Disease - Drug Discovery Digest

GSK to buy liver disease drug for $1.2B

BioPharma Drive: Drug Pricing

MAY 14, 2025

The new acquisition from Boston Pharmaceuticals adds to a wave of dealmaking undertaken by GSK to build its liver disease franchise.

Disease

Disease Pharmaceuticals Drugs

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment

Science Daily: Pharmacology News

MAY 15, 2025

A research team has developed and safely delivered a personalized gene editing therapy to treat an infant with a life-threatening, incurable genetic disease. The infant, who was diagnosed with the rare condition carbamoyl phosphate synthetase 1 (CPS1) deficiency shortly after birth, has responded positively to the treatment.

Treatment

Treatment Therapies Disease Research

Combo Drug Treatment More Effective For Kidney Disease in Type 2 Diabetics

Drugs.com

JUNE 9, 2025

MONDAY, June 9, 2025 — Prompt treatment with a drug combo can effectively manage chronic kidney disease in people with type 2 diabetes, a new clinical trial shows. Patients prescribed the combination of finerenone and empagliflozin.

Treatment

Treatment Disease Clinical Trials Drugs

Diabetes Drug, Dapagliflozin, Effective For Fatty Liver Disease

Drugs.com

JUNE 6, 2025

FRIDAY, June 6, 2025 — A repurposed diabetes drug can be an effective tool against fatty liver disease, a new clinical trial has found. Dapagliflozin helped people reduce fat levels in their liver and avoid liver scarring that comes with the.

Disease

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

Navigating the AI Landscape 🤖 Explore the opportunities and challenges with integrating AI in healthcare and disease prevention. From Research to Real-World Care 🌎 Understand how AI-driven advancements are shaping personalized treatments and patient outcomes. Register today to save your seat!

Clinical Trials

A cholesterol secret inside ticks may halt Lyme disease spread

Science Daily: Pharmacology News

JULY 4, 2025

Scientists have discovered that the bacteria behind Lyme disease and anaplasmosis have a sneaky way of surviving inside ticks—they hijack the tick’s own cell functions to steal cholesterol they need to grow. The research opens the door to new methods of stopping these diseases before ticks ever get the chance to bite.

Disease

Disease Research

Diabetes Drug Effective For Fatty Liver Disease

Drugs.com

JUNE 6, 2025

FRIDAY, June 6, 2025 — A repurposed diabetes drug can be an effective tool against fatty liver disease, a new clinical trial has found.Dapagliflozin helped people reduce fat levels in their liver and avoid liver scarring that comes with the c.

Disease

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Lilly to acquire Verve in $1B bet on gene editing for heart disease

BioPharma Drive: Drug Pricing

JUNE 17, 2025

The deal centers around a medicine that could “shift the treatment paradigm for cardiovascular disease,” Lilly said, but also follows a yearslong in decline in Verve’s share price amid skepticism over the need for such a therapy.

Disease

Disease Therapies Treatment

Ultrafast 12-minute MRI maps brain chemistry to spot disease before symptoms

Science Daily: Pharmacology News

JULY 1, 2025

Illinois engineers fused ultrafast imaging with smart algorithms to peek at living brain chemistry, turning routine MRIs into metabolic microscopes. The system distinguishes healthy regions, grades tumors, and forecasts MS flare-ups long before structural MRI can. Precision-medicine neurology just moved closer to reality.

Disease

Disease Engineering

Autoimmune Diseases Increase Risk Of Mood Disorders

Drugs.com

JUNE 25, 2025

WEDNESDAY, June 25, 2025 — People living with an autoimmune disease are nearly twice as likely to suffer from mood problems like depression, anxiety or bipolar disorder, a new large-scale study says. The risk of mood disorders is 87% to 97%.

Disease

Parkinson's Disease: New theory on the disease's origins and spread

Science Daily: Pharmacology News

APRIL 11, 2024

New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.

Disease

Researchers devise new way to target and correct disease-related proteins

Broad Institute

JANUARY 6, 2025

Related groups Xavier lab Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits and diseases. Yet, correcting the effects of those variants to treat disease has been hampered in part by the lack of precise molecular tools to do so.

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Disease Research DNA Small Molecule

A bespoke CRISPR therapy suggests a blueprint for treating ‘N-of-1’ diseases

BioPharma Drive: Drug Pricing

MAY 15, 2025

A gene editing drug custom-made for a critically ill baby showed that, for some ultra-rare diseases, it’s possible to design and test a new CRISPR medicine in just a few months.

