Drug Discovery World

APRIL 8, 2024

Scientists from Gwangju Institute of Science and Technology in Korea have discovered compound 11c, a potentially ground-breaking oral treatment for metabolic dysfunction-associated steatohepatitis. The post Potent drug candidate could transform liver disease treatment appeared first on Drug Discovery World (DDW).

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Drug Discovery World

DECEMBER 2, 2022

The UK Medicines and Healthcare Products Regulatory Agency (MHRA) has approved a CBD/THC combination treatment under its Named Patient programme and other compassionate areas. The post UK approval for CBD pain treatment appeared first on Drug Discovery World (DDW).

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Drug Discovery World

JANUARY 4, 2024

Ariceum Therapeutics is focused on developing novel targeted radiopharmaceuticals for the treatment of cancer. The post Developing novel targeted radiopharmaceuticals for cancer treatment appeared first on Drug Discovery World (DDW). In this episode, Megan Thomas is in conversation with Manfred Ruediger, CEO of Ariceum Therapeutics.

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Drug Discovery World

APRIL 21, 2023

Lengthening the duration of treatment as well as broadening the patient population that may benefit from these treatments address the highest obstacles of ICB therapies today.” The post New drug could help overcome tumour resistance to treatment appeared first on Drug Discovery World (DDW).

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Drug Discovery World

FEBRUARY 19, 2024

PrecisionLife and the Metrodora Institute have agreed a partnership to jumpstart the diagnosis and treatment options for a range of complex, chronic diseases. In Metrodora we have a partner that is focused on the diagnosis and treatment of some of the most challenging and intractable diseases,” said Steve Gardner, PrecisionLife’s CEO.

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Drug Discovery World

APRIL 5, 2024

Corteria Pharmaceuticals has initiated a Phase I study to evaluate the company’s first-in-class corticotropin-releasing hormone receptor 2 (CRF2) agonist, COR-1167, for the treatment of Worsening Heart Failure (WHF). The post Phase I study to evaluate treatment of worsening heart failure appeared first on Drug Discovery World (DDW).

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Drug Discovery World

APRIL 11, 2023

Owing to the complexity of severe asthma, many patients have unclear or multiple drivers of airway inflammation resulting in some patients not responding to the current standard of treatment, and being at increased risk of asthma attacks, hospitalisations, and a poor quality of life 3,4,5,6. Final draft guidance is subject to appeal.

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Drug Discovery World

FEBRUARY 29, 2024

For Rare Disease Day 2024, Diana Spencer provides a round-up of the latest breakthroughs in the treatment of rare disease. million from the French government to advance the development of a gene therapy for the treatment of cerebrotendinous xanthomatosis (CTX), a rare neurodegenerative disease.

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Drug Discovery World

JANUARY 17, 2024

Researchers in Japan have revealed the key underlying mechanisms in muscle atrophy, paving the way towards potential new treatments. Treatment with gamma-secretase inhibitors In healthy cells, there are regions in the ER called mitochondria-associated membranes (MAMs) that can be reversibly tethered to the mitochondria.

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Drug Discovery World

MARCH 15, 2024

MTX325, a CNS penetrant which is a potential disease-modifying treatment for Parkinson’s disease, is about to enter Phase I trials; while peripherally-restricted MTX652 is currently in Phase II investigating acute kidney injury (AKI) associated with cardiac surgery. Megan Thomas, Multimedia Editor, DDW The post £25.2

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Drug Discovery World

FEBRUARY 1, 2024

At present there is no cure for CTX, only treatment to slow disease progression. The funding programme Vivet will use the funds to further develop its gene therapy product VTX-806 as an effective treatment option to stop or reverse disease progression over the long-term, or potentially cure CTX in patients.

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Drug Discovery World

JANUARY 4, 2024

AstraZeneca and Ionis’ Wainua (eplontersen) has been approved in the US for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults (hATTR-PN or ATTRv-PN). The post Wainua approval marks important milestone in amyloidosis treatment appeared first on Drug Discovery World (DDW).

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Drug Discovery World

APRIL 4, 2024

The US Food and Drug Administration (FDA) has approved Vafseo (vadadustat) Tablets for the treatment of anaemia due to chronic kidney disease (CKD) in adults who have been receiving dialysis for at least three months. Vafseo is now approved in 37 countries.

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Science Daily: Pharmacology News

MAY 13, 2024

An experimental treatment made from a plant virus is effective at protecting against a broad range of metastatic cancers in mice, shows a new study.

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Drug Discovery World

JANUARY 31, 2024

While there has been successful development of intravitreally administered products for patients with late-stage disease, treatment options are currently limited for patients in the early or moderate stages. Breye is developing novel, oral ophthalmology drugs fordiabetic retinopathy (DR) or age-related macular degeneration (AMD).

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Drug Discovery World

DECEMBER 19, 2023

Despite VMS, or hot flushes, being a common symptom of menopause, until now, hormone replacement therapy (HRT) was the only treatment. Veoza was also approved by the European Commission on 7 December 2023 at a dose of 45mg once daily for the treatment of moderate to severe VMS.

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Drug Discovery World

MARCH 21, 2024

It found that patients with rare kidney diseases are 28 times more likely to experience kidney failure than those with chronic kidney disease (CKD), but are less than half as likely to die before kidney failure treatment is needed. Rare kidney diseases are a group of conditions that each affect fewer than one in 2,000 people.

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Drug Discovery World

FEBRUARY 13, 2024

AM1476, a first-in-class, peripheral-acting serotonin receptor antagonist, has been granted US and EU Orphan Drug Designation as an anti-fibrotic treatment for systemic sclerosis. There are currently no treatments on the market that effectively stop or reverse scarring in both skin and lung tissue.

