February, 2024

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2024 predictions: Experts comment on AI, ML and automation

Drug Discovery World

DDW’s Megan Thomas spoke to experts from the drug discovery industry about their predictions on what 2024 holds for our sector. This is part of a series of predictions based on different themes. Here, experts weigh in on the impact of artificial intelligence (AI), machine learning (ML) and automation in the sector. Updesh Dosanjh, Practice Leader for Pharmacovigilance Technology Solutions, IQVIA “In 2024, the traditional pain points of the pharmacovigilance (PV) space will not disappear.

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50 years after founding, NIDA urges following science to move beyond stigma

National Institute on Drug Abuse: Nora's Blog

50 years after founding, NIDA urges following science to move beyond stigma area Thu, 02/01/2024 - 11:20 Nora's Blog February 1, 2024 Image NIDA Image In 2024, NIDA celebrates its 50th anniversary. On May 14, 1974, an act of Congress established the National Institute on Drug Abuse (NIDA), and since then NIDA has led the world in funding and conducting research on drug use and addiction.

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Ice cores provide first documentation of rapid Antarctic ice loss in the past

Science Daily: Pharmacology News

Researchers have uncovered the first direct evidence that the West Antarctic Ice Sheet shrunk suddenly and dramatically at the end of the Last Ice Age, around eight thousand years ago. The evidence, contained within an ice core, shows that in one location the ice sheet thinned by 450 meters -- that's more than the height of the Empire State Building -- in just under 200 years.

Research 145
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Optimizing OpenFold Training for Drug Discovery

Nvidia Developer: Drug Discovery

Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep. Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep learning–based computational methods have been emerging and have shown promising results.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Alnylam change to heart drug trial sparks doubts, sinking shares

BioPharma Drive: Drug Pricing

Analysts pressed Alnylam executives on the reasons for the changes to HELIOS-B, a Phase 3 study in ATTR amyloidosis with cardiomyopathy that is important to the company’s future.

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Genetic risk prediction for 10 chronic diseases moves closer to the clinic

Broad Institute

Genetic risk prediction for 10 chronic diseases moves closer to the clinic By Corie Lok February 19, 2024 Breadcrumb Home Genetic risk prediction for 10 chronic diseases moves closer to the clinic As part of a nationwide collaboration, Broad Clinical Labs researchers have optimized 10 polygenic scores for use in clinical research as part of a study on how to implement genetic risk prediction for patients.

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More Trending

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Eye Ointments Sold at Walmart, CVS Recalled Due to Infection Risk

Drugs.com

TUESDAY, Feb. 27, 2024 -- Eye ointment products made in India and sold in the United States at Walmart, CVS and other retailers are being recalled due to a danger of infection.Brassica Pharma Pvt. Ltd., of Maharastra, India, said it is recalling.

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Method identified to double computer processing speeds

Science Daily: Pharmacology News

Scientists introduce what they call 'simultaneous and heterogeneous multithreading' or SHMT. This system doubles computer processing speeds with existing hardware by simultaneously using graphics processing units (GPUs), hardware accelerators for artificial intelligence (AI) and machine learning (ML), or digital signal processing units to process information.

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Finding the Right Fit—Is Your Respirator “The One”?

NIOSH Science Blog: Drugs

Finding the right fit is one of the most important parts of a relationship. You don’t just grab any old fish from the sea that swims by and hope for the best. First, it’s necessary to test the waters and ensure you’re simpatico before settling on a partner. It’s Valentine’s Day, and yes, this advice could apply to your romantic life, but we also love to use today to show our love of respirators and we love to play matchmaker on your behalf as well.

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Viking data suggest obesity drug could rival Zepbound, Wegovy

BioPharma Drive: Drug Pricing

The biotech’s drug led to significant weight loss in a Phase 2 trial, causing shares to double as analysts compared results to the marks set by drugs from Eli Lilly and Novo Nordisk.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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An overview of endometrial cancer

Antidote

Endometrial cancer, also known as endometrial carcinoma or uterine cancer , is a condition that approximately 66,000 individuals are diagnosed with annually, and instances rise roughly 2% in the United States each year. Because it is often caught early, a person’s prognosis is typically good — but it is still a disheartening diagnosis that significantly impacts the lives of those who experience it.