Disease

Disease Therapies Drugs

HIV Drug, Lamivudine, Potentially Effective Against Diabetic Eye Disease

Drugs.com

JUNE 20, 2025

FRIDAY, June 20, 2025 — A cheap HIV drug might be able to help people with diabetes reverse a complication that can lead to blindness, a new small-scale study says. The drug, lamivudine, appears to improve vision that’s being threatened.

Disease

Disease Drugs

Genetics is a missing link in kidney disease drug development

BioPharma Drive: Drug Pricing

JUNE 2, 2025

Genetic research is driving progress in kidney disease drug discovery.

Disease

Disease Drug Development Drugs Research

Cullinan doubles down on bispecifics for autoimmune disease with Genrix deal

BioPharma Drive: Drug Pricing

JUNE 5, 2025

A deal worth up to $712 million with the China-based biotech gives Cullinan T cell engagers aimed at BCMA and CD19, two targets of interest in inflammatory conditions.

Disease

HIV Drug Potentially Effective Against Diabetic Eye Disease

Drugs.com

JUNE 20, 2025

FRIDAY, June 20, 2025 — A cheap HIV drug might be able to help people with diabetes reverse a complication that can lead to blindness, a new small-scale study says.The drug, lamivudine, appears to improve vision that’s being threatened by diabetic m.

Disease

Disease Drugs

Ozempic Can Treat Fatty Liver Disease

Drugs.com

MAY 1, 2025

THURSDAY, May 1, 2025 -- The cutting-edge weight-loss drug Ozempic/Wegovy can stop and even reverse fatty liver disease, a new clinical trial has found.Nearly twice as many people taking semaglutide stopped their fatty liver disease without further.

Disease

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Moderate coffee and caffeine consumption is associated with lower risk of developing multiple cardiometabolic diseases, new study finds

Science Daily: Pharmacology News

SEPTEMBER 17, 2024

Consuming moderate amounts of coffee and caffeine regularly may offer a protective effect against developing multiple cardiometabolic diseases, including type 2 diabetes, coronary heart disease and stroke, according to new research.

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Disease Research

Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

Science Daily: Pharmacology News

JANUARY 3, 2025

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests. Researchers drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank.

Disease

Disease Research

Ozempic Could Curb Progression of Diabetes-Linked Liver Disease

Drugs.com

SEPTEMBER 16, 2024

16, 2024 -- Fatty liver disease linked to diabetes and obesity can easily progress to liver cirrhosis, but new research suggests that GLP-1 medicines like Ozempic can help stop that. MONDAY, Sept. In a new decades-long study, veterans with diabetes.

Disease

Disease Research

Xenon gas could protect against Alzheimer's disease: Mouse study

Science Daily: Pharmacology News

JANUARY 15, 2025

Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research points to a novel -- and noble -- approach: using Xenon gas. A phase 1 clinical trial of the treatment in healthy volunteers will begin in early 2025.

Disease

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New tRNA tech aims to rewrite rare disease treatment

Drug Target Review

JUNE 9, 2025

The landscape of genetic medicine is undergoing a profound transformation, driven by innovative approaches that challenge the traditional, disease-specific paradigms. My transition to biotech and rare diseases was deeply personal – my son was diagnosed with Duchenne muscular dystrophy in 2020. “My

Disease

Disease Treatment Engineering Protein Production

Highly accurate blood test diagnoses Alzheimer's disease, measures extent of dementia

Science Daily: Pharmacology News

MARCH 31, 2025

A newly developed blood test for Alzheimer's disease not only aids in the diagnosis of the neurodegenerative condition but also indicates how far it has progressed, according to a new study.

Disease

New Blood Test Can Diagnose, Track Alzheimer’s Disease

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- An experimental blood test for Alzheimers disease not only can aid in its diagnosis but also indicate how far the brain condition has progressed, a new study says.The test tracks levels of a protein called MTBR-tau243, w.

Disease

Physical activity reduces stress-related brain activity to lower cardiovascular disease risk

Science Daily: Pharmacology News

APRIL 15, 2024

Over a ten-year period, biobank participants who met recommended levels of physical activity had a 23% lower risk of cardiovascular disease, and the protective effects were even more pronounced in individuals with depression.

Disease

A new approach to detecting Alzheimer's disease

Science Daily: Pharmacology News

FEBRUARY 3, 2025

Research has revealed clear evidence that changes in the orchestration of brain oxygenation dynamics and neuronal function in Alzheimer's disease contribute to the neurodegeneration.