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Drugs.com

MAY 17, 2024

FRIDAY, May 17, 2024 -- Cutting-edge cancer treatments are essentially useless for patients barely clinging to life, a new study shows.Chemotherapies, immunotherapies, targeted therapies and hormone therapies do not improve survival rates in.

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Drug Discovery World

OCTOBER 2, 2023

The European Commission (EC) has approved INAQOVI (oral decitabine and cedazuridine) as monotherapy for the treatment of adult patients with newly diagnosed acute myeloid leukaemia (AML) who are ineligible for standard induction chemotherapy.

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Drug Discovery World

DECEMBER 18, 2023

Co-author Dr Marlena Fejzo from the Department of Population and Public Health Sciences at the University of Southern California, added: “Hopefully, now that we understand the cause of hyperemesis gravidarum, we’re a step closer to developing effective treatments to stop other mothers going through what I and many other women have experienced.”

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Fierce BioTech

MAY 2, 2024

Robert Barrow, Chief Executive Officer of MindMed | Generalized anxiety disorder afflicts millions however, the latest treatment was approved in 2007. Now MindMed is advancing a new treatment paradigm.

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Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 (HealthDay) -- Between 2018 and the spring of 2023, a cluster of clients who had gotten 'vampire facial' microneedling skin treatments at a New Mexico spa were diagnosed with HIV, probably via poorly cleaned instruments, a new.

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Drug Discovery World

NOVEMBER 29, 2023

Leniolisib, marketed under the brand name Joenja in the US, received approval from the US Food and Drug Administration (FDA) for the treatment of APDS in adult and paediatric patients 12 years of age and older in March 2023.

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Drug Discovery World

JUNE 28, 2023

Biopharmaceutical company InflaRx has launched Gohibic (vilobelimab) in the US for the treatment of Covid-19. Gohibic is currently the only drug directed against the complement factor C5a that is authorised for the treatment of certain critically ill Covid-19 patients. compared to placebo in the global data set.

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Drug Discovery World

OCTOBER 11, 2023

Collaborators Boehringer Ingelheim and CDR-Life have commenced a Phase I evaluation of BI 771716, their antibody fragment-based treatment developed to preserve the vision of people with geographic atrophy (GA).

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Drug Discovery World

JULY 3, 2023

PrecisionLife and the University of Oxford have signed a data access agreement to license the Oxford Endometriosis Gene (OXEGENE) dataset to develop new personalised treatments for endometriosis patients. The post Endometriosis partners to discover personalised treatments appeared first on Drug Discovery World (DDW).

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Drug Discovery World

JUNE 21, 2023

Citius Pharmaceuticals has revealed positive results from its Phase IIb Study of Halo-Lido (CITI-002) for the treatment of haemorrhoids. For the trial, Citius developed a PRO instrument to assess the efficacy of treatments in this disease.

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Drug Discovery World

DECEMBER 11, 2023

MC2-25 CKD is a first-in-class drug candidate and could represent a potential breakthrough in the understanding and treatment of urea associated skin diseases. We look forward to the data next year and to completing our discussions with regulatory authorities to fast track this treatment to patients globally.”

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Drug Discovery World

DECEMBER 4, 2023

Looking ahead, we are committed to advancing QN-01 into the next stage of clinical development and will be working closely with FDA and MHRA to bring this treatment option to the millions of smokers who want to quit.” The post Inhaled smoking cessation therapy superior to other treatments appeared first on Drug Discovery World (DDW).

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Drug Discovery World

OCTOBER 25, 2023

By characterising these resistance mechanisms, iOnctura is designing novel, safe combination treatments that promise to override resistance. The post New research highlights potential of combination cancer treatment appeared first on Drug Discovery World (DDW).

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Drug Discovery World

OCTOBER 27, 2023

The US Food and Drug Administration (FDA) has granted clearance for Endogena’s Investigational New Drug (IND) application for EA 2351, a potential treatment for geographic atrophy (GA). The post FDA gives green light for AMD treatment trials appeared first on Drug Discovery World (DDW).

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Drug Discovery World

NOVEMBER 8, 2023

The UK lags comparable countries, including France and Germany, on the degree of availability of treatments for rare diseases, according to a new report. The report by the BIA and consultancy firm PwC has highlighted the progress that has been made in improving access to rare disease treatments in the UK, and the challenges that remain.

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Drug Discovery World

OCTOBER 4, 2023

Biotech company 4SC has announced positive new data for its treatment for patients with advanced-stage cutaneous T-cell lymphoma (CTCL). Findings from the RESMAIN study of 4SC’s resminostat (Kinselby) treatment show that the therapy can postpone disease progression in advanced CTCL.

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Drug Discovery World

JANUARY 3, 2024

The grant will be used to conduct a Phase I clinical study of IRL757, a drug candidate in development as a novel treatment of apathy. The post Michael J Fox Foundation awards $2 million to Parkinson’s apathy treatment appeared first on Drug Discovery World (DDW).

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Drug Discovery World

SEPTEMBER 14, 2023

The post Delivering transformative treatments to cancer patients appeared first on Drug Discovery World (DDW). You can listen below, or find The Drug Discovery World Podcast on Spotify , Google Play and Apple Podcasts.

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Drug Discovery World

FEBRUARY 2, 2023

This will improve outcomes by using current treatments better through predicting who they will work for and for whom they won’t before giving a treatment. The post Commission tackles global access to precision cancer treatments appeared first on Drug Discovery World (DDW).

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