February, 2024

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The brain is 'programmed' for learning from people we like

Science Daily: Pharmacology News

Our brains are 'programmed' to learn more from people we like -- and less from those we dislike. This has been shown by researchers in cognitive neuroscience in a series of experiments.

Research 140
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Optimizing OpenFold Training for Drug Discovery

Nvidia Developer: Drug Discovery

Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep. Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep learning–based computational methods have been emerging and have shown promising results.

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50 years after founding, NIDA urges following science to move beyond stigma

National Institute on Drug Abuse: Nora's Blog

50 years after founding, NIDA urges following science to move beyond stigma area Thu, 02/01/2024 - 11:20 Nora's Blog February 1, 2024 Image NIDA Image In 2024, NIDA celebrates its 50th anniversary. On May 14, 1974, an act of Congress established the National Institute on Drug Abuse (NIDA), and since then NIDA has led the world in funding and conducting research on drug use and addiction.

Science 130
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Alnylam change to heart drug trial sparks doubts, sinking shares

BioPharma Drive: Drug Pricing

Analysts pressed Alnylam executives on the reasons for the changes to HELIOS-B, a Phase 3 study in ATTR amyloidosis with cardiomyopathy that is important to the company’s future.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Genetic risk prediction for 10 chronic diseases moves closer to the clinic

Broad Institute

Genetic risk prediction for 10 chronic diseases moves closer to the clinic By Corie Lok February 19, 2024 Breadcrumb Home Genetic risk prediction for 10 chronic diseases moves closer to the clinic As part of a nationwide collaboration, Broad Clinical Labs researchers have optimized 10 polygenic scores for use in clinical research as part of a study on how to implement genetic risk prediction for patients.

Disease 124
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An overview of endometrial cancer

Antidote

Endometrial cancer, also known as endometrial carcinoma or uterine cancer , is a condition that approximately 66,000 individuals are diagnosed with annually, and instances rise roughly 2% in the United States each year. Because it is often caught early, a person’s prognosis is typically good — but it is still a disheartening diagnosis that significantly impacts the lives of those who experience it.

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More Trending

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Oregon Man Struck by Bubonic Plague Likely Got It From Pet Cat

Drugs.com

WEDNESDAY, Feb. 14, 2024 -- An Oregonian who was diagnosed with the bubonic plague -- the disease that killed millions of Europeans in the Middle Ages -- probably got it from an infected pet cat, health officials said. The patient and all close.

Disease 119
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Do You Have An Enterprise Data Strategy?

Perficient: Drug Development

This time of year, I like to talk about updating the data strategy for the new year to include new business goals and new technology and in doing so I sometimes forget that there are still many companies that do not have a data strategy to update. What is a Data Strategy and why do I need one? Most organizations have multiple data management initiatives underway including master data management, data governance, data migration, data modernization, OLTP operational data cleanup, data ingestion, a

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Venture firm Scion Life Sciences launches with $310M to back new biotechs

BioPharma Drive: Drug Pricing

The new firm intends to carefully select its startups and fund them for the long haul. “We're not a company formation factory,” said Aaron Kantoff, the firm’s co-founder.

Science 128
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Global survey of gut microbes uncovers 18 new bacterial species and clues to antibiotic resistance

Broad Institute

Global survey of gut microbes uncovers 18 new bacterial species and clues to antibiotic resistance By Leah Eisenstadt February 29, 2024 Breadcrumb Home Global survey of gut microbes uncovers 18 new bacterial species and clues to antibiotic resistance Researchers examined scat from hundreds of animals around the world and pinpointed genes that could fuel drug-resistant infections.

Hospitals 116
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Joining a clinical trial: Helpful hints for discussions with loved ones

Antidote

Individuals living with an illness are likely well-versed in the art of discussing difficult topics with their family and friends. However, for those who are considering taking part in a clinical trial, there may be extra questions to consider when sharing their intent to enroll.

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What turned Earth into a giant snowball 700m years ago? Scientists now have an answer

Science Daily: Pharmacology News

Inspired during field work in South Australia's Flinders Ranges, geoscientists have proposed that all-time low volcanic carbon dioxide emissions triggered a 57 million year-long global 'Sturtian' ice age.