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First UK patients receive experimental mRNA therapy for cancer

Drug Discovery World

The first UK patients have received an mRNA cancer therapy – mRNA-4359 – as part of a Phase I/II clinical trial investigating its potential for treating melanoma, lung cancer and other solid tumour cancers. The Mobilize trial is run in partnership between Imperial College London and Imperial College Healthcare NHS Trust, with the first patients in the UK receiving the treatment at the NIHR Imperial Clinical Research Facility at Hammersmith Hospital.

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Seniors, FDA Has 5 Medication Tips to Keep You Safe

Drugs.com

MONDAY, Feb. 19, 2024 -- When settling into your senior years, you need to be especially careful when taking medicines, herbal remedies and supplements, the U.S. Food and Drug Administration says.That’s because older adults are likely to use.

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The brain is 'programmed' for learning from people we like

Science Daily: Pharmacology News

Our brains are 'programmed' to learn more from people we like -- and less from those we dislike. This has been shown by researchers in cognitive neuroscience in a series of experiments.

Research 136
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Global survey of gut microbes uncovers 18 new bacterial species and clues to antibiotic resistance

Broad Institute

Global survey of gut microbes uncovers 18 new bacterial species and clues to antibiotic resistance By Leah Eisenstadt February 29, 2024 Breadcrumb Home Global survey of gut microbes uncovers 18 new bacterial species and clues to antibiotic resistance Researchers examined scat from hundreds of animals around the world and pinpointed genes that could fuel drug-resistant infections.

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Venture firm Scion Life Sciences launches with $310M to back new biotechs

BioPharma Drive: Drug Pricing

The new firm intends to carefully select its startups and fund them for the long haul. “We're not a company formation factory,” said Aaron Kantoff, the firm’s co-founder.

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Do You Have An Enterprise Data Strategy?

Perficient: Drug Development

This time of year, I like to talk about updating the data strategy for the new year to include new business goals and new technology and in doing so I sometimes forget that there are still many companies that do not have a data strategy to update. What is a Data Strategy and why do I need one? Most organizations have multiple data management initiatives underway including master data management, data governance, data migration, data modernization, OLTP operational data cleanup, data ingestion, a

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Vaccine successfully lowers cholesterol in preclinical studies

Drug Discovery World

New studies have demonstrated that Vaxxinity’s vaccine VXX-401 reproducibly lowers low-density lipoprotein cholesterol (LDL-C) in non-human primates. The results support the continued clinical development of VXX-401 as a candidate for the treatment of hypercholesterolemia and prevention of atherosclerotic cardiovascular disease. VXX-401 is a synthetic peptide vaccine designed to stimulate the immune system to produce antibodies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), whi

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Oregon Man Struck by Bubonic Plague Likely Got It From Pet Cat

Drugs.com

WEDNESDAY, Feb. 14, 2024 -- An Oregonian who was diagnosed with the bubonic plague -- the disease that killed millions of Europeans in the Middle Ages -- probably got it from an infected pet cat, health officials said. The patient and all close.

Disease 119
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Scandinavia's first farmers slaughtered the hunter-gatherer population, study finds

Science Daily: Pharmacology News

Following the arrival of the first farmers in Scandinavia 5,900 years ago, the hunter-gatherer population was wiped out within a few generations, according to a new study. The results, which are contrary to prevailing opinion, are based on DNA analysis of skeletons and teeth found in what is now Denmark.

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Joining a clinical trial: Helpful hints for discussions with loved ones

Antidote

Individuals living with an illness are likely well-versed in the art of discussing difficult topics with their family and friends. However, for those who are considering taking part in a clinical trial, there may be extra questions to consider when sharing their intent to enroll.

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NEJM paper fills in details on ‘remarkable’ CAR-T result in autoimmune disease

BioPharma Drive: Drug Pricing

The full results spotlight cell therapy’s potential to treat lupus and other inflammatory conditions, but also the problems drug developers must solve first.

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Salesforce: A Growth Mindset for 2024 and Beyond

Perficient: Drug Development

We’re in Our #GrowthEra It’s a new year, and with that, there is always change. One of those changes is that I’m now leading Perficient’s Salesforce business unit as the Managing Director. I’ve had the opportunity to work in the Salesforce ecosystem for 8+ years with top-notch talent. Our team continues to do amazing work for our clients, maximizing the value they’ve invested in the Salesforce platform, bringing innovation to life, and driving business outcomes.

