Drug Discovery World

MARCH 23, 2023

A series of new measures will be introduced by the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) to make it faster and easier to gain approval and run clinical trials in the UK. For example, the regulatory and ethics reviews of clinical trial applications will be integrated.

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Drug Discovery World

APRIL 16, 2024

Axoltis Pharma has received authorisation from ANSM, the French agency for the safety of health products, to launch the SEALS study for Amyotrophic Lateral Sclerosis (ALS). This Phase II clinical trial of drug candidate NX210c in patients with ALS is the first to target the integrity of the blood brain barrier (BBB).

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Drug Discovery World

MARCH 15, 2024

We look forward to a continuation of the relationship as Exonate progresses to Phase IIb clinical trials in 2024.” Megan Thomas, Multimedia Editor, DDW The post Partners enhance clinical trial design using cloud-based simulation appeared first on Drug Discovery World (DDW).

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Antidote

APRIL 4, 2024

Before it is released onto the market, the development of any new drug or medical device must undergo rigorous testing , part of which involves clinical trials. Clinical trials are integral to making sure that any new therapy is both safe and effective for individuals, and volunteers are a vital part of the process.

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Drug Discovery World

SEPTEMBER 19, 2023

The University of Oxford has revealed that researchers are currently in the advanced stages of preparing for a clinical trial of a Nipah vaccine using the ChAdOx1 vector. The post UK scientists prepare for Nipah virus clinical trial appeared first on Drug Discovery World (DDW).

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Drug Discovery World

OCTOBER 2, 2023

Sophie Winandy , Executive Director of Medical Imaging at ICON explores the benefits of AI and how it can be integrated throughout medical imaging within clinical trials. However, a judicious use of AI is warranted in clinical trials. This is in part due to the tumour’s heterogeneity in appearance and its irregular shape.

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Drug Discovery World

JUNE 8, 2023

Grown in vitro, these cells can provide patient specific human brain models from a large cohort of AD patients – to create a ‘clinical trial in a dish’. has paved the way for the use of cell-based assays to investigate drug safety and efficacy, including this innovative ‘clinical trial in a dish’ approach.

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Drug Discovery World

OCTOBER 20, 2023

A new free service will offer insights in under ten days to sponsors conducting clinical trials, identifying potential ‘zombie trials’ and providing actionable recommendations for failing trials. The Health Check and Trial Rescue Service is an initiative of data software and services company Phesi.

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Drug Discovery World

JANUARY 16, 2024

The post Clinical trial will test novel inhaled TB vaccine appeared first on Drug Discovery World (DDW). The BCG vaccine works well against disease in childhood, but it is not good enough at protecting against disease in adulthood, which is when the majority of TB deaths occur.

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Conversations in Drug Development Trends

MAY 10, 2024

Over the past two decades, industry-sponsored clinical trials have targeted treatments for BPD, yielding some promising outcomes; however, broader psychiatric research often excludes BPD patients, a trend that extends to the emerging field of psychedelic studies.

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Drug Discovery World

SEPTEMBER 1, 2023

Accurate dose prediction for clinical trials is essential to ensure patient safety and trial success. This new whitepaper from the Jackson Laboratory discusses evidence-based selection of starting doses in first-in-human clinical trials through the utilisation of humanised mouse models.

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Drug Discovery World

MAY 17, 2023

Leveraging historical trial databases has become commonplace in assessing the feasibility of trials in therapeutic areas with a large breadth of clinical development history. EHR data also has a key role to play in designing future clinical trials.

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Drug Discovery World

FEBRUARY 9, 2023

Stitch Health is a London-based start-up, on a mission to improve clinical trials by measuring and surfacing each patient’s experience. million seed funding to create the definitive patient retention platform for clinical trials. MT: What other aspects of clinical trials do you feel could be improved upon?

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Drug Discovery World

AUGUST 25, 2023

Educational campaign, Clinical Trials For All, has been launched to drive greater understanding, participation and diversity in clinical trials. Clinical research isn’t what many people think it is,” said Cinda Orr, Founder of SCORR Marketing, the company that is leading this initiative. “Low

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Drug Discovery World

JUNE 8, 2023

The US Food and Drug Administration has published draft guidance with updated recommendations for good clinical practices (GCPs) to modernise the design and conduct of clinical trials. The updates are intended to help pave the way for more efficient clinical trials. To read this content in full, you need to login.

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Drug Discovery World

OCTOBER 16, 2023

The UK’s Medicines and Healthcare products Regulatory Agency (MHRA) has revealed plans to reduce the time taken to approve the lowest-risk clinical trials by more than 50%. It will reduce the time taken to get the lowest-risk clinical trials up and running without undermining patient safety.”

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Drug Discovery World

MARCH 6, 2023

The Duke Clinical Research Institute (DCRI) and Protas, led by Oxford University clinical trialist Professor Sir Martin Landray, will collaborate to develop new approaches to large randomised clinical trials.