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Seniors, FDA Has 5 Medication Tips to Keep You Safe

Drugs.com

MONDAY, Feb. 19, 2024 -- When settling into your senior years, you need to be especially careful when taking medicines, herbal remedies and supplements, the U.S. Food and Drug Administration says.That’s because older adults are likely to use.

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How 3D human tissue models are transforming drug discovery

Drug Target Review

What specific limitations in mirroring diseases in humans are commonly observed when using animal models for preclinical research? The standard animal model paradigm for drug discovery does not translate well to effects in patients for a number of reasons. For one, animal models require disease induction, either genetic or surgical modifications, diet, or application of a disease inducing agent or toxin, yet this is nothing like how diseases progress in humans, which typically take years to deve

Drugs 116
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Viking data suggest obesity drug could rival Zepbound, Wegovy

BioPharma Drive: Drug Pricing

The biotech’s drug led to significant weight loss in a Phase 2 trial, causing shares to double as analysts compared results to the marks set by drugs from Eli Lilly and Novo Nordisk.

Drugs 125
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Perficient’s Thoughts on use of GenAI in Commerce Solutions

Perficient: Drug Development

Revolutionizing B2C Commerce: The Impact of Generative AI In the dynamic landscape of commerce and consumer-driven markets, Business-to-Consumer (B2C) organizations are increasingly turning to generative AI to revolutionize their operations and enhance customer experiences. Generative AI, a subset of artificial intelligence, empowers these organizations to create content, personalize interactions, and optimize various aspects of their business processes.

Marketing 115
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Stop the Presses! DEA and DOJ Fine eBay for not Reporting Sales of Tableting and Pill Press Machines

FDA Law Blog: Biosimilars

By John A. Gilbert — Last week, DEA and DOJ announced a $59 million civil penalty settlement with eBay related to the failure to comply with Controlled Substances Act (CSA) requirements for identifying purchasers, maintaining records, and filing reports of individuals selling/purchasing pill presses and encapsulating machines. As stated in the press release , this was the fourth largest civil penalty settlement under the CSA and, ironically, did not involve the sale or distribution of any contr

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Method identified to double computer processing speeds

Science Daily: Pharmacology News

Scientists introduce what they call 'simultaneous and heterogeneous multithreading' or SHMT. This system doubles computer processing speeds with existing hardware by simultaneously using graphics processing units (GPUs), hardware accelerators for artificial intelligence (AI) and machine learning (ML), or digital signal processing units to process information.

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Weight-Loss Med Zepbound Lowers High Blood Pressure in Obese People

Drugs.com

MONDAY, Feb. 5, 2024 -- The weight-loss drug Zepbound provides more health benefits than dropping pounds and controlling diabetes, a new study shows.It also appears to help people with obesity manage their high blood pressure, results show.Patients.

Drugs 119
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Rare Disease Day: Understanding the power of diagnosis and connection

Antidote

Rare Disease Day, typically observed on February 28th, will be celebrated this year on February 29th! Rare Disease Day is an awareness holiday intended to generate change for the 300 million people who are diagnosed with a rare disease worldwide, as well as their families and caregivers.

Disease 111
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NEJM paper fills in details on ‘remarkable’ CAR-T result in autoimmune disease

BioPharma Drive: Drug Pricing

The full results spotlight cell therapy’s potential to treat lupus and other inflammatory conditions, but also the problems drug developers must solve first.

Disease 127
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Salesforce: A Growth Mindset for 2024 and Beyond

Perficient: Drug Development

We’re in Our #GrowthEra It’s a new year, and with that, there is always change. One of those changes is that I’m now leading Perficient’s Salesforce business unit as the Managing Director. I’ve had the opportunity to work in the Salesforce ecosystem for 8+ years with top-notch talent. Our team continues to do amazing work for our clients, maximizing the value they’ve invested in the Salesforce platform, bringing innovation to life, and driving business outcomes.

