Disease - Drug Discovery Digest

Parkinson's Disease: New theory on the disease's origins and spread

Science Daily: Pharmacology News

APRIL 11, 2024

New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.

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Researchers devise new way to target and correct disease-related proteins

Broad Institute

JANUARY 6, 2025

Related groups Xavier lab Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits and diseases. Yet, correcting the effects of those variants to treat disease has been hampered in part by the lack of precise molecular tools to do so.

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Ozempic Can Treat Fatty Liver Disease

Drugs.com

MAY 1, 2025

THURSDAY, May 1, 2025 -- The cutting-edge weight-loss drug Ozempic/Wegovy can stop and even reverse fatty liver disease, a new clinical trial has found.Nearly twice as many people taking semaglutide stopped their fatty liver disease without further.

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Sweat health monitor measures levels of disease markers

Science Daily: Pharmacology News

JUNE 20, 2024

The 3D-printed monitor could someday provide a simple and non-invasive way to track health conditions and diagnose common diseases, such as diabetes, gout, kidney disease or heart disease. A wearable health monitor can reliably measure levels of important biochemicals in sweat during physical exercise.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

Navigating the AI Landscape 🤖 Explore the opportunities and challenges with integrating AI in healthcare and disease prevention. From Research to Real-World Care 🌎 Understand how AI-driven advancements are shaping personalized treatments and patient outcomes. Register today to save your seat!

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Alcohol raises heart disease risk, particularly among women

Science Daily: Pharmacology News

MARCH 28, 2024

Young to middle-aged women who reported drinking eight or more alcoholic beverages per week--more than one per day, on average--were significantly more likely to develop coronary heart disease compared with those who drank less, finds a study presented at the American College of Cardiology's Annual Scientific Session.

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Increasing physical activity in middle age may protect against Alzheimer's disease

Science Daily: Pharmacology News

APRIL 30, 2025

An increase in physical activity between the ages of 45 and 65 could help prevent Alzheimer's disease, while inactivity may be detrimental to brain health.

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Semaglutide treats liver disease in two thirds of patients

Science Daily: Pharmacology News

APRIL 30, 2025

Semaglutide effectively treats liver disease in two thirds of patients, new research has found.

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Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

Science Daily: Pharmacology News

JUNE 4, 2024

Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to cardiovascular disease (CVD) conditions are likely to triple by 2050, according to recent projections. At least 6 in 10 U.S. trillion price tag in direct and indirect costs.

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Taming Parkinson's disease with intelligent brain pacemakers

Science Daily: Pharmacology News

AUGUST 19, 2024

Two new studies are pointing the way toward round-the-clock personalized care for people with Parkinson's disease through an implanted device that can treat movement problems during the day and insomnia at night.

Disease

New Evidence Links Microplastics with Chronic Disease

Science Daily: Pharmacology News

MARCH 25, 2025

Higher exposure to these microplastics, which can be inadvertently consumed or inhaled, is associated with a heightened prevalence of chronic noncommunicable diseases, according to new research. Tiny fragments of plastic have become ubiquitous in our environment and our bodies.

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Eating ultra processed foods may speed up early signs of Parkinson's disease

Science Daily: Pharmacology News

MAY 7, 2025

People who eat more ultra processed foods like cold breakfast cereal, cookies and hot dogs are more likely to have early signs of Parkinson's disease when compared to those who eat very few ultra processed foods, according to a new study.

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Common Meds Appear To Delay Onset Of Parkinson's Disease

Drugs.com

APRIL 17, 2025

THURSDAY, April 17, 2025 -- Common medications like aspirin, ibuprofen, statins and beta blockers appear to slow the progress of Parkinsons disease, a new study says.Parkinsons symptoms took nearly a decade longer to crop up in patients taking the.

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Moderate coffee and caffeine consumption is associated with lower risk of developing multiple cardiometabolic diseases, new study finds

Science Daily: Pharmacology News

SEPTEMBER 17, 2024

Consuming moderate amounts of coffee and caffeine regularly may offer a protective effect against developing multiple cardiometabolic diseases, including type 2 diabetes, coronary heart disease and stroke, according to new research.

