Sat.Feb 08, 2025 - Fri.Feb 14, 2025

article thumbnail

AI-Designed Enzymes

Codon

One of the ultimate aims of protein design has long been to build entirely new enzymes — proteins that perform specific chemical reactions — from scratch. These molecular machines power various cellular processes, from converting sugar into energy to switching genes on and off. Both Cas9 and hydrolases (widely used in the dairy and laundry industries) are also enzymes.

article thumbnail

Boosting evolution: How humans unintentionally altered the skulls of pigs

Science Daily: Pharmacology News

Short snouts and a flat profile -- within a span of 100 years, humans have significantly changed the shape of the skulls of German domestic pigs. This is likely down to new breeding practices introduced at the beginning of the 20th century. The researchers analyzed 3D scans of 135 skulls of wild boars and domestic pigs from the early 20th and 21st centuries.

Research 117
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Can GLP-1 Meds Harm Your Eyes?

Drugs.com

MONDAY, Feb. 10, 2025 -- Yes, rare cases of vision issues have arisen in people taking popular GLP-1 weight loss drugs, but the jury's out on whether the medications caused the eye trouble, according to a new small study.The study reviewed the.

Drugs 113
article thumbnail

AbbVie, Pfizer gain FDA OK for novel antibiotic

BioPharma Drive: Drug Pricing

The drug is cleared to treat complicated intra-abdominal infections, including those caused by tough-to-control, gram-negative bacteria.

FDA 100
article thumbnail

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

article thumbnail

Site-Specific Molecular Glues for the 14-3-3/Tau pS214 ProteinProtein Interaction via Reversible Covalent Imine Tethering

Covalent Modifiers

DOI Ansgar Oberheide, Maxime van den Oetelaar, Jakob Scheele, Jan Borggrfe, Semmy Engelen, Michael Sattler, Christian Ottmann, Peter Cossar and Luc Brunsveld RSC Med Chem 2025 [link] Protein-protein interactions (PPIs) are key regulators of various cellular processes. Modulating PPIs with small molecules has gained increasing attention in drug discovery, particularly targeting the 14-3-3 protein family, which interacts with several hundred client proteins and plays a central role in cellular net

More Trending

article thumbnail

UNAIDS Warns HIV Infections Could Skyrocket Without U.S. Funding

Drugs.com

MONDAY, Feb. 10, 2025 -- The head of the United Nations AIDS agency (UNAIDS) is warning that a major spike in HIV infections and deaths could occur if the U.S. follows through on freezing foreign aid for HIV programs.UNAIDS Executive Director.

110
110
article thumbnail

New cell therapy model accelerates cancer treatment development

Drug Target Review

In the rapidly advancing field of cell therapies, Dr Jason Bock has emerged as a leader, known for his innovative approach to optimising the development process. With over 25 years of experience in therapeutics, Bock has played a pivotal role in shaping the future of cell therapies, particularly through his work at CTMC. In a recent conversation, he shared his vision for transforming the development and commercialisation of novel cell therapies, focusing on cutting-edge approaches like tumour in

article thumbnail

A brain biotech launches with Roche’s spare parts

BioPharma Drive: Drug Pricing

Backed by Goldman Sachs, Novo Nordisk’s parent company and others, Newleos Therapeutics debuted Thursday with $94 million and a plan to develop drugs for brain function and health.

Drugs 62
article thumbnail

Physician's medical decisions benefit from chatbot, study suggests

Science Daily: Pharmacology News

A study showed that chatbots alone outperformed doctors when making nuanced clinical decisions, but when supported by artificial intelligence, doctors performed as well as the chatbots.

Doctors 113
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

More Evidence Ozempic Can Curb Alcoholism

Drugs.com

WEDNESDAY, Feb. 12, 2025 -- Yet another study is supporting the notion that the blockbuster GLP-1 drug Ozempic can help problems drinkers curb their intake. The research found that, compared to placebo, weekly injections of semaglutide (also.

article thumbnail

Covalent-Allosteric Inhibitors: Do We Get the Best of Both Worlds?

Covalent Modifiers

Hui Tao, Bo Yang, Atena Farhangian, Ke Xu, Tongtong Li, Zhong-Yin Zhang, and Jianing Li Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.4c02760 Covalent-allosteric inhibitors (CAIs) may achieve the best of both worlds: increased potency, long-lasting effects, and reduced drug resistance typical of covalent ligands, along with enhanced specificity and decreased toxicity inherent in allosteric modulators.

Drugs 59
article thumbnail

Axsome secures top drug’s future with Teva patent settlement

BioPharma Drive: Drug Pricing

Shares in the brain drug developer rose by more than 20% Monday on news of the deal, which will forestall Teva's generic copy of Auvelity from entering the U.S. market until at least 2038.

article thumbnail

Truly autonomous AI is on the horizon

Science Daily: Pharmacology News

Researchers have developed a new AI algorithm, called Torque Clustering, that significantly improves how AI systems independently learn and uncover patterns in data, without human guidance.

Research 112
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

GLP-1 Meds Can Work Wonders for Kidney Health

Drugs.com

TUESDAY, Feb. 11, 2025 -- Ozempic, Wegovy, Saxenda, Trulicity: These and other GLP1-RA diabetes/weight-loss meds can also boost outcomes for folks battling chronic kidney disease, new research shows.Compared to another common class of kidney.