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UK university partnership wins £1.8m for drug discovery research

Drug Discovery World

A team from Aston University and the University of Warwick has secured a £1.8 ($2.2) million grant to engineer microbial cell factories to produce membrane proteins which will support future drug screening and sustainable chemical production. The Engineering Biology Mission Award was given by UK Research and Innovation (UKRI). Membrane proteins are crucial molecules on the surface of cells with numerous biological functions, such as sensing hormones or cell communication.

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Scientists Develop Sensor That Tests Saliva for Breast Cancer

Drugs.com

TUESDAY, Feb. 13, 2024 -- Mammograms are a lifesaving misery for middle-aged women, but a new tool could make getting a breast cancer screening as easy as spitting.Literally.A new hand-held biosensor can detect breast cancer biomarkers from a tiny.

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What turned Earth into a giant snowball 700m years ago? Scientists now have an answer

Science Daily: Pharmacology News

Inspired during field work in South Australia's Flinders Ranges, geoscientists have proposed that all-time low volcanic carbon dioxide emissions triggered a 57 million year-long global 'Sturtian' ice age.

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Stop the Presses! DEA and DOJ Fine eBay for not Reporting Sales of Tableting and Pill Press Machines

FDA Law Blog: Biosimilars

By John A. Gilbert — Last week, DEA and DOJ announced a $59 million civil penalty settlement with eBay related to the failure to comply with Controlled Substances Act (CSA) requirements for identifying purchasers, maintaining records, and filing reports of individuals selling/purchasing pill presses and encapsulating machines. As stated in the press release , this was the fourth largest civil penalty settlement under the CSA and, ironically, did not involve the sale or distribution of any contr

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Iovance, with approval of ‘TIL’ cell therapy, readies for complex launch

BioPharma Drive: Drug Pricing

The biotech set a price of roughly $515,000 per patient for its therapy Amtagvi, the first to be approved based on a decades-old technique of using tumor-infiltrating lymphocytes.

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Perficient’s Thoughts on use of GenAI in Commerce Solutions

Perficient: Drug Development

Revolutionizing B2C Commerce: The Impact of Generative AI In the dynamic landscape of commerce and consumer-driven markets, Business-to-Consumer (B2C) organizations are increasingly turning to generative AI to revolutionize their operations and enhance customer experiences. Generative AI, a subset of artificial intelligence, empowers these organizations to create content, personalize interactions, and optimize various aspects of their business processes.

Marketing 115
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Novo Holdings acquires Catalent for $16.5 billion 

Drug Discovery World

Catalent and Novo Holdings, a holding and investment company that manages the assets and wealth of the Novo Nordisk Foundation, have entered into a merger agreement under which Novo Holdings will acquire Catalent in an all-cash transaction that values Catalent at $16.5 billion. Novo Holdings will acquire all outstanding shares of Catalent for $63.50 per share in cash.

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Parents Scrambling After Asthma Inhaler Flovent Removed From Market

Drugs.com

WEDNESDAY, Feb. 21, 2024 -- A popular asthma inhaler was discontinued on Jan. 1, and the business move has left families scrambling to find a replacement for their kids.Flovent was one of the most commonly prescribed drugs for childhood asthma, but.

Marketing 117
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Study challenges the classical view of the origin of the Antarctic Circumpolar Current and warns of its vulnerability

Science Daily: Pharmacology News

The Circumpolar Current works as a regulator of the planet's climate. Its origins were thought to have caused the formation of the permanent ice in Antarctica about 34 million years ago. Now, a study has cast doubt on this theory, and has changed the understanding of how the ice sheet in Antarctic developed in the past, and what this could mean in the future as the planet's climate changes.

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Rare Disease Day: Understanding the power of diagnosis and connection

Antidote

Rare Disease Day, typically observed on February 28th, will be celebrated this year on February 29th! Rare Disease Day is an awareness holiday intended to generate change for the 300 million people who are diagnosed with a rare disease worldwide, as well as their families and caregivers.

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Frontier gets $80M, Galapagos’ backing to make a better KRAS drug

BioPharma Drive: Drug Pricing

The startup’s Series C round will support a clinical-stage drug the company thinks could address some of the weaknesses of other KRAS-targeting medicines.

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