Thu.Feb 13, 2025

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AI-Designed Enzymes

Codon

One of the ultimate aims of protein design has long been to build entirely new enzymes — proteins that perform specific chemical reactions — from scratch. These molecular machines power various cellular processes, from converting sugar into energy to switching genes on and off. Both Cas9 and hydrolases (widely used in the dairy and laundry industries) are also enzymes.

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Dessert stomach emerges in the brain

Science Daily: Pharmacology News

Who hasn't been there? The big meal is over, you're full, but the craving for sweets remains. Researchers have now discovered that what we call the 'dessert stomach' is rooted in the brain. The same nerve cells that make us feel full after a meal are also responsible for our craving for sweets afterwards.

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A brain biotech launches with Roche’s spare parts

BioPharma Drive: Drug Pricing

Backed by Goldman Sachs, Novo Nordisk’s parent company and others, Newleos Therapeutics debuted Thursday with $94 million and a plan to develop drugs for brain function and health.

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Phoenix galaxy cluster in the act of extreme cooling

Science Daily: Pharmacology News

New findings explain the Phoenix cluster's mysterious starburst. Data confirm the cluster is actively cooling and able to generate a huge amount of stellar fuel on its own.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Experts Warn Marijuana Ads Are Reaching Kids Through Social Media

Drugs.com

THURSDAY, Feb. 13, 2025 -- A legal loophole is allowing marijuana ads to slip past regulations and land right in front of kids on social media, a new report shows.Although the federal Controlled Substances Act prohibits advertising the sale or use.

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Certain Birth Control Pills, Devices Linked to Higher Heart Risks

Drugs.com

THURSDAY, Feb. 13, 2025 -- The most common formulation of birth control pills has been linked to a doubling of relative risk of heart attack and stroke, a new study finds.Contraceptive vaginal rings and skin patches formulated in the same way were.

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Sanofi to take $250M charge on study failure for E. Coli vaccine

BioPharma Drive: Drug Pricing

The French drugmaker said the vaccine it agreed to develop with Johnson & Johnson a year ago was “not sufficiently effective.

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Covalent-Allosteric Inhibitors: Do We Get the Best of Both Worlds?

Covalent Modifiers

Hui Tao, Bo Yang, Atena Farhangian, Ke Xu, Tongtong Li, Zhong-Yin Zhang, and Jianing Li Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.4c02760 Covalent-allosteric inhibitors (CAIs) may achieve the best of both worlds: increased potency, long-lasting effects, and reduced drug resistance typical of covalent ligands, along with enhanced specificity and decreased toxicity inherent in allosteric modulators.

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Remix vs. Next.js: A Comprehensive Look at Modern React Frameworks

Perficient: Drug Development

In the ever-evolving landscape of web development, choosing the right framework can significantly impact the performance and user experience of your applications. Two of the most prominent frameworks in the React ecosystem today areRemixandNext.js. Both are designed to enhance web development efficiency and performance, but they cater to different needs and use cases.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Number Infected Now 24 in Texas County Measles Outbreak

Drugs.com

THURSDAY, Feb. 13, 2025 -- New numbers have been released by the Texas Department of State Health Services (DSHS) in an update on the measles outbreak in Gaines County: 22 children and two adults have been infected as of Feb. 11.All cases have been.

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Neumora shakes up its C-suite; Biogen cuts early-stage pipeline

BioPharma Drive: Drug Pricing

Henry Gosebruch, Neumora’s CEO since 2023, will depart. Elsewhere, Biogen dropped two antisense drugs in a pipeline cull and Voyager hit a setback for its ALS gene therapy.

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RFK Jr. Confirmed as Health Secretary in Near Party-Line Vote

Drugs.com

THURSDAY, Feb. 13, 2025 -- Robert F. Kennedy Jr., a vocal vaccine skeptic and activist lawyer, was confirmed Thursday as the nation's new health secretary.The Senate voted largely along party lines to put Kennedy at the helm of the $1.7 trillion.

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CRISPR 101: Cytosine and Adenine Base Editors

addgene Blog

Early CRISPR applications were often limited by the low editing efficiency of homology-directed repair (HDR) , the pathway for resolving DNA double-strand breaks (DSBs) preferred by researchers. Compared to non-homologous end joining (NHEJ) , HDR occurs at a relatively low frequency, especially in nondividing cells. Scientists everywhere wistfully imagined being able to specify and correct single-base mutations without introducing DSBs at all.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Depression Can Speed Onset of Chronic Illnesses, Study Finds

Drugs.com

THURSDAY, Feb. 13, 2025 -- Depression hits the whole body, speeding the onset of long-term physical ills as people age, new research contends.People whove experienced depression are more likely to develop long-term physical health conditions such.

