Drug Discovery World

NOVEMBER 29, 2022

Using artificial intelligence, researchers at Chalmers University of Technology, Sweden have succeeded in designing synthetic DNA that controls the cells’ protein production. . The technology can contribute to the development and production of vaccines and drugs for severe diseases much faster and at lower cost. .

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Chemical Biology and Drug Design

AUGUST 23, 2023

We hypothesized that ligustrazine could protect liver by decreasing the inflammation response, protein production, and apoptosis in THS rats. The protein expressions were detected via western blot. It also decreases the platelets' bioactivity and reduces reactive oxygen species formation.

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Drug Discovery World

OCTOBER 24, 2022

The synthesis of mRNA is fast, affordable and scalable, and LNP-delivered mRNA can be repeated as necessary to sustain protein production until the infection subsides. “The soluble enzyme effectively inhibited live SARS-CoV-2 from infecting host cells,” said OSU postdoctoral researcher Jeonghwan Kim.

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Drug Discovery World

FEBRUARY 13, 2023

Using AI, researchers at Chalmers University of Technology, Sweden succeeded in designing synthetic DNA that controls the cells’ protein production. While companies make these commitments and partner for a better future, others shared successes in 2022.

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Drug Discovery World

JULY 24, 2023

Cell-Free Protein Synthesis (CFPS) CFPS, by contrast, brings the key advantages of greater speed and flexibility than cell- and fermentation-based production.

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Drug Discovery World

NOVEMBER 27, 2023

Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production. Biotechnol Bioeng 2012;118:2326. Budge JD, Knight TJ, Povey J, et al. Metab Eng 2020;57:203. Patel T, Ingham C, Fleming J, et al. CHOSOURCE™ ADCC+ cell line for enhanced therapeutic potency.

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FDA Law Blog: Biosimilars

MARCH 5, 2024

Gaulkin & Riëtte van Laack — As readers of this blog know, there is a lot of contention about the naming of alternative protein products (APPs), including both plant-based and cell-cultured alternatives for (traditional) animal products. By Sophia R.

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Drug Target Review

OCTOBER 10, 2023

The company specialises in recombinant protein production and antibody development. All of Sino Biological’s products are independently developed and produced with a stringent quality management system, and include unique bioreagents addressing areas such as cell therapy, stem cell, and infectious disease research.

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Sygnature Discovery

APRIL 26, 2022

Sygnature have acquired Peak Proteins Ltd. Following an extensive partnership between the two companies, this deal will enable seamless integration of protein production and related structure determination projects within Sygnature. The Peak Proteins leadership team will also remain with the business.

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The Pharma Data

JANUARY 16, 2021

Etta Biotech”), to set up a high titer transient protein expression platform for high quality protein production using JS Bio’s transient transfection media. JS Bio becomes the exclusive cell culture supplier for Etta Biotech’s transient transfection high titer protein expression platform.

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Drug Discovery World

APRIL 17, 2024

CAMP4 is the only company modulating gene expression at the transcriptional level to increase mRNA production and thereby increase healthy protein production. DS: You say on your website that your approach is applicable to any disease where increasing protein expression is beneficial. Can you give some examples?

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Drug Target Review

MARCH 15, 2024

Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production. Budge JD, Knight TJ, Povey J, et al. Wright C, Alves C, Kshirsagar R, et al. Leveraging a CHO cell line toolkit to accelerate biotherapeutics into the clinic. Biotechnol Prog.

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The Pharma Data

OCTOBER 18, 2021

Tofersen binds to SOD1 mRNA, allowing for its declination by RNase-H in an trouble to reduce conflation of SOD1 protein product. About Tofersen Tofersen is an antisense medicine being estimated for the implicit treatment of SOD1-ALS.

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FDA Law Blog: Biosimilars

JULY 11, 2023

To set the stage for this case, we need to go back to March 2020 , when a new definition of “biological product” threw the world of protein products into a tizzy. As a result of the Biologics Price Competition and Innovation Act (BPCIA) passed in 2010, the definition of a “biological product” expanded to include “proteins.”

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Science Daily: Pharmacology News

JULY 5, 2023

An antisense therapy restores production of the protein FMRP in cell samples taken from patients with fragile X syndrome.

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Drug Target Review

NOVEMBER 1, 2023

We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production. With all these diverse methods we characterise protein-ligand interactions in many ways.

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The Pharma Data

MARCH 23, 2022

Without the stop sign, viral transcription no longer follows the correct order, which has a negative impact on viral protein production,” says Fang. “The virus hijacks this protein and makes it do something different than its normal job in cells. “We weren’t expecting to see this,” says Fang.

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Broad Institute

AUGUST 24, 2022

LIG1 ’s protein product is a critical component of lagging strand DNA synthesis that connects Okazaki fragments (small DNA segments that must be connected to complete the synthesis reaction).

