Sat.Sep 21, 2024 - Fri.Sep 27, 2024

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Bristol Myers schizophrenia drug, the first of its kind, approved by FDA

BioPharma Drive: Drug Pricing

In testing, Cobenfy eased schizophrenia symptoms without some of the disruptive side effects typical of existing drugs. The results have been met with excitement, as well as caution.

FDA 334
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Almost 200 Chemicals Linked to Breast Cancer Are Found in Food Packaging

Drugs.com

TUESDAY, Sept. 24, 2024 -- Food sold in shrink wrap, on cardboard trays or in paper containers might contain any of nearly 200 chemicals linked to breast cancer, a new study warns.Commonly used food packaging materials contain 189 chemicals that.

Packaging 306
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Climate science: How a believer becomes a skeptic

Science Daily: Pharmacology News

Researchers explored the powerful effect of repetition on people's beliefs.

Science 302
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AI Module Insights

Collaborative Drug

Learn how CDD Vault is utilizing AI to improve your drug discovery process.

Drugs 298
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Arch raises another $3B biotech fund in pursuit of ‘coolest’ new science

BioPharma Drive: Drug Pricing

Despite working in a restrictive funding climate, the prolific startup creator is “in the ‘taking lots of risk’ mode,” said co-founder and managing director Robert Nelsen.

Science 316
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Trial Confirms 'Life-Changing' Impact of Gene Therapy, Beqvez, for Hemophilia B

Drugs.com

THURSDAY, Sept. 25, 2024 -- A new gene therapy approved earlier this year can serve as a sustainable single-dose treatment for people with hemophilia B, newly published clinical trial data shows. People with hemophilia B saw their bleeding episodes.

Therapies 289

More Trending

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CDD Vault Update (September 2024 #3) - Release Notes

Collaborative Drug

New Default ELN Editor: The new ELN editor that had been pre-released for testing is now the default editor for all newly created entries. You can continue to edit entries created with the previous editor, but new features will only be available in the new editor. Existing entries that are duplicated will continue to use the old editor. We recommend copying contents over to a new entry and taking advantage of the new templates feature.

Treatment 278
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Biogen, UCB get the lupus data they’ve waited two decades for

BioPharma Drive: Drug Pricing

The companies now plan on starting this year another large study of their drug, dapirolizumab pegol, in the hopes that they can confirm its safety and effectiveness to drug regulators.

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Treatment Could Be New Option for People Battling Ulcerative Colitis

Drugs.com

FRIDAY, Sept. 27, 2024 -- An experimental monoclonal antibody treatment appears to ease the digestive disorder ulcerative colitis in patients who've failed other medications, a new trial shows.The treatment, tulisokibart, spurred remission of.

Treatment 278
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Researchers discover new bacterium that causes gut immunodeficiency

Science Daily: Pharmacology News

Researchers have discovered a new bacterium that weakens the immune system in the gut, potentially contributing to certain inflammatory and infectious gut diseases. The team identified the bacterium, Tomasiella immunophila (T. immunophila), which plays a key role in breaking down a crucial immune component of the gut's multi-faceted protective immune barrier.

Research 291
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Upcoming Webinar: Enhancing Small Molecule Discovery – A Customer Perspective on Integration of Torx Software and CDD Vault for Global Collaboration and Seamless Compound Registration

Collaborative Drug

Upcoming Webinar 9-26-24: Generative Chemistry, Deep Learning and Traditional Models - Practical Insights and Emerging Technologies

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FDA, after delay, clears Regeneron and Sanofi drug for COPD

BioPharma Drive: Drug Pricing

Dupixent is the first biologic medicine approved in the U.S. for the lung condition, though competitors from GSK, AstraZeneca and Roche could follow.

FDA 306
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Could Ozempic Help Prevent Opioid Overdoses?

Drugs.com

WEDNESDAY, Sept. 25, 2024 -- In a finding that suggests Ozempic and Wegovy have powers that extend beyond weight loss, a new study finds the medications might also lower people’s risk of opioid overdose. People with type 2 diabetes prescribed.

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These fish use legs to taste the seafloor

Science Daily: Pharmacology News

Sea robins are unusual animals with the body of a fish, wings of a bird, and walking legs of a crab. Now, researchers show that the legs of the sea robin aren't just used for walking. In fact, they are bona fide sensory organs used to find buried prey while digging.

Research 288
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes

Covalent Modifiers

Yuanjin Zhang, Zhonglin Liu, Marscha Hirschi, Oleg Brodsky, Eric Johnson, Sang Joon Won, Asako Nagata, Divya Bezwada, Matthew D. Petroski, Jaimeen D. Majmudar, Sherry Niessen, Todd VanArsdale, Adam M. Gilbert, Matthew M. Hayward, Al E. Stewart, Andrew R. Nager, Bruno Melillo & Benjamin F. Cravatt Nat Chem Biol , 2024 [link] More than half of the ~20,000 protein-encoding human genes have paralogs.

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After setback, Biohaven to seek approval of neurological disorder drug

BioPharma Drive: Drug Pricing

With fresh, positive data in hand, Biohaven now believes its medicine could be the first to receive FDA approval for spinocerebellar ataxia.

