Codon

JUNE 9, 2025

Several decades of effort to create “artificial life” in the laboratory have produced biochemical machines and self-sustained protein production systems but, as yet, no organisms capable of cell division or robust metabolism. Biotechnologists know this firsthand.

Science

BioPharma Drive: Drug Pricing

JANUARY 29, 2024

A successor medicine to Sarepta's Exondys 51 appeared better at boosting dystrophin protein production, but was associated with electrolyte imbalances.

Protein Production

Broad Institute

JULY 19, 2024

A new study reveals that C1q can also enter neurons, where it influences protein production, and can accumulate within neurons over time. They also suggest that C1q influences learning, memory, and flexibility in the adult brain, potentially by interacting with specific complexes within neurons that impact protein production.

Protein Production

Drug Target Review

APRIL 5, 2024

Together, these attributes provide a strong foundation for protein expression with enough adaptability to produce much of the commercial and therapeutic protein market. Skilled CDMOs can also locate or create favourable genomic microenvironments where transcription factors are efficiently recruited, further boosting protein production.

Protein Production

SCIENMAG: Medicine & Health

JULY 13, 2023

Transfer RNAs (tRNAs) are among the most common types of RNA in a cell and are indispensable for protein production in all known organisms.

Protein Production

Chemical Biology and Drug Design

AUGUST 23, 2023

We hypothesized that ligustrazine could protect liver by decreasing the inflammation response, protein production, and apoptosis in THS rats. The protein expressions were detected via western blot. It also decreases the platelets' bioactivity and reduces reactive oxygen species formation.

Protein Expression

Broad Institute

JUNE 29, 2023

In the future, the researchers imagine using RIBOmap to compare healthy and diseased tissue or see how drugs impact protein production within different cell types or areas of a tissue. By Sarah C.P. Williams June 29, 2023 Credit: Zeng H, Huang J, Ren J, et al. and Virginia W.

Protein Production

Drug Target Review

OCTOBER 10, 2023

The company specialises in recombinant protein production and antibody development. All of Sino Biological’s products are independently developed and produced with a stringent quality management system, and include unique bioreagents addressing areas such as cell therapy, stem cell, and infectious disease research.

Protein Production

Sygnature Discovery

SEPTEMBER 12, 2024

Protein Purification Standard chromatography methods for purification of high grade protein. In vivo biotinylation of target protein. Dedicated Membrane protein production team. Protein refolding from inclusion bodies. Low endotoxin batches. Low endotoxin batches.

Science

Sygnature Discovery

SEPTEMBER 11, 2024

We’ve successfully tackled targets for: Unprecedented membrane proteins Intrinsically disordered proteins Refolding from inclusion bodies Large protein complexes Labelled proteins for NMR studies RNA structures by crystallography Across our capabilities Protein Expression & Purification Vast diversity of proteins produced.

Science

FDA Law Blog: Biosimilars

MARCH 5, 2024

Gaulkin & Riëtte van Laack — As readers of this blog know, there is a lot of contention about the naming of alternative protein products (APPs), including both plant-based and cell-cultured alternatives for (traditional) animal products. By Sophia R.

Protein Production

Sygnature Discovery

APRIL 26, 2022

Sygnature have acquired Peak Proteins Ltd. Following an extensive partnership between the two companies, this deal will enable seamless integration of protein production and related structure determination projects within Sygnature. The Peak Proteins leadership team will also remain with the business.

Fragment Screening

FDA Law Blog: Biosimilars

JULY 11, 2023

To set the stage for this case, we need to go back to March 2020 , when a new definition of “biological product” threw the world of protein products into a tizzy. As a result of the Biologics Price Competition and Innovation Act (BPCIA) passed in 2010, the definition of a “biological product” expanded to include “proteins.”

FDA

Sygnature Discovery

SEPTEMBER 12, 2024

High quality protein production in-house Protein quality is the key factor for structure projects. We have extensive experience in producing difficult proteins, including membrane proteins. PANDDA analysis for rapid delivery of a hit list. Fragment analogs identified for rapid follow-up.

Fragment Screening

Drug Target Review

NOVEMBER 1, 2023

We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production. With all these diverse methods we characterise protein-ligand interactions in many ways.

Fragment Screening

The Pharma Data

OCTOBER 18, 2021

Tofersen binds to SOD1 mRNA, allowing for its declination by RNase-H in an trouble to reduce conflation of SOD1 protein product. About Tofersen Tofersen is an antisense medicine being estimated for the implicit treatment of SOD1-ALS.

Biosimilars

The Pharma Data

OCTOBER 14, 2020

Premature stop codons are point mutations that disrupt protein synthesis from messenger RNA. As a consequence, patients with premature stop codon diseases have reduced or eliminated protein production from the mutation bearing allele accounting for some of the most severe phenotypes in these genetic diseases.