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Drug Target Review

APRIL 5, 2024

Together, these attributes provide a strong foundation for protein expression with enough adaptability to produce much of the commercial and therapeutic protein market. Skilled CDMOs can also locate or create favourable genomic microenvironments where transcription factors are efficiently recruited, further boosting protein production.

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PLOS: DNA Science

JUNE 13, 2024

The most compelling evidence for the origin lies in the RNA genome sequence similarities between RaTG13 and SARS-CoV-2 – specifically, a part that encodes the “furin binding site” of the spike protein with which the virus adheres to host cells. Coincidence? I’ve never thought so.

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Drug Discovery World

NOVEMBER 17, 2022

To show the versatility of METIS, the team used it for a variety of applications, including optimisation of protein production, genetic constructs, combinatorial engineering of the enzyme activity, and a complex CO2 fixation metabolic cycle. .

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Drug Discovery World

NOVEMBER 9, 2023

Thereafter, there will be the following presentations: Georgios Skretas, PhD, Director, Institute for Bio-innovation, Biomedical Sciences Research Center “Alexander Fleming;” Founder & CEO, ResQ Biotech, on: ‘Development of specialised bacterial strains for high-level production of recombinant membrane proteins’.

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Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

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Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

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Dark Matter Blog

JULY 16, 2021

At Biogen, my group’s work covered a range of technology development areas including protein production in mammalian cells, intracellular protein delivery (our work on HIV Tat started the field of cell-penetrating peptides) and novel gene delivery vehicles, as well as biological drug discovery and development.

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Drug Discovery World

MARCH 6, 2024

Mutations in a gene may cause structural changes in its protein product, which can lead to a loss of function and consequently to the onset of a disease. This is comparatively easier to accomplish in these diseases because they are relatively monogenic.

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Drug Discovery World

APRIL 30, 2024

This novel approach allows for the modulation of mRNA biology to either increase or decrease protein production, offering the versatility to target a wide range of mechanisms of action (MOA),” Slonim states. We can see this versatility in the various treatments that are currently being researched.

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Drug Discovery World

OCTOBER 11, 2023

Others, like tetracycline and aminoglycosides, inhibit the function of ribosomes, the cellular machinery responsible for protein production. For example, some drugs like penicillin, carbapenem, and vancomycin disrupt the synthesis of bacterial cell walls.

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Drug Discovery World

NOVEMBER 8, 2023

Morten Nørholm, PhD, Research Group Leader, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, on: “A next generation pET system for bacterial protein production”. Claudia Rinnofner, PhD, Founder & CEO, myBIOS GmbH, on: “Novel strategies for protein production using Pichia pastoris”.

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Drug Discovery World

NOVEMBER 30, 2023

Not to mention, Polypus, a French lab technology company acquired by Sartorius earlier this year, had expert Marine Houdou on hand to discuss modular DNA assembly to recombinant protein production at Polyplus, as well as poster presentations on how to improve protein production yields in mammalian cells through plasmid engineering and transfection (..)

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Drug Discovery World

NOVEMBER 13, 2023

These topics include: High-throughput (HTP) protein production and AI and automation in bioprocess development. Roundtable breakout discussions Breakout Discussions are informal, moderated discussions, which allow participants to exchange ideas and experiences and develop future collaborations around a focused topic.

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Drug Discovery World

JANUARY 12, 2023

Altering one base pair can drastically change how the gene’s protein product functions, while mutations can lead to the development of a range of genetic disorders. . Oksana Sirenko looks at the advantages and limitations of using organoids from human cell sources in drug development and drug screening. .

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Broad Institute

MAY 14, 2024

With the T7 promoter placed next to the gene for the COVID-19 spike protein, the T7 polymerase could generate many kilograms of mRNA — the active molecule in the vaccines — at a time. “I

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Drug Discovery World

AUGUST 1, 2023

As per a definition provided by AstraZeneca: “Once inside, ASOs bind with high specificity to target mRNA or pre-mRNA, inducing its degradation – effectively silencing it – to prevent its translation into a detrimental protein product.

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Codon

MARCH 24, 2024

In 2012, an Israeli company called Protalix gained approval for their plant-based enzyme product for Gaucher’s disease. Kanuma, their FDA-approved protein product for rare lysosomal diseases, is “purified from the egg white of transgenic hens.”

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The Pharma Data

DECEMBER 22, 2020

Using the obtained sequencing data, Kao Corporation was able to produce an antibody sample in one week using protein production technology such as enzymes cultivated by our technology. Comment from Fumiharu Muroga, Growth Manager at Real Tech Fund] “Proteins are an important structural component of living things.

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The Pharma Data

OCTOBER 14, 2020

Premature stop codons are point mutations that disrupt protein synthesis from messenger RNA. As a consequence, patients with premature stop codon diseases have reduced or eliminated protein production from the mutation bearing allele accounting for some of the most severe phenotypes in these genetic diseases.

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