Reports in Medicinal Chemistry , 2024 [link] Proteolysis targeting chimeras (PROTACs) are hetero-bifunctional molecules that remove disease-causing proteins through the means of targeted protein degradation (TPD).
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Covalent Modifiers
JULY 9, 2025
link] Targeted protein degradation (TPD) is an emerging therapeutic approach for the selective elimination of disease-related proteins. While molecular glue degraders exhibit drug-like properties, their discovery has traditionally been serendipitous and often requires post-hoc rationalization. 2025 , e202508427.
The Pharma Data
JUNE 12, 2025
Expanding Targeted Protein Degradation in Hematologic Malignancies Targeted protein degradation is a powerful therapeutic approach designed to destroy disease-driving proteins within cells, thereby inhibiting their ability to contribute to disease progression.
BMG Labtech
MARCH 17, 2025
At the most fundamental level you can think of a degron as a sequence of amino acids or a structural motif that can facilitate the degradation of protein substrates.
Covalent Modifiers
JANUARY 7, 2025
Second, we highlight various recent examples of protein functionalization using NASA/ArNASA chemistry, such as visualization of membrane proteins including therapeutically important G-protein coupled receptors, gel-based ligand screening assays, photochemical control of protein activity, and targeted protein degradation.
BioPharma Drive: Drug Pricing
JULY 8, 2025
Love Employee via Getty Images For decades now, scientists have been experimenting with a new way to target and destroy proteins linked to disease. Unlike most approved drugs, which work by turning cell signaling up or down like a dimmer switch, this approach aims to rid cells of problem proteins entirely.
Expert insights. Personalized for you.
130 
Let's personalize your content