Drug Discovery World

AUGUST 20, 2024

Mirit Eldor , Managing Director, Life Sciences Solutions, Elsevier, looks at how artificial intelligence (AI) can improve the hit-to-lead process for small molecules. Early drug discovery takes an average of three-to-six years and accounts for 42% of total costs 1 in the development of a new drug. It’s therefore no surprise that pharmaceutical companies are increasingly interested in using artificial intelligence (AI) to accelerate development and reduce costs.

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Small Molecule Pharmaceutical Companies Drugs Pharmaceuticals 275

BioPharma Drive: Drug Pricing

AUGUST 29, 2024

Far fewer venture funding rounds were closed by cell and gene therapy developers over the first six months of 2024 than in prior years. Experts say there are several factors.

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Therapies 142

Science Daily: Pharmacology News

AUGUST 23, 2024

A study found that nondeceptive placebos, or placebos given with people fully knowing they are placebos, effectively manage stress -- even when the placebos are administered remotely.

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National Institute on Drug Abuse: Nora's Blog

AUGUST 28, 2024

Older Black Men Are Disproportionately Affected by the Overdose Crisis mfleming Wed, 08/28/2024 - 16:08 Nora's Blog August 30, 2024 Image ©Getty Images/ xavierarnau Saturday, August 31, is International Overdose Awareness Day , when we collectively remember those who have lost their lives to drug overdose, support those who grieve those losses, and offer encouragement to those who seek recovery from addiction.

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Treatment Research Disease Drugs 131

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

AUGUST 30, 2024

FRIDAY, Aug.30, 2024 -- New trials are showing how the blockbuster diabetes and weight-loss meds Ozempic and Wegovy can boost health in even more ways.These two injected drugs are versions of semaglutide. In multiple new data analyses, the drugs.

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Trials Drugs 117

Broad Institute

AUGUST 19, 2024

A common fatty acid may help restore healthy vaginal bacteria after infection By Ari Navetta August 19, 2024 Breadcrumb Home A common fatty acid may help restore healthy vaginal bacteria after infection Treatments using oleic acid, a naturally occurring oil used in cells, could improve treatment of recurrent bacterial vaginosis infections. By Ari Navetta August 19, 2024 Credit: Meilin Zhu Lactobacillus iners after treatment with oleic acid Related people Paul Blainey Related programs Metabolomi

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Hospitals Medical Schools Treatment Science 121

BioPharma Drive: Drug Pricing

AUGUST 6, 2024

Through a new deal, Roche has exclusive rights to Sangamo molecules designed to repress the gene that makes “tau,” a protein many scientists view as a main driver of Alzheimer’s.

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Licensing Licensing Drugs 131

Science Daily: Pharmacology News

AUGUST 22, 2024

Non-living hydrogels can play the video game Pong and improve their gameplay with more experience, researchers report. The researchers hooked hydrogels up to a virtual game environment and then applied a feedback loop between the hydrogel's paddle -- encoded by the distribution of charged particles within the hydrogel -- and the ball's position -- encoded by electrical stimulation.

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Research 141

Drug Target Review

AUGUST 28, 2024

What are the main challenges currently faced in the treatment of chronic liver diseases, and how does Resolution Therapeutics aim to address these challenges? Once a patient develops advanced cirrhosis/end-stage liver disease there are no specific therapies to significantly avoid major decompensations and death in the next few years. This is caused by the high amounts of inflammation and fibrosis (scarring) in the liver, suppressing the liver’s natural ability to regenerate or perform its functi

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Therapies Disease Engineering Medical Schools 114

Drugs.com

AUGUST 23, 2024

FRIDAY, Aug. 23, 2024 -- Research has already proven that the blockbuster weight-loss drug Wegovy (semaglutide) can slash a person's odds for heart attacks and strokes, and now more data from the same trial suggests that's even true for very ill.

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Trials Research Drugs 118

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Fierce BioTech

AUGUST 20, 2024

Alzheimer’s disease research and drug development is evolving at a rapid pace. Decades of research has led to the approval of the first disease-modifying drugs and new pathological discoveries.

