Drug Discovery World
JULY 15, 2024
New survey findings have revealed that 77% of R&D professionals are not using in vitro cell-based alternatives to animal testing, and only 23% describe themselves as ‘very familiar’ with any kind of animal model alternative. More than 350 survey respondents participated in the survey by The Pistoia Alliance, including representatives from pharma companies, regulators, and CROs.
Science Daily: Pharmacology News
JULY 17, 2024
Have you ever wondered how insects are able to go so far beyond their home and still find their way? The answer to this question is not only relevant to biology but also to making the AI for tiny, autonomous robots. Drone-researchers felt inspired by biological findings on how ants visually recognize their environment and combine it with counting their steps in order to get safely back home.
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BioPharma Drive: Drug Pricing
JULY 18, 2024
The offering comes days after the publication of a paper showing what analysts said was early proof that “off-the-shelf” cell therapies can treat inflammatory diseases.
Chemical Biology and Drug Design
JULY 19, 2024
Demethylcantharidin (DEM) is a widely used antitumor drug; however, its poor tumor targeting and serious organotoxicity limit its application. The aim of this study was to develop a new drug delivery system for efficient delivery of DEM. DEM, demethylcalcin; DNLNs, nanoemulsion based lipid nanoparticles containing demethylcantharidin; EPR, enhanced permeability and retention; PEG-400, polyethylene glycol 400.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
JULY 19, 2024
News round-up for 15-19 July by DDW Senior Digital Content Editor Diana Spencer. The chosen news stories this week all feature therapies that could have significant impact on the future treatment of cancer, particularly haematological malignancies, but also solid tumours. The top stories: Bacteriophage study offers new hope in treating GVHD Researchers from Japan have identified a bacteriophage-derived enzyme that holds promise for future applications in preventing or treating acute graft-versus
Science Daily: Pharmacology News
JULY 17, 2024
Researchers report that psilocybin, the active ingredient in magic mushrooms, destabilizes a critical network of brain areas involved in introspective thinking. The findings provide a neurobiological explanation for the drug's mind-bending effects.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
JULY 16, 2024
This study provides preliminary elucidation of multiple pharmacological targets, biological processes and signaling pathways of VD against TC. These findings offer valuable insights for future therapeutic strategies targeting TC. Abstract Thyroid cancer (TC) is one of the most common endocrine malignancies worldwide. Increasing evidence suggests that vitamin D (VD) has potential benefits in the treatment of TC.
Drug Discovery World
JULY 19, 2024
Biotechnology company Draupnir Bio has received equity investments totalling €12 million to support the company’s work in the field of targeted protein degradation (TPD). TPD is a rapidly emerging field in drug development, exploiting a cell’s own destruction machinery to tackle disease-causing proteins that have historically been highly challenging to target with conventional therapies.
Science Daily: Pharmacology News
JULY 19, 2024
A new study describes a chemical reaction that can convert Styrofoam into a high-value conducting polymer known as PEDOT:PSS. Researchers also noted that the upgraded plastic waste can be successfully incorporated into functional electronic devices, including silicon-based hybrid solar cells and organic electrochemical transistors.
Drugs.com
JULY 18, 2024
THURSDAY, July 18, 2024 -- A new monoclonal antibody treatment called Kesimpta (ofatumumab) appears to improve on an older drug in pushing multiple sclerosis (MS) into remission, a new trial shows.Funded by Kesimpta's maker, Novartis, the trial.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Chemical Biology and Drug Design
JULY 16, 2024
Several Bruton's tyrosine kinase (BTK) inhibitors have been shown in studies to be effective in the inhibition of biological activity analysis and in animal models. This review focuses on the BTK inhibition mechanism and its possible impact on immune-mediated disease, as well as the types being investigated for RA, preclinical and clinical investigations and future research opportunities.
Drug Discovery World
JULY 19, 2024
Dr Gloria Gonzalez-Aseguinolaza, Co-Founder & Chief Scientific Officer of Vivet Therapeutics, has been awarded the Rosalind Franklin Society (RFS) Special Award in Science given by Mary Ann Liebert, Inc. and the Rosalind Franklin Society. The award recognises Dr Gonzalez-Aseguinolaza’s remarkable contributions and dedication to advancing scientific knowledge.
Science Daily: Pharmacology News
JULY 15, 2024
One of the most important controversies about human evolution and expansion is when and by what route the first hominids arrived in Europe from the African continent. Now, geological dating techniques at the Orce sites (Baza basin, Granada, Spain) place the human remains found in this area as the oldest in Europe, at approximately 1.3 million years old.
Drugs.com
JULY 19, 2024
FRIDAY, July 19, 2024 -- A German man has become the seventh person to apparently be cured of HIV, researchers report.The 60-year-old man, referred to as the “next Berlin Patient,” was treated with a stem cell transplant in October 2015 for acute my.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Chemical Biology and Drug Design
JULY 15, 2024
The ability of binding pose metadynamics to improve the rankings of true targets predicted via pharmacophore mapping was investigated using three diverse ligands and their six true targets. Binding pose metadynamics improved the predicted rankings for four out of the six true targets, while also providing the highest-ranked predictions. Abstract Computational target fishing plays an important role in target identification, particularly in drug discovery campaigns utilizing phenotypic screening.
Drug Discovery World
JULY 19, 2024
Briefly Bio, a software company that hopes to make lab work more reproducible by helping scientists capture and share their work, has launched with a $1.2m pre-seed funding round. The financing was led by Compound VC, with participation from NP Hard, Tiny VC and angel investors across tech and biotech. In preclinical research, it’s estimated that over 50% of efforts to reproduce experiments fail, costing the industry over $50bn each year.
