Sat.Jun 22, 2024 - Fri.Jun 28, 2024

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A therapy candidate for fatal prion diseases turns off disease-causing gene

Broad Institute

A therapy candidate for fatal prion diseases turns off disease-causing gene By Corie Lok June 27, 2024 Breadcrumb Home A therapy candidate for fatal prion diseases turns off disease-causing gene Whitehead and Broad scientists have developed a gene-silencing tool that could pave the way for a new class of genetic approaches to treat certain diseases.

Disease 142
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These microscopic tunnels are a goldmine for new medicines

BioPharma Drive: Drug Pricing

A growing cohort of biotechs, from Biohaven to Neurocrine to Jazz, hope research on ion channels will bring them new drugs and big business — much like it has done for Vertex.

Research 138
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We date, marry people who are attractive as we are, new analysis finds

Science Daily: Pharmacology News

Men and women were good at judging their own attractiveness, and tended to partner up with people who were similarly attractive.

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CDC Advises Updated COVID Vaccine for Everyone Over 6 Months of Age

Drugs.com

FRIDAY, June 28, 2024 -- As a summer wave of COVID infections rolls across the country, U.S. health officials have recommended that all Americans over the age of 6 months get one of the updated COVID vaccines when they become available this.

Vaccine 124
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Gut microbiome changes align with increased risk of type 2 diabetes

Broad Institute

Gut microbiome changes align with increased risk of type 2 diabetes By Tom Ulrich June 25, 2024 Breadcrumb Home Gut microbiome changes align with increased risk of type 2 diabetes Specific species and strains of bacteria linked to changes in the functioning of the gut microbiome and a person's risk of type 2 diabetes By Jennifer Welsh, Brigham and Women's Hospital June 25, 2024 Credit: Donny Bliss, NIH Illustration depicting gut bacteria.

Virus 135

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Myths about intermittent fasting, debunked

Science Daily: Pharmacology News

Research shows that the increasingly popular weight-loss strategy is safe. Intermittent fasting has become an increasingly popular way to lose weight without counting calories. And a large body of research has shown it s safe. Still, several myths about fasting have gained traction.

Research 128
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Migraine Prevention Med, Quilipta, Might Stop 'Rebound' Headaches, Too

Drugs.com

THURSDAY, June 27, 2024 -- It's a nasty cycle: Chronic migraine sufferers who use too much pain medication sometimes get smacked with rebound headaches. But new research suggests that a medication commonly used to prevent migraines may also help.

Research 111
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Hero, Villain, or Victim? Stories that Sabotage

Perficient: Drug Development

In 1968, psychiatrist Stephen Karpman modeled what he called the Drama Triangle. With this, he illustrated dysfunctional mindsets that can derail social interactions. The three roles defined in this model are the rescuer (hero), persecutor (villain), and victim. This is another view of the lies we tell ourselves. Since the dawn of history, we’ve loved stories.

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Exsilio debuts with $82M, pitching a ‘leap’ forward for genetic medicine

BioPharma Drive: Drug Pricing

The company claims it can address some of the field’s limitations with medicines delivered via messenger RNA and lipid nanoparticles.

RNA 117
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Tiny bright objects discovered at dawn of universe baffle scientists

Science Daily: Pharmacology News

A recent discovery by NASA's James Webb Space Telescope (JWST) confirmed that luminous, very red objects previously detected in the early universe upend conventional thinking about the origins and evolution of galaxies and their supermassive black holes.

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Cholesterol Med, Fenofibrate, Might Slow Vision Loss in People With Diabetes

Drugs.com

TUESDAY, June 25, 2024 -- A well-established cholesterol-lowering drug appears to significantly slow the progression of a diabetes-related eye disease, a new trial shows. Fenofibrate (Tricor) has been approved since 2004 as a means of lowering.

Trials 111
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Best Practices for Drug Patent Portfolio Management

Drug Patent Watch

Introduction Patent portfolios are critical assets for pharmaceutical companies, providing market exclusivity and protecting revenue streams for drug products. Effective management of drug patent portfolios requires strategic planning, ongoing evaluation, and adaptation to the evolving pharmaceutical landscape. This article explores key best practices for optimizing drug patent portfolios to maximize value and maintain competitive advantage.

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First-of-its-kind Intellia data suggest CRISPR drug could be given more than once

BioPharma Drive: Drug Pricing

The findings provide early proof that multiple doses of a gene editing medicine can be safely administered with additive effects, overcoming a key constraint of the complex therapies.

Therapies 113
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Light-controlled artificial maple seeds could monitor the environment even in hard-to-reach locations

Science Daily: Pharmacology News

Researchers have developed a tiny robot replicating the aerial dance of falling maple seeds. In the future, this robot could be used for real-time environmental monitoring or delivery of small samples even in inaccessible terrain such as deserts, mountains or cliffs, or the open sea. This technology could be a game changer for fields such as search-and-rescue, endangered species studies, or infrastructure monitoring.