Disease 101
article thumbnail

Remix vs. Next.js: A Comprehensive Look at Modern React Frameworks

Perficient: Drug Development

In the ever-evolving landscape of web development, choosing the right framework can significantly impact the performance and user experience of your applications. Two of the most prominent frameworks in the React ecosystem today areRemixandNext.js. Both are designed to enhance web development efficiency and performance, but they cater to different needs and use cases.

article thumbnail

Novartis pays $925M to reel in a startup it helped launch

BioPharma Drive: Drug Pricing

The acquisition of Anthos Therapeutics could be worth up to $3.1 billion and returns to Novartis a blood thinner it licensed to the Blackstone-backed startup six years ago.

article thumbnail

Euclid discovers a stunning Einstein ring

Science Daily: Pharmacology News

Euclid, the European Space Agency's dark Universe detective, has made an astonishing discovery -- right in our cosmic backyard.

111
111
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Possible Listeria Contamination Prompts Recall of 2 Million Baked Goods

Drugs.com

MONDAY, Feb. 10, 2025 -- About 2 million baked goods have been recalled over concerns of potential contamination with Listeria monocytogenes, according to federal safety regulators.The recall went into effect on Jan. 7, 2025, and was upgraded on.

104
104
article thumbnail

Drug Discovery Industry Roundup with Barry Bunin — February 12th, 2025

Collaborative Drug

Drug Discovery Industry Roundup with Barry Bunin February 10th, 2025

Drugs 59
article thumbnail

Aardvark prices $94M IPO to fund Prader-Willi, obesity drug work

BioPharma Drive: Drug Pricing

Proceeds will support testing of drugs designed to suppress hunger in people with the tough-to-treat rare disease and, potentially, more common obesity-related conditions.

Drugs 67
article thumbnail

Biomarker test can detect Alzheimer's pathology earlier

Science Daily: Pharmacology News

Years before tau tangles show up in brain scans of patients with Alzheimer's disease, a biomarker test can detect small amounts of the clumping-prone tau protein and its misfolded pathological forms that litter the brain, cerebrospinal fluid and potentially blood, new research suggests.

Disease 106
article thumbnail

Most People Worldwide Lack Good Treatment for Mental Illness

Drugs.com

TUESDAY, Feb. 11, 2025 -- About 93% of people worldwide who struggle with mental health or substance abuse issues aren't getting adequate care, a new report finds.In many cases, people affected by mental illness do not recognize that they have a.

article thumbnail

CRISPR 101: Cytosine and Adenine Base Editors

addgene Blog

Early CRISPR applications were often limited by the low editing efficiency of homology-directed repair (HDR) , the pathway for resolving DNA double-strand breaks (DSBs) preferred by researchers. Compared to non-homologous end joining (NHEJ) , HDR occurs at a relatively low frequency, especially in nondividing cells. Scientists everywhere wistfully imagined being able to specify and correct single-base mutations without introducing DSBs at all.

DNA 52
article thumbnail

New study offers hints of GLP-1 drugs’ potential in curbing alcohol cravings

BioPharma Drive: Drug Pricing

A small semaglutide trial suggests the medicine's suppression of appetite may extend to alcohol, but larger tests are needed to establish a conclusive benefit.

Trials 67
article thumbnail

For Valentine's Day: Measure your relationship with a scientific self-test

Science Daily: Pharmacology News

Answer seven questions and get an indication of how your relationship is right now. Just in time for Valentine's Day, researchers are publishing a new study that introduces a scientifically validated scale, the 'Valentine's Scale'. The scale measures how satisfied you are in your love relationship.

Research 101
article thumbnail

Mass Shootings That Claim Most Kids' Lives Are Done by Family Members

Drugs.com

MONDAY, Feb. 10, 2025 -- When most people think of kids killed in mass shootings, they imagine it occurring at the hands of a stranger, and at school.The reality, according to a new report, is that most children who lose their lives to a mass.

92
article thumbnail

MPG Primer: Setting up a Biobank: Who? What? Why?

Broad Institute

MPG Primer: Setting up a Biobank: Who? What? Why? By admin February 13, 2025 Breadcrumb Home MPG Primer: Setting up a Biobank: Who? What? Why? The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of core concepts and practical tutorials on tools for

article thumbnail

Sanofi to take $250M charge on study failure for E. Coli vaccine

BioPharma Drive: Drug Pricing

The French drugmaker said the vaccine it agreed to develop with Johnson & Johnson a year ago was “not sufficiently effective.

Vaccine 57
article thumbnail

Earth's inner core is less solid than previously thought

Science Daily: Pharmacology News

Earth's inner core is undergoing structural transformation.

101
101
article thumbnail

Boston Surgeons Successfully Transplant Pig Kidney in Fourth Patient

Drugs.com

MONDAY, Feb. 10, 2025 -- Surgeons at Massachusetts General Hospital have successfully performed the fourth pig kidney transplant in the U.S. The recipient of the genetically modified pig organ was a 66-year-old man with kidney failure, surgeons.