Sat.Oct 05, 2024 - Fri.Oct 11, 2024

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Silly Things Large Language Models Do With Molecules

Practical Cheminformatics

“Pay no attention to the man behind the curtain” - The Wizard of Oz Introduction Recently, a few groups have proposed general-purpose large language models (LLMs) like ChatGPT , Claude , and Gemini as tools for generating molecules. This idea is appealing because it doesn't require specialized software or domain-specific model training. One can provide the LLM with a relatively simple prompt like the one below, and it will respond with a list of SMILES strings.

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Fossils and fires: Insights into early modern human activity in the jungles of Southeast Asia

Science Daily: Pharmacology News

Studying microscopic layers of dirt dug from the Tam Pa Ling cave site in northeastern Laos has provided a team of archaeologists further insights into some of the earliest evidence of Homo sapiens in mainland Southeast Asia. The site, which has been studied for the past 14 years, has produced some of the earliest fossil evidence of our direct ancestors in Southeast Asia but now a new study has reconstructed the ground conditions in the cave between 52,000 and 10,000 years ago.

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VU Researchers Publish Study on the Mechanism of CRISPR-Cas “Protein Scissors” in Molecular Cell

Drug Discovery Today

Researchers from the Institute of Biotechnology at the Life Sciences Center of Vilnius University – Dalia Smalakyte, Audrone Rukšenaite, Dr Giedrius Sasnauskas, Dr Giedre Tamulaitiene, and Dr Gintautas Tamulaitis – have revealed the structure of the CRISPR-Cas "protein scissors" found in bacteria and provided mechanistic details on how they function.

Research 113
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U.S. Scrambles to Find Hospital IV Fluids After Helene Damages NC Plant

Drugs.com

THURSDAY, Oct. 10, 2024 -- After Hurricane Helene knocked out a North Carolina production plant for a major supplier of IV fluids for U.S. hospitals, officials said the federal government is reaching out internationally to help restore supply.The.

Hospitals 115
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Viruses are teeming on your toothbrush, showerhead

Science Daily: Pharmacology News

Microbiologists found that showerheads and toothbrushes are teeming with an extremely diverse collection of viruses -- most of which have never been seen before.

Virus 132
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Judo Bio debuts with $100M and a plan to take RNA drugs to the kidney

BioPharma Drive: Drug Pricing

The Cambridge, Massachusetts-based biotech is using what it calls ligand-siRNA conjugates to reach drug targets in the kidney, which historically have been difficult to reach with RNA therapies.

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More Trending

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Hope for New Test, Treatment for Endometriosis

Drugs.com

FRIDAY, Oct. 11, 2024 -- Endometriosis could be linked to the health of a woman’s microbiome, a new study says. The discovery might help lead to an early test for the painful condition, and possible new treatments.A specific set of bacteria in w.

Treatment 116
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Catastrophically warm predictions are more plausible than we thought

Science Daily: Pharmacology News

Researchers developed a rating system to evaluate the plausibility of climate model simulations in the IPCC's latest report, and show that models that lead to potentially catastrophic warming are to be taken seriously.

Research 137
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Ex-Pfizer execs ‘threatened’ for supporting plans to shake up company, Starboard says

BioPharma Drive: Drug Pricing

In a letter to Pfizer’s board, the activist investor claimed former CEO Ian Read and CFO Frank D’Amelio were pressured to abandon a Starboard-led attempt to change the company’s direction.

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From Chaos to Clarity: Streamlining Your Generic Drug Portfolio

Drug Patent Watch

The pharmaceutical industry plays a crucial role in global healthcare, providing essential medications that improve and save lives. Within this industry, generic pharmaceuticals are particularly important due to their affordability and accessibility.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Could Lingering Infection Be Causing Long COVID?

Drugs.com

THURSDAY, Oct. 10, 2024 -- Some people might have Long COVID symptoms because the coronavirus is still active inside their bodies, a new study finds.People with wide-ranging Long COVID symptoms were twice as likely to have SARS-CoV-2 proteins in.