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Drug Discovery World

NOVEMBER 1, 2023

Enfortumab vedotin-ejfv, Astellas and Seagen The Phase III EV-302 clinical trial showed that PADCEV (enfortumab vedotin-ejfv) plus pembrolizumab improved OS and PFS vs. chemotherapy by more than 50% in patients with previously untreated locally advanced or metastatic urothelial cancer. Median PFS was 4.4 months versus 3.7

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ProRelix Research

FEBRUARY 20, 2024

Crafting impactful oncology clinical trial protocols requires a strategic approach to ensure rigorous research, patient safety, and meaningful outcomes.

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Drug Discovery World

APRIL 14, 2023

Clinical trials are, undoubtedly, an essential part of the drug development process, providing us with valuable information about the safety and efficacy of new treatments and therapies. of participants 2 Covid-19 vaccination trials. In fact, these demographics which make up 13.8% of the UK population represented only 5.7%

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Drug Discovery World

JULY 17, 2023

Analysis of 13,490 clinical trials finds almost a third have been cancelled during Phase II amidst an overall decline in clinical development productivity. Data analytics company Phesi has released the results of its mid-year global analysis of all clinical trials conducted in 2023 to date.

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Drug Discovery World

SEPTEMBER 4, 2023

A new whitepaper has introduced the concept of ‘cross-over’ options in cancer clinical trials, as a way to make trials more patient-centric in design. It also encourages sponsors, investigators and regulators to advance patient-centric trial designs.

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Drug Discovery World

JANUARY 17, 2023

In this latest episode, DDW’s Megan Thomas is in conversation with two experts when it comes to clinical trials. Walz was recently selected in the 2022 PharmaVoice 100 for the company’s innovative work in the space, and speaks about how real world data can help to boost diversity rates in clinical trials.

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Drug Discovery World

JULY 24, 2023

Paul O’Donohoe , Senior Director, eCOA Product and Science at Medidata, looks at the potential of decentralised clinical trials following the Covid-19 pandemic and how the industry will be affected going forward. The role that Covid-19 played in advancing decentralised clinical trials (DCTs) cannot be underestimated.

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Drug Discovery World

JANUARY 26, 2024

He will go on to discuss the company’s move to Phase I clinical trials with a drug targeting Fragile-X Syndrome, a leading cause of autism and intellectual disabilities. The post SLAS2024 speaker update: How tech is reducing failure rates in clinical trials appeared first on Drug Discovery World (DDW).

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Drug Discovery World

JULY 26, 2022

This is the latest episode of the free DDW podcast, “Now is the time for the transformation of clinical trials”. They are called “Clinical trials, the pandemic and technology” and “Pharma and the benefits of Real World Data ”. . It covers two narrated articles written for Volume 22, Issue 4 – Fall 2021 of DDW.

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Drug Discovery World

JANUARY 17, 2023

In this latest episode, DDW’s Megan Thomas is in conversation with two experts when it comes to clinical trials. Walz was recently selected in the 2022 PharmaVoice 100 for the company’s innovative work in the space, and speaks about how real world data can help to boost diversity rates in clinical trials.

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Drug Discovery World

JANUARY 4, 2023

As a result, the number of clinical trials conducted in the country for this indication is gradually increasing, driven mostly by international pharmaceutical companies. The post China’s clinical trial activity in NAFLD increasing appeared first on Drug Discovery World (DDW). According to GlobalData’s [.]. Remember Me.

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Drug Discovery World

MARCH 1, 2023

First Phase I trial The first Phase I clinical trial is currently underway at the new facility in partnership with the Infection Innovation Consortium (iiCON) and Alderley Park-based Infex Therapeutics. The post New clinical trial facility opens in Liverpool appeared first on Drug Discovery World (DDW).

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Antidote

SEPTEMBER 25, 2023

Clinical trials are how researchers advance their knowledge about potential new treatments, including medications, medical devices, and lifestyle interventions. Clinical trials are divided into phases , each with a distinct duration, purpose, and number of volunteers needed.

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Drug Discovery World

SEPTEMBER 18, 2023

Against this backdrop, the Government & Public Health Solutions team at ICON will execute a Phase IIb clinical trial to assess the relative efficacy of a next generation Covid-19 vaccine compared to currently approved/authorised Covid-19 vaccines in the prevention of symptomatic, PCR confirmed SARS-CoV-2 infection.

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Drug Discovery World

JANUARY 30, 2023

Dominic Elliston , Managing Director of Evoke Galliard and Evoke Incisive Health, shares his take on how effective clinical trial communications is the key to expediting the delivery of new and extraordinary treatments. What’s that got to do with clinical trials? Tell us about yourself, Dominic. The fast-paced variety!

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Antidote

JANUARY 5, 2024

Though clinical trial patient recruitment is an integral part of the medical research process, it is often one of the most difficult aspects of conducting a study.

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Drug Discovery World

MARCH 31, 2023

Clinical trial technology platform Inato, based in Paris, France, has closed a $20 million Series A funding from investors including Cathay Innovation, Obvious Ventures, La Maison and Top Harvest Capital. Today, 70% of clinical research happens at the same 5% of sites, and only 5% of patients participate in a clinical trial.

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Vial

MAY 13, 2024

However, progress from molecule to approved drug is hampered by extremely high costs and lengthy clinical trials , and approximately 90% of drugs that reach clinical trials fail. only 5% of molecules in oncology Phase I trials reach the market taking, on average, 7.5 According to Rodríguez-Molinero et al.,

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