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mRNA pioneers Katalin Karikó and Drew Weissman receive Nobel prize

Drug Discovery World

In further studies published in 2008 and 2010, Karikó and Weissman showed that the delivery of mRNA generated with base modifications markedly increased protein production compared to unmodified mRNA. The effect was due to the reduced activation of an enzyme that regulates protein production.

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UK university partnership wins £1.8m for drug discovery research

Drug Discovery World

Together these new technologies will increase yields of high-quality functional proteins, simplifying and shortening the time required to produce key biomedical proteins for drug screening.

Research 263
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Positive initial results for srRNA rabies vaccine

Drug Discovery World

“Achieving a broad therapeutic window is an important step-up from other existing mRNA and srRNA approaches, which allows us to expand applications of our self-replicating RNA to complex infectious diseases, off-the-shelf cancer vaccines, and as a platform for protein production.”

Vaccine 130
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Sarepta data show new Duchenne drug’s potency, but highlight side effects

BioPharma Drive: Drug Pricing

A successor medicine to Sarepta's Exondys 51 appeared better at boosting dystrophin protein production, but was associated with electrolyte imbalances.

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First therapy for very rare blood clotting disorder gets US greenlight

Drug Discovery World

Takeda’s Adzynma has become the first recombinant protein product approved in the US for prophylactic or on-demand enzyme replacement therapy (ERT) for congenital thrombotic thrombocytopenic purpura (cTTP).

Therapies 130
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Structural biology: Molecular scissors caught in the act

SCIENMAG: Medicine & Health

Transfer RNAs (tRNAs) are among the most common types of RNA in a cell and are indispensable for protein production in all known organisms.

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Ligustrazine improves the compensative effect of Akt survival signaling to protect liver Kupffer cells in trauma?hemorrhagic shock rats

Chemical Biology and Drug Design

We hypothesized that ligustrazine could protect liver by decreasing the inflammation response, protein production, and apoptosis in THS rats. The protein expressions were detected via western blot. It also decreases the platelets' bioactivity and reduces reactive oxygen species formation.