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Bilingualism makes the brain more efficient, especially when learned at a young age

Science Daily: Pharmacology News

A new study from The Neuro (Montreal Neurological Institute-Hospital) of McGill university, the University of Ottawa and the University of Zaragoza in Spain elaborates on bilingualism's role in cognition, showing increased efficiency of communication between brain regions.

Hospitals 136
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Sanofi may have found a buyer for its consumer health business

BioPharma Drive: Drug Pricing

The French pharmaceutical giant said it’s in negotiations to sell a controlling stake of Opella to the private equity firm CD&R, in a deal that reportedly could be worth more than $16 billion.

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The Role of China in the Global Generic Drug API Market

Drug Patent Watch

China has emerged as a significant player in the global generic drug active pharmaceutical ingredient (API) market. The country’s vast production capacity, low costs, and strategic location have made it an attractive destination for pharmaceutical companies seeking to source APIs.

Marketing 115
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Young Vilnius University Scientist I. Mogila Received Birnstiel Award for Breakthrough in CRISPR-Cas10 Research

Drug Discovery Today

Irmantas Mogila, a young scientist from Vilnius University (VU) Life Sciences Center (LSC), has joined the ranks of the most talented early-career life science researchers. He was given the prestigious international Birnstiel Award for his outstanding research results in the field of molecular biology.

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Climate report warns of escalating crisis, urges immediate action as UN summit nears

Science Daily: Pharmacology News

An international coalition of scientists concludes that the Earth's worsening vital signs indicate a 'critical and unpredictable new phase of the climate crisis' and that 'decisive action is needed, and fast.

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AI startup Basecamp allies with the Broad to dream up ‘programmable’ genetic medicines

BioPharma Drive: Drug Pricing

The company, which is building a database of biological interactions found in nature, revealed $60 million in funding and a collaboration with David Liu’s lab.

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About 6% of U.S. Adults Have ADHD, Drug Shortages Are Affecting Treatment

Drugs.com

THURSDAY, Oct. 10, 2024 -- More than 15.5 million U.S. adults have been diagnosed with ADHD, and nearly three-quarters of those taking medication to treat it say drug shortages are hampering their ability to get help, a new report finds. According.

Treatment 111
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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The Role of Pharmacokinetics in Generic Drugs

Drug Patent Watch

Pharmacokinetics (PK) plays a crucial role in the development and approval of generic drugs. PK studies help ensure that generic drugs are bioequivalent to their brand-name counterparts, meaning they have similar absorption, distribution, metabolism, and excretion (ADME) profiles.

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Antarctic 'greening' at dramatic rate

Science Daily: Pharmacology News

Vegetation cover across the Antarctic Peninsula has increased more than tenfold over the last four decades, new research shows.

Research 127
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The sudden progress in rare kidney disease is built on years of dedication

Fierce BioTech

By Jula Inrig, M.D. Chief Medical Officer, Travere Therapeutics | When a specialized field of medicine has long been quiet, a buzz of breakthrough can seem like a sudden development. The reality is more nuanced.

Disease 105
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Were FDA's 'Black Box' Warnings on Antidepressants a Mistake? Youth Suicides Rose Afterwards

Drugs.com

TUESDAY, Oct. 8, 2024 -- "Black Box” warnings added to antidepressants might have contributed to an increase in suicide attempts and deaths among young people, a new evidence review claims.The warnings say that antidepressants might be associated w.

FDA 111
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Perficient Included in IDC Market Glance: Digital Business Professional Services Report

Perficient: Drug Development

Today’s digital landscape is dynamic. It favors speed over size, agility over efficiency, and cross-functional collaboration over rigid structures. You must be prepared to adapt and scale your teams as priorities shift. Moving forward requires a comprehensive digital strategy that outlines the capabilities, agility, and alignment needed to stay ahead of digital disruption.