Disease

Disease Research

New Blood Test Promises Pain-Free Diagnosis Of Celiac Disease

Drugs.com

JUNE 20, 2025

FRIDAY, June 20, 2025 — Celiac disease patients currently must make themselves sicker before they're able to seek treatment.The tests now used to diagnose celiac disease require patients to eat gluten, the protein that provokes an autoimmune r.

Disease

Once Again, Tuberculosis Becomes World's Top Infectious Disease Killer

Drugs.com

OCTOBER 30, 2024

30, 2024 -- In the highest tally ever recorded for tuberculosis cases, the World Health Organization reported Tuesday that over 8 million people worldwide were diagnosed with the lung disease last year.Of WEDNESDAY, Oct. that number, 1.25

Disease

Ozempic Curbs Kidney Disease in Obese People Without Diabetes

Drugs.com

OCTOBER 28, 2024

28, 2024 -- The weight-loss drug Ozempic can guard against kidney disease in obese people, a new study shows.Patients taking semaglutide -- the active agent in Ozempic and Wegovy -- had as much as a 52% reduction in kidney damage, as. MONDAY, Oct.

Disease

Disease Drugs

Common Meds Appear To Delay Onset Of Parkinson's Disease

Drugs.com

APRIL 17, 2025

THURSDAY, April 17, 2025 -- Common medications like aspirin, ibuprofen, statins and beta blockers appear to slow the progress of Parkinsons disease, a new study says.Parkinsons symptoms took nearly a decade longer to crop up in patients taking the.

Disease

New Evidence Links Microplastics with Chronic Disease

Science Daily: Pharmacology News

MARCH 25, 2025

Higher exposure to these microplastics, which can be inadvertently consumed or inhaled, is associated with a heightened prevalence of chronic noncommunicable diseases, according to new research. Tiny fragments of plastic have become ubiquitous in our environment and our bodies.

Disease

Disease Research

Smartphone App Can Track Huntington's Disease Symptoms

Drugs.com

JUNE 12, 2025

THURSDAY, June 12, 2025 — Most folks tap away at their smartphone for fun, communication or information.But such tapping may also help them track the progress of a rare degenerative brain disease, researchers say.Five simple smartphone-measured t.

Disease

Disease Research

Vera drug scores in closely watched study in rare kidney disease

BioPharma Drive: Drug Pricing

JUNE 2, 2025

Phase 3 results revealed Monday led shares to surge and should yield an approval application in IgA nephropathy, a competitive corner of drug research, later this year.

Disease

Disease Drugs Drug Research Research

Novel bone marrow transplant can cure sickle cell disease, study suggests

Science Daily: Pharmacology News

FEBRUARY 25, 2025

A bone marrow transplant process is safe and curative for adults with sickle cell disease, according to results of a trial completed at about 20 cancer centers.

Disease

Disease Trials

Increasing physical activity in middle age may protect against Alzheimer's disease

Science Daily: Pharmacology News

APRIL 30, 2025

An increase in physical activity between the ages of 45 and 65 could help prevent Alzheimer's disease, while inactivity may be detrimental to brain health.

Disease

Scientists reverse Parkinson’s symptoms in mice — Could humans be next?

Science Daily: Pharmacology News

JULY 5, 2025

Scientists at the University of Sydney have uncovered a malfunctioning version of the SOD1 protein that clumps inside brain cells and fuels Parkinson’s disease.

Therapies

Therapies Disease

Restricting sugar consumption in utero and in early childhood significantly reduces risk of midlife chronic disease

Science Daily: Pharmacology News

OCTOBER 31, 2024

Biobank, a database of medical histories and genetic, lifestyle and other disease risk factors, to study the effect of those early-life sugar restrictions on health outcomes of adults conceived in the U.K. The researchers used contemporary data from the U.K. just before and after the end of wartime sugar rationing.

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Disease Research

New study reveals how a 'non-industrialized' style diet can reduce risk of chronic disease

Science Daily: Pharmacology News

JANUARY 23, 2025

Researchers have found that a newly developed diet inspired by the eating habits of non-industrialized societies can significantly reduce the risk of a number of chronic diseases -- and are to share recipes with the public.