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Disease Drug Development Research Drugs 116

NIOSH Science Blog: Drugs

AUGUST 30, 2024

Each Labor Day we honor workers and the role they play in building a strong and prosperous nation. Much like the first Labor Day more than a century ago, many of us mark this federal holiday with festivities such as parades or picnics. This year, as you head out to celebrate the end of summer with friends and loved ones, I urge you to take a moment to reflect on the contributions of the workers all around us.

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BioPharma Drive: Drug Pricing

AUGUST 9, 2024

The decision to turn down an application from Lykos Therapeutics comes at a pivotal time for psychedelics research, which, after decades of dismissal, has recently gained momentum.

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Therapies FDA Research 126

Science Daily: Pharmacology News

AUGUST 5, 2024

Seeds, twigs, and insect parts found under two miles of ice confirm Greenland's ice sheet melted in the recent past, the first direct evidence that the center -- not just the edges -- of the two-mile-deep ice melted away in the recent geological past. The new research indicates that the giant ice sheet is more fragile than scientists had realized until the last few years -- and reveals increased risk of sea-level catastrophe in a warmer future.

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Research 145

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Target Review

AUGUST 6, 2024

What are the main therapeutic areas beyond oncology where ADCs show potential? A number of areas represent significant opportunities for Antibody Drug Conjugates (ADCs) beyond oncology, leveraging their ability to deliver therapeutic agents specifically to diseased cells or tissues while minimising off-target effects. The development of ADCs in these areas is ongoing, with several preclinical and clinical studies exploring their potential.

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Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- As syphilis cases surge throughout the United States, the U.S. Food and Drug Administration on Friday approved the first diagnostic at-home test to spot the bacterial disease."This is the first at-home, over-the-counter.

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FDA Disease Drugs 119

Perficient: Drug Development

AUGUST 28, 2024

This post is the first in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Coming Soon: Part 2: Dependencies & Creep Part 3: Assumptions & Uncertainty Part 4: The Emotional Conclusion Estimating is a precarious business – part science, a lot of guesswork, and a bit of psychic magic! The goal is to forecast the effort, time, and cost of a project with enough accuracy to avoid disaster.

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Drug Patent Watch

AUGUST 29, 2024

Ensuring that a generic drug meets FDA standards is crucial for maintaining the high quality and efficacy of medications. The FDA’s Office of Generic Drugs (OGD) plays a vital role in this process by following a rigorous review process to ensure that generic medications meet the same standards as their brand-name counterparts. The FDA’s review process for generic drugs involves several key steps.

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FDA Drugs 105

BioPharma Drive: Drug Pricing

AUGUST 9, 2024

Recent data from J.P. Morgan indicates early-stage startups are getting smaller upfront payments in alliances than a few years ago, a trend industry insiders attribute to weaker leverage in deal talks.

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Drugs 128

Science Daily: Pharmacology News

AUGUST 14, 2024

A new brain-computer interface translates brain signals into speech with up to 97 percent accuracy. Researchers implanted sensors in the brain of a man with severely impaired speech due to amyotrophic lateral sclerosis (ALS). The man was able to communicate his intended speech within minutes of activating the system.

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Research 142

FDA Law Blog: Biosimilars

AUGUST 26, 2024

By Larry K. Houck — Who says nothing happens in Washington, D.C., in August? The Drug Enforcement Administration (“DEA”) will announce Thursday in the Federal Register that it will hold a hearing on the proposed rescheduling of marijuana to schedule III at DEA Headquarters in Arlington, Virginia on December 2, 2024. DEA received over 43,500 public comments in response to the agency’s Notice of Proposed Rulemaking in the Federal Register on May 21, 2024.

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Drugs 104

Drugs.com

AUGUST 26, 2024

MONDAY, Aug. 24, 2024 -- A type of drug used to treat Alzheimer’s disease appears to slow the progression of Lewy body dementia, the brain disease that afflicted comedian Robin Williams prior to his suicide.Cholinesterase inhibitors prevent the b.

