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Potent drug candidate could transform liver disease treatment

Drug Discovery World

Their research signals a transformative leap in liver disease management, addressing both inflammation and fibrosis. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a burgeoning global health concern, posing a significant threat to public health and escalating the burden on healthcare resources.

Disease 130
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Exendin?4: A potential therapeutic strategy for Alzheimer's disease and Parkinson's disease

Chemical Biology and Drug Design

The figure depicts the neuroprotective role of exendin-4 in Alzheimer's disease and Parkinson's disease. Exendin-4's diverse therapeutic targets suggest its potential therapeutic uses in neurodegenerative ailments like Alzheimer's disease and Parkinson's disease and have garnered an increasing amount of attention.

Disease 189
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€1.6m grant supports drug discovery in metabolic diseases

Drug Discovery World

Class B GPCRs are recognised as important targets for new medicines, particularly in chronic endocrine and metabolic diseases. grant supports drug discovery in metabolic diseases appeared first on Drug Discovery World (DDW). Diana Spencer, Senior Digital Content Editor, DDW The post €1.6m

Disease 130
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Parkinson's Disease: New theory on the disease's origins and spread

Science Daily: Pharmacology News

New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.

Disease 116
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Potential disease-modifying therapy for Parkinson’s disease

Drug Discovery World

An experimental drug has shown potential as a disease-modifying therapy for Parkinson’s disease, according to a new study published in Nature Communications. Parkinson’s disease is highly associated with mitochondrial dysfunction. Mission is planning to initiate a MTX325 Phase I trial in humans in early 2024.

Disease 130
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Using patient-specific cells for disease modelling

Drug Discovery World

Induced pluripotent stem cell (iPSC)-derived cells are a significant resource for disease modelling. They allow the use of cells directly from affected patients and have the potential to guide these cells towards multiple lineages.

Disease 130
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Focus on rare disease treatments to beat kidney failure, says study

Drug Discovery World

Focusing on rare conditions could significantly reduce the burden of kidney disease, according to a new study led by University College London (UCL) and the UK Kidney Association. The study, published in The Lancet to mark World Kidney Day on 14 March, draws on the largest rare kidney disease dataset ever created.

Disease 130