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MPG Primer: Setting up a Biobank: Who? What? Why?

Broad Institute

MPG Primer: Setting up a Biobank: Who? What? Why? By admin February 13, 2025 Breadcrumb Home MPG Primer: Setting up a Biobank: Who? What? Why? The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of core concepts and practical tutorials on tools for

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Belly Fat, Diabetes and Drinking Doubles Liver Disease Risk

Drugs.com

THURSDAY, Feb. 13, 2025 -- If you've got a big belly, diabetes or high blood pressure, you may want to limit your alcohol, experts warn, as drinking could significantly raise your odds for serious liver disease.The research, published recently in.

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The Role of Partnerships in Generic Drug Development

Drug Patent Watch

The Unsung Heroes of Generic Drug Development: The Power of Partnerships As we navigate the complex landscape of pharmaceuticals, it's easy to overlook the crucial role that partnerships play in bringing affordable, life-saving medications to market. But the truth is, partnerships are the backbone of generic drug development, and their impact cannot be overstated.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Could Yogurt Lower Your Odds for Deadly Colon Cancers?

Drugs.com

THURSDAY, Feb. 13, 2025 -- You may be less likely to develop an especially lethal form of colon cancer if you're a longtime consumer of yogurt, new research finds.Folks who ate two or more servings of yogurt per week for years had a 20% lower odds.

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RFK Jr. confirmed by Senate as health secretary

BioPharma Drive: Drug Pricing

All but one Senate Republican voted for Kennedy, a controversial vaccine critic who used a crusade to "Make America Healthy Again" to win one of the most powerful jobs in Washington.

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Enjoying Valentine's Day When a Loved One Has Alzheimer's

Drugs.com

THURSDAY, Feb. 13, 2025 -- Love doesn't fade when one member of a family develops Alzheimer's disease, but times of intimacy like Valentine's Day can become tougher.Experts at the Alzheimer's Foundation of America (AFA) acknowledge that a loved one.

Disease 52
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Jumping workouts could help astronauts on the moon and Mars, study in mice suggests

Science Daily: Pharmacology News

Jumping workouts could help astronauts prevent the type of cartilage damage they are likely to endure during lengthy missions to Mars and the Moon, a new study suggests. The researchers found that mice in a nine-week program of reduced movement experienced cartilage thinning and cellular clustering, both early indicators of arthritis. But mice that performed jump training three times a week showed the opposite effect -- thicker, healthier cartilage with normal cellular structure.

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More Sunshine in Pregnancy, Infancy Could Benefit Kids With MS

Drugs.com

THURSDAY, Feb. 13, 2025 -- Children who develop multiple sclerosis appear to fare better if they were exposed to safe amounts of summer sunshine as infants, new research shows.If their moms got some summer sun while pregnant, that seemed to help.

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SAP and Databricks: Better Together

Perficient: Drug Development

SAP Databricks is important because convenient access to governed data to support business initiatives is important. Breaking down silos has been a drumbeat of data professionals since Hadoop, but this SAP <-> Databricks initiative may help to solve one of the more intractable data engineering problems out there. SAP has a large, critical data footprint in many large enterprises.

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Ready for a Romantic Relationship? Your Friends' Opinions Matter

Drugs.com

THURSDAY, Feb. 13, 2025 -- This Valentine's Day, are you ready for something real or still playing the field?New research suggests your friends probably share similar notions about your readiness for lasting love.Researchers at Michigan State.

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Computational biology and bioinformatics

Broad Institute

Computational biology and bioinformatics By lcopelan@broadinstitute.

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What does Trump’s order on deregulation mean for the chemicals industry?

Agency IQ

By Xiaolu Wang, Esq., Julia John, MS The recent executive order on unleashing prosperity through deregulation instructs federal agencies to carry out the Trump administrations deregulatory agenda, calling on each agency to eliminate at least 10 regulations for every new one it issues or proposes. The move casts uncertainty over the future of many Toxic Substances Control Act (TSCA) rules finalized or planned by the previous administration.

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Analysis Chemical Thank You What does Trump’s order on deregulation mean for the chemicals industry

Agency IQ

What does Trumps order on deregulation mean for the chemicals industry? The recent executive order on unleashing prosperity through deregulation instructs federal agencies to carry out the Trump administrations deregulatory agenda, calling on each agency to eliminate at least 10 regulations for every new one it issues or proposes. The move casts uncertainty over the future of many Toxic Substances Control Act (TSCA) rules finalized or planned by the previous administration.

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