Marketing 104
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Do fungi recognize shapes?

Science Daily: Pharmacology News

Fungi don't have eyes or a brain, but their intelligent behaviors may surprise you. New research suggests that fungi may be able to recognize shapes.

Research 122
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The protective effect of Amitriptyline on experimental colitis through inhibiting TLR4/MD2 signaling pathway [Gastrointestinal, Hepatic, Pulmonary, and Renal]

ASPET

Amitriptyline, a pleiotropic tricyclic antidepressant, possesses anti-oxidant and anti-inflammatory properties. Despite its diverse benefits, the specific effects of amitriptyline on IBD are not yet well defined. To explore this, we utilized a DSS-induced colitis model to examine the anti-inflammatory effects of amitriptyline and the underlying mechanisms by which it operates.

RNA 100
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Scientists Discover the Brain's Waste-Disposal System, With Clues to Alzheimer's Disease

Drugs.com

TUESDAY, Oct. 8, 2024 -- The brain has a waste-disposal system that clears away junk proteins that contribute to the development of dementia and Alzheimer’s disease, a new study finds.Advanced imaging scans have revealed a network of fluid-filled s.

Disease 111
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Recent Advances in Medicinal Chemistry of Memantine Against Alzheimer's Disease

Chemical Biology and Drug Design

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disorder characterized by loss of memory and other cognitive functions. The problem of this disease is even more fundamental because the available therapies only provide symptomatic relief without addressing the basic factor of the disease. This review article comprehensively summarized the recent advancement in memantine and its hybrid analogs as potential disease-modifying agents for the management of AD.

Disease 100
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How your skin tone could affect your meds

Science Daily: Pharmacology News

Skin pigmentation may act as a 'sponge' for some medications, potentially influencing the speed with which active drugs reach their intended targets, a pair of scientists report.

Drugs 122
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CH6824025, potent and selective DDR1 inhibitor, reduces kidney fibrosis in UUO mice [Drug Discovery and Translational Medicine]

ASPET

Discoidin domain receptor 1 (DDR1) is a collagen receptor with tyrosine kinase activity, and its expression is enhanced in various disease conditions. Although previous research suggests that DDR1 contributes to renal disease progression, DDR1 inhibitors for renal fibrosis have yet to be developed. In this study, we used unilateral ureteral obstruction (UUO) mice to investigate whether CH6824025, a strong and selective DDR1 phosphorylation inhibitor, can improve renal fibrosis.

Disease 100
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Yellowjackets and Bees Swarm in NC in Helene's Aftermath

Drugs.com

MONDAY, Oct. 7, 2024 -- Even as folks in North Carolina continue to clean up following the devastation of Hurricane Helene, a new health danger has emerged: The massive flooding that swept away roads and towns also uprooted the underground nests of.

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Using de-identified lab data to find patients, target physicians and expedite treatment

BioPharma Drive: Drug Pricing

Many pharma companies are now using de-identified lab data to identify potential patients and their physicians in time to impact the patient’s treatment plan. In this Q&A, learn how lab data can be used to increase patient access.

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Will AI tools revolutionize public health? Not if they continue following old patterns, researchers argue

Science Daily: Pharmacology News

A new article shares findings from an extensive literature analysis of AI's current trajectory in health care.

Research 120
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COSMIC Database and Structural Modeling Analysis of CYP2D6 Mutations in Human Cancers [Drug Discovery and Translational Medicine]

ASPET

Single nucleotide polymorphisms (SNPs) in cytochrome P450 (CYP450) enzymes alter the metabolism of a variety of drugs. Numerous medications, including chemotherapies, are metabolized by CYP450 enzymes, making the expression of this suite of enzymes in tumor cells relevant to prescription regimens for cancer patients. We analyzed the characteristics of mutations of the CYP2D6 enzymes in cancer patients obtained from the Catalogue of Somatic Mutations in Cancer (COSMIC), including mutation type, a

Drugs 100