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Psilocybin Equals or Exceeds SSRI Antidepressants at Easing Depression

Drugs.com

MONDAY, Sept. 23, 2024 -- Psilocybin, the active ingredient in magic mushrooms, appears to ease depression symptoms at least as well as one of the most commonly used antidepressants, a new clinical trial shows.Patients showed significant.

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A method of 'look twice, forgive once' can sustain social cooperation

Science Daily: Pharmacology News

Using mathematical modeling, researchers found a way to maintain cooperation without relying on complex norms or institutions.

Research 278
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Nuclear Receptors: A new mode of inhibition

Covalent Modifiers

Andrew D Huber, Taosheng Chen eLife 2024, 13 :e101446. [link] The article presents the discussion on interaction of covalent inhibitors GW9662 and T0070907 with the peroxisome proliferator-activated receptor gamma (PPARγ), revealing new insights into how these compounds influence receptor activity. Topics include the role of PPARγ in regulating fatty tissue and glucose levels; and the effects of covalent inhibitors on PPARγ's ligand-binding site and its interaction with co-activators and co-repr

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Novo CEO pressed by Senate to cut prices of obesity, diabetes drugs

BioPharma Drive: Drug Pricing

CEO Lars Fruergaard Jørgensen told lawmakers the company would consider new talks with insurers about the list prices of Wegovy and Ozempic if they pledge to keep the medicines on their formularies.

Drugs 290
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Gum Disease Germs Could Help Trigger Cancer

Drugs.com

THURSDAY, Sept. 26, 2024 -- Bacteria that causes gum disease can also raise a person’s risk of head and neck cancers, a new study says.More than a dozen bacterial species have been linked to a collective 50% increased risk of head and neck cancer, r.

Disease 276
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The heart of the question: Who can get Medicare-covered weight loss medicine?

Science Daily: Pharmacology News

With Medicare now covering semaglutide for people with obesity and cardiovascular disease who don't have diabetes, a study looks at who that might include, depending on what cutoffs prescription plans apply.

Disease 277
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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CDD Vault Update (September 2024 #4) - Release Notes

Collaborative Drug

Inventory Index Updates: Search, sort, and filter by Synonym, FW, and Exact Mass. Add metadata columns to the index table using the pencil icon in the right corner. Inventory Alerts: Users can set email alerts based on their inventory sample current amount. Set a threshold and the alert email will list all samples below that threshold at the frequency specified.

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Pfizer to pull sickle cell drug from market, shut down trials

BioPharma Drive: Drug Pricing

The withdrawal comes as trial results indicate safety concerns with the drug, Oxbryta, which was first approved in the U.S. in 2019.

Trials 285
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Federal Assault Weapons Ban Could Have Stopped 38 Mass Shootings Since 2005

Drugs.com

TUESDAY, Sept. 24, 2024 -- The Federal Assault Weapons Ban (FAWB) would have prevented as many as 38 mass shootings that have taken place since the law lapsed in 2005, a new study estimates.Enacted by Congress in 1994, the ban prohibited the sale.

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Major boost in carbon capture and storage essential to reach 2°C climate target

Science Daily: Pharmacology News

Large expansion of carbon capture and storage is necessary to fulfill the Paris Climate Agreement. Yet a new study shows that without major efforts, the technology will not expand fast enough to meet the 2 C target and even with major efforts it is unlikely to expand fast enough for the 1.5 C target.

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Peptide and Protein Cysteine Modification Enabled by Hydrosulfuration of Ynamide

Covalent Modifiers

Changliu Wang, Zhenguang Zhao, Reem Ghadir, Dechun Yang, Zhenjia Zhang, Zhe Ding, Yuan Cao, Yuqing Li, Rosi Fassler, Dana Reichmann, Yujie Zhang, Yongli Zhao, Can Liu, Xiaobao Bi, Norman Metanis, and Junfeng Zhao ACS Central Science 2024 10 (9), 1742-1754 DOI: 10.1021/acscentsci.4c01148 Efficient functionalization of peptides and proteins has widespread applications in chemical biology and drug discovery.

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An Italian biotech gets $52M to advance pediatric gene therapies

BioPharma Drive: Drug Pricing

The financing will support a technology designed to make delivery of lentiviral gene therapies, which are typically administered through a complex process, more convenient.

Therapies 246
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Free COVID Tests Back Again by End of September

Drugs.com

WEDNESDAY, Sept. 25, 2024 -- As Americans get ready for fall and winter, the U.S. government is offering another round of free COVID tests, available by the end of this month."U.S. households will be eligible to order 4 free COVID-19 tests at.

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Another Franklin expedition crew member has been identified

Science Daily: Pharmacology News

The skeletal remains of a senior officer of Sir John Franklin's 1845 Northwest Passage expedition have been identified using DNA and genealogical analyses.

DNA 271
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Magnetic Control of Proteins: More than a Dream

addgene Blog

Lots of scientists work to invent novel techniques or to engineer improved tools for familiar applications. But how does one invent a tool for applications that don’t even exist yet? Andrew York , Maria Ingaramo, and their team at Calico Life Sciences recently set out to do just that — by developing a new fluorescent protein tool that responds strongly to magnetic fields ( Frank Hayward et al., 2024 ).

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Streamlining IND applications for cell and gene therapy innovations

BioPharma Drive: Drug Pricing

Regulatory and strategic challenges can delay the delivery of life-changing cell and gene therapies.

Therapies 246