Pharmaceuticals

Drug Target Review

JULY 5, 2023

5 And for the latter, the development of a technique to temporally track gene expression in CHO cells, which therefore has the potential to lead to the identification of targets to improve recombinant protein production. 6 As a result, we may well see more options when it comes to host cell lines offered by companies in the future.

Engineering

The Pharma Data

DECEMBER 22, 2020

Using the obtained sequencing data, Kao Corporation was able to produce an antibody sample in one week using protein production technology such as enzymes cultivated by our technology. Comment from Fumiharu Muroga, Growth Manager at Real Tech Fund] “Proteins are an important structural component of living things.

Engineering

The Pharma Data

MARCH 23, 2022

Without the stop sign, viral transcription no longer follows the correct order, which has a negative impact on viral protein production,” says Fang. “The virus hijacks this protein and makes it do something different than its normal job in cells. “We weren’t expecting to see this,” says Fang.

Virus

Broad Institute

AUGUST 24, 2022

LIG1 ’s protein product is a critical component of lagging strand DNA synthesis that connects Okazaki fragments (small DNA segments that must be connected to complete the synthesis reaction).

DNA

Dark Matter Blog

JULY 16, 2021

At Biogen, my group’s work covered a range of technology development areas including protein production in mammalian cells, intracellular protein delivery (our work on HIV Tat started the field of cell-penetrating peptides) and novel gene delivery vehicles, as well as biological drug discovery and development.

Small Molecule

Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

Production

Drug Target Review

MARCH 15, 2024

Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production. Budge JD, Knight TJ, Povey J, et al. Wright C, Alves C, Kshirsagar R, et al. Leveraging a CHO cell line toolkit to accelerate biotherapeutics into the clinic. Biotechnol Prog.

Engineering

The Pharma Data

JANUARY 16, 2021

Etta Biotech”), to set up a high titer transient protein expression platform for high quality protein production using JS Bio’s transient transfection media. JS Bio becomes the exclusive cell culture supplier for Etta Biotech’s transient transfection high titer protein expression platform.

Protein Expression

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

Engineering

PLOS: DNA Science

JUNE 13, 2024

The most compelling evidence for the origin lies in the RNA genome sequence similarities between RaTG13 and SARS-CoV-2 – specifically, a part that encodes the “furin binding site” of the spike protein with which the virus adheres to host cells. Coincidence? I’ve never thought so.

Virus

The Pharma Data

DECEMBER 3, 2020

These forward-looking statements may be accompanied by such words as “aim,” “anticipate,” “believe,” “could,” “estimate,” “expect,” “forecast,” “goal,” “intend,” “may,” “might,” “plan,” “potential,” “possible,” “will,” “would,” and other words and terms of similar meaning.

Clinical Trials

Codon

MARCH 20, 2023

Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast. Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production. Metabolic Engineering. Assembly of metabolons in yeast using Cas6-mediated RNA scaffolding. ACS Synthetic Biology.

Virus

Codon

MARCH 24, 2024

In 2012, an Israeli company called Protalix gained approval for their plant-based enzyme product for Gaucher’s disease. Kanuma, their FDA-approved protein product for rare lysosomal diseases, is “purified from the egg white of transgenic hens.”

Vaccine

The Pharma Data

JANUARY 24, 2021

Elasmogen is unique in its capacity to isolate and develop soloMERs, with a multi-layered IP position covering the platform, humanisation, formats, products and process including over 25 patents granted in the US, Europe and other territories.

Research

Broad Institute

MAY 14, 2024

With the T7 promoter placed next to the gene for the COVID-19 spike protein, the T7 polymerase could generate many kilograms of mRNA — the active molecule in the vaccines — at a time. “I

RNA

The Pharma Data

JANUARY 13, 2021

The resulting target cell types could provide researchers with improved access to important proteins found in human cell types that are difficult to obtain and allow for more efficient protein production.

Licensing

PLOS: DNA Science

AUGUST 8, 2024

Imprinting disorders can also result from differences between parental genders in gene expression – that is, protein production from the encoded information. In Prader-Willi and Angelman syndromes, a tiny section of the same chromosome is absent.

Small Molecule

Codon

MAY 30, 2023

Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. Read Modular metabolic engineering and synthetic coculture strategies for the production of aromatic compounds in yeast. Materials Today Bio. Read Living microecological hydrogels for wound healing.

DNA

Codon

MAY 30, 2023

Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. Read Modular metabolic engineering and synthetic coculture strategies for the production of aromatic compounds in yeast. Materials Today Bio. Read Living microecological hydrogels for wound healing.

DNA

Codon

AUGUST 10, 2023

Link The PURE system for the cell-free synthesis of membrane proteins , by Kuruma Y. & Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. & Ueda T. Nature Protocols (2015). Molecular Systems Biology (2008). & Voigt C.A.

DNA