Sat.Apr 06, 2024 - Fri.Apr 12, 2024

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Will Biopharma Companies Shun Vaccine R&D In A New Pandemic?

Forbes: Drug Truths

Only biopharma could have combated Covid-19; no other industry has the capacity to do so. When the world was in crisis, this industry responded. If need be, it will again, despite the financial consequences.

Vaccine 213
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Meet the Researcher: Stefano Gullà, Kling Biotherapeutics

Drug Discovery World

DDW’s Megan Thomas speaks to Stefano Gullà, Chief Scientific Officer at Kling Biotherapeutics. MT: Where do you work, and can you tell us what you’re working on at the moment? SG: I am the Chief Scientific Officer at Kling Biotherapeutics. Together with my colleagues, I am tackling what is one of the most pressing problems in biotech, the discovery of targets to serve as the basis for new therapies for cancer and infectious diseases.

Research 147
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Psychiatry drugs finally have pharma’s attention. Can they keep it?

BioPharma Drive: Drug Pricing

Recent biotech company acquisitions have put emerging schizophrenia treatments in focus. But many development hurdles still stand in the way of new medicines for the brain.

Treatment 137
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Chlamydia Vaccine Shows Promise in Early Trial

Drugs.com

FRIDAY, April 12, 2024 -- A chlamydia vaccine has triggered immune responses in an early trial, raising hopes that one day it might help curb the spread of the sexually transmitted infection (STI).There is currently no vaccine for chlamydia, which.

Vaccine 103
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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After being insulted, writing down your feelings on paper then getting rid of it reduces anger

Science Daily: Pharmacology News

Researchers have discovered a simple, but effective, strategy to help people reduce their feelings of anger. Disposing of a piece of paper containing your written thoughts on the cause of your anger can effectively neutralize it. This process is like a Japanese tradition called hakidashisara, in which people write their negative thoughts on a plate then destroy it.

Science 118
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Vodcast: Dr Adriano Flora, The Jackson Laboratory

Drug Discovery World

The latest sponsored DDW Sitting Down With vodcast features Dr Adriano Flora, Director of Business Development at The Jackson Laboratory (JAX). He discusses alternatives to non-human primates, the key benefits of this, and what impact will they have on the future of drug development. Moreover, he answers questions on the key breakthroughs in recent years in this field and how have these impacted future success, as well as challenges in the clinic that must be overcome to ensure this success is a

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Household Radon Can Lead to Lung Cancer -- Has Your Home Been Tested?

Drugs.com

THURSDAY, April 11, 2024 -- Kentucky resident Chasity Harney embraced a thoroughly healthy lifestyle -- eating right, exercising and never touching tobacco.So, her 2018 diagnosis of advanced lung cancer, which came at the age of 40, was a complete.

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Tiny plastic particles are found everywhere

Science Daily: Pharmacology News

Microplastic particles can be found in the most remote ocean regions on earth. In Antarctica, pollution levels are even higher than previously assumed.

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This week in drug discovery (8-12 April) 

Drug Discovery World

News round-up for 8-12 April by DDW Digital Content Editor Diana Spencer. The cancer research news has been coming thick and fast from the American Association of Cancer Research (AACR) Annual Meeting in San Diego this week, so our Friday round-up focuses on drug discovery in oncology. The top stories: Genetically engineered dendritic cells enhance lung cancer therapy A study by researchers at the UCLA Health Jonsson Comprehensive Cancer Center in the US suggests that injecting engineered dendri

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Novartis pauses some trials of cancer drug Kisqali to fix manufacturing

BioPharma Drive: Drug Pricing

The company said the pause is necessary to meet regulatory limits on nitrosamine, but added it will not affect commercial supply nor regulatory review of the drug in early breast cancer.

Trials 112
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Many Cancer Drugs Still Unproven 5 Years After Accelerated Approval

Drugs.com

MONDAY, April 8, 2024 -- New research questions the effectiveness of the U.S. Food and Drug Administration's accelerated drug approval program after finding that many cancer drugs remain unproven five years later.The study, published Sunday in the.