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Women in Stem with Dr Amber D. Van Laar

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? From a very young age, I was drawn to science and medicine. My interest in the field of STEM sharpened when, in my early teens, I had the chance to work in a neuro-oncology lab. This early exposure to bench science had a long-lasting impact. It propelled me to continue lab work during my undergraduate training, my medical training, and to an academic appointment in the Movement Disorders Div

Therapies 111
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Ice cores provide first documentation of rapid Antarctic ice loss in the past

Science Daily: Pharmacology News

Researchers have uncovered the first direct evidence that the West Antarctic Ice Sheet shrunk suddenly and dramatically at the end of the Last Ice Age, around eight thousand years ago. The evidence, contained within an ice core, shows that in one location the ice sheet thinned by 450 meters -- that's more than the height of the Empire State Building -- in just under 200 years.

Research 137
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Scientists Develop Sensor That Tests Saliva for Breast Cancer

Drugs.com

TUESDAY, Feb. 13, 2024 -- Mammograms are a lifesaving misery for middle-aged women, but a new tool could make getting a breast cancer screening as easy as spitting.Literally.A new hand-held biosensor can detect breast cancer biomarkers from a tiny.

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#ScienceSaturday: February 24, 2024

KIF1A

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research A Model for Chemomechanical Coupling of Kinesin‑3 Motor Like humans, KIF1A pairs walk one step at a time, one foot in front of the other.

Disease 111
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Iovance, with approval of ‘TIL’ cell therapy, readies for complex launch

BioPharma Drive: Drug Pricing

The biotech set a price of roughly $515,000 per patient for its therapy Amtagvi, the first to be approved based on a decades-old technique of using tumor-infiltrating lymphocytes.

Therapies 120
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Cognizant and Takeda Discuss Digital Transformation in Life Sciences

Fierce BioTech

In this digital interview hosted at Fierce JPM Week, Gaurav Marya of Cognizant is joined by Samer Ansari of Takeda to discuss what digital transformation means in today’s biopharma world. | Cognizant's Gaurav Marya and Takeda's Samer Ansari discuss what digital transformation means in today’s biopharma world and how key technological advances, such as generative AI, will help create elevated human experiences.

Science 111
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International Day for Women and Girls in Science: Denise Bowser

Drug Target Review

Denise, could you share some insights into your journey at Onyx Scientific, highlighting key milestones and challenges you’ve faced during your nearly 25 years with the company? At the turn of the millennium in early 2000, I was approached by the founders of Onyx Scientific to join the company as their Business Development Manager. I considered this to be an exciting opportunity and became part of the original team that established the company.

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Study challenges the classical view of the origin of the Antarctic Circumpolar Current and warns of its vulnerability

Science Daily: Pharmacology News

The Circumpolar Current works as a regulator of the planet's climate. Its origins were thought to have caused the formation of the permanent ice in Antarctica about 34 million years ago. Now, a study has cast doubt on this theory, and has changed the understanding of how the ice sheet in Antarctic developed in the past, and what this could mean in the future as the planet's climate changes.

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Eye Ointments Sold at Walmart, CVS Recalled Due to Infection Risk

Drugs.com

TUESDAY, Feb. 27, 2024 -- Eye ointment products made in India and sold in the United States at Walmart, CVS and other retailers are being recalled due to a danger of infection.Brassica Pharma Pvt. Ltd., of Maharastra, India, said it is recalling.

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#ScienceSaturday: February 10, 2024

KIF1A

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Unraveling the genetic landscape of undiagnosed cerebellar ataxia in Brazilian patients In this week’s article, researchers in Brazil performed genetic sequencing on 87 patients with cerebe

Therapies 111
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Frontier gets $80M, Galapagos’ backing to make a better KRAS drug

BioPharma Drive: Drug Pricing

The startup’s Series C round will support a clinical-stage drug the company thinks could address some of the weaknesses of other KRAS-targeting medicines.

Drugs 125
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Biotech in 2024: Opportunities, Trends & Challenges

Fierce BioTech

The annual J.P. Morgan Healthcare Conference is a key date in the industry calendar that is always met with reflection and anticipation. | In this exclusive interview, ICON Biotech President Chris Smyth paints a picture of the operating environment facing biotechs in 2024.

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