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Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

Science Daily: Pharmacology News

JANUARY 3, 2025

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests. Researchers drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank.

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Some diabetes drugs tied to lower risk of dementia, Parkinson's disease

Science Daily: Pharmacology News

SEPTEMBER 18, 2024

A class of drugs for diabetes may be associated with a lower risk of dementia and Parkinson's disease, according to a new study.

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New research lays groundwork for early detection of Alzheimer's disease

Science Daily: Pharmacology News

APRIL 21, 2025

A new study suggests that risk factors and biomarkers related to Alzheimer's disease are associated with cognition much earlier in life than previously recognized. The study highlights significant associations between cognition and Alzheimer's disease risk factors as young as ages 24 to 44 and underscores the importance of early prevention.

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A new approach to detecting Alzheimer's disease

Science Daily: Pharmacology News

FEBRUARY 3, 2025

Research has revealed clear evidence that changes in the orchestration of brain oxygenation dynamics and neuronal function in Alzheimer's disease contribute to the neurodegeneration.

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Xenon gas could protect against Alzheimer's disease: Mouse study

Science Daily: Pharmacology News

JANUARY 15, 2025

Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research points to a novel -- and noble -- approach: using Xenon gas. A phase 1 clinical trial of the treatment in healthy volunteers will begin in early 2025.

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Human 'domainome' reveals root cause of heritable disease

Science Daily: Pharmacology News

JANUARY 8, 2025

Unstable proteins are the main drivers of many different heritable diseases, according to a new study, including genetic disorders responsible for the formation of cataracts, and different types of rare neurological, developmental and muscle-wasting diseases.

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Popular diabetes and weight-loss drug may reduce risk of Alzheimer's disease

Science Daily: Pharmacology News

OCTOBER 24, 2024

Researchers have found that semaglutide may lower the risk of Alzheimer's disease in people with type 2 diabetes (T2D).

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'Weekend warrior' physical activity may help protect against more than 200 diseases

Science Daily: Pharmacology News

SEPTEMBER 26, 2024

The findings indicate that concentrated physical activity patterns may be just as effective for disease prevention as patterns where exercise is spread out throughout the week.

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Highly accurate blood test diagnoses Alzheimer's disease, measures extent of dementia

Science Daily: Pharmacology News

MARCH 31, 2025

A newly developed blood test for Alzheimer's disease not only aids in the diagnosis of the neurodegenerative condition but also indicates how far it has progressed, according to a new study.

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Ozempic Could Curb Progression of Diabetes-Linked Liver Disease

Drugs.com

SEPTEMBER 16, 2024

16, 2024 -- Fatty liver disease linked to diabetes and obesity can easily progress to liver cirrhosis, but new research suggests that GLP-1 medicines like Ozempic can help stop that. MONDAY, Sept. In a new decades-long study, veterans with diabetes.

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Gum Disease Germs Could Help Trigger Cancer

Drugs.com

SEPTEMBER 26, 2024

26, 2024 -- Bacteria that causes gum disease can also raise a person’s risk of head and neck cancers, a new study says.More than a dozen bacterial species have been linked to a collective 50% increased risk of head and neck cancer, r. THURSDAY, Sept.

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Novel bone marrow transplant can cure sickle cell disease, study suggests

Science Daily: Pharmacology News

FEBRUARY 25, 2025

A bone marrow transplant process is safe and curative for adults with sickle cell disease, according to results of a trial completed at about 20 cancer centers.

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Physical activity reduces stress-related brain activity to lower cardiovascular disease risk

Science Daily: Pharmacology News

APRIL 15, 2024

Over a ten-year period, biobank participants who met recommended levels of physical activity had a 23% lower risk of cardiovascular disease, and the protective effects were even more pronounced in individuals with depression.