Research 124
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Slow-Release Ketamine Pill Eases Depression: Study

Drugs.com

TUESDAY, June 25, 2024 -- A new slow-release pill form of ketamine can quell hard-to-treat depression without producing psychedelic side effects normally associated with the drug, early research suggests. Patients on the strongest dose of ketamine.

Research 111
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Introducing DrugChatter: Revolutionizing Information Access

Drug Patent Watch

DrugChatter is an innovative AI-powered search and answer engine designed to revolutionize how we access and comprehend information. Harnessing the power of advanced natural language processing, DrugChatter provides concise, accurate, and contextually relevant answers to a wide array of questions, making information retrieval faster and more intuitive than ever before.

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2seventy slims down with sale of hemophilia assets to Novo

BioPharma Drive: Drug Pricing

Novo will pay $38 million in cash under the deal, which will also see 2seventy employees working on the program transfer to the Danish drugmaker.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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First case of Down syndrome in Neanderthals documented in new study

Science Daily: Pharmacology News

A new study documents the first case of Down syndrome in Neanderthals and reveals that they were capable of providing altruistic care and support for a vulnerable member of their social group.

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Twice-a-Year Injection Gives Women Full Protection Against HIV, Trial Finds

Drugs.com

MONDAY, June 24, 2024 -- Just two injections a year of a new HIV drug protected young women in Africa from infection with the sexually transmitted disease, new trial results show.In announcing the findings, Gilead Sciences Inc. said its HIV.

Trials 111
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Leveraging 505(b)(2) to Innovate Beyond Existing Drug Patents

Drug Patent Watch

The 505(b)(2) regulatory pathway provides an attractive avenue for drug developers to bring new products to market by leveraging existing data on approved drugs. This pathway allows modifications and improvements to be made to existing drugs, while potentially reducing development costs and timelines compared to the traditional new drug application (NDA) route.

Drugs 105
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Supreme Court overturns Chevron doctrine, limiting reach of federal agencies

BioPharma Drive: Drug Pricing

Federal courts will no longer have to defer to agency regulations for interpretation of ambiguous statutes, a ruling that could have significant impact on the FDA and CMS.

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Microrobot-packed pill shows promise for treating inflammatory bowel disease in mice

Science Daily: Pharmacology News

Engineers have developed a pill that releases microscopic robots, or microrobots, into the colon to treat inflammatory bowel disease (IBD). The experimental treatment, given orally, has shown success in mice. It significantly reduced IBD symptoms and promoted the healing of damaged colon tissue without causing toxic side effects.

Disease 123
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Supreme Court Rejects Purdue Pharma Opioid Settlement

Drugs.com

FRIDAY, June 28, 2024 -- The U.S. Supreme Court on Thursday struck down a controversial settlement that drug maker Purdue Pharma had reached with victims of the opioid epidemic.The ruling threatens a massive bankruptcy plan that would have.

Drugs 105
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What is the market forecast for Ozempic?

Drug Patent Watch

This is an example from the DrugPatentWatch AI Research Assistant, which is available with DrugPatentWatch subscriptions. The DrugPatentWatch AI Research Assistantuses sophisticated AI algorithms to understand and process your questions, delivering precise answers. It goes beyond simple keyword matching, comprehending the intent and context of questions to provide meaningful and relevant responses.

Marketing 102
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How to Configure ServiceNow Catalog Items for Microsoft Search

Perficient: Drug Development

If you are using ServiceNow as your IT service management platform, you might want to make your catalog items searchable in Microsoft Search. Microsoft Search is a unified search experience that helps you find what you need across your organization, including files, sites, people, and more. By connecting your ServiceNow catalog items to Microsoft Search, you can enable your users to find and request them directly from the Microsoft 365 apps.

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Wireless receiver blocks interference for better mobile device performance

Science Daily: Pharmacology News

Researchers developed a new wireless receiver that can block strong interference signals at the earliest opportunity, which could improve the performance of a mobile device.

Research 123
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Combo Drug, Kadcyla, Boosts Survival in Some Women With Early Breast Cancer

Drugs.com

FRIDAY, June 28, 20204 (HealthDay news) -- An immunotherapy/chemotherapy combo drug can help early-stage breast cancer patients remain cancer-free following treatment, a new trial shows. The combo drug, Kadcyla, is already approved to treat.

Drugs 105
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The Double-Edged Sword: Opportunities and Challenges in China’s Patent Litigation System

Drug Patent Watch

Introduction In the rapidly evolving landscape of pharmaceutical patent disputes in China, injunctive relief has emerged as a critical tool for patent holders. This legal remedy, which aims to halt infringement activities swiftly, plays a pivotal role in protecting intellectual property (IP) rights and fostering innovation.

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Chemical Biology and Drug Design

Cover Image © molekuul_be/Shutterstock.

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Creating supranormal hearing in mice

Science Daily: Pharmacology News

A new study has produced supranormal hearing in mice, while also supporting a hypothesis on the cause of hidden hearing loss in people.

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