Science Daily: Pharmacology News
JULY 17, 2024
An environmental engineering team has discovered that specific bacterial species can cleave the strong fluorine-to-carbon bond certain kinds of 'forever chemical' water pollutants, offering promise for low-cost treatments of contaminated drinking water.
Drugs.com
JULY 19, 2024
FRIDAY, July 19, 2024 -- It's long been known that popping the antibiotic doxycycline within 72 hours of a risky sexual encounter can greatly reduce a person's risk for a sexually transmitted infection (STI). In fact, the U.S. Centers for Disease.
Broad Institute
JULY 19, 2024
An immune factor in the brain plays critical roles in neuron function and aging By Tom Ulrich July 19, 2024 Breadcrumb Home An immune factor in the brain plays critical roles in neuron function and aging Study highlights unexpected interactions between innate immune system and neurons, raises questions about additional roles for immune system in the brain with aging.
Drug Discovery World
JULY 19, 2024
Scientists have created the first bioengineered bone marrow model which can support the type of human stem cells that are crucial for bone marrow transplants and in vitro study work. The research – published in Nature Communications and led by the University of Glasgow – replicates key aspects of the human bone marrow microenvironment, to enable the support of rare long-term hematopoietic stem cells, or LT-HSCs.
Science Daily: Pharmacology News
JULY 16, 2024
For the first time, scientists have found that sleep can be detected by patterns of neuronal activity just milliseconds long, 1000 times shorter than a second, revealing a new way to study and understand the basic brain wave patterns that govern consciousness.
BioPharma Drive: Drug Pricing
JULY 16, 2024
The well-funded startup says drugs AbbVie abandoned last year could form a combination regimen with “superior efficacy” to Vertex’s market-leading medicines.
Antidote
JULY 15, 2024
Obesity, a condition that impacts 2 out of 5 adults in the United States , has become a significant health concern, both due to the impacts it has on individuals with the condition and the effect it can have on the overall medical system. It is estimated that obesity is responsible for nearly $1.73 billion in excess treatment costs annually, compounded by the fact that individuals with obesity are far more likely to have other conditions such as hypertension, diabetes, and osteoarthritis.
Drug Discovery World
JULY 18, 2024
The UK has the potential to become the global leader in pharmaceutical cannabinoid R&D, according to a new report published by the Cannabinoid Research and Development Group (CRDG). The report suggests the UK can build on the success of GW Pharmaceuticals, whose multiple sclerosis treatment product nabiximols was the first natural cannabis plant derivative to gain market approval in any country.
Science Daily: Pharmacology News
JULY 19, 2024
A new species of fossil snake unearthed in Wyoming is rewriting our understanding of snake evolution. The discovery, based on four remarkably well-preserved specimens found curled together in a burrow, reveals a new species named Hibernophis breithaupti. This snake lived in North America 34 million years ago and sheds light on the origin and diversification of boas and pythons.
BioPharma Drive: Drug Pricing
JULY 17, 2024
Treatment led to "clinically meaningful" weight loss over four weeks, but longer studies will be needed to compare it to Wegovy and Zepbound.
Drugs.com
JULY 17, 2024
WEDNESDAY, July 17, 2024 (HeathDay News) -- Sleeping long hours one night but only a few hours the next can be unhealthy, with a new study finding "irregular" sleep patterns could be a risk factor for type 2 diabetes.The results "underscore the.
Drug Discovery World
JULY 18, 2024
CatalYm has completed a $150 million Series D financing to support the Phase II development of its cancer therapy visugromab. The oversubscribed round was led by new investors, Canaan Partners and Bioqube Ventures, and joined by Forbion’s Growth Opportunities Fund, Omega Funds and Gilde Healthcare. Existing investors Jeito Capital, Brandon Capital Partners, Novartis Venture Fund and Vesalius Biocapital III also participated in the round.
Science Daily: Pharmacology News
JULY 17, 2024
Cut marks on fossils could be evidence of humans exploiting large mammals in Argentina more than 20,000 years ago, according to a new study.
Fierce BioTech
JULY 19, 2024
InMed’s INM-901 Demonstrates Potential as a Multi-factorial Approach to Treating Alzheimer’s Disease jpiatt Fri, 07/19/2024 - 09:56
Drugs.com
JULY 19, 2024
FRIDAY, July 19, 2024 -- Cancer growth can be fueled by flecks of ancient viral DNA lodged into the genetics of modern humans, a new study says.Overall, about 8% of the human genome is made of bits of DNA left behind by viruses that infected our.
Drug Discovery World
JULY 18, 2024
The US Food and Drug Administration (FDA) has granted Fast Track designation to Sumitomo Pharma’s DSP-5336 for relapsed or refractory acute myeloid leukaemia (AML). The drug is intended for patients with a KMT2A rearrangement, also known as, mixed lineage leukaemia rearrangement (MLLr) or nucleophosmin mutation (NPM1m). DSP-5336 is an investigational small molecule inhibitor of the menin and mixed-lineage leukaemia (MLL) protein interaction, which plays key roles in gene expression and protein i
Science Daily: Pharmacology News
JULY 17, 2024
High-protein diets, known as 'Paleolithic diets', are popular. Using mouse models, scientists have studied their impact. While effective in regulating weight and stabilizing diabetes, these diets are not without risks. Excess protein greatly increases ammonium production, overwhelming the liver. Excess ammonium can cause neurological disorders and, in severe cases, lead to coma.
Perficient: Drug Development
JULY 18, 2024
Perficient’s Giving Employee Resource Group (ERG) recently introduced the Perficient Gives Global Grants Program , which gives colleagues the opportunity to nominate charitable organizations from around the world to receive a $5,000 donation from Perficient. After carefully evaluating each nomination, Perficient’s Giving ERG leadership team selected the first five organizations to receive a donation.
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