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Drugs Disease 115

Perficient: Drug Development

AUGUST 28, 2024

Perficient continues to make strategic investments to grow our global footprint. This is great for our clients because we span time zones, cultures and capabilities. However, it can present a challenge fostering a cohesive company culture and opportunities for colleagues to connect. That is why Perficient invests in its people by supporting Employee Resource Groups (ERGs), Special Interest Groups (SIGs), and Innovation Groups (IGs).

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Drug Target Review

AUGUST 16, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I grew up in California where I developed a natural curiosity to understand how a living organism functions. Majoring in physiology in college allowed me to nourish this interest, and I knew medicine would be my path as it enabled me to learn the structure and function of the human body.

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Medical Schools Nurses Research Production 106

BioPharma Drive: Drug Pricing

AUGUST 6, 2024

The funding from Apple Tree Partners will help the startup advance an antiviral drug pipeline that includes a COVID treatment nearing mid-stage testing.

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Treatment Drugs 131

Science Daily: Pharmacology News

AUGUST 13, 2024

Linked to cardiovascular and respiratory diseases in people, nanoplastics continue to build up, largely unnoticed, in the world's bodies of water. The challenge remains to develop a cost-effective solution to get rid of nanoplastics while leaving clean water behind. That's where Mizzou comes in. Recently, researchers created a new liquid-based solution that eliminates more than 98% of these microscopic plastic particles from water.

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Disease Research 144

Nvidia Developer: Drug Discovery

AUGUST 27, 2024

Now available—NIM Agent Blueprints for digital humans, multimodal PDF data extraction, and drug discovery. Now available—NIM Agent Blueprints for digital humans, multimodal PDF data extraction, and drug discovery.

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Drugs 98

Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- Tirzepatide, the blockbuster GLP-1 medicine known as Mounjaro for diabetes and Zepbound for weight loss, cut the odds that an obese, prediabetic person will develop diabetes by 94%, a new trial shows. The three-year-long.

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Trials 115

Perficient: Drug Development

AUGUST 4, 2024

In today’s rapidly evolving digital landscape, financial services organizations are increasingly relying on cutting-edge technologies to stay competitive and deliver exceptional services to their clients. Microsoft’s Azure Integration Services , a suite of tools designed to seamlessly connect applications, data, and processes, is emerging as a game-changer for the financial services industry.

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Compliance Marketing Production 110

Collaborative Drug

AUGUST 16, 2024

Burlingame, CA (USA), Kyiv (Ukraine) – August 16, 2024 — Collaborative Drug Discovery (CDD), a leader in providing scientific informatics solutions, announced today that its flagship platform, CDD Vault , now includes the complete compound collection of Enamine , a leading provider of chemical compounds and early discovery services, within its AI module for structural similarity searches.

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Research Drugs 102

BioPharma Drive: Drug Pricing

AUGUST 28, 2024

Under a collaboration with NextRNA Therapeutics, Bayer will access the biotech’s platform to target long, non-coding RNA interactions with small molecule drugs.

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RNA Small Molecule Therapies Drugs 114

Science Daily: Pharmacology News

AUGUST 9, 2024

Scientists have recovered the first long section of rocks that originated in the Earth's mantle, the layer below the crust and the planet's largest component. The rocks will help unravel the mantle's role in the origins of life on Earth, the volcanic activity generated when it melts, and how it drives the global cycles of important elements such as carbon and hydrogen.

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Quanticate

AUGUST 2, 2024

Real-world evidence (RWE) is changing clinical drug development, bridging the gap between controlled clinical trial environments and the complexities of everyday patient experiences. By using Real-World Data (RWD) from various sources like electronic health records (EHRs), insurance claims, and digital health tools, researchers can gather valuable insights into how drugs work in a wide range of populations.

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Drug Development Clinical Trials Drugs Trials 104

Drugs.com

AUGUST 29, 2024

THURSDAY, Aug. 29, 2024 -- A migraine drug can help stop the devastating headaches in their tracks, allowing sufferers to go about their daily lives with little to no symptoms, a new clinical trial has found.People who took ubrogepant (Ubrelvy).

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Clinical Trials Drugs Trials 110