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Microrobot-packed pill shows promise for treating inflammatory bowel disease in mice

Science Daily: Pharmacology News

JUNE 26, 2024

Engineers have developed a pill that releases microscopic robots, or microrobots, into the colon to treat inflammatory bowel disease (IBD). The experimental treatment, given orally, has shown success in mice. It significantly reduced IBD symptoms and promoted the healing of damaged colon tissue without causing toxic side effects.

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Doctors could soon use facial temperature for early diagnosis of metabolic diseases

Science Daily: Pharmacology News

JULY 2, 2024

With further research, doctors could one day use this simple and non-invasive approach for early detection of diseases. These temperature differences are not easily perceptible by one's own touch but can instead be identified using specific AI-derived spatial temperature patterns that require a thermal camera and a data-trained model.

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Gum Disease & Diabetes: A Strong Link

Drugs.com

NOVEMBER 14, 2024

14, 2024 -- Periodontal (gum) disease and diabetes are locked in a grim partnership aimed at undermining your health, experts warn.“Recent THURSDAY, Nov. Recent research has shown that diabetes is not only a major risk factor for periodontitis but that t.

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Biological organ ages predict disease risk decades in advance

Science Daily: Pharmacology News

FEBRUARY 25, 2025

Our organs age at different rates, and a blood test determining how much they've each aged could predict the risk of conditions like lung cancer and heart disease decades later, finds a new study.

Disease

Spinal cord stimulation restores neural function, targets key feature of progressive neurodegenerative disease

Science Daily: Pharmacology News

FEBRUARY 5, 2025

Boosting communication between the spinal nerves and the muscles using the spinal cord stimulation reverses spinal muscle atrophy (SMA) progression and could be applied to other motoneuron diseases, including ALS.

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Treatment for mitochondrial diseases within reach

Science Daily: Pharmacology News

APRIL 9, 2025

A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt cellular energy production. Researchers have identified a molecule that helps more mitochondria function properly.

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Low-level traffic air pollution linked to liver damage and fatty liver disease

Science Daily: Pharmacology News

JANUARY 31, 2025

Low levels of traffic-related air pollution harms the liver and may raise the risk of metabolic-associated fatty liver disease, a new study in mice suggests.

Disease

New Blood Test Can Diagnose, Track Alzheimer’s Disease

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- An experimental blood test for Alzheimers disease not only can aid in its diagnosis but also indicate how far the brain condition has progressed, a new study says.The test tracks levels of a protein called MTBR-tau243, w.

Disease

All in the eyes: High resolution retinal maps aid disease diagnoses

Science Daily: Pharmacology News

FEBRUARY 4, 2025

Researchers have conducted one of the largest eye studies in the world to reveal new insights into retinal thickness, highlighting its potential in the early detection of diseases like type 2 diabetes, dementia and multiple sclerosis.

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Once Again, Tuberculosis Becomes World's Top Infectious Disease Killer

Drugs.com

OCTOBER 30, 2024

30, 2024 -- In the highest tally ever recorded for tuberculosis cases, the World Health Organization reported Tuesday that over 8 million people worldwide were diagnosed with the lung disease last year.Of WEDNESDAY, Oct. that number, 1.25

Disease

Healthy eating in midlife linked to overall healthy aging

Science Daily: Pharmacology News

MARCH 24, 2025

The study is among the first to examine multiple dietary patterns in midlife in relation to overall healthy aging.

Disease

Ozempic Curbs Kidney Disease in Obese People Without Diabetes

Drugs.com

OCTOBER 28, 2024

28, 2024 -- The weight-loss drug Ozempic can guard against kidney disease in obese people, a new study shows.Patients taking semaglutide -- the active agent in Ozempic and Wegovy -- had as much as a 52% reduction in kidney damage, as. MONDAY, Oct.

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How integrated real-world data helps identify and improve outcomes for rare disease patients

BioPharma Drive: Drug Pricing

APRIL 28, 2025

Pharmaceutical companies are turning to integrated RWD approaches to overcome challenges in rare disease research.