Drugs 116
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Innovative Financing Models for Repurposing Generic Drugs

Drug Patent Watch

A paper presented at the 2nd International Conference on Systems Medicine, AI, and Drug Repurposing proposes a novel approach to overcoming the financial barriers associated with repurposing generic drugs through… Source

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First tumour agnostic HER2 directed ADC gets US approval

Drug Discovery World

Daiichi Sankyo and AstraZeneca’s Enhertu (fam-trastuzumab deruxtecan-nxki) has been approved in the US for the treatment of adult patients with unresectable or metastatic HER2 positive (immunohistochemistry [IHC] 3+) solid tumours. Enhertu has been granted accelerated approval to treat patients who have received prior systemic treatment and have no satisfactory alternative treatment options.

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Engineers design soft and flexible 'skeletons' for muscle-powered robots

Science Daily: Pharmacology News

Engineers designed modular, spring-like devices to maximize the work of live muscle fibers so they can be harnessed to power biohybrid robots.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Wegovy Helps Those With Both Diabetes, Heart Failure: Study

Drugs.com

TUESDAY, April 9, 2024 -- For people struggling with both diabetes and a common type of heart failure, the weight-loss drug Wegovy may do more for their health than help them shed pounds, new research suggests.In the study, published Saturday in.

Research 111
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Azure SQL Server Performance Check Automation

Perficient: Drug Development

On Operational projects that involves heavy data processing on a daily basis, there’s a need to monitor the DB performance. Over a period of time, the workload grows causing potential issues. While there are best practices to handle the processing by adopting DBA strategies (indexing, partitioning, collecting STATS, reorganizing tables/indexes, purging data, allocating bandwidth separately for ETL/DWH users, Peak time optimization, effective DEV query Re-writes etc.,), it is necessary to be awar

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FDA green light for trial of allogeneic regulatory T cell therapy

Drug Discovery World

The US Food and Drug Administration (FDA) has accepted an Investigational New Drug (IND) application for Tr1X’s TRX103 for the prevention of Graft versus Host Disease (GvHD) in patients undergoing HLA-mismatched haematopoietic stem cell transplantation (HSCT). The company plans to initiate a Phase I study of the investigational allogeneic off-the-shelf Tr1 Treg therapy for this indication in the second quarter of 2024.

FDA 130
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Pregnancy accelerates biological aging in a healthy, young adult population

Science Daily: Pharmacology News

Pregnancy may carry a cost, reports a new study. The research shows that women who reported having been pregnant looked biologically older than women who had never been pregnant, and women who had been pregnant more often looked biologically older than those who reported fewer pregnancies.

Research 115
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Therapeutic Vaccine Prevents Pancreatic Cancer's Recurrence in 3-Year Trial

Drugs.com

MONDAY, April 8, 2024 -- A pancreatic cancer vaccine has continued to protect a small group of patients from their cancer coming back, three years after receiving the jab, a new study says.Eight patients have not had their pancreatic cancer recur.

Vaccine 111
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Pfizer, with new study results, seeks to bring RSV shot to adults aged 18-59

BioPharma Drive: Drug Pricing

The company plans to submit the trial data to regulators in a bid to win approval of its vaccine Abrysvo in adults as young as 18 years old.

Vaccine 108
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Study casts doubt on benefit of ‘accelerated approval’ cancer drugs

Drug Discovery World

Forty-one percent of cancer drugs granted accelerated approval from 2013 to 2017 did not demonstrate clinical benefit in confirmatory trials, according to a study in the Journal of the American Medical Association ( JAMA). The paper ‘Clinical Benefit and Regulatory Outcomes of Cancer Drugs Receiving Accelerated Approval’ reviewed 46 drugs granted approval under the US Food and Drug Administration’s (FDA) accelerated approval pathway.