Disease

Disease Research

Scientists Discover the Brain's Waste-Disposal System, With Clues to Alzheimer's Disease

Drugs.com

OCTOBER 8, 2024

8, 2024 -- The brain has a waste-disposal system that clears away junk proteins that contribute to the development of dementia and Alzheimer’s disease, a new study finds.Advanced imaging scans have revealed a network of fluid-filled s. TUESDAY, Oct.

Disease

Spinal cord stimulation restores neural function, targets key feature of progressive neurodegenerative disease

Science Daily: Pharmacology News

FEBRUARY 5, 2025

Boosting communication between the spinal nerves and the muscles using the spinal cord stimulation reverses spinal muscle atrophy (SMA) progression and could be applied to other motoneuron diseases, including ALS.

Disease

Link Between Gum Disease, Brain Function Exists, Small Study Says

Drugs.com

JANUARY 13, 2025

13, 2025 -- Gum disease appears to disrupt brain activity, potentially increasing a persons risk of cognitive decline.People with gum disease experienced altered connections between different brain regions, compared to folks with good. MONDAY, Jan.

Disease

Healthy eating in midlife linked to overall healthy aging

Science Daily: Pharmacology News

MARCH 24, 2025

The study is among the first to examine multiple dietary patterns in midlife in relation to overall healthy aging.

Disease

How integrated real-world data helps identify and improve outcomes for rare disease patients

BioPharma Drive: Drug Pricing

APRIL 28, 2025

Pharmaceutical companies are turning to integrated RWD approaches to overcome challenges in rare disease research.

Disease

Disease Pharmaceutical Companies Pharmaceuticals Research

GSK to buy liver disease drug for $1.2B

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment

Trending Sources

Combo Drug Treatment More Effective For Kidney Disease in Type 2 Diabetics

Diabetes Drug, Dapagliflozin, Effective For Fatty Liver Disease

Bridging Innovation & Patient Care: The Growing Role of AI

A cholesterol secret inside ticks may halt Lyme disease spread

Diabetes Drug Effective For Fatty Liver Disease

Lilly to acquire Verve in $1B bet on gene editing for heart disease

Ultrafast 12-minute MRI maps brain chemistry to spot disease before symptoms

Autoimmune Diseases Increase Risk Of Mood Disorders

Parkinson's Disease: New theory on the disease's origins and spread

Researchers devise new way to target and correct disease-related proteins

A bespoke CRISPR therapy suggests a blueprint for treating ‘N-of-1’ diseases

HIV Drug, Lamivudine, Potentially Effective Against Diabetic Eye Disease

Genetics is a missing link in kidney disease drug development

Cullinan doubles down on bispecifics for autoimmune disease with Genrix deal

HIV Drug Potentially Effective Against Diabetic Eye Disease

Ozempic Can Treat Fatty Liver Disease

Moderate coffee and caffeine consumption is associated with lower risk of developing multiple cardiometabolic diseases, new study finds

Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

Ozempic Could Curb Progression of Diabetes-Linked Liver Disease

Xenon gas could protect against Alzheimer's disease: Mouse study

New tRNA tech aims to rewrite rare disease treatment

Highly accurate blood test diagnoses Alzheimer's disease, measures extent of dementia

New Blood Test Can Diagnose, Track Alzheimer’s Disease

Physical activity reduces stress-related brain activity to lower cardiovascular disease risk

A new approach to detecting Alzheimer's disease

New Blood Test Promises Pain-Free Diagnosis Of Celiac Disease

Once Again, Tuberculosis Becomes World's Top Infectious Disease Killer

Ozempic Curbs Kidney Disease in Obese People Without Diabetes

Common Meds Appear To Delay Onset Of Parkinson's Disease

New Evidence Links Microplastics with Chronic Disease

Smartphone App Can Track Huntington's Disease Symptoms

Vera drug scores in closely watched study in rare kidney disease

Novel bone marrow transplant can cure sickle cell disease, study suggests

Increasing physical activity in middle age may protect against Alzheimer's disease

Scientists reverse Parkinson’s symptoms in mice — Could humans be next?

Restricting sugar consumption in utero and in early childhood significantly reduces risk of midlife chronic disease

New study reveals how a 'non-industrialized' style diet can reduce risk of chronic disease

Scientists Discover the Brain's Waste-Disposal System, With Clues to Alzheimer's Disease

Spinal cord stimulation restores neural function, targets key feature of progressive neurodegenerative disease

Link Between Gum Disease, Brain Function Exists, Small Study Says

Healthy eating in midlife linked to overall healthy aging

How integrated real-world data helps identify and improve outcomes for rare disease patients

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