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Mapping 1.6 million gut cells to find new ways treat disease

Science Daily: Pharmacology News

NOVEMBER 20, 2024

By combining 25 datasets, researchers have created the largest cohesive cell atlas of the human gut and uncovered a new way that stomach cells may play a role in Inflammatory Bowel Disease.

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Are you curious? It might help you stay sharp as you age

Science Daily: Pharmacology News

MAY 7, 2025

Older adults who maintain curiosity and want to learn new things relevant to their interests may be able to offset or even prevent Alzheimer's disease. Psychologists shows one type of curiosity can increase well into old age, contradicting prior research.

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Restricting sugar consumption in utero and in early childhood significantly reduces risk of midlife chronic disease

Science Daily: Pharmacology News

OCTOBER 31, 2024

Biobank, a database of medical histories and genetic, lifestyle and other disease risk factors, to study the effect of those early-life sugar restrictions on health outcomes of adults conceived in the U.K. The researchers used contemporary data from the U.K. just before and after the end of wartime sugar rationing.

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New study reveals how a 'non-industrialized' style diet can reduce risk of chronic disease

Science Daily: Pharmacology News

JANUARY 23, 2025

Researchers have found that a newly developed diet inspired by the eating habits of non-industrialized societies can significantly reduce the risk of a number of chronic diseases -- and are to share recipes with the public.

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Parkinson's Disease: New theory on the disease's origins and spread

Researchers devise new way to target and correct disease-related proteins

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Ozempic Can Treat Fatty Liver Disease

Webinars

Sweat health monitor measures levels of disease markers

Bridging Innovation & Patient Care: The Growing Role of AI

Alcohol raises heart disease risk, particularly among women

Increasing physical activity in middle age may protect against Alzheimer's disease

Semaglutide treats liver disease in two thirds of patients

Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

Taming Parkinson's disease with intelligent brain pacemakers

New Evidence Links Microplastics with Chronic Disease

Eating ultra processed foods may speed up early signs of Parkinson's disease

Common Meds Appear To Delay Onset Of Parkinson's Disease

Moderate coffee and caffeine consumption is associated with lower risk of developing multiple cardiometabolic diseases, new study finds

Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

Some diabetes drugs tied to lower risk of dementia, Parkinson's disease

New research lays groundwork for early detection of Alzheimer's disease

A new approach to detecting Alzheimer's disease

Xenon gas could protect against Alzheimer's disease: Mouse study

Human 'domainome' reveals root cause of heritable disease

Popular diabetes and weight-loss drug may reduce risk of Alzheimer's disease

'Weekend warrior' physical activity may help protect against more than 200 diseases

Highly accurate blood test diagnoses Alzheimer's disease, measures extent of dementia

Ozempic Could Curb Progression of Diabetes-Linked Liver Disease

Gum Disease Germs Could Help Trigger Cancer

Novel bone marrow transplant can cure sickle cell disease, study suggests

Physical activity reduces stress-related brain activity to lower cardiovascular disease risk

Microrobot-packed pill shows promise for treating inflammatory bowel disease in mice

Doctors could soon use facial temperature for early diagnosis of metabolic diseases

Gum Disease & Diabetes: A Strong Link

Biological organ ages predict disease risk decades in advance

Spinal cord stimulation restores neural function, targets key feature of progressive neurodegenerative disease

Treatment for mitochondrial diseases within reach

Low-level traffic air pollution linked to liver damage and fatty liver disease

New Blood Test Can Diagnose, Track Alzheimer’s Disease

All in the eyes: High resolution retinal maps aid disease diagnoses

Once Again, Tuberculosis Becomes World's Top Infectious Disease Killer

Healthy eating in midlife linked to overall healthy aging

Ozempic Curbs Kidney Disease in Obese People Without Diabetes

How integrated real-world data helps identify and improve outcomes for rare disease patients

Mapping 1.6 million gut cells to find new ways treat disease

Are you curious? It might help you stay sharp as you age

Restricting sugar consumption in utero and in early childhood significantly reduces risk of midlife chronic disease

New study reveals how a 'non-industrialized' style diet can reduce risk of chronic disease

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