Drugs 130
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Revolutionary molecular device unleashes potential for targeted drug delivery and self-healing materials

Science Daily: Pharmacology News

In a new breakthrough that could revolutionise medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force.

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Acetaminophen Use During Pregnancy Poses No Risk of Autism, ADHD in Kids

Drugs.com

TUESDAY, April 9, 2024 -- There’s no evidence that acetaminophen use during pregnancy increases the risk of childhood autism, ADHD or intellectual disability, the largest study to date on the subject has concluded.The analysis of more than 2.4.

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How to move from diversity to inclusion in medical research

Antidote

Increasing racial diversity in clinical research is a common topic in the industry, and for good reason. The purpose of a clinical trial is to ensure that any new medications are safe and effective for the patient population, so it is of the utmost importance that studies have participant pools that reflect the diversity of real-world individuals.

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GSK’s endometrial cancer therapy approved in Scotland

Drug Discovery World

The Scottish Medicines Consortium (SMC) has accepted GSK’s dostarlimab as a treatment for adult patients with endometrial cancer when used in combination with platinum-containing chemotherapy. Specifically, dostarlimab will be used for patients with mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) primary advanced or recurrent endometrial cancer and who are candidates for systemic therapy.

Therapies 130
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Parkinson's Disease: New theory on the disease's origins and spread

Science Daily: Pharmacology News

New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.

Disease 111
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New Investigational Drug, Olezarsen, Could Slash Blood Triglyceride Levels

Drugs.com

WEDNESDAY, April 10, 2024 -- A new drug can slash triglyceride levels nearly in half by targeting a genetic driver of high fat levels in the bloodstream, researchers said. The injectable drug, olezarsen, lowered triglyceride levels by 49% at the 50.

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Three Principles for Writing Effective Analytics Documentation

Perficient: Drug Development

Documentation is a crucial part of your analytics implementation. From your Solution Design Reference document to your internal wiki for all resources, making sure that you can write and edit your documentation is key to ensuring a cohesive and thorough understanding of your implementation. With effective documentation, you can: Prevent knowledge gaps among team members and assist in onboarding efforts.

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AMR: Steps in the right direction

Drug Discovery World

News that the UK is supporting two new initiatives to help further the development of antimicrobials alongside other solutions to tackle resistant infections is welcome news for a sector that has, in recent years, struggled to attract the funding and attention it deserves. The Pathways to Antimicrobial Clinical Efficacy (PACE) initiative and another project being led by The Infection Innovation Consortium: iiCON will serve as important stepping stones for companies looking towards support fo

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New drug prevents flu-related inflammation and lung damage

Science Daily: Pharmacology News

Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection.

Virus 116
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EPA Sets Strict Limit on PFAS 'Forever Chemicals' in U.S. Drinking Water

Drugs.com

WEDNESDAY, April 10, 2024 -- The Environmental Protection Agency announced Wednesday that it has finalized a first-ever rule that will drastically lower the amount of PFAS, also known as "forever chemicals," in the nation's drinking.

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Women want to participate in clinical trials. Lack of flexibility is still a problem.

BioPharma Drive: Drug Pricing

Underrepresentation of women in clinical trials affects the resulting drugs that become available later. Even small changes could boost participation.

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Positive results announced for COPD therapy

Drug Discovery World

Biopharmaceutical company EpiEndo has completed a Phase IIA clinical trial for its therapy addressing chronic obstructive pulmonary disease (COPD). EpiEndo is developing orally available, non-antibiotic macrolides, or Barriolides, that reduce inflammation while also limiting antimicrobial resistance (AMR). The company’s lead asset is EP395 and it focuses on the role of epithelial function in chronic inflammatory disorders.

Therapies 130
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How the moon turned itself inside out

Science Daily: Pharmacology News

Linking analyses of the moon's gravity field with models of its earliest evolution, scientists tell a story of the moon turning itself inside out after it solidified from a primordial magma ocean. The process left behind a vestige of dense, titanium-rich material beneath its Earth-facing side that makes its presence known by gravity anomalies.

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