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CAR-T therapy could “alter the treatment paradigm” of multiple sclerosis

Drug Discovery World

. “This approval is a critically necessary step that paves the way to enrol patients with treatment-refractory progressive MS for whom there are no currently available treatment options in the KYSA-7 trial. CAR T-cell therapy involves modifying a patient’s T cells to recognise and remove B cells in the patient’s body.

Therapies 312
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Funding to advance gene therapy for cerebrotendinous xanthomatosis treatment 

Drug Discovery World

Vivet is a clinical stage biotech company developing gene therapies for rare inherited metabolic disorders. At present there is no cure for CTX, only treatment to slow disease progression. The post Funding to advance gene therapy for cerebrotendinous xanthomatosis treatment appeared first on Drug Discovery World (DDW).

Therapies 130
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First CAR-T therapy approved for earlier use in treatment of myeloma

Drug Discovery World

Bristol-Myers Squibb has received manufacturing and marketing approval in Japan for Abecma (idecabtagene vicleucel) as a third-line therapy for relapsed or refractory multiple myeloma (RRMM). We remain committed to researching and developing innovative therapies to transform patient lives with serious diseases through science.”

Therapies 147
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Inhaled smoking cessation therapy superior to other treatments

Drug Discovery World

Qnovia has announced positive results from its first in-human study of QN-01, an inhaled smoking cessation therapy. QN-01 is designed to meet the urgent need for new safe and effective pharmacotherapies that address the shortcomings of currently available nicotine replacement therapies (NRTs).

Therapies 130
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The killer instinct: Using investigational natural killer therapy to treat Alzheimer’s

Drug Discovery World

DDW Editor Reece Armstrong speaks to Dr Paul Song , MD, NKGen and Dr Vince DeOrchis , clinician, to find out more about the investigational natural killer therapy SNK01 and the benefit of using a patient’s own cells to treat Alzheimer’s. RA: What are the clinical benefits of using the patient’s own cells as a treatment?

Therapies 306
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Cell and gene therapy: Global Innovation and Opportunity

Drug Discovery World

Hailed as a revolution in the treatment of many diseases, cell and gene therapy (CGT) is the fastest growing area of therapeutics. The post Cell and gene therapy: Global Innovation and Opportunity appeared first on Drug Discovery World (DDW). 2024 is potentially shaping up to break this record.

Therapies 147
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Antibody therapy shows anti-tumour activity in advanced cancer

Drug Discovery World

In this first-in-human multicentre, open-label study conducted at nine study sites in Australia and China, Phase Ia involved monotherapy dose-escalation (Part 1), which was followed by Phase Ib combination therapy dose escalation (Part 2) and expansion (Part 3). Various dosing schedules of CS1002 (